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All Journal Majalah Farmaseutik CERATA Jurnal Ilmu Farmasi Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Indonesian Journal of Global Health research Journal of Holistics and Health Sciences (JHHS) Jurnal Kesehatan Tambusai Nusantara Hasana Journal Jurnal Pengabdian Masyarakat (ABDIRA) Jurnal Impresi Indonesia Prosiding University Research Colloquium KOLONI Journal of Engineering Science and Technology Management Business and Economic Publication CERATA Journal of Innovative and Creativity Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis SEARCH: Science Education Research Jurnal Informatika dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan Multicore International Journal of Multidisciplinary (MIJM) Jurnal Abdimas Indonesia Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Muhammad Nurul Fadel
Universitas Muhammadiyah Kudus
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
UJI EFEKTIVITAS ANTIBAKTERI KRIM EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP PERTUMBUHAN BAKTERI Pseudomonas aeruginosa Fadel, Muhammad Nurul; Besan, Emma Jayanti; Hamzah, Hasyrul; Prasetyawan, Fendy
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Desember 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i2.643

Abstract

Infeksi bakteri masih menjadi masalah kesehatan yang signifikan. Sejumlah bakteri yang bersifat resisten dapat menyebabkan infeksi bakteri salah satunya bakteri Pseudomonas aeruginosa. Salah satu Tanaman yang memiliki aktivitas antibakteri yaitu tanaman Kersen (Muntingia calabura L.) terutama pada daunya dimana beberapa penelitian dinyatakan mengandung zat Saponin, Tanin, flavonoid dan Akaloid. Tujuan dari penelitian ini untuk mengetahui aktivitas antibakteri krim ekstrak etanol Daun Kersen (Muntingia calabura L.) terhadap pertumbuhan bakteri Pseudomonas aeruginosa. Penelitian yang dilakukan adalah penelitian eksperimental laboratorium. Metode untuk mengujian aktivitas antibakteri melalui metode difusi cakram dengan formulasi 0%, 5%, 10%, 15%, dan gentamicin. Metode menganalisis data menggunakan One Way Anova untuk mengetahui perbedaan data. Hasil uji aktivitas antibakteri krim terhadap bakteri Pseudomonas aeruginosa dengan konsentrasi 5% daya hambat sebesar 17,33 mm kategori kuat, 10% daya hambar sebesar 19,00 mm kategori kuat, dan 15% daya hambat 22,66 mm kategori sangat kuat.Berdasarkan penelitian dapat disimpulkan bahwa krim ektrak etanol Daun Kersen (Muntingia calabura L.) memiliki kemampuan untuk menghambat pertumbuhan bakteri Pseudomonas aeruginosa.
Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
PENINGKATAN KESEHATAN HOLISTIK MELALUI EDUKASI PEMBUATAN SIROP HERBAL “SiHebat” KEPADA MASYARAKAT Fadel, Muhammad Nurul; Besan, Emma Jayanti; Rosnarita, Intan Adevia; Yuliasari, Aulia Wahyu; Besan, Ulfa Nabila
Jurnal Abdi Insani Vol 12 No 2 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i2.2093

Abstract

The diversity of herbal plants around us is a potential that has not been optimally utilized. The Nasyiatul Aisyiyah Branch Leadership for the 2024 period requires socialization and education related to health as part of filling the routine monthly religious study activities. This community service program aims to provide education to the Nasyiatul Aisyiyah group in Getas Pejaten, Kudus Regency, regarding the production process and utilization of "SiHebat" herbal syrup based on local plants such as ginger, turmeric, temulawak, and lemongrass, which have various health benefits. Educational activities are carried out through the delivery of material using power point presentation media, with a participatory method that includes a pre-test, material presentation, presentation of herbal syrup making material, and a post-test. The results of the activity showed a significant increase in participants' understanding of the use of herbal plants for health, as indicated by an increase in the average post-test score compared to the pre-test. In addition to providing education, this program also aims to encourage community independence in utilizing local natural resources and opening up business opportunities based on herbal products, in addition it can be used by the community as a reference for developing a product that can increase independence, especially in entrepreneurship. The success of the program is measured through the enthusiasm of the participants, increased knowledge, and the ability to instill the making of herbal syrup, from the results of the Pre-test and Post-test, an increase in community knowledge was obtained in understanding starting from raw materials, efficacy and how to make and rules for using efficacious herbal syrup. From the results of community service in making efficacious herbal syrup, it can provide information and benefits to the community in developing innovations in making herbal preparations, especially in making herbal syrup and in the future this program can be further developed through product diversification and joint research to optimize the benefits of herbal plants for public health.
FORMULASI UJI AKTIVITAS ANTIOKSIDAN DAN UJI KARAKTERITIK FISIK SEDIAAN KRIM EKSTRAK DAUN PEPAYA (Carica Papaya L.) SEBAGAI KRIM PELEMBAB KULIT Muhammad Lathoiful Minan; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1546

Abstract

Papaya leaves are known to contain high levels of antioxidants such as flavonoids, α- tocopherol, and ascorbic acid, which help combat free radicals that cause premature aging. This study aimed to evaluate the stability and antioxidant activity of a cream formulated with 70% ethanol extract of papaya leaves using the DPPH method. A total of 3000 g of young papaya leaves were macerated with 70% ethanol, yielding 56.38 g of thick extract, which was then formulated into a cream. The cream was evaluated through organoleptic tests, homogeneity, pH, spreadability, emulsion type, viscosity, and antioxidant activity. Results showed the cream was stable in terms of odor and form, with a pH range of 5–7, spreadability between 5.8–6.2 cm, homogeneous emulsion, and viscosity ranging from 5003–5990 cP. The highest antioxidant activity was observed at 3.5% concentration (78.45%), while the negative control was 222.4 and quercetin as a reference showed 9.08%. It was concluded that the cream formulated from 70% ethanol extract of papaya leaves demonstrated good stability and strong antioxidant activity.
FORMULASI DAN UJI FISIK SEDIAAN KRIM KOMBINASI MINYAK BIJI JINTEN HITAM (Nigella Sativa L.) DAN EKSTRAK DAUN PEPAYA (Papaya Carica L.) SEBAGAI TABIR SURYA Akbar Seno Syafriansyah; Muhammad Nurul Fadel; Muhammad Khudzaifi
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1547

Abstract

Prolonged exposure to sunlight can have harmful effects on the skin, both immediate and long-term. To prevent the negative impact of sun exposure, the use of additional protective products such as sunscreen is essential. To reduce the level of damage caused by the use of synthetic materials, the use of natural ingredients can be considered as components in the formulation of sunscreen creams. This study aims to evaluate the physical quality and determine the sunscreen activity of a cream formulation combining black cumin seed oil (Nigella sativa L.) and papaya leaf extract (Carica papaya L.). The evaluation was conducted through several tests, including organoleptic testing, homogeneity, emulsion type, pH, viscosity, and SPF testing using UV-Vis spectrophotometry. The results showed that the formulation met the required standards: organoleptic tests indicated that the scent and texture of the cream remained stable, although a change in color occurred. The formulation had good homogeneity with a pH ranging from 5 to 7. The recorded viscosities were 9732 cP, 1450 cP, 3030 cP, and 4414 cP, respectively. In the SPF test, the values obtained were 0.22; 4.37; 14.23; and 20.52. Based on these results, it can be concluded that the cream combining black cumin seed oil and papaya leaf extract demonstrated good stability and exhibited effective sunscreen activity.
FORMULASI DAN UJI ANTIBAKTERI EKSTRAK BIJI KETUMBAR (Coriandrum sativum L.) PADA SEDIAAN SPRAY GEL ANTIJERAWAT DENGAN VARIASI CARBOPOL 940 Muhammad Zielal Askari; Muhammad Nurul Fadel; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1559

Abstract

Acne is a skin problem or infection that generally appears on the face, neck, chest, and back. Acne is caused by the bacteria Propionibacterium acnes. Acne treatments that are often used are topical medications containing synthetic antibiotics. However, the use of these drugs can cause adverse resistance. Another alternative for acne therapy is using natural ingredients. This study aims to determine the antibacterial activity of coriander seed extract in a spray gel preparation. Flavonoid, terpenoid, saponin and tannin compounds contained in seeds This study is an experimental laboratory study using the disc diffusion method with 5 treatments, namely coriander seed extract with a concentration of carbopol F1 0.1%, F2 0.2%, F3 0.3%, a positive control spray gel brand "X" and a negative control only base without extract. The process of making coriander seed extract is carried out through the maceration method for 3x24 hours with 70% ethanol solvent. The filtrate obtained is then evaporated using a water bath to become a thick extract and continued for making spray gel preparations and antibacterial testing. The results of the research on the spray gel formulation from coriander seed extract showed the organoleptic physical characteristics of F1, F2, F3 were yellowish brown, liquid, and had a distinctive coriander odor. The pH test was 6.46; 6.32; 6.04, the viscosity test was 93.43 cP; 81.10 cP; 78.67 cP, the adhesiveness test of all formulas was stated not to drip for 10 seconds, and the spreadability was 6.01 cm; 5.48 cm; 4.42 cm. In the antibacterial test of the spray gel preparation, the inhibition zone value was obtained, namely F1 5.97 mm, F2 6.05 mm, F3 6.08 mm, and the positive control 10.10 mm. Based on the research of the three formulations, the most optimal spray gel preparation was F2 because it met the requirements of the physical test and antibacterial test.
UJI FISIK DAN UJI IRITASI SEDIAAN MASKER GEL EKSTRAK ETANOL DAUN DEWA (Gynura pseudochina (Lour.) DC.) Ummi Nurus Salamah; Muhammad Nurul Fadel; Eko Retnowati
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1581

Abstract

The gel mask preparation containing (Gynura pseudochina) extract was evaluated through physical and irritation tests, including organoleptic observation, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and potential skin irritation. Organoleptic results showed that all formulas had consistent color, odor, and texture, aligning with topical product standards. Homogeneity testing confirmed that the formulations were evenly mixed without visible clumps or phase separation. The pH values ranged between 5 and 6, which are considered safe and comfortable for skin application. The addition of extract affected viscosity levels low to moderate concentrations increased thickness, while higher concentrations led to a decrease due to disruption of the gel matrix structure. Spreadability and adhesion tests indicated that all formulas had appropriate consistency for topical use, allowing ease of application and suitable adherence to the skin. Drying times were consistent across formulas, supporting efficient user experience. Irritation testing revealed no visible reactions on the skin, indicating that all formulas are safe for topical application.
Formulation Research and Antibacterial Activity Test of Face Mist Preparation from Ethanol Extract of Papaya Leaves (Carica Papaya L.) Against Propionibacterium Acnes Mustaanah, Aulia Nur; Fadel, Muhammad Nurul; Khudzaifi, Muhamad
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.559

Abstract

Purpose: The purpose of this study was to formulate a face mist preparation containing ethanol extract of papaya leaves (Carica papaya L.) at concentrations of 10%, 15%, and 20%, and to evaluate its antibacterial activity against Propionibacterium acnes, a primary acne-causing bacterium. Research Method: This study employed a laboratory-based experimental design with a post-test-only control group. Data were collected through experimental observations. The face mist was formulated with three extract concentrations (F1: 10%, F2: 15%, and F3: 20%), with a face mist base as the negative control and clindamycin as the positive control. The preparations underwent organoleptic, pH, homogeneity, and spreadability tests. Antibacterial activity was evaluated using the disc diffusion method, and the data were analyzed using One-Way ANOVA with a significance level of p < 0.005. Results and Discussion: The formulations met the physical property standards, showing a brownish-green color, liquid consistency, and a characteristic papaya leaf aroma. All samples were homogeneous, with pH values ranging from 5.08 to 5.16, and spreadability between 5.33 and 5.75 cm. The highest antibacterial activity was observed in F3 (20%) with an average inhibition zone of 16.3 mm. Implications: The findings suggest that papaya leaf ethanol extract is a promising natural ingredient for face mist formulations with antibacterial properties, offering potential as an alternative acne treatment product.
Formulation and Antioxidant Activity Test of Micellar Water Extracted from Mangosteen Fruit Peel (Garcinia mangostana L.) Using the DPPH Method with Variations in the Concentration of PEG-7 Glyceryl Cocoate as a Surfactant Andriyani, Yunita; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.588

Abstract

Purpose: This study aims to determine the effect of PEG-7 glyceryl cocoate at concentrations of F1 0.2%, F2 0.4%, and F3 0.6% on the physical stability and cleaning power of micellar water preparations containing mangosteen peel extract. The best formulation was then tested for its antioxidant activity using the DPPH method. Research Method: This study used a laboratory experimental method. The variations in PEG-7 glyceryl cocoate concentration used in the micellar water extract of mangosteen peel were F1 (0.2%), F2 (0.4%), F3 (0.6%), and negative control F0 (0%). Evaluations were conducted on physical stability tests (organoleptic, pH, homogeneity, and viscosity) and cleaning power. The best micellar water formulation was then tested for antioxidant activity using the DPPH method. The test results were analyzed using a One-Way ANOVA test. Results and Discussion: The results of testing F3 micellar water, with the highest concentration of PEG-7 glyceryl cocoate, demonstrated that it was the best formula and exhibited the best cleaning ability. The results of the analysis using one-way ANOVA showed a p-value of < 0.05. The antioxidant activity of F3 was determined to have an IC50 of 103.81 μg/ml, which falls within the moderate category. Implications: The results of this study indicate that PEG-7 glyceryl cocoate at a concentration of 0.6% can be used as a surfactant in micellar water preparations of mangosteen peel extract. Further research is needed to determine the long-term stability of the preparation.
Co-Authors Achmad Ridwan Afina Mahmudah Ahmad Kholis Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Anisa Sholikhati Aqfianti Fadilatunnisa Ardianto, Nanda Astutik, Widhi Aulia Nur Mustaanah Ayu Sri Lestari Ayuningsih, Safitri Besan, Ema Jayanti Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Bintari Tri Sukoharjanti Chandra Arifin Charliandri Saputra Wahab Dahbul, Nura Ali Dameria, Gempita Hutami Diah Andriani Kusumastuti Dicky Bayu Setiyono Dzukharian Munandar Dzukharian Munandar Eko Retnowati Elfanesya Silva Emma Jayanti Besan Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Fania Nurul Khoirunnisa Faza Rusyda Febriana, Laela Febrianisa, Sabila Fendy Prasetyawan Findasari Firdyansyah, Diah Aprilia Fitri Apriliani Fitri Apriliani Galih Kurniawan GALIH KURNIAWAN Hamzah, Hasyrul Hardiyani Presticasari Hartini, Putri Tri Hasriyani Hasriyani Hasriyani, Hasriyani Husna, Ulviani Yulia Husnunnisa Ika Lismayani Ilyas Ika Mulyasari Indah Puspitasari Indana Farikha Mawa Indanah Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Julia Megawati Djamal Kadir, Mujtahid Bin And Khoirul Umami Lailatul Farikah Lathifatun Nida Noor Lisa Savitri M. Wahyu Ariawan Manik, Nirmala Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Khudzaifi Muhammad Lathoiful Minan Muhammad Ridwanto Muhammad Zielal Askari Mulyasari, Ika Mustaanah, Aulia Nur Nadela Wahyu Wijaya Nauval Alfarizi Nihayatus Sholekhah Nina Irmayanti Harahap Nirmala Manik Noor, Lathifatun Nida Nor Asiyah Nur Masyithah Zamruddin Nurul Huda Oktadiana, Isma Presticasari, Hardiyani Puteri, Cut Intan Annisa Rahma, Siti Sofia Rahmawati, Izda Rahmawati, Riana Putri Ratna Mildawati Rhomah, Eka Hayati Ria Etikasari Riana Putri Rahmawati Rika Wahyu Pujiastini Rofiq, Abd Sabaan, Wahid Safira Selly Sakila Jauza Adiba Salma Karimah Salmasfattah, Novyananda Salmasfattah, Novynanda Salsabila Khairunnisa Sholekhah, Nihayatus Siti Mulyani Siti Sofia Rahma Tsamrotul Ilmi Ulfa Nabila Besan Ummi Nurus Salamah Utami, Mega Putri Viren Ramadhan Wan Ismahanisa Ismail Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zahra, Ilhawa