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All Journal Majalah Farmaseutik JMM (Jurnal Masyarakat Mandiri) CERATA Jurnal Ilmu Farmasi Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Indonesian Journal of Global Health research Jurnal Kesehatan Tambusai Nusantara Hasana Journal Jurnal Impresi Indonesia Prosiding University Research Colloquium Jurnal Abdimas Indonesia Journal of Engineering Science and Technology Management Business and Economic Publication CERATA Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis SEARCH: Science Education Research Jurnal Informatika dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Muhammad Nurul Fadel
Universitas Muhammadiyah Kudus
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ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
UJI EFEKTIVITAS ANTIBAKTERI KRIM EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP PERTUMBUHAN BAKTERI Pseudomonas aeruginosa Fadel, Muhammad Nurul; Besan, Emma Jayanti; Hamzah, Hasyrul; Prasetyawan, Fendy
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Desember 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i2.643

Abstract

Infeksi bakteri masih menjadi masalah kesehatan yang signifikan. Sejumlah bakteri yang bersifat resisten dapat menyebabkan infeksi bakteri salah satunya bakteri Pseudomonas aeruginosa. Salah satu Tanaman yang memiliki aktivitas antibakteri yaitu tanaman Kersen (Muntingia calabura L.) terutama pada daunya dimana beberapa penelitian dinyatakan mengandung zat Saponin, Tanin, flavonoid dan Akaloid. Tujuan dari penelitian ini untuk mengetahui aktivitas antibakteri krim ekstrak etanol Daun Kersen (Muntingia calabura L.) terhadap pertumbuhan bakteri Pseudomonas aeruginosa. Penelitian yang dilakukan adalah penelitian eksperimental laboratorium. Metode untuk mengujian aktivitas antibakteri melalui metode difusi cakram dengan formulasi 0%, 5%, 10%, 15%, dan gentamicin. Metode menganalisis data menggunakan One Way Anova untuk mengetahui perbedaan data. Hasil uji aktivitas antibakteri krim terhadap bakteri Pseudomonas aeruginosa dengan konsentrasi 5% daya hambat sebesar 17,33 mm kategori kuat, 10% daya hambar sebesar 19,00 mm kategori kuat, dan 15% daya hambat 22,66 mm kategori sangat kuat.Berdasarkan penelitian dapat disimpulkan bahwa krim ektrak etanol Daun Kersen (Muntingia calabura L.) memiliki kemampuan untuk menghambat pertumbuhan bakteri Pseudomonas aeruginosa.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
Prediction of Augenol in Cinnamon (Cinnamomum burmannii) Boiled as a Carminative to Overcome Floating Stomach Rika Wahyu Pujiastini; Fendy Prasetyawan; Yuneka Saristiana; M. Wahyu Ariawan; Muhammad Nurul Fadel; Emma Jayanti Besan
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.2

Abstract

Flatulence (meteorismus) is a common condition caused by excess gas accumulation in the digestive tract. One alternative traditional treatment to overcome this condition is the use of herbal plants, such as cinnamon (Cinnamomum burmannii). This study aims to predict the potential of eugenol, an active compound in cinnamon, as a carminative agent using an in silico approach. Data were obtained from PubChem and analyzed using PASS Online to predict its pharmacological activity. The results of the analysis showed that eugenol has a probability of activity as a carminative of 0.941 and a probability of inactivity of 0.001, indicating high potential in helping to relieve flatulence. Thus, eugenol in cinnamon has the potential as an alternative natural treatment to overcome digestive disorders, especially bloating.
Antibacterial Potential of Ethanol Extract Cream of Kersen Leaves (muntingia Calabura L) Against Pseudomonas Aeruginosa Muhammad Nurul Fadel; Emma Jayanti Besan; Muhammad Ridwanto
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5187

Abstract

Bacterial infections remain a substantial health concern. Several resistant microorganisms can induce bacterial infections, including Pseudomonas aeruginosa. Some research indicate that Kersen leaves (Muntingia calabura L), due to its flavonoids, tannins, and saponins that have undergone clinical testing, possess antibacterial characteristics. This study seeks to evaluate the antibacterial efficacy of a 96% ethanol extract cream derived from Kersen leaves (Muntingia calabura L) against the proliferation of Pseudomonas aeruginosa bacteria. The research performed was experimental in a laboratory setting. The procedure for evaluating antibacterial efficacy via the disc diffusion method utilising formulations of 0%, 5%, 10%, 15%, and gentamicin. The technique of data analysis employing One Way ANOVA to discover differences in data. The antibacterial activity of the cream against Pseudomonas aeruginosa was tested, yielding a 5% inhibition of 17.33 mm (strong category), 10% inhibition of 19.00 mm (strong category), and 15% inhibition of 22.66 mm (very strong category). The research concludes that a 96% ethanol extract cream of Kersen leaves (Muntingia calabura L) possesses the potential to suppress the growth of Pseudomonas aeruginosa bacteria.
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Kulit Jeruk Manis (Citrus sinensis) Dan Daun Pepaya (Carica papaya L.) Terhadap Bakteri Salmonella typhi Penyebab Tipes Wijaya, Nadela Wahyu; Fadel, Muhammad Nurul; Arif, Fahrudin
Jurnal Impresi Indonesia Vol. 4 No. 6 (2025): Indonesian Impression Journal (JII)
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i6.6524

Abstract

Salmonella typhi, sweet orange peel, papaya leaves, antibacterial activity, MIC-MICD. AbstractThe background of this study is based on the high incidence of typhoid fever caused by Salmonella typhi bacteria in Indonesia and the increasing resistance of bacteria to conventional antibiotics. Therefore, alternative natural treatments are needed, such as a combination of sweet orange peel extract (Citrus sinensis) and papaya leaves (Carica papaya L.), which are known to contain antibacterial compounds. The objective of this study was to test the antibacterial activity of the ethanol extract combination of the two plants against Salmonella typhi, determine the optimal concentration, and measure the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The research methods included ethanol extraction, phytochemical testing, disk diffusion testing, and dilution testing. The results showed that the 75%:25% extract combination produced the largest inhibition zone (26.43 mm) with a very strong category, while the MIC and MBC were 6.25% and 25%, respectively. Statistical analysis confirmed significant differences between concentrations. The implications of this study are the potential of the extract combination as a safe and environmentally friendly alternative treatment for typhoid fever, as well as promoting the utilization of local natural resources.
PENINGKATAN PEMAHAMAN KADER NASYIATUL AISYIYAH TENTANG PENGELOLAAN OBAT AMAN MELALUI EDUKASI DAGUSIBU BERBASIS KOMUNITAS DI KABUPATEN LAMONGAN Sakti, Aditya Sindu; Negara, Sri Bintang Sahara Mahaputra Kusuma; Mayangsari, Fransisca Dita; Rokhman, Abdul; Fadel, Muhammad Nurul; Zuhri, Mukhammad Syaifuddin; Imtiyaaz, Moh Thaariq Zelda; Setianingsih, Elfrida Rosselly; Nurin, Eka Filza; Mutamimah, Siti; Adhimi, Cici Sayyidatul
JMM (Jurnal Masyarakat Mandiri) Vol 9, No 4 (2025): Agustus
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v9i4.32002

Abstract

Abstrak: Pemahaman masyarakat mengenai pengelolaan obat yang aman dan rasional masih rendah, berpotensi meningkatkan risiko Drug-Related Problems (DRPs). Kegiatan ini bertujuan untuk meningkatkan pemahaman kader Nasyiatul Aisyiyah tentang konsep DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) agar mereka dapat menjadi agen perubahan dalam edukasi kesehatan komunitas. Penyuluhan berbasis komunitas dilakukan terhadap 49 kader di Desa Blawi, Lamongan, dengan evaluasi melalui pre-test dan post-test. Hasil menunjukkan peningkatan signifikan dalam tingkat pengetahuan kader setelah intervensi,sebanyak 68% kader mengalami peningkatan pengetahuan setelah mengikuti penyuluahan berbasis komunitas ini. Mayoritas peserta juga menyatakan kepuasan terhadap metode edukasi yang diterapkan. Edukasi berbasis komunitas melalui kader terbukti efektif dalam meningkatkan literasi kesehatan terkait pengelolaan obat yang tepat.Abstract: Public awareness of safe and rational drug management remains low, increasing the risk of Drug-Related Problems (DRPs). This program aimed to enhance the knowledge of Nasyiatul Aisyiyah cadres on DAGUSIBU (Obtain, Use, Store, Dispose) so they can act as community health educators. A community-based counseling session was conducted for 49 cadres in Blawi Village, Lamongan, with pre-test and post-test evaluations. The results demonstrated a significant improvement in participants’ knowledge, with 68% of the cadres showing increased understanding following the intervention. Most participants also expressed satisfaction with the educational method applied. Community-based education through cadres has proven effective in improving health literacy related to proper drug management.
PENINGKATAN KESEHATAN HOLISTIK MELALUI EDUKASI PEMBUATAN SIROP HERBAL “SiHebat” KEPADA MASYARAKAT Fadel, Muhammad Nurul; Besan, Emma Jayanti; Rosnarita, Intan Adevia; Yuliasari, Aulia Wahyu; Besan, Ulfa Nabila
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2093

Abstract

The diversity of herbal plants around us is a potential that has not been optimally utilized. The Nasyiatul Aisyiyah Branch Leadership for the 2024 period requires socialization and education related to health as part of filling the routine monthly religious study activities. This community service program aims to provide education to the Nasyiatul Aisyiyah group in Getas Pejaten, Kudus Regency, regarding the production process and utilization of "SiHebat" herbal syrup based on local plants such as ginger, turmeric, temulawak, and lemongrass, which have various health benefits. Educational activities are carried out through the delivery of material using power point presentation media, with a participatory method that includes a pre-test, material presentation, presentation of herbal syrup making material, and a post-test. The results of the activity showed a significant increase in participants' understanding of the use of herbal plants for health, as indicated by an increase in the average post-test score compared to the pre-test. In addition to providing education, this program also aims to encourage community independence in utilizing local natural resources and opening up business opportunities based on herbal products, in addition it can be used by the community as a reference for developing a product that can increase independence, especially in entrepreneurship. The success of the program is measured through the enthusiasm of the participants, increased knowledge, and the ability to instill the making of herbal syrup, from the results of the Pre-test and Post-test, an increase in community knowledge was obtained in understanding starting from raw materials, efficacy and how to make and rules for using efficacious herbal syrup. From the results of community service in making efficacious herbal syrup, it can provide information and benefits to the community in developing innovations in making herbal preparations, especially in making herbal syrup and in the future this program can be further developed through product diversification and joint research to optimize the benefits of herbal plants for public health.
FORMULASI UJI AKTIVITAS ANTIOKSIDAN DAN UJI KARAKTERITIK FISIK SEDIAAN KRIM EKSTRAK DAUN PEPAYA (Carica Papaya L.) SEBAGAI KRIM PELEMBAB KULIT Muhammad Lathoiful Minan; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1546

Abstract

Papaya leaves are known to contain high levels of antioxidants such as flavonoids, α- tocopherol, and ascorbic acid, which help combat free radicals that cause premature aging. This study aimed to evaluate the stability and antioxidant activity of a cream formulated with 70% ethanol extract of papaya leaves using the DPPH method. A total of 3000 g of young papaya leaves were macerated with 70% ethanol, yielding 56.38 g of thick extract, which was then formulated into a cream. The cream was evaluated through organoleptic tests, homogeneity, pH, spreadability, emulsion type, viscosity, and antioxidant activity. Results showed the cream was stable in terms of odor and form, with a pH range of 5–7, spreadability between 5.8–6.2 cm, homogeneous emulsion, and viscosity ranging from 5003–5990 cP. The highest antioxidant activity was observed at 3.5% concentration (78.45%), while the negative control was 222.4 and quercetin as a reference showed 9.08%. It was concluded that the cream formulated from 70% ethanol extract of papaya leaves demonstrated good stability and strong antioxidant activity.
FORMULASI DAN UJI FISIK SEDIAAN KRIM KOMBINASI MINYAK BIJI JINTEN HITAM (Nigella Sativa L.) DAN EKSTRAK DAUN PEPAYA (Papaya Carica L.) SEBAGAI TABIR SURYA Akbar Seno Syafriansyah; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1547

Abstract

Prolonged exposure to sunlight can have harmful effects on the skin, both immediate and long-term. To prevent the negative impact of sun exposure, the use of additional protective products such as sunscreen is essential. To reduce the level of damage caused by the use of synthetic materials, the use of natural ingredients can be considered as components in the formulation of sunscreen creams. This study aims to evaluate the physical quality and determine the sunscreen activity of a cream formulation combining black cumin seed oil (Nigella sativa L.) and papaya leaf extract (Carica papaya L.). The evaluation was conducted through several tests, including organoleptic testing, homogeneity, emulsion type, pH, viscosity, and SPF testing using UV-Vis spectrophotometry. The results showed that the formulation met the required standards: organoleptic tests indicated that the scent and texture of the cream remained stable, although a change in color occurred. The formulation had good homogeneity with a pH ranging from 5 to 7. The recorded viscosities were 9732 cP, 1450 cP, 3030 cP, and 4414 cP, respectively. In the SPF test, the values obtained were 0.22; 4.37; 14.23; and 20.52. Based on these results, it can be concluded that the cream combining black cumin seed oil and papaya leaf extract demonstrated good stability and exhibited effective sunscreen activity.
Co-Authors Abd Rofiq ABDUL ROKHMAN Adhimi, Cici Sayyidatul Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Arif Fahrudin Arif, Fahrudin Astutik, Widhi Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Eko Retnowati Ema Jayanti Besan Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Fransisca Dita Mayangsari Galih Kurniawan Gempita Hutami Dameria Hamzah, Hasyrul Hardiyani Presticasari Hasriyani Hasriyani Ika Mulyasari Ilhawa Zahra Imtiyaaz, Moh Thaariq Zelda Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Izda Rahmawati Julia Megawati Djamal Kadir, Mujtahid Bin And Khudzaifi, Muhamad Lailatul Farikah Lathifatun Nida Noor M. Wahyu Ariawan Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Khudzaifi Muhammad Lathoiful Minan Muhammad Ridwanto Muhammad Zielal Askari Mustaanah, Aulia Nur Nanda Ardianto Negara, Sri Bintang Sahara Mahaputra Kusuma Nihayatus Sholekhah Nirmala Manik Nura Ali Dahbul Nurin, Eka Filza Nurul Huda Oktadiana, Isma Rahma, Siti Sofia Ratna Mildawati Rhomah, Eka Hayati Rika Wahyu Pujiastini Rofiq, Abd Rosnarita, Intan Adevia Sabaan, Wahid Sabila Febrianisa Safitri Ayuningsih Sakti, Aditya Sindu Salmasfattah, Novyananda Salsabila Khairunnisa savitri, Lisa Setianingsih, Elfrida Rosselly Siti Mutamimah, Siti Ulviani Yulia Husna Ummi Nurus Salamah Viren Ramadhan Wijaya, Nadela Wahyu Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zuhri, Mukhammad Syaifuddin