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Hidayati, Agriana Rosmalina
Fakultas Kedokteran Universitas Mataram
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Antibacterial Testing of Moringa oleifera L. Fruit Extract Against The Growth of The Bacteria Staphylococcus aureus Anisa Febriani; Agriana Rosmalina Hidayati; Dewi Suryani
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.6149

Abstract

Staphylococcus aureus is one of the pathogenic bacteria that causes infectious diseases in humans. Controlling infections caused by pathogenic bacteria can be done by developing new antibacterial agents derived from natural plant-based medicines. Moringa oleifera L is a medicinal plant used in traditional medicine and has antibacterial activity. This study aims to determine the secondary metabolites content and antibacterial activity of Moringa fruit extract against the growth of Staphylococcus aureus bacteria. Moringa fruit simplicia was dechlorophyllated using n-hexane, then extracted using the sonication method with 70% ethanol solvent. The results of the phytochemical screening were that the ethanol extract of Moringa fruit contained flavonoid, tannin and saponin compounds. The diameter of the inhibition zone at concentrations of 25%, 50% and 75% were 1.17 mm, 2.00 and 6.00 mm respectively. Based on the description above, it can be concluded that Moringa fruit extract has the potential to be an antibacterial agent.
Antibacterial Activity of Metanol Extract and n-Butanol Fraction of Euphorbia milii Leaves Against Staphylococcus aureus Dia Ul Aulia; Agriana Rosmalina Hidayati; Dewi Suryani
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.6154

Abstract

Euphorbia milii is a common garden plant and its leaves have antibacterial activity, due to the presence of saponins, flavonoids, and tannins. As there is an increasing antibiotic resistance to Staphylococcus aureus, there is potential for E. milii as a new antibacterial candidate. The purpose of this study was to determine secondary metabolites of saponins, flavonoids, tannins and to determine the antibacterial activity of E. milii leaves in inhibiting the growth of Staphylococcus aureus (in vitro). Simplisia was extracted by sonication method, then fractionated with a separatory funnel. Extracts and fractions were analyzed qualitatively by tube test and thin layer chromatograpy (TLC). The antibacterial activity of methanol extract (320; 160; and 80 mg/ml) and n-butanol fraction (32; 16; and 8 mg/ml) was tested by disc diffusion method. The results of qualitative test showed that the extracts and fractions were positive for saponins, flavonoids, and tannins.  In antibacterial test, extract at a concentration of 320 mg/ml was able to inhibit bacterial growth with moderate activity category (6.5 mm). Extracts at 160 mg/ml and 80 mg/ml, as well as n-butanol fractions at all concentration showed weak antibacterial activity (<5 mm). Theseresult suggest that the extracts and fractions positively contain metabolites of saponins, flavonoids, and tannins. The extracts and fractions were able to inhibit the growth of staphylococcus aureus, but the activity was not greater than the positive control.
In Silico Analgesic and Toxicity Analysis of Modified Paracetamol on COX-2 Receptor (PDB ID: 3LN1) Hidayah, Nurul; Lina Permatasari; Agriana Rosmalina Hidayati; Handa Muliasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.312-324

Abstract

Background: Paracetamol is often used as the main analgesic in Indonesia. The use of more than 4 g/day or a single dose above 10 g can cause hepatotoxicity. This can be overcome by modifying the structure through a computer-aided drug design (CADD) approach, particularly molecular docking, which aims to produce compounds with greater potency and fewer side effects. Objective: This study aimed to determine the analgesic activity and toxicity of paracetamol derivatives modified using the Topliss method. Methods: Analgesic activity was tested by molecular docking of the COX-2 receptor (PDB ID 3LN1) using AutoDock Tool 4.2 and toxicity testing using pkCSM and Protox Online Tool. Results: The results of docking showed that the free binding energy values ​​for test compounds 1 to 5 are -10.59 kcal/mol, -10.17 kcal/mol, -8.79 kcal/mol, -10.01 kcal/mol, and -9.32 kcal/mol, respectively, with corresponding inhibition constants of 17.29 nM, 35.21 nM, 360.88 nM, 46.36 nM, and 146.65 nM. These values are lower than paracetamol, which has a free binding energy of -6.21 kcal/mol and an inhibition constant of 28,043 nM. The results showed that the test compound was more stable in ligand-receptor binding. Toxicity tests showed that all the test compounds and paracetamol belonged to toxicity class IV. The test compound had an LD50 value of 1551 mg/kg, which was higher than that of paracetamol (338 mg/kg), indicating better effectiveness. Conclusions: Compound 2 was predicted to have the best biological activity and potential as an alternative to paracetamol.
Pelatihan Pembuatan Sabun Dari Minyak Jelantah Pada Kader PKK Di Desa Bengkaung Hanifa, Nisa Isneni; Hidayati, Agriana Rosmalina; Mukhlishah, Neneng Rachmalia Izzatul; Subaidah, Windah Anugrah; Purnomo, Indra; Bayani, Faizul
Jurnal Pengabdian Magister Pendidikan IPA Vol 7 No 4 (2024): Oktober-Desember 2024
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v7i4.9588

Abstract

The repeated use of cooking oil more than twice is still common in Indonesian society. However, used cooking oil can negatively affect health, being even more detrimental than saturated fatty acids. Additionally, it contributes to pollution in soil and water. One effective method for repurposing used cooking oil is by converting it into soap. This community service initiative aims to promote the utilization of used cooking oil in economically valuable products while reducing the amount of waste oil that is discarded into the environment. The training was conducted for PKK cadres in Bengkaung Village and facilitated by pharmacists, dermatologists, and students from the Faculty of Medicine and Health Sciences at the University of Mataram. The soap-making process begins by adding charcoal to the used cooking oil for 72 hours. This step helps remove hazardous substances and unpleasant odors. Afterward, the oil is filtered and combined with essential soap-making ingredients, including sunflower oil, virgin coconut oil (VCO), olive oil, sodium hydroxide (NaOH), and water. NaOH is critical for the saponification process, which transforms the oil into soap. To enhance the aesthetic value and benefits of the soap, ingredients like honey, yogurt, or natural dyes such as butterfly pea flowers can be incorporated. The mixture is then poured into molds and allowed to harden. Given the simple process and the ease of obtaining the necessary tools and materials, the PKK cadres in Bengkaung Village have shown enthusiasm for making soap from used cooking oil. This activity is expected to broaden their knowledge and provide business opportunities to help increase family income in the village.
STANDARDISASI PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETIL ASETAT DAUN KEDONDONG (SPONDIAS DULCIS) zahra, nisrina; Mukhlishah, Neneng Rachmalia Izzatul; Hidayati, Agriana Rosmalina
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.40091

Abstract

Tanaman kedondong (Spondias dulcis) merupakan tanaman yang dapat digunakan sebagai bahan baku obat. Tanaman ini secara empiris digunakan oleh masyarakat Desa Kembang Paseban Kecamatan Mersam Kabupaten Batanghari Provinsi Jambi sebagai obat barut (obat tempel melahirkan). Aktivitas farmakologi ekstrak etil asetat daun kedondong yaitu sebagai antidiabetes dan antioksidan. Sebagai bahan baku sediaan OHT, ekstrak etil asetat daun kedondong perlu distandardisasi agar sediaan OHT terjamin mutu dan keamanannya. Penelitian ini bertujuan untuk mengetahui kesesuaian mutu ekstrak etil asetat daun kedondong dengan melakukan standardisasi berdasarkan Farmakope Herbal Indonesia edisi II dan Materia Medika Indonesia. Daun kedondong diekstraksi dengan metode sonikasi pada suhu 35°C selama 30 menit. Hasil standardisasi parameter spesifik menunjukkan identitas tanaman merupakan tanaman kedondong, organoleptik ekstrak yaitu kental, bewarna hitam kehijauan, rasa pahit, berbau aromatik, dengan kandungan senyawa larut air sebesar 2,0% dan senyawa larut etanol sebesar 11,91%. Hasil uji parameter non spesifik menunjukkan kadar susut pengeringan sebesar 2,94%; bobot jenis 0,98370 g/mL; kadar air 4,49%; kadar abu total 0,2%; kadar abu larut air 0,007%; kadar abu tidak larut asam 0,1%; sisa pelarut 1,0018 g/mL;  kadar logam Pb 1,70 ppm; ALT & AKK tidak dapat dihitung. Pada penetapan angka lempeng total dan penetapan angka kapang khamir tidak dapat diuji. Berdasarkan pengujian standardisasi ekstrak etil asetat daun kedondong memenuhi standar ekstrak secara umum dan dapat dikembangkan menjadi obat herbal terstandar (OHT).
STANDARDISASI PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETANOL ANGGUR LAUT (CAULERPA LENTILLIFERA) Indriani, Zulfia Ika; Hidayati, Agriana Rosmalina; Mukhlishah, Neneng Rachmalia Izzatul
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.42413

Abstract

Anggur laut (Caulerpa lentillifera) banyak dimanfaatkan oleh masyarakat sebagai bahan makanan dan secara empiris digunakan untuk pengobatan diabetes. C. lentillifera memiliki kandungan metabolit sekunder dan berbagai kandungan nutrisi serta aktivitas farmakologi yang meliputi antioksidan, antipiretik, antikanker, antiinflamasi, antikoagulan, dan antidiabetes sehingga dapat dikembangkan menjadi bahan baku obat herbal terstandar (OHT). Berdasarkan hal tersebut perlu dilakukan standardisasi untuk memenuhi persyaratan sebagai bahan baku terstandar untuk OHT. Penelitian ini bertujuan untuk menentukan nilai standar parameter spesifik dan non spesifik ekstrak etanol anggur laut. Penentuan nilai tersebut dilakukan berdasarkan pemeriksaan uji parameter spesifik dan non spesifik. Hasil uji parameter spesifik pada uji organoleptis diperoleh ekstrak berbentuk kental; berwarna hijau tua pekat; bau khas laut dan memiliki rasa asin. Ekstrak mengandung flavonoid, fenolik, saponin, dan tanin. Kandungan senyawa larut air sebesar 19,27% dan senyawa larut etanol 8,54%. Sedangkan hasil uji parameter non spesifik pada penetapan susut pengeringan sebesar 9,20%, kadar air 10,84%, susut pengeringan sebesar 9,20%, bobot jenis sebesar 1,02 g/mL dan sisa pelarut sebesar 0,80%. Pada pemeriksaan kadar abu total diperoleh sebesar 39,54%; kadar abu larut air 38,04%; kadar abu tidak larut asam 3,68%; kadar logam Pb <0,001 ppm; kadar logam Hg <0,001 ppb. Nilai ALT sebesar 1,5x 102 dan nilai AKK sebesar 3,46 x102. Berdasarkan hasil data parameter spesifik dan non spesifik ekstrak etanol anggur laut sudah memenuhi syarat standar secara umum sehingga data tersebut dapat dijadikan acuan penelitian selanjutnya untuk pengembangan OHT.
Artikel Review : Potensi Ashitaba (Angelica keiskei) sebagai Alternatif Terapi di Bidang Dermatologi Anindiya, Naya Wahyu; Hidajat, Dedianto; Hidayati, Agriana Rosmalina
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.30595

Abstract

Ashitaba ( Angelica keiskei ) merupakan tanaman asal Jepang yang telah banyak dibudidayakan di Indonesia. Penelitian tentang ashitaba sudah banyak berkembang dalam bidang dermatologi sehingga tinjauan pustaka ini bertujuan untuk melihat perkembangan potensi ashitaba sebagai terapi alternatif di bidang dermatologi. Metode penelusuran artikel yang digunakan yaitu penelusuran artikel ilmiah melalui database seperti Google Scholar, ResearchGate dan Proquest dalam rentang waktu 2014-2024. Hasil tinjauan pustaka menunjukkan ashitaba berpotensi menjadi pengobatan alternatif dalam bidang dermatologi karena mengandung bioaktif yang memiliki aktivitas antibakteri, antiinflamasi, antioksidan, menghambat enzim tirosinase dan mengurangi ukuran tumor melanoma. Namun, penelitian lebih lanjut secara in vivo diperlukan untuk terapi jerawat vulgaris, serta uji klinis pada manusia untuk terapi penyembuhan luka, penuaan dini, hiperpigmentasi, dan melanoma.
KARAKTERISTIK PENGETAHUAN, SIKAP DAN PERILAKU MAHASISWA PENDERITA AKNE VULGARIS DI UNIVERSITAS MATARAM TERHADAP PENYAKIT DAN PENGOBATAN Prianggawe, Prianggawe; Andanalusia, Mahacita; Hidajat, Dedianto; Hidayati, Agriana Rosmalina; Hanifa, Nisa Isneni; Hajrin, Wahida
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49895

Abstract

Penelitian ini mengkaji pengetahuan, sikap, dan perilaku mahasiswa di Universitas Mataram terhadapAV yaitu suatu kondisi kulit inflamasi kronis yang umum disebabkan oleh Cutibacterium acnes danStaphylococcus epidermidis. Kondisi ini banyak ditemukan pada remaja akhir dan dewasa muda berusia 18-25tahun yang sebagian besar adalah mahasiswa. Tujuan penelitian ini yaitu mengetahui karakteristik pengetahuan,sikap dan perilaku mahasiswa penderita AV terhadap penyakit dan pengobatan. Metode penelitian inimenggunakan desain deskriptif dengan pendekatan cross-sectional yang melibatkan 81 responden yang dipilihdengan metode purposive sampling. Teknik pengambilan data dikumpulkan menggunakan kuesioner dandianalisis secara deskriptif. Data disajikan dalam bentuk tabel untuk memvisualisasikan persebaran jawaban.Hasil penelitian menunjukan sebagian besar responden memiliki pengetahuan baik (81,4%), sikap yang positif(100%) dan perilaku (96%). Instrumen penelitian ini telah menunjukkan validitas dan reliabilitas yang dapatdiuji ulang pada scope penelitian yang lebih besar dengan populasi yang lebih beragam meliputi masyarakatumum, mahasiswa, dan kelompok usia berbeda.Kata kunci: Akne vulgaris, Mahasiswa, Pengetahuan, Perilaku, Sikap
Comparative Analysis of a Secondary Metabolite Profile from Leaves, Peel and Bulbs of Allium sativum L. by GC-MS Hafizah, Gina Tasya Rizka; Hidayati, Agriana Rosmalina; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7058

Abstract

Garlic is a herbal plant that is widely used as a medicinal ingredient, because it contains secondary metabolite compounds such as alkaloids, flavonoids, tannins, phenols, terpenoids and saponins. The secondary metabolite content of plants is influenced by genetic, ontogenic, morphogenetic and environmental factors that can influence the biosynthesis and accumulation of secondary metabolites. Garlic is generally only used for the bulbs, while other parts such as the leaves and skin are still not widely used. This study aims to identify the secondary metabolite profile of ethanol extract of garlic leaves, bulbs and peels using the gas chromatography mass spectrometry (GC-MS) method. Identification of secondary metabolite compounds contained in each 70% ethanol extract was analyzed using the tube test, thin layer chromatography (TLC) and GC-MS methods. The results of analysis of secondary metabolite content using the tube test and TLC method showed that the ethanol extract of garlic leaves, skin and bulbs positively contained flavonoids, tannins, phenols and saponins. The results of secondary metabolite profile analysis using the GC-MS method from the ethanol extract of garlic skin and bulbs showed that 5 compounds were obtained with the main compound being 3,4-Dihydroxyphenylacetic acid and 23 compounds with the main compound being 1,2-Benzenedicaboxylic acid and palmitic acid, while the leek extract white only detected 1 compound. The conclusion is that the ethanol extract of garlic leaves, skin and bulbs has secondary metabolites in the form of flavonoids, tannins, phenols and saponins. There are differences in the profile of secondary metabolite compounds in the ethanol extract of garlic leaves, skin and bulbs in terms of the results of GC-MS analysis.
Anifungi Activity Test of Ethanoled Extract of Cashew Gua Leaves (Anacardium occidentale) Against Candida albicans Yunita, Yunita; Hidayati, Agriana Rosmalina; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7402

Abstract

Cashew leaves (Western cashew) contains compounds belonging to the class of flavonoids, tannins, and saponins which are thought to have antifungal activity against Candida albicans. This study aims to determine the antifungal activity of the ethanol extract of cashew leaves on growth Candida albicans based on the inhibition zone formed. The method for determining antifungal activity was carried out through disc diffusion. Cashew leaf extract was made into three different concentrations namely, 5%, 7.5%, and 10%, the negative control used 10% DMSO, and 2% ketoconazole as a positive control. Based on the results of the phytochemical screening, the ethanol extract of cashew leaves contains compounds belonging to the class of flavonoids, tannins and saponins. The results of the antifungal activity test of the ethanol extract of cashew leaves at concentrations of 5%, 7.5%, and 10% could inhibit the growth Candida albicans with the diameter of the inhibition zone respectively, 10.35 mm, 11.93 mm, 14.12 mm. The diameter of the inhibition zone on ketoconazole was 21.75 mm and no inhibition zone was formed in the negative control group. From the results of the study it was concluded that the ethanol extract of cashew leaves has activity against Candida albicans.
Co-Authors Abdillah, Lalu Khairi Achmad Fuad Hafid Achmad Fuad Hafid Agustini, Nur Indah Aini, Siti Rahmatul Aliefman Hakim Amira Amira Amni Hamid Anggit L. Sunarwidhi Anggit Listyacahyani Sunarwidhi Anindiya, Naya Wahyu Anisa Febriani Ariani, Fitri Aryana, Baiq Putri Aty Widyawaruyanti Aty Widyawaruyanti Aulia, Dia Ul Avida In Amy Baiq Ihda Nanda Safriyana Baiq Ridho Amalia Bayani, Faizul Cahyani, Dina Fathia Candra Eka Puspitasari Dedianto Hidajat Devanus lahardo Dewi Suryani Dia Ul Aulia Djoko Agus Purwanto Dyke Gita Wirasisya Dyke Gita Wirasisya Dyke Gita Wirasisya Einstenia Kemalahayati Firman Wicaksana Hafizah, Gina Tasya Rizka Hajrin, Wahida Handa Muliasari Handa Muliasari Haryanto, Wahyu Hidayati, Regina Tria Hidayaturrohman, Achmad Hilkatul Ilmi Hilkatul Ilmi Iman Surya Pratama Iman Surya Pratama Pratama Indah Permata Sari Indra Purnomo Indriani, Zulfia Ika Julia Harpina Kadar Riansyah Khairatun, Laziza Iklima Kurniasih Sukenti Lidya Tumewu Lina Permatasari Lisnasari, Baiq Risky Wahyu Mahacita Andanalusia Mahacita Andanalusia Marsih Wijayanti Maylisa Natalia Corry Muhamad Haikhal Muhammad Amir Hasan Muhammad Robby Rizky Mukhlishah, Neneng Rachmalia Izzatul Muktiali, Abdul Hamid Muliasari, Handa Muthia Cenderadewi, Muthia Narendrani Sasmitaning Edhi Neneng Rachmalia Izzatul Mukhlishah Nisa Isneni Hanifa NURUL HIDAYAH Permatasari, Lina Permatasari, Ni Made Ayu Dinda Pramudya, Muhammad Zaidan Pratama, Iman Surya Pratiwi, Eskarani Tri Prianggawe, Prianggawe Pujiarohman, Pujiarohman Purnomo, Indra Purwitasari, Neny Putri Nuryana Raissa, Talitha Hasna Ramadhan, Muhammad Rafi Bintang Retno Widyowati Riadi, Putri Oktaviati Riesta Primaharinastiti Risnata, Richa Poetri rizki, alpa alfi Rizkika, Adila Safriyana, Baiq Ihda Nanda Sasvania, Anisa Siti Rahmatul Aini Suciati Suciati Suciati Suciati Sukardiman Sukardiman sulistanti, Erly Sunarwidhi, Anggit Listyacahyani suryani, Bunga Tri Widiandani Wahida Hajrin Wardani, Ray Haerul Windah Anugrah Subaidah Wirasisya, Dyke Gita Yayuk Andayani Yunita Yunita Zahra, Nisrina