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All Journal International Journal of Public Health Science (IJPHS) Jurnal Kesehatan Lingkungan indonesia Althea Medical Journal Journal of Biomedicine and Translational Research Elkawnie The Indonesian Journal of Public Health The Indonesian Journal of Occupational Safety and Health Jurnal Penelitian Kesehatan Suara Forikes Health Notions Journal Of Vocational Health Studies 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Journal of Community Empowerment for Health Media Gizi Kesmas International Journal Of Science, Technology & Management (IJSTM) Diversity: Disease Preventive of Research Integrity Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat AloHA International Journal of Health Advancement (AIJHA) Moluccas Health Journal An Idea Health Journal Global Health Science (GHS) Aloha International Journal of Multidisciplinary Advancement (AIJMU) JUMANTIK (Scientific Journal of Health research) Jurnal Sains dan Kesehatan Kegiatan Positif : Jurnal Hasil Karya Pengabdian Masyarakat Medical Laboratory Journal Jurnal Pengabdian Kepada Masyarakat Radisi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) Jurnal Kesehatan Maluku Husada
Sahrir Sillehu
STIKes Maluku Husada
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Other

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Literature Review: Pengaruh Enzim ALDH2 dalam Detoksifikasi Alkohol terhadap Sirosis Hati Anindia Istifara; Abdul Rohim Tualeka; Sahrir Sillehu
Media Gizi Kesmas Vol 12 No 2 (2023): MEDIA GIZI KESMAS (DECEMBER 2023)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgk.v12i2.2023.1125-1132

Abstract

Background: Ethyl alcohol or also known as ethanol is organic compound and one of the active substances that is often abused by human. Currently alcohol misuse yhat cause health problems become a global issue. Alcohol has toxic effect to the body. Some disease caused by alcohol consumption such as alcoholic liver disease. The liver as main organ in the binding of chemical substances (detoxification) will occur fatty liver, cirrhosis, or even liver function damage if alcohol level that accumulate in the liver is excessive. Objectives: The purpose of the study is to analyzed the effect of ALDH2 enzyme on alcohol detoxification process in alcoholics. Methods: This research study used literature review method on previous studies with similar topic. The articles were obtained from Google Scholar, Science Direct, and PubMed that published in 2013-2023 by applying inclusion and exclusion criteria so the article that fulfilled criteria could be analyzed. Results: The result of the literature review from 5 articles showed that the ALDH2 enzyme had a role in alcohol detoxification process. This enzyme was inhibitor for the rate of acetaldehyde metabolism which had cytotoxic and carcinogenics effect. Excessive amount of alcohol, especially with ALDH2 defficiency caused accumulation of acetaldehyde in human body that could increase the risk of liver cirrhosis Conclusions: ALDH2 levels in human body have an influence on the occurrence of liver cirrhosis in alcoholic.
Uji Efektivitas Antibakteri Dengan Perbedaan Konsentrasi Ekstrak Tinta Cumi-Cumi (Loligo Sp) dan Ekstrak Rumput Laut (Eucheuma cottonii) Pada Perairan Desa Buano Terhadap Bakteri Streptococcus mutans Penyebab Karies Gigi Lukman La Basy; Epi Dusra; Muhammad Azril Hardiman Mahulauw; Sahrir Sillehu; Siti Rahmawaty Tombalissa
Calory Journal Medical Laboratory Journal Vol. 1 No. 4 (2023): December : Medical Laboratory Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/caloryjournal.v1i4.47

Abstract

Squid ink and seaweed have the potential to be utilized as medicines, one of which is as an antibacterial medicinal material. because it contains secondary metabolite compounds that can inhibit the growth of Streptococcus Mutans bacteria. This type of research is a laboratory experiment with the method used, namely maceration for phytochemical screening tests and agar diffusion for antibacterial effectiveness tests with concentrations used in squid ink (Loligo sp) namely 5%, 10%, 15% 20% and in seaweed (Eucheuma cottonii) 1%, 5%, 10%, 15%. The results of the research conducted on phytochemical screening tests contained secondary metabolite compounds in squid ink (Loligo sp) triterpenoids, steroids and seaweed (Eucheuma cottonii) alkaloids, flavonoids, hodroquinone phenols, and tannins. From the research conducted on the antibacterial effectiveness test of squid ink (Loligo sp) and seaweed (Eucheuma cottonii) extracts against Streptococcus mutans bacteria, namely in both samples have the effectiveness in inhibiting Streptococcus mutans bacteria, with a high inhibition of squid ink concentration of 20% by 20.5 mm, and in seaweed concentration of 15% by 23 mm. The analysis used is spss using two tests, namely the shapiro wilk test and the mann whitney test. The conclusion of the mann-whitney test results with a p-value = 0.663 indicates there is no significant difference between squid ink extract (Loligo sp) and seaweed extract (Eucheuma cottonii).
Pengetahuan Diet Hipertensi dengan Kekambuhan Hipertensi ada Lansia di Wilayah Kerja Puskesmas Haun Abd Basir; Sahrir Sillehu
JURNAL KESEHATAN MALUKU HUSADA Vol 3, No 2 (2025): JULI-DESEMBER 2025
Publisher : STIKes Maluku Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/jkmh3201

Abstract

Latar Belakang : Hipertensi adalah masalah kesehatan akibat dari proses degenerative yang diakibatkan karena penurunan fungsi kerja pembuluh darah terutama terjadi pada lansia. Tujuan : untuk mengetahui hubungan pengetahuan diet hipertensi dengan kekambuhan hipertensi pada lansia. Metode : Penelitian ini menggunakan metode deskriptif korelasional, Populasi dalam penelitian ini sejumlah 30 pasien lansia besar sampel yang digunakan sejumlah 30 responden. Teknik sampling yang digunakan adalah total sampling. Uji statistic yang digunakan dalam penelitian ini adalah chi-square α < 0,05. Hasil : Berdasarkan hasil uji statistic chi-square diperoleh nilai p = 0,002 yang berarti lebih kecil dari nilai α < 0,05, dengan demikian Ha diterima dan Ho ditolak hal ini menunjukan bahwa ada hubungan pengetahuan diet hipertensi dengan kekambuhan hipertensi pada lansia di Puskesmas Nania Ambon. Kesimpulan : didapatkan ada hubungan pengetahuan diet hipertensi dengan kekambuhan hipertensi pada lansia di Puskesmas Nania Ambon
Peran BST-2 (Bone Marrow Stromal Antigen-2) terhadap Infeksi HIV Isak Roberth Akollo; Vernando Yanry Lameky; Sahrir Sillehu; Syulce Luselya Tubalawony
MOLUCCAS HEALTH JOURNAL Vol. 7 No. 2 (2025): Agustus
Publisher : Lembaga Penerbitan Fakultas Kesehatan Universitas Kristen Indonesia Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54639/mhj.v7i2.1610

Abstract

Infeksi Human Immunodeficiency Virus (HIV) merupakan masalah kesehatan global yang menyebabkan melemahnya sistem imun dan berkembang menjadi Acquired Immunodeficiency Syndrome (AIDS). Dalam merespons infeksi HIV, tubuh manusia mengaktifkan berbagai faktor pertahanan intraseluler, salah satunya adalah Bone Marrow Stromal Antigen 2 (BST-2), yang juga dikenal sebagai tetherin, CD317, atau HM1.24. BST-2 merupakan protein transmembran yang berfungsi sebagai faktor restriksi host terhadap virus envelop, termasuk HIV. Artikel ini merupakan kajian literatur yang bertujuan untuk menelaah secara mendalam peran BST-2 terhadap infeksi HIV. Hasil telaah dari tujuh artikel penelitian eksperimen menunjukkan bahwa BST-2 memiliki peran penting dalam menghambat pelepasan virion HIV dari sel inang, menurunkan infektivitas HIV, mencegah penyebaran HIV secara langsung antar sel, aktivasi antibody-dependent cellular cytotoxicity (ADCC), dan aktivasi respon inflamasi.
Hubungan antara Aktivitas Fisik Kebiasaan Merokok dengan Tingkat Hipertensi pada Lansia Abd Rijali Lapodi; Sahrir Sillehu; Herlien Sinay; Narwan Majida
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 9, No 2 (2024)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/jumantik.v9i2.17586

Abstract

AbstractHypertension is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg on two measurements with an interval of five minutes in a state of sufficient rest/quiet. Elderly is part of the final stage of development in the human life cycle. The purpose of this study was to determine the relationship between physical activity and smoking habits with the incidence of hypertension in the elderly in the elderly posyandu, Batu Merah village, the work area of the Air Besar Health Center, Ambon City. The type of research used is quantitative with a descriptive analytical research design with a cross-sectional study method, the sampling technique was carried out using a purposive sampling technique whit predetermined criteria. The total population in this study were all elderly people in the elderly posyandu in Batu Merah village, the working area of the Air Besar Public Health Center and a sample of 102 respondent. Data analysis using Spearman Rho test. Based on the results of the study, physical activity was obtained with p value = 0.000 < 0.05, and smoking habits with p value = 0.000 < 0.05. The conclusion of this study shows that there is a relationship between physical activity and the incidence of hypertension in the elderly at the village health post in Batu Merah, the work area of the Air Besar Public Health Center and there is a relationship between smoking habits and the incidence of hypertension in the elderly at the Posyandu for the elderly in Batu Merah Village, the working area of the Air Besar Public Health Center City Ambon.Keywords: Hypertension, Physical Activity, Smoking Habit, Elderly
Evaluasi Kepuasan Pelayanan Kesehatan Berdasarkan Indeks Kepuasan Masyarakat (IKM) di Puskesmas Sanggeng Hans Sammy Marthin Salakory; Febby Sonya Matulessy; Sahrir Sillehu
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 9, No 2 (2024)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/jumantik.v9i2.20904

Abstract

Public services are activities that benefit the community organised by the government, these activities are communal and have an impact on the satisfaction of service recipients. Puskesmas as one of the public service units is not always able to provide maximum satisfaction for the community, which in turn will have an impact on community dissatisfaction. In its activities, the Sanggeng Community Health Centre as a public service provider institution has not been able to provide excellent service to the community, causing many complaints from the community, especially regarding the attitude of officers who are less friendly, long in serving patients, and the cleanliness of the puskesamas that are less clean. This research was conducted with the aim of finding out the level of community satisfaction with services at the Sanggeng health centre. To answer the research problem, a quantitative descriptive method was used with the Community Satisfaction Index (CSI) analysis tool. The survey results show that the Sanggeng Health Centre received an CSI score of 77 with a quality score of B and good service performance. The service indicator with the highest CSI value is Facilities and infrastructure of 89 with a very good quality number (A), the indicator with the lowest CSI value is Service Time of 68 with a quality number C and service performance is not good. The other two indicators with Poor CSI are the first System, Mechanism, and Procedure, the CSI Value is 75. Second, Executor Behaviour, the CSI score is 76.
Co-Authors Abd. Rijali Lapodi Abdul Rohim Tualeka Abu Khoiri Acob, Joel Rey U Acob, Joel Rey U. Agung Dwi Laksono Agustina, Agustina Akollo, Isak Roberth Alan Pattilouw Angga Delima Sari Anindia Istifara Aprilia, Annisa Nadya Apriliawati, Anita Apriliawati, Anita Arief Budiono Ascobat Gani Atik Badiah Bagus Wicaksono Bambang Hadi Sugito Catur Prasastia Dewi Lukita Cici Nila Ardila Destanul Aulia, Destanul Dewi Kartika Eka Mishbahatul Mar'ah Has Eka Safitri Sillehu Endah Fitriasari Epi Dusra Erlin Kiriwenno Erma Sulistyaningsih Erma Sulistyaningsih Erma Sulistyaningsih Ernawati, Meirina Evi Irianti Fatima Tatroman Febby Sonya Matulessy Ferrina, Lucy Frisca P.A Wattimena Hans Sammy Marthin Salakory Hariyanto, Rohadi Hasna Tunny Haun Abd Basir Heny Arwati Herlien Sinay Herlien Sinay Heru Santoso Wahito Nugroho Hidayati, Syariefah Huwae, Lourenz Simon I Putu Suiraoka Ibrahim, Ilyas ilyas - ibrahim Ilyas Ibrahim Indah Susanti Indarwati , Retno Indriati Paskarini Ira Fanty Wakan Ira Sandi Tunny Irawan Fajar Kusuma Irawan Fajar Kusuma Irawan Fajar Kusuma Iswandi Fataruba Joel Rey U. Acob Joel Rey U. Acob Joel Rey Ugsang Acob Joina Stella Ruhulessin Ketut Ima Ismara Koekoeh Hardjito Kristoforus, Josefus Lameky, Vernando Yanry Lapodi, Abd Rijali Lating, Zulfikar Lestari & Catur Prasatia, Indah Lukman La Basy M Dahlan Sely Made Yenny Puspitarini Makayaino, Hafis Manik, Hubban Fathani Mariene Wiwin Dolang Maryam Lihi Maryam Lihi Maryam Lihi Maryam Lihi, Maryam Mohammad Dahlan Sely Muhammad Aji Satria Muhammad Azril Hardiman Mahulauw Muhammad Rakib Latuconsina Nafiah, Nilam Cahya Narwan Majida Ni Made Parwati Noer Saudah Nur Aini Nur Laili Khumaidah Nurfadila Tutupoho Nyoman Anita Damayanti Pius Selasa Ratna Dwi Wulandari Ratna Wulandari Resy Metri Belizani Revita Savitri Sebe Rohadi Hariyanto Rosita Dewi Rosita Dewi Rosita Dewi Sanglar Polnok Sartika Maya Sary Sumanjaya Satriya Wijaya Setiawan Setya Haksama Sheena Ramadhia Asmara Dhani Sheilla Rachmania, Sheilla Siti Rahmawaty Tombalissa Siti Rochmaeda Siti Rochmaedah Soulissa, Fathmy F Sudjajadi Keman Sunarto, Sunarto Sunik Cahyawati Sunik Cahyawati Sunik Cahyawati Suparji Suparji Suparji Suparji Syariefah Hidayati Syariefah Hidayati Waliulu Syulce Luselya Tubalawony Taufan Umasugi Tina Amnah Ningsih Tunny, Ira Sandi Tunny, Rahma Umasugi, Muhammad Taufan Utami, Tri Niswati Vernando Yanry Lameky Victor E. D Palapessy Windarti Rumaolat Wiwi Rumaolat Wiwin Martiningsih Yerry Soumokil Yoes Prijatna Dachlan Yustinus Denny Ardyanto Wahyudiono