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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Gizi dan Pangan Jurnal Teknologi Dan Industri Pangan Jurnal Pengolahan Hasil Perikanan Indonesia VALENSI Jurnal Veteriner JURNAL KIMIA SAINS DAN APLIKASI BIOTROPIA - The Southeast Asian Journal of Tropical Biology Current Biochemistry Indonesian Journal of Pharmaceutical Science and Technology Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Media Gizi Indonesia (MGI) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Aplikasi Teknologi Pangan QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Jambura Journal of Chemistry Jurnal Entomologi Indonesia Journal of Telenursing (JOTING) JSMARTech : Journal of Smart Bioprospecting and Technology Indonesian Journal of Applied Research (IJAR) Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society Jurnal Pusat Inovasi Masyarakat Jurnal Sylva Lestari JURNAL AGROINDUSTRI HALAL Jurnal Sosial dan Sains Jurnal Ilmiah Multidisiplin Nusantara Jurnal Veteriner dan Biomedis Journal of Fisheries & Marine Halal Studies and Society Buitenzorg: Journal of Tropical Science
DIMAS ANDRIANTO
Departemen Biokimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor 16680
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Journal : Current Biochemistry

 1 
Phytochemical Analysis, α-glucosidase Inhibition Activity in-vitro and Enzyme Kinetics of Ethyl Acetate and Hexane Extracts of Graptophylum pictum (L.) Griff Waras Nurcholis; I Made Artika; Djarot Sasongko Hami Seno; Dimas Andrianto; Apipah Aprianti; Fina Febrianti; Inawati Inawati; Antonius Padua Ratu; Arya Arendra
Current Biochemistry Vol. 1 No. 2 (2014)
Publisher : IPB University

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Abstract

The species Graptophylum pictum (L.) Griff, also known as “daun ungu” in Indonesia, is a traditional herbaceous plant believed to have antidiabetic potential. The number of people in the world with diabetes has increased dramatically over the recent years. The treatment of type II diabetes is complicated by several factors inherent to the disease. Elevated postprandial hyperglycemia is one of the risk factors and the intestinal digestive enzyme α-glucosidase plays a vital role in carbohydrate metabolism. One of the antidiabetic therapeutic approaches which reduces the postprandial glucose level in blood is by the inhibition of α-glucosidase. In this study, phytochemical analysis, α- glucosidase inhibitory activity and enzyme kinetics of ethyl acetate- and hexane extracts of G. pictum were evaluated with the aim to analyze its antidiabetic potential. Phytochemical analysis revealed the presence of tannins, steroids, and alkaloids. Steroids were present in ethyl acetate extract but absent in hexane extract, while alkaloids were present in hexane extract but absent in ethyl acetate extract. The ethyl acetate and hexane extracts had 30.68 and 49.82 % inhibitory effect on α-glucosidase activity respectively. The kinetics of glucosidase enzyme of ethyl acetate and hexane extracts were determined by Lineweaver Burk plots. These exhibited uncompetitive and noncompetitive inhibition to alpha-glucosidase activity respectively. From the enzyme assay, we infer that ethyl acetate and hexane extracts of G. pictum contain potential α-glucosidase inhibitors that have the potential to be exploited for use in the treatment of diabetes
The Usage of Momordica charantia as Face Cleansing Cosmetics: Momordica charantia Leaves Extract as Absorbent of Heavy Metal, Surface Tension Reducer and Skin Antibacterial Dimas Andrianto; Popi Asri Kurniatin; Silvy Aulya; Dewi Eriyanti
Current Biochemistry Vol. 3 No. 3 (2016)
Publisher : IPB University

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Abstract

Momordica charantia (daun pare in Indonesian) is one of Indonesian herbal plants which useful property has not been explored. M. charantia contains chemical substances such as oil and saponin. Nowadays, the society possesses a high awareness regarding the risk of using artificial chemicals for skin care and more people are switching to use herbal cosmetics. The extract of M. charantiahas been proven to be able to be used as one of the active components of herbal based facial cleansing cosmetics. Its active properties include its ability to absorb heavy metal from air pollution and motor vehicles emission, decrease surface tension, and to act as an antibacterial agent.In the research, M.charantia was extracted using 4 (four) solvents, namely water, ethanol, methanol, and hexane. The research then examined the property of each extract in metal absorption (using Atomic Absorption Spectrophotometry / AAS), decreasing surface tension, and antibacterial activities. The result of the test showed that the water based extract was the most effective extract in reducing surface tension and in inhibiting the development of Escherichia coli and Staphylococcus aureus bacteria, while the ethanol based extract was the most effective one in absorption of Pb and Hg metals and in inhibiting the development of Staphylococcus epidermidis bacteria. The result indicated that M. charantiaextract has the potentials to be used as facial cleanser and can also counter the bacterial infection which could cause acnes.
Perbedaan Penggunaan Metode untuk Produksi Glukosamin dari Limbah Cangkang Bekicot Achatina fulica Siti Maesunah Gilang Maya; Raden Roro Fine Ayu Putri; Aisyah Sahara; Galuh Adhiyaksa Ashari; Abdurrahman Zaky; Dimas Andrianto
Current Biochemistry Vol. 4 No. 1 (2017)
Publisher : IPB University

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Abstract

Osteoarthritis is a degenerative joint disease. This disease occurs when the joint feels painful due to mild inflammation that arises due to activity with the bone of end friction joints. Glucosamine has been proven to stimulate the production of cartilage and inhibit the enzyme that destroys cartilage. Glucosamine which was obtained from the hydrolysis of chitin occurs in a variety of animals such as the shell of crustacea, insects, arthropods, and the shell of molluscs (snail shells). There is a large snail population in Indonesia. Some restaurants and people make use by product snails as food sources. However, this process leaves snail shell as a by product. The high yield of glucosamine produced from snail shells use methods such as reflux+water bath and reflux+magnetic stirrer was 1.47%. Glucosamine hydrochloride was obtained through autoclave at 121 °C and pressure 1 atm for 70 minutes. The presence of chitin, chitosan, glucosamine was confirmed using FTIR spectroscopy. A joint pain ointment was prepared using glucosamine hydrochloride from snail shells concentration at 1 % w/w. Results of this research will be very useful for the reduction of agricultural pests while simultaneously generating a new product that can lift the economic value of snail shells. Keywords: Chitin, Chitosan, Glucosamine, Osteoarthritis, Snail Shells
Antibiotic-Resistant-Bacterial Infection of Diabetes Mellitus-Induced Ulcers: A Narrative Review on a Healing Ointment Jaka Aryantara Kuntala; Mutmainnah Agustiawan Umar; Qurrotu Ayni; Dimas Andrianto
Current Biochemistry Vol. 7 No. 2 (2020)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.7.2.4

Abstract

Gangrene is the main reason why diabetes mellitus patient’s leg amputation should be done. Natural compounds which are contained in coffee grounds extract can actually act as antibacterial substances by inhibiting the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) that resistant to several antibiotics. Coffee grounds become waste caused by people are underusing this material and the high production level of coffee grounds in Indonesia. The purpose of this study was to examine the content of antimicrobial compounds from coffee grounds that can heal wounds caused by diabetes mellitus and to create a formulation of coffee ground based ointment for diabetes mellitus wound healing. Methods used in this research are narrative review from literatures, normality test, and T-test. The conclusion of this narrative review, natural compounds such a trigonelline, caffeine, and chlorogenic acid found in coffee grounds are capable of MRSA growth inhibition at concentration 44%. Coffee grounds based ointment with 1% (w/w) of ointment preparation is expected to reduce coffee grounds waste by developing new product as diabetes mellitus wound healer.
A Novel Plaster Dressing: A Combination of Chicken Eggshell Hydrogel Plus Button-Fungus Extract Enhances Wound Healing in Diabetic Patients Rafiqi, Akbar; Nabilatusyifa, Alivianisa; Putri, Oyi Candra Santoso; Hasanah, Ikromatul; Rahmah, Sabrina Firdayani; Andrianto, Dimas
Current Biochemistry Vol. 10 No. 2 (2023)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.10.2.1

Abstract

Diabetic patients are susceptible to severe wound conditions due to high blood sugar levels and bacterial infections. This study aims to determine the formulation and effectiveness of the hydrogel plaster combination of laying hen eggshells with button mushrooms in curing diabetic wounds. The research methods consisted of making the hydrogel, coagulation test, and antibacterial tests. Hydrogels were made with 5%, 10%, and 20% eggshell concentrations. The coagulation activity test used rabbit blood, which was added with glucose. Antibacterial test was performed using Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). This research shows that the coagulation activity of F2 and F3 formulations significantly differed from the control, with an average blood clotting time of 64.67 minutes and 63.00 minutes. The antibacterial test results produced a clear zone for S. aureus and E. coli with diameters of 10.27 mm and 9.18 mm for F2, 6.90 mm, and 11.66 mm for F3. This research concludes that hydrogel formulation 3, with 20% eggshell and 6.4% button mushroom, had the best blood clotting effect and antibacterial activity.
Phytochemical and Organoleptic Tests of Combined Extracts of Turmeric, Black Tea, and Ginger Rosyidah, Rara Annisaur; Andrianto, Dimas
Current Biochemistry Vol. 11 No. 1 (2024)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.11.1.4

Abstract

Phytochemical screening to conduct a preliminary evaluation of the chemical content of black tea (Camellia sinensis), Turmeric (Curcuma longa), and Ginger (Zingiber officinale). In addition, the content of secondary metabolites in black tea, turmeric and ginger can be used as an indication of the quality of these plants. the need for a combination of black tea extract act, turmeric, and ginger from various people so that it can be liked by the public. This study aims to test the phytochemical extracts of black tea, turmeric, and ginger as well as organoleptic tests on the most optimum combination of -glucosidase enzyme inhibitory activity. Phytochemical screening showed that black tea and ginger extract contains alkaloids, flavonoids, tannins, saponins, terpenoids, quinones, glycosides, and phenolics, while turmeric extract contains alkaloids, flavonoids, tannins, terpenoids, quinones, glycosides, and phenolics. The organoleptic test of the F7 combination consisting of a combination of black tea extract, turmeric, and ginger showed the highest level of preference by P3 and P2 on color, aroma, consistency, and aftertaste, while taste was at P3.
Combination of Pulai Leaf (Alstonia scholaris (L.) R. Br.) and Papaya Leaf (Carica papaya L.) Water Extract as HMG-CoA Reductase Inhibitor Sulistiyani; Andrianto, Dimas; Mariati, Sri
Current Biochemistry Vol. 11 No. 1 (2024)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.11.1.3

Abstract

Heart disease has become the leading cause of death in the world in the last 15 years. This disease has several primary risk factors, one of which is hypercholesterolemia. Cholesterol biosynthesis in the liver is influenced by the activity of the rate-limiting enzyme, HMG-CoA reductase. Traditional herbal medicine provides alternative treatment for hypercholesterolemia. Both pulai and papaya leaves were reported as HMG-CoA reductase inhibitors. There has been very limited study however, on the efficacy of a mixture of aqueous extracts of the two in inhibiting HMG-CoA reductase. This study aims to determine the activity of a mixture of water extracts of both pulai and papaya leaves. The activity of the enzyme HMG-CoA reductase was measured by Abcam® kit No. Ab204701 by spectrophotometric method at 334 nm. The results showed that the three extracts of the combination of pulai and papaya leaves had four times better inhibitory action than the single extract (p0.05). The results of the phytochemical literature study showed that the aqueous extract contained flavonoids, alkaloids, tannins, and saponins
Co-Authors Abdjad Asih Nawangsih Abdul Aziz Abdurrahman Zaky Achyar, Catellia Auliany Agus Setiyono Ahmad Faqih Aisyah Sahara Akhmad Endang Zainal Hasan Al Malik, Ahmad Fauzan Aldri Frinaldi Alexandra, Angelya Cintania Amrista Fanzani Kananga Anja Meryandini Antonius Padua Ratu Apipah Aprianti Arya Arendra Assa’addah, Habibah Aulya, Silvy Ayu Tri Nursyarah Azizah, Annisa Nur Wahida Bella Fatima Dora Zaelani Dadan Rohdiana Daeli, Gavriel Allenfar Danty Oktiana Prastiwi Dara Anggun Vachyra Dasman Lanin Dea Khalissa Anidya Destiandani, Khansa Dewi Eriyanti Dewi Kurniasih Dewi Purnamasari Djarot Sasongko Hami Seno Dwicesaria, Maheswari Alfira Eka Wahyu Purnama Elgiani Yassifa Yulia Nur Insari Emidar Khusnu Eny Ida Riyanti Eriyanti, Dewi Etik Mardliyati, Etik Eva Harlina Fahmi Hafid Faisal Rahman Falah, Samsul Febrina, Adella Fina Febrianti Firdaus, Dzikri Anfasa Firdaus, Muhamad Fajar Firmansyah, Muhammad Ade Fitrilia, Tiana Galuh Adhiyaksa Ashari Ghifari, Muhammad Nabil Gholam, Gusnia Meilin Gina Oktaviani Sabrina Hanifati, Qisthina Hardinsyah Hasanah, Ikromatul Hasim - HASIM DANURI Hasim Hasim Hazim, Naufal Wildan Heddy Julistiono Heddy Julistiono Hudayanti, Martini Husnawati, . I MADE ARTIKA Ike Agustiani Ilham Gilang Cahya Ahmada Iman, Ramadhan Nur Imelia Dewi Inawati Inawati Iqrima Basri Irfan Abdul Aziz Irsal, Riyan Alifbi Putera Istikorini, Yunik Jaka Aryantara Kuntala Kusnaedi, Anggi LAKSMI AMBARSARI Latifah Kosim Darusman Latifah, Aminahtun Lestari, Ella Deffi Lukman, Zulfiqar Madyastuti, Rini Marfiana, Arila Safa Maria Bintang Mega Safithri Mhd. Ridha Muhamad Alvin Adriyan Muhammad Farhan Muhammad Irfansyah Pradika Muhammad Zulkifli Mutholaah Mutmainnah Agustiawan Umar Nabilatusyifa, Alivianisa Nabilla, Rahmah Najmah, Najmah Nayanda, Najwa Putri Nina Tri Kusumawati Noor Farikhah Haneda Noviyan Darmawan Nurliani Bermawie Nusyarah, Ayu Tri Olive Wisepti Pratama Prasetyo, Dwiandra Hadi Purwanto, Ukhradiya Magharaniq Safira Putri, Oyi Candra Santoso Putri, Salsabila Yasmin Budi Qolbiyah, Syifa Ainul Qomariah Hasanah Qurrotu Ayni R. Haryo Bimo Setiarto, R. Haryo Bimo Raden Roro Fine Ayu Putri Rafiqi, Akbar Rahmah, Sabrina Firdayani Raisyadikara, Fadila Rara Annisaur Rosyidah Rembrandt Rimbawan Rimbawan Rini Kurniasih, Rini Riska Susila Putri Rosyidah, Rara Annisaur Sanro Tachibana Sari, Sintia Permata Sigiro, Ria Heni Silvy Aulya Sitanggang, Rianta Faustina Siti Maesunah Gilang Maya Slamet Hamzah Sobari, M Hilmy Rifq Sri Anna Marliyati Sri Mariati Sri Wahyuni Suci Hermita Sulistiyani Sulistiyani Sulistiyani SULISTIYANI SULISTIYANI Syaefudin Syaefudin Syaefudin Syamsul Falah Syarthibi, Ahmad Syifa Khaerani Tukan, Maria Magdalena Nona Motu Ukhradiya Magharaniq Safira Purwanto Ulfah Juniarti Siregar Vina Oktovianti Walidayyin, Sekar Wangi Waras Nurcholis Wilujeng, Retno Winata, Grace Marlina Yudono, Nur Annisa Windi Yupi Yulianita Arifin Yusriya, Rifqi Zaelani, Bella Fatima Dora Zulfikar Muchammad