Claim Missing Document
Check
Articles

Found 40 Documents
Search

UJI FISIK DAN UJI IRITASI SEDIAAN MASKER GEL EKSTRAK ETANOL DAUN DEWA (Gynura pseudochina (Lour.) DC.) Ummi Nurus Salamah; Muhammad Nurul Fadel; Eko Retnowati
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1581

Abstract

The gel mask preparation containing (Gynura pseudochina) extract was evaluated through physical and irritation tests, including organoleptic observation, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and potential skin irritation. Organoleptic results showed that all formulas had consistent color, odor, and texture, aligning with topical product standards. Homogeneity testing confirmed that the formulations were evenly mixed without visible clumps or phase separation. The pH values ranged between 5 and 6, which are considered safe and comfortable for skin application. The addition of extract affected viscosity levels low to moderate concentrations increased thickness, while higher concentrations led to a decrease due to disruption of the gel matrix structure. Spreadability and adhesion tests indicated that all formulas had appropriate consistency for topical use, allowing ease of application and suitable adherence to the skin. Drying times were consistent across formulas, supporting efficient user experience. Irritation testing revealed no visible reactions on the skin, indicating that all formulas are safe for topical application.
Formulation Research and Antibacterial Activity Test of Face Mist Preparation from Ethanol Extract of Papaya Leaves (Carica Papaya L.) Against Propionibacterium Acnes Mustaanah, Aulia Nur; Fadel, Muhammad Nurul; Khudzaifi, Muhamad
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.559

Abstract

Purpose: The purpose of this study was to formulate a face mist preparation containing ethanol extract of papaya leaves (Carica papaya L.) at concentrations of 10%, 15%, and 20%, and to evaluate its antibacterial activity against Propionibacterium acnes, a primary acne-causing bacterium. Research Method: This study employed a laboratory-based experimental design with a post-test-only control group. Data were collected through experimental observations. The face mist was formulated with three extract concentrations (F1: 10%, F2: 15%, and F3: 20%), with a face mist base as the negative control and clindamycin as the positive control. The preparations underwent organoleptic, pH, homogeneity, and spreadability tests. Antibacterial activity was evaluated using the disc diffusion method, and the data were analyzed using One-Way ANOVA with a significance level of p < 0.005. Results and Discussion: The formulations met the physical property standards, showing a brownish-green color, liquid consistency, and a characteristic papaya leaf aroma. All samples were homogeneous, with pH values ranging from 5.08 to 5.16, and spreadability between 5.33 and 5.75 cm. The highest antibacterial activity was observed in F3 (20%) with an average inhibition zone of 16.3 mm. Implications: The findings suggest that papaya leaf ethanol extract is a promising natural ingredient for face mist formulations with antibacterial properties, offering potential as an alternative acne treatment product.
Formulation and Antioxidant Activity Test of Micellar Water Extracted from Mangosteen Fruit Peel (Garcinia mangostana L.) Using the DPPH Method with Variations in the Concentration of PEG-7 Glyceryl Cocoate as a Surfactant Andriyani, Yunita; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.588

Abstract

Purpose: This study aims to determine the effect of PEG-7 glyceryl cocoate at concentrations of F1 0.2%, F2 0.4%, and F3 0.6% on the physical stability and cleaning power of micellar water preparations containing mangosteen peel extract. The best formulation was then tested for its antioxidant activity using the DPPH method. Research Method: This study used a laboratory experimental method. The variations in PEG-7 glyceryl cocoate concentration used in the micellar water extract of mangosteen peel were F1 (0.2%), F2 (0.4%), F3 (0.6%), and negative control F0 (0%). Evaluations were conducted on physical stability tests (organoleptic, pH, homogeneity, and viscosity) and cleaning power. The best micellar water formulation was then tested for antioxidant activity using the DPPH method. The test results were analyzed using a One-Way ANOVA test. Results and Discussion: The results of testing F3 micellar water, with the highest concentration of PEG-7 glyceryl cocoate, demonstrated that it was the best formula and exhibited the best cleaning ability. The results of the analysis using one-way ANOVA showed a p-value of < 0.05. The antioxidant activity of F3 was determined to have an IC50 of 103.81 μg/ml, which falls within the moderate category. Implications: The results of this study indicate that PEG-7 glyceryl cocoate at a concentration of 0.6% can be used as a surfactant in micellar water preparations of mangosteen peel extract. Further research is needed to determine the long-term stability of the preparation.
PENGARUH KONSENTRASI EKSTRAK KOMBINASI DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN BERAS (Oryza sativa) PADA SEDIAAN KRIM TERHADAP SIFAT FISIK DAN AKTIVITAS ANTIBAKTERI Staphylococcus aureus Rahma, Siti Sofia; Fadel, Muhammad Nurul; Arif, Fahrudin
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49439

Abstract

Diabetes melitus (DM) disebabkan oleh hiperglikemia, metabolisme protein, karbohidrat dan lemak yang tidak normal, sekresi insulin dan juga dapat diakibatkan oleh keturunan atau genetik. Penderita diabetes bila dibiarkan tanpa pengobatan yang tepat dapat memicu berbagai macam komplikasi, diantaranya ulkus diabetikum yang di akibatkan oleh bakteri Staphylococcus aureus. Keparahan pada ulkus diabetikum dapat menyebabkan amputasi. Penelitian ini bertujuan untuk mengevaluasi efektivitas sediaan krim kombinasi daun binahong dan beras dengan konsentrasi ekstrak 5%:15%, 10%:10%, 15%:5% dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Metode penelitian yang digunakan yaitu metode eksperimental dengan pengujian pH, homogenitas, daya sebar, daya lekat dan uji antibakteri dengan difusi cakram. Hasil menunjukkan bahwa formula F3 (15% binahong : 5% beras) memiliki zona hambat antibakteri paling luas (8,9 mm), termasuk kategori sedang, dan nilai pH dalam rentang aman untuk kulit. Formula ini juga memenuhi kriteria fisik sediaan krim topikal. Dengan demikian, kombinasi ekstrak daun binahong dan beras berpotensi sebagai alternatif pengobatan topikal luka infeksi diabetes.
Analisis Cost-Benefit Terapi Simvastatin dengan Atorvastatin pada Pasien Dislipidemia di Apotek 71 Kota Kediri dengan Pendekatan Human Capital Method Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Fadel, Muhammad Nurul; Besan, Emma Jayanti; Astutik, Widhi; Arifin, Chandra; Rofiq, Abd; Rhomah, Eka Hayati
Business and Economic Publication Vol. 3 No. 2 (2025): Business and Economic Publication
Publisher : Fakultas Ekonomi Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/bep.v3i2.1571

Abstract

This study aims to analyze the cost-benefit of simvastatin therapy compared to atorvastatin in dyslipidemia patients at Apotek 71 Kediri City using the Human Capital Method. Using a cross-sectional study design, this study analyzed 60 patients (30 simvastatin users, 30 atorvastatin users). Productivity loss data was collected through a patient self-report questionnaire and valued monetarily using the assumption of a uniform daily wage. Results showed that direct costs of simvastatin were lower (IDR 75,000/month) than atorvastatin (IDR 210,000/month), but lost productivity in the simvastatin group was higher (IDR 384,000) than atorvastatin (IDR 180,000). The Net Benefit value of simvastatin therapy was -Rp 39,000 with a Benefit Cost Ratio (BCR) of 0.91, while atorvastatin produced a Net Benefit of +Rp 210,000 with a BCR of 1.54. The difference in Net Benefit was statistically significant based on an independent t-test (p=0.002). Thus, atorvastatin is more economically efficient than simvastatin because it provides higher productivity benefits despite higher direct costs.
AKTIVITAS ANTIBAKTERI DAN UJI KARAKTERISTIK FISIK CLAY MASK EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume) Terhadap Bakteri Staphylococcus aureus Alya Narulita; Muhammad Nurul Fadel; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1594

Abstract

Natural ingredients are used as an alternative to the use of synthetic drugs and antibiotics, due to the small side effects caused compared to synthetic drugs. Parijoto fruit (Medinilla speciosa Blume) has many benefits, one of which is as an acne-causing antibacterial with the content of flavonoid compounds, tannins, and saponins. The use of natural ingredients of parijoto fruit in the form of clay mask preparations was chosen because it has advantages and is popular among teenagers compared to other types of masks. This study aims to determine the effectiveness of clay mask preparation with 70% ethanol extract of parijoto fruit in inhibiting the activity of Staphylococus aaureus bacteria using the disc diffusion method. Parijoto fruit is extracted using the maceration method with 70% ethanol solvent to obtain a thick extract, then physical characteristics tests and antibacterial tests are carried out on clay mask preparations. Antibacterial testing of parijoto fruit extract used disc diffusion method with concentrations of 10%, 15%, and 20%. The results of the study showed that 70% ethanol extract clay mask preparations of parijoto fruit had moderate to strong antibacterial effectiveness against S. aureus in formulas F1 (10%), F2 (15%), and F3 (20%) with consecutive inhibition zones of 6.3 mm, 14.1 mm, 15.3 mm. The concentration of F3 (20%) showed the most optimal activity in inhibiting acne-causing S.aureus bacteria.
FORMULASI MASKER GEL LIDAH BUAYA (Aloe Vera) UNTUK PENGENDALIAN BAKTERI Propionibacterium acnes Irvan Shahrul Hidayat; Muhammad Nurul Fadel; Intan Adevia Rosnarita
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1662

Abstract

Acne (Acne vulgaris) is a common skin problem, especially among adolescents, with a prevalence reaching 80-85% in Indonesia. One of the main causes of acne is the bacteria Propionibacterium acnes. Acne treatment usually uses synthetic antibiotics, but long-term use can cause side effects and bacterial resistance. Alternative natural treatments are needed to address this problem. Aloe vera is known to have antibacterial, anti-inflammatory, and cell regeneration-accelerating properties, making it potentially useful in skin care products. The active ingredients of aloe vera, such as anthraquinones, saponins, and flavonoids, are effective in inhibiting the growth of Propionibacterium acnes. Peel-off gel masks were chosen as topical preparations because they are practical, have a cooling effect, and can increase the penetration of active ingredients. This study aims to develop a gel mask formulation with aloe vera extract and test its effectiveness in inhibiting the growth of Propionibacterium acnes bacteria. This study used a laboratory experimental method with a post-test only control group design. The formulas used included various concentrations of aloe vera extract (5%, 10%, and 15%) and a positive control using 1% clindamycin. Evaluation of the preparations included organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and antibacterial activity testing using the disc diffusion method. Antibacterial effectiveness testing was divided into 5 treatment groups. The inhibition zone test against Propionibacterium acnes was conducted to assess the effectiveness of each formulation. The test data were analyzed using the One Way ANOVA statistical method with SPSS 25 software to determine significant differences between groups. Antibacterial testing was conducted by disc diffusion. The results of the study on the aloe vera extract peel-off gel mask formulation showed good organoleptic physical quality, homogeneity, adhesiveness, and drying time of the preparation, while the viscosity and spreadability tests did not meet the requirements, and the pH test on formula F3 did not meet the pH requirements for mouthwash preparations. In the antibacterial activity test of the peel-off gel mask preparation, the inhibition zone values ​​were obtained at F0 2.23 mm; F1 4.8 mm; F2 6 mm; F3 7.2 mm; and the positive control 33.5 mm.
Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Emma Jayanti Besan; Muhammad Nurul Fadel; Charliandri Saputra Wahab; Muhammad Alviyan Shutiawan
Jurnal Informatika dan Kesehatan Vol. 1 No. 1 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i1.3024

Abstract

The global COVID-19 pandemic has presented unprecedented challenges to global health. The Dr. Soedomo Regional General Hospital in Trenggalek has been at the forefront of managing COVID-19 patients, with a primary focus on the use of ibuprofen to alleviate symptoms such as fever and pain. Despite the widespread use of ibuprofen, knowledge regarding its interaction with the circadian rhythm, especially in COVID-19 patients, remains limited. This study employed an analytical observational approach with a Cross-Sectional design to analyze the use of ibuprofen in COVID-19 patients at Dr. Soedomo Regional General Hospital in Trenggalek. The study included 100 patients, emphasizing body temperature at three different times. Data analysis revealed a significant decrease in body temperature after therapy, particularly at 4:00 PM. These findings lay the foundation for the development of more targeted and personalized treatment strategies by understanding the body's response patterns to therapy at different times.   Abstrak Pandemi global COVID-19 telah menciptakan tantangan kesehatan global yang belum pernah terjadi sebelumnya. Rumah Sakit Umum Daerah Dr. Soedomo di Trenggalek telah menjadi pusat perhatian dalam menangani pasien COVID-19. Fokus utama adalah penggunaan ibuprofen untuk mengelola gejala, seperti demam dan nyeri. Meskipun ibuprofen umum digunakan, pengetahuan tentang interaksi dengan siklus sirkadian tubuh, terutama pada pasien COVID-19, masih terbatas. Penelitian ini menggunakan pendekatan observasional analitik dengan desain Cross Sectional untuk menganalisis penggunaan ibuprofen pada pasien COVID-19 di RSUD Dr. Soedomo Trenggalek. Hasil penelitian melibatkan 100 pasien, dengan fokus pada suhu tubuh pada tiga waktu berbeda. Analisis data menunjukkan penurunan suhu tubuh yang signifikan setelah terapi, terutama pada pukul 16.00 WIB. Hasil ini memberikan dasar untuk pengembangan strategi pengobatan yang lebih terarah dan personalisasi, dengan memahami pola respons tubuh terhadap terapi pada waktu yang berbeda.
Aktivitas Antibakteri Krim Ekstrak Daun Putri Malu (Mimosa pudica L.) Terhadap Bakteri Propionibacterium acnes Penyebab Jerawat Utami, Mega Putri; Kholis, Ahmad; Mulyasari, Ika; Noor, Lathifatun Nida; Fadel, Muhammad Nurul
Prosiding University Research Colloquium Proceeding of The 14th University Research Colloquium 2021: Bidang Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Putri malu (Mimosa pudica L.) merupakan salah satu jenis tanaman liar dan gulma yang memiliki kandungan senyawa flavonoid, alkaloid dan tanin yang bermanfaat sebagai antibakteri dan antijamur. Daun putri malu dapat menghambat pertumbuhan bakteri bakteri Pseudomonas aeruginosa yang berperan dalam pembentukan infeksi pada luka bakar dan dermatitis. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri krim ekstrak daun putri malu (Mimosa pudica L.) terhadap bakteri Propionibacterium acnes dalam menghambat pertumbuhan jerawat pada berbagai konsentrasi. Metode penelitian ini menggunakan metode difusi cakram dengan konsentrasi krim ekstrak daun putri malu yang digunakan yaitu 10%, 20% dan 30%, diletakkan pada media NA yang telah ditumbuhi oleh bakteri Propionibacterium acnes yang kemudian diinkubasi serta diukur diameter zona hambat (zona bening). Hasil penelitian pada konsentrasi 10% pada hari ke 1 dan hari ke 14 didapatkan diameter zona hambat sebesar 4,6 mm, hal ini termasuk dalam klasifikasi zona hambat lemah (kurang dari 5 mm). Konsentrasi 20% pada hari ke 1 sebesar 8 mm dan hari ke 14 sebesar 7 mm, hal ini termasuk dalam klasifikasi zona hambat sedang (5 mm sampai 10 mm), sedangkan konsentrasi 30% pada hari ke 1 sebesar 11,6 mm dan hari ke 14 sebesar 10,6 mm, hal ini termasuk dalam klasifikasi zona hambat kuat (lebih dari 10 mm). Kontrol positif didapatkan hasil sebesar 17 mm pada hari ke 1 dan pada hari ke 14 sebesar 18,3 mm. Berdasarkan data tersebut dapat disimpulkan bahwa krim ekstrak daun putri malu (Mimosa pudica L.) dapat menghambat bakteri Propionibacterium acnes.
Uji Aktivitas Antioksidan Fraksi n-Heksan, Etil Asetat dan Air Ektrak Etanol Daun Pisang Kepok (Musa paradisiaca L.) dengan Metode DPPH (1,1 dipheniyl-2- picrylhidrazyl) Fadel, Muhammad Nurul; Besan, Emma Jayanti; Apriliani, Fitri; Djamal, Julia Megawati; Sholekhah, Nihayatus
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia merupakan negara tropis yang mempunyai keragaman flora yang berpotensi besar untuk dikembangkan dalam pengobatan tradisional. Salah satu tumbuhan yang terdistribusi secara luas di Indonesia dan memiliki aktivitas antioksidan yaitu daun pisang kepok (Musa Paradisiaca L.). Daun pisang memiliki kandungan senyawa flavonoid, polifenol, tannin, alkoloid, dan saponin. Penelitian ini bertujuan untuk mengetahui aktivitas antipksidan dari fraksi n-heksan, fraksi etil asetat, dan fraksi air ekstrak etanol daun pisang kepok (Musa Paradisiaca L.) dengan metode DPPH. Penelitian ini menggunakan jenis penelitian eksperimental. Metode pembuatan ekstrak menggunakan maserasi dengan pelarut etanol 70%. Setelah didapatkan ekstrak dilanjutkan dengan proses fraksinasi dengan pelarut n-heksan, etil asetat, dan air. Hasil dari fraksi diuji aktivitas antioksidannya dengan metode DPPH menggunakan alat spektrofotometri UV- Vis. Aktivitas antioksidan dari berbagai fraksi dinyatakan dalam bentuk nilai IC50. Hasil skrinning fitokimia ekstrak etanol 70% daun pisang kepok (Musa Paradisiaca L.) mengandung senyawa flavonoid, alkoloid, tanin, saponin, dan polifenol. Hasil penelitian ini diperoleh bahwa uji aktivitas antioksidan yang dinyatakan dengan nilai IC50 pada fraksi n-heksana, fraksi etil asetat, fraksi air ekstrak etanol daun pisang kepok (Musa Paradisiaca L.) berturut-turut yaitu: 53,87 ppm, 12,96 ppm, dan 34,11 ppm. Fraksi etil asetat, fraksi air, dan kontrol positif vitamin C memiliki aktivitas antioksidan sangat kuat, sedangkan fraksi n-heksan memiliki aktivitas antioksidan kuat.
Co-Authors Abd Rofiq ABDUL ROKHMAN Adhimi, Cici Sayyidatul Ahmad Kholis Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Ardianto, Nanda Arif Fahrudin Arif, Fahrudin Astutik, Widhi Ayuningsih, Safitri Besan, Ema Jayanti Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Chandra Arifin Charliandri Saputra Wahab Dahbul, Nura Ali Dameria, Gempita Hutami Eko Retnowati Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Febriana, Laela Febrianisa, Sabila Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Fitri Apriliani Fransisca Dita Mayangsari GALIH KURNIAWAN Hamzah, Hasyrul Hasriyani Hasriyani, Hasriyani Husna, Ulviani Yulia Ika Mulyasari Imtiyaaz, Moh Thaariq Zelda Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Julia Megawati Djamal Kadir, Mujtahid Bin And Khudzaifi, Muhamad Lailatul Farikah Lathifatun Nida Noor M. Wahyu Ariawan Manik, Nirmala Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Khudzaifi Muhammad Lathoiful Minan Muhammad Zielal Askari Mulyasari, Ika Mustaanah, Aulia Nur Nihayatus Sholekhah Nirmala Manik Noor, Lathifatun Nida Nurin, Eka Filza Nurul Huda Oktadiana, Isma Presticasari, Hardiyani Rahma, Siti Sofia Rahmawati, Izda Ratna Mildawati Rhomah, Eka Hayati Ridwanto, Muhammad Rika Wahyu Pujiastini Rofiq, Abd Rosnarita, Intan Adevia Sabaan, Wahid Sakti, Aditya Sindu Salmasfattah, Novyananda Salmasfattah, Novynanda Salsabila Khairunnisa savitri, Lisa Setianingsih, Elfrida Rosselly Sholekhah, Nihayatus Siti Mutamimah, Siti Sri Bintang Sahara Mahaputra Kusumanegara Tsamrotul Ilmi Ummi Nurus Salamah Utami, Mega Putri Viren Ramadhan Wijaya, Nadela Wahyu Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zahra, Ilhawa Zuhri, Mukhammad Syaifuddin