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Hidayati, Agriana Rosmalina
Fakultas Kedokteran Universitas Mataram
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Antibacterial Activity of Metanol Extract and n-Butanol Fraction of Euphorbia milii Leaves Against Staphylococcus aureus Dia Ul Aulia; Agriana Rosmalina Hidayati; Dewi Suryani
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.6154

Abstract

Euphorbia milii is a common garden plant and its leaves have antibacterial activity, due to the presence of saponins, flavonoids, and tannins. As there is an increasing antibiotic resistance to Staphylococcus aureus, there is potential for E. milii as a new antibacterial candidate. The purpose of this study was to determine secondary metabolites of saponins, flavonoids, tannins and to determine the antibacterial activity of E. milii leaves in inhibiting the growth of Staphylococcus aureus (in vitro). Simplisia was extracted by sonication method, then fractionated with a separatory funnel. Extracts and fractions were analyzed qualitatively by tube test and thin layer chromatograpy (TLC). The antibacterial activity of methanol extract (320; 160; and 80 mg/ml) and n-butanol fraction (32; 16; and 8 mg/ml) was tested by disc diffusion method. The results of qualitative test showed that the extracts and fractions were positive for saponins, flavonoids, and tannins.  In antibacterial test, extract at a concentration of 320 mg/ml was able to inhibit bacterial growth with moderate activity category (6.5 mm). Extracts at 160 mg/ml and 80 mg/ml, as well as n-butanol fractions at all concentration showed weak antibacterial activity (<5 mm). Theseresult suggest that the extracts and fractions positively contain metabolites of saponins, flavonoids, and tannins. The extracts and fractions were able to inhibit the growth of staphylococcus aureus, but the activity was not greater than the positive control.
Pelatihan Pembuatan Sabun Dari Minyak Jelantah Pada Kader PKK Di Desa Bengkaung Hanifa, Nisa Isneni; Hidayati, Agriana Rosmalina; Mukhlishah, Neneng Rachmalia Izzatul; Subaidah, Windah Anugrah; Purnomo, Indra; Bayani, Faizul
Jurnal Pengabdian Magister Pendidikan IPA Vol 7 No 4 (2024): Oktober-Desember 2024
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v7i4.9588

Abstract

The repeated use of cooking oil more than twice is still common in Indonesian society. However, used cooking oil can negatively affect health, being even more detrimental than saturated fatty acids. Additionally, it contributes to pollution in soil and water. One effective method for repurposing used cooking oil is by converting it into soap. This community service initiative aims to promote the utilization of used cooking oil in economically valuable products while reducing the amount of waste oil that is discarded into the environment. The training was conducted for PKK cadres in Bengkaung Village and facilitated by pharmacists, dermatologists, and students from the Faculty of Medicine and Health Sciences at the University of Mataram. The soap-making process begins by adding charcoal to the used cooking oil for 72 hours. This step helps remove hazardous substances and unpleasant odors. Afterward, the oil is filtered and combined with essential soap-making ingredients, including sunflower oil, virgin coconut oil (VCO), olive oil, sodium hydroxide (NaOH), and water. NaOH is critical for the saponification process, which transforms the oil into soap. To enhance the aesthetic value and benefits of the soap, ingredients like honey, yogurt, or natural dyes such as butterfly pea flowers can be incorporated. The mixture is then poured into molds and allowed to harden. Given the simple process and the ease of obtaining the necessary tools and materials, the PKK cadres in Bengkaung Village have shown enthusiasm for making soap from used cooking oil. This activity is expected to broaden their knowledge and provide business opportunities to help increase family income in the village.
STANDARDISASI PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETIL ASETAT DAUN KEDONDONG (SPONDIAS DULCIS) zahra, nisrina; Mukhlishah, Neneng Rachmalia Izzatul; Hidayati, Agriana Rosmalina
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.40091

Abstract

Tanaman kedondong (Spondias dulcis) merupakan tanaman yang dapat digunakan sebagai bahan baku obat. Tanaman ini secara empiris digunakan oleh masyarakat Desa Kembang Paseban Kecamatan Mersam Kabupaten Batanghari Provinsi Jambi sebagai obat barut (obat tempel melahirkan). Aktivitas farmakologi ekstrak etil asetat daun kedondong yaitu sebagai antidiabetes dan antioksidan. Sebagai bahan baku sediaan OHT, ekstrak etil asetat daun kedondong perlu distandardisasi agar sediaan OHT terjamin mutu dan keamanannya. Penelitian ini bertujuan untuk mengetahui kesesuaian mutu ekstrak etil asetat daun kedondong dengan melakukan standardisasi berdasarkan Farmakope Herbal Indonesia edisi II dan Materia Medika Indonesia. Daun kedondong diekstraksi dengan metode sonikasi pada suhu 35°C selama 30 menit. Hasil standardisasi parameter spesifik menunjukkan identitas tanaman merupakan tanaman kedondong, organoleptik ekstrak yaitu kental, bewarna hitam kehijauan, rasa pahit, berbau aromatik, dengan kandungan senyawa larut air sebesar 2,0% dan senyawa larut etanol sebesar 11,91%. Hasil uji parameter non spesifik menunjukkan kadar susut pengeringan sebesar 2,94%; bobot jenis 0,98370 g/mL; kadar air 4,49%; kadar abu total 0,2%; kadar abu larut air 0,007%; kadar abu tidak larut asam 0,1%; sisa pelarut 1,0018 g/mL;  kadar logam Pb 1,70 ppm; ALT & AKK tidak dapat dihitung. Pada penetapan angka lempeng total dan penetapan angka kapang khamir tidak dapat diuji. Berdasarkan pengujian standardisasi ekstrak etil asetat daun kedondong memenuhi standar ekstrak secara umum dan dapat dikembangkan menjadi obat herbal terstandar (OHT).
STANDARDISASI PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETANOL ANGGUR LAUT (CAULERPA LENTILLIFERA) Indriani, Zulfia Ika; Hidayati, Agriana Rosmalina; Mukhlishah, Neneng Rachmalia Izzatul
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.42413

Abstract

Anggur laut (Caulerpa lentillifera) banyak dimanfaatkan oleh masyarakat sebagai bahan makanan dan secara empiris digunakan untuk pengobatan diabetes. C. lentillifera memiliki kandungan metabolit sekunder dan berbagai kandungan nutrisi serta aktivitas farmakologi yang meliputi antioksidan, antipiretik, antikanker, antiinflamasi, antikoagulan, dan antidiabetes sehingga dapat dikembangkan menjadi bahan baku obat herbal terstandar (OHT). Berdasarkan hal tersebut perlu dilakukan standardisasi untuk memenuhi persyaratan sebagai bahan baku terstandar untuk OHT. Penelitian ini bertujuan untuk menentukan nilai standar parameter spesifik dan non spesifik ekstrak etanol anggur laut. Penentuan nilai tersebut dilakukan berdasarkan pemeriksaan uji parameter spesifik dan non spesifik. Hasil uji parameter spesifik pada uji organoleptis diperoleh ekstrak berbentuk kental; berwarna hijau tua pekat; bau khas laut dan memiliki rasa asin. Ekstrak mengandung flavonoid, fenolik, saponin, dan tanin. Kandungan senyawa larut air sebesar 19,27% dan senyawa larut etanol 8,54%. Sedangkan hasil uji parameter non spesifik pada penetapan susut pengeringan sebesar 9,20%, kadar air 10,84%, susut pengeringan sebesar 9,20%, bobot jenis sebesar 1,02 g/mL dan sisa pelarut sebesar 0,80%. Pada pemeriksaan kadar abu total diperoleh sebesar 39,54%; kadar abu larut air 38,04%; kadar abu tidak larut asam 3,68%; kadar logam Pb <0,001 ppm; kadar logam Hg <0,001 ppb. Nilai ALT sebesar 1,5x 102 dan nilai AKK sebesar 3,46 x102. Berdasarkan hasil data parameter spesifik dan non spesifik ekstrak etanol anggur laut sudah memenuhi syarat standar secara umum sehingga data tersebut dapat dijadikan acuan penelitian selanjutnya untuk pengembangan OHT.
KARAKTERISTIK PENGETAHUAN, SIKAP DAN PERILAKU MAHASISWA PENDERITA AKNE VULGARIS DI UNIVERSITAS MATARAM TERHADAP PENYAKIT DAN PENGOBATAN Prianggawe, Prianggawe; Andanalusia, Mahacita; Hidajat, Dedianto; Hidayati, Agriana Rosmalina; Hanifa, Nisa Isneni; Hajrin, Wahida
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49895

Abstract

Penelitian ini mengkaji pengetahuan, sikap, dan perilaku mahasiswa di Universitas Mataram terhadapAV yaitu suatu kondisi kulit inflamasi kronis yang umum disebabkan oleh Cutibacterium acnes danStaphylococcus epidermidis. Kondisi ini banyak ditemukan pada remaja akhir dan dewasa muda berusia 18-25tahun yang sebagian besar adalah mahasiswa. Tujuan penelitian ini yaitu mengetahui karakteristik pengetahuan,sikap dan perilaku mahasiswa penderita AV terhadap penyakit dan pengobatan. Metode penelitian inimenggunakan desain deskriptif dengan pendekatan cross-sectional yang melibatkan 81 responden yang dipilihdengan metode purposive sampling. Teknik pengambilan data dikumpulkan menggunakan kuesioner dandianalisis secara deskriptif. Data disajikan dalam bentuk tabel untuk memvisualisasikan persebaran jawaban.Hasil penelitian menunjukan sebagian besar responden memiliki pengetahuan baik (81,4%), sikap yang positif(100%) dan perilaku (96%). Instrumen penelitian ini telah menunjukkan validitas dan reliabilitas yang dapatdiuji ulang pada scope penelitian yang lebih besar dengan populasi yang lebih beragam meliputi masyarakatumum, mahasiswa, dan kelompok usia berbeda.Kata kunci: Akne vulgaris, Mahasiswa, Pengetahuan, Perilaku, Sikap
Comparative Analysis of a Secondary Metabolite Profile from Leaves, Peel and Bulbs of Allium sativum L. by GC-MS Hafizah, Gina Tasya Rizka; Hidayati, Agriana Rosmalina; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7058

Abstract

Garlic is a herbal plant that is widely used as a medicinal ingredient, because it contains secondary metabolite compounds such as alkaloids, flavonoids, tannins, phenols, terpenoids and saponins. The secondary metabolite content of plants is influenced by genetic, ontogenic, morphogenetic and environmental factors that can influence the biosynthesis and accumulation of secondary metabolites. Garlic is generally only used for the bulbs, while other parts such as the leaves and skin are still not widely used. This study aims to identify the secondary metabolite profile of ethanol extract of garlic leaves, bulbs and peels using the gas chromatography mass spectrometry (GC-MS) method. Identification of secondary metabolite compounds contained in each 70% ethanol extract was analyzed using the tube test, thin layer chromatography (TLC) and GC-MS methods. The results of analysis of secondary metabolite content using the tube test and TLC method showed that the ethanol extract of garlic leaves, skin and bulbs positively contained flavonoids, tannins, phenols and saponins. The results of secondary metabolite profile analysis using the GC-MS method from the ethanol extract of garlic skin and bulbs showed that 5 compounds were obtained with the main compound being 3,4-Dihydroxyphenylacetic acid and 23 compounds with the main compound being 1,2-Benzenedicaboxylic acid and palmitic acid, while the leek extract white only detected 1 compound. The conclusion is that the ethanol extract of garlic leaves, skin and bulbs has secondary metabolites in the form of flavonoids, tannins, phenols and saponins. There are differences in the profile of secondary metabolite compounds in the ethanol extract of garlic leaves, skin and bulbs in terms of the results of GC-MS analysis.
Anifungi Activity Test of Ethanoled Extract of Cashew Gua Leaves (Anacardium occidentale) Against Candida albicans Yunita, Yunita; Hidayati, Agriana Rosmalina; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7402

Abstract

Cashew leaves (Western cashew) contains compounds belonging to the class of flavonoids, tannins, and saponins which are thought to have antifungal activity against Candida albicans. This study aims to determine the antifungal activity of the ethanol extract of cashew leaves on growth Candida albicans based on the inhibition zone formed. The method for determining antifungal activity was carried out through disc diffusion. Cashew leaf extract was made into three different concentrations namely, 5%, 7.5%, and 10%, the negative control used 10% DMSO, and 2% ketoconazole as a positive control. Based on the results of the phytochemical screening, the ethanol extract of cashew leaves contains compounds belonging to the class of flavonoids, tannins and saponins. The results of the antifungal activity test of the ethanol extract of cashew leaves at concentrations of 5%, 7.5%, and 10% could inhibit the growth Candida albicans with the diameter of the inhibition zone respectively, 10.35 mm, 11.93 mm, 14.12 mm. The diameter of the inhibition zone on ketoconazole was 21.75 mm and no inhibition zone was formed in the negative control group. From the results of the study it was concluded that the ethanol extract of cashew leaves has activity against Candida albicans.
Standardization of Specific and Non-Specific Parameters of Methanol Extract from Poinsettia Red Leaves (Euphorbia pulcherrima Willd.) Abdillah, Lalu Khairi; Hanifa, Nisa Isneni; Mukhlishah, Neneng Rachmalia Izzatul; Hidayati, Agriana Rosmalina
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7412

Abstract

The poinsettia red leaves (Euphorbia pulcherrima Willd.) have the potential as antibacterial and antioxidant agents and are widely utilized by the community for wound healing purposes. This research aims to determine the specific and non-specific parameter values of methanol extract from poinsettia red leaves. Samples of poinsettia red leaves were processed into extracts using the maceration method with 96% methanol as the solvent. The extract was standardized by determining specific and non-specific parameters. The test result data were analyzed descriptively in both qualitative and quantitative manners. The standardization results of specific parameters showed the identity of the extract as methanol extract of poinsettia red leaves, with organoleptic properties of a thick greenish-black extract, distinctive poinsettia aroma, and bitter taste. The water-soluble compound content was 51,47% ± 0,437 and ethanol-soluble 61,22% ± 0,117. Results for non-specific parameters indicated drying loss of 12,50% ± 0,419, moisture content of 12,62% ± 0,173, total ash content of 5,25% ± 0,538, acid-insoluble ash of 0,34% ± 0,048, residual solvent 0,00% ± 0,000, total plate count was TFTC (Too Few To Count), and mold and yeast count was 1,5 x 104 colonies/g sample. This research can serve as a reference for determining specific and non-specific parameters of methanol extract from poinsettia red leaves.
Effect of Solvent Extraction on Yield and Phytochemical Screening of Kedondong (Spondias dulcis) Leaf Extracts Zahra, Nisrina; Mukhlishah, Neneng Rachmalia Izzatul; Hidayati, Agriana Rosmalina
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7465

Abstract

Kedondong (Spondias dulcis) is empirically used as a cough medicine, skin pain, burns, and antimicrobials. in addition, the people of Kembang Paseban Village, Mersam Subdistrict, Batanghari District, Jambi Province use kedondong leaves as a barut medicine (birth patch medicine). The pharmacological activity of kedondong leaf extract is as a wound healer, antibacterial, anti-inflammatory, antifungal, antipyretic, and as a larvicide. The yield value greatly affects the amount of bioactive content contained in the extract and can affect the results of phytochemical screening. The purpose of this study was to determine the effect of solvent comparison on yield and phytochemical screening of ethyl acetate extract of kedondong leaves. The method used in this study was sonication with a solvent ratio of 1:5 and 1:10, the temperature and time used were 35oC and 30 minutes. The results obtained in the ratio of 1:5 obtained a higher % yield of 5.53% compared to the solvent ratio of 1:10 of 4.67%. While the metabolite compounds identified from ethyl acetate extract are flavonoids and alkaloids.
Article Review: Pharmacological Activities of Renggak Plant (Amomum dealbatum Roxb.) Cahyani, Dina Fathia; Hidayati, Agriana Rosmalina
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7599

Abstract

The renggak plant (Amomum dealbatum Roxb.) is a native plant of Lombok Island that belongs to the Zingiberaceae family and is traditionally used as a remedy for coughs, diarrhea, arthritis, and eye washes. Ethanol extract from the renggak fruit is reported to contain secondary metabolites such as flavonoids, tannins, terpenoids, alkaloids, steroids, saponins, polyphenols, and several other types of fatty acids, which have various pharmacological activities. This review article aims to provide information on the various pharmacological activities of the renggak plant, including antidiabetic, antiurease, antioxidant, antibacterial, and antifungal activities. The method used in this article is a systematic review of various literature sources. Articles were collected using the Google Scholar and PubMed databases with keywords such as Renggak, Amomum dealbatum Roxb., and pharmacological activities. Based on the data results, it can be concluded that the renggak plant (Amomum dealbatum Roxb.) exhibits pharmacological activities as an antidiabetic, antiurease, antibacterial, antioxidant, and antifungal agent.
Co-Authors Abdillah, Lalu Khairi Achmad Fuad Hafid Agustini, Nur Indah Aini, Siti Rahmatul Aliefman Hakim Amira Amira Amni Hamid Anggit L. Sunarwidhi Anggit Listyacahyani Sunarwidhi Anindiya, Naya Wahyu Anisa Febriani Ariani, Fitri Aryana, Baiq Putri Aty Widyawaruyanti Aulia, Dia Ul Avida In Amy Baiq Ihda Nanda Safriyana Baiq Ridho Amalia Baiq Ridho Amalia Bayani, Faizul Cahyani, Dina Fathia Candra Eka Puspitasari Dedianto Hidajat Dedianto Hidajat Devanus lahardo Dewi Suryani Dia Ul Aulia Djoko Agus Purwanto Dyke Gita Wirasisya Dyke Gita Wirasisya Dyke Gita Wirasisya Einstenia Kemalahayati Eskarani Tri Pratiwi Firman Wicaksana Hafizah, Gina Tasya Rizka Hajrin, Wahida Handa Muliasari Handa Muliasari Hidayati, Regina Tria Hidayaturrohman, Achmad Hilkatul Ilmi Hilkatul Ilmi Iman Surya Pratama Iman Surya Pratama Pratama Indah Permata Sari Indra Purnomo Indriani, Zulfia Ika Julia Harpina Kadar Riansyah Khairatun, Laziza Iklima Kurniasih Sukenti Lidya Tumewu Lisnasari, Baiq Risky Wahyu Mahacita Andanalusia Mahacita Andanalusia Marsih Wijayanti Maylisa Natalia Corry Muhamad Haikhal Muhammad Amir Hasan Muhammad Robby Rizky Mukhlishah, Neneng Rachmalia Izzatul Muktiali, Abdul Hamid Muliasari, Handa Muthia Cenderadewi Narendrani Sasmitaning Edhi Naya Wahyu Anindiya Neneng Rachmalia Izzatul Mukhlishah Nisa Isneni Hanifa Permatasari, Lina Permatasari, Ni Made Ayu Dinda Pramudya, Muhammad Zaidan Pratama, Iman Surya Prianggawe, Prianggawe Pujiarohman, Pujiarohman Purnomo, Indra Purwitasari, Neny Putri Nuryana Raissa, Talitha Hasna Ramadhan, Muhammad Rafi Bintang Retno Widyowati Riadi, Putri Oktaviati Riesta Primaharinastiti Risnata, Richa Poetri rizki, alpa alfi Rizkika, Adila Safriyana, Baiq Ihda Nanda Sasvania, Anisa Siti Rahmatul Aini Suciati Suciati Suciati Suciati Sukardiman Sukardiman sulistanti, Erly Sunarwidhi, Anggit Listyacahyani suryani, Bunga Tri Widiandani Wahida Hajrin Wardani, Ray Haerul Windah Anugrah Subaidah Wirasisya, Dyke Gita Yayuk Andayani Yunita Yunita Zahra, Nisrina