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All Journal Majalah Farmaseutik JMM (Jurnal Masyarakat Mandiri) CERATA Jurnal Ilmu Farmasi Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Indonesian Journal of Global Health research Jurnal Kesehatan Tambusai Nusantara Hasana Journal Jurnal Impresi Indonesia Prosiding University Research Colloquium Jurnal Abdimas Indonesia Journal of Engineering Science and Technology Management Business and Economic Publication CERATA Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis SEARCH: Science Education Research Jurnal Informatika dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Muhammad Nurul Fadel
Universitas Muhammadiyah Kudus
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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FORMULASI DAN UJI ANTIBAKTERI EKSTRAK BIJI KETUMBAR (Coriandrum sativum L.) PADA SEDIAAN SPRAY GEL ANTIJERAWAT DENGAN VARIASI CARBOPOL 940 Muhammad Zielal Askari; Muhammad Nurul Fadel; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1559

Abstract

Acne is a skin problem or infection that generally appears on the face, neck, chest, and back. Acne is caused by the bacteria Propionibacterium acnes. Acne treatments that are often used are topical medications containing synthetic antibiotics. However, the use of these drugs can cause adverse resistance. Another alternative for acne therapy is using natural ingredients. This study aims to determine the antibacterial activity of coriander seed extract in a spray gel preparation. Flavonoid, terpenoid, saponin and tannin compounds contained in seeds This study is an experimental laboratory study using the disc diffusion method with 5 treatments, namely coriander seed extract with a concentration of carbopol F1 0.1%, F2 0.2%, F3 0.3%, a positive control spray gel brand "X" and a negative control only base without extract. The process of making coriander seed extract is carried out through the maceration method for 3x24 hours with 70% ethanol solvent. The filtrate obtained is then evaporated using a water bath to become a thick extract and continued for making spray gel preparations and antibacterial testing. The results of the research on the spray gel formulation from coriander seed extract showed the organoleptic physical characteristics of F1, F2, F3 were yellowish brown, liquid, and had a distinctive coriander odor. The pH test was 6.46; 6.32; 6.04, the viscosity test was 93.43 cP; 81.10 cP; 78.67 cP, the adhesiveness test of all formulas was stated not to drip for 10 seconds, and the spreadability was 6.01 cm; 5.48 cm; 4.42 cm. In the antibacterial test of the spray gel preparation, the inhibition zone value was obtained, namely F1 5.97 mm, F2 6.05 mm, F3 6.08 mm, and the positive control 10.10 mm. Based on the research of the three formulations, the most optimal spray gel preparation was F2 because it met the requirements of the physical test and antibacterial test.
UJI FISIK DAN UJI IRITASI SEDIAAN MASKER GEL EKSTRAK ETANOL DAUN DEWA (Gynura pseudochina (Lour.) DC.) Ummi Nurus Salamah; Muhammad Nurul Fadel; Eko Retnowati
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1581

Abstract

The gel mask preparation containing (Gynura pseudochina) extract was evaluated through physical and irritation tests, including organoleptic observation, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and potential skin irritation. Organoleptic results showed that all formulas had consistent color, odor, and texture, aligning with topical product standards. Homogeneity testing confirmed that the formulations were evenly mixed without visible clumps or phase separation. The pH values ranged between 5 and 6, which are considered safe and comfortable for skin application. The addition of extract affected viscosity levels low to moderate concentrations increased thickness, while higher concentrations led to a decrease due to disruption of the gel matrix structure. Spreadability and adhesion tests indicated that all formulas had appropriate consistency for topical use, allowing ease of application and suitable adherence to the skin. Drying times were consistent across formulas, supporting efficient user experience. Irritation testing revealed no visible reactions on the skin, indicating that all formulas are safe for topical application.
Formulation Research and Antibacterial Activity Test of Face Mist Preparation from Ethanol Extract of Papaya Leaves (Carica Papaya L.) Against Propionibacterium Acnes Mustaanah, Aulia Nur; Fadel, Muhammad Nurul; Khudzaifi, Muhamad
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.559

Abstract

Purpose: The purpose of this study was to formulate a face mist preparation containing ethanol extract of papaya leaves (Carica papaya L.) at concentrations of 10%, 15%, and 20%, and to evaluate its antibacterial activity against Propionibacterium acnes, a primary acne-causing bacterium. Research Method: This study employed a laboratory-based experimental design with a post-test-only control group. Data were collected through experimental observations. The face mist was formulated with three extract concentrations (F1: 10%, F2: 15%, and F3: 20%), with a face mist base as the negative control and clindamycin as the positive control. The preparations underwent organoleptic, pH, homogeneity, and spreadability tests. Antibacterial activity was evaluated using the disc diffusion method, and the data were analyzed using One-Way ANOVA with a significance level of p < 0.005. Results and Discussion: The formulations met the physical property standards, showing a brownish-green color, liquid consistency, and a characteristic papaya leaf aroma. All samples were homogeneous, with pH values ranging from 5.08 to 5.16, and spreadability between 5.33 and 5.75 cm. The highest antibacterial activity was observed in F3 (20%) with an average inhibition zone of 16.3 mm. Implications: The findings suggest that papaya leaf ethanol extract is a promising natural ingredient for face mist formulations with antibacterial properties, offering potential as an alternative acne treatment product.
Formulation and Antioxidant Activity Test of Micellar Water Extracted from Mangosteen Fruit Peel (Garcinia mangostana L.) Using the DPPH Method with Variations in the Concentration of PEG-7 Glyceryl Cocoate as a Surfactant Andriyani, Yunita; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Advances in Healthcare Research Vol. 3 No. 2 (2025): March - August
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v3i2.588

Abstract

Purpose: This study aims to determine the effect of PEG-7 glyceryl cocoate at concentrations of F1 0.2%, F2 0.4%, and F3 0.6% on the physical stability and cleaning power of micellar water preparations containing mangosteen peel extract. The best formulation was then tested for its antioxidant activity using the DPPH method. Research Method: This study used a laboratory experimental method. The variations in PEG-7 glyceryl cocoate concentration used in the micellar water extract of mangosteen peel were F1 (0.2%), F2 (0.4%), F3 (0.6%), and negative control F0 (0%). Evaluations were conducted on physical stability tests (organoleptic, pH, homogeneity, and viscosity) and cleaning power. The best micellar water formulation was then tested for antioxidant activity using the DPPH method. The test results were analyzed using a One-Way ANOVA test. Results and Discussion: The results of testing F3 micellar water, with the highest concentration of PEG-7 glyceryl cocoate, demonstrated that it was the best formula and exhibited the best cleaning ability. The results of the analysis using one-way ANOVA showed a p-value of < 0.05. The antioxidant activity of F3 was determined to have an IC50 of 103.81 μg/ml, which falls within the moderate category. Implications: The results of this study indicate that PEG-7 glyceryl cocoate at a concentration of 0.6% can be used as a surfactant in micellar water preparations of mangosteen peel extract. Further research is needed to determine the long-term stability of the preparation.
PENGARUH KONSENTRASI EKSTRAK KOMBINASI DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DAN BERAS (Oryza sativa) PADA SEDIAAN KRIM TERHADAP SIFAT FISIK DAN AKTIVITAS ANTIBAKTERI Staphylococcus aureus Rahma, Siti Sofia; Fadel, Muhammad Nurul; Arif, Fahrudin
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49439

Abstract

Diabetes melitus (DM) disebabkan oleh hiperglikemia, metabolisme protein, karbohidrat dan lemak yang tidak normal, sekresi insulin dan juga dapat diakibatkan oleh keturunan atau genetik. Penderita diabetes bila dibiarkan tanpa pengobatan yang tepat dapat memicu berbagai macam komplikasi, diantaranya ulkus diabetikum yang di akibatkan oleh bakteri Staphylococcus aureus. Keparahan pada ulkus diabetikum dapat menyebabkan amputasi. Penelitian ini bertujuan untuk mengevaluasi efektivitas sediaan krim kombinasi daun binahong dan beras dengan konsentrasi ekstrak 5%:15%, 10%:10%, 15%:5% dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Metode penelitian yang digunakan yaitu metode eksperimental dengan pengujian pH, homogenitas, daya sebar, daya lekat dan uji antibakteri dengan difusi cakram. Hasil menunjukkan bahwa formula F3 (15% binahong : 5% beras) memiliki zona hambat antibakteri paling luas (8,9 mm), termasuk kategori sedang, dan nilai pH dalam rentang aman untuk kulit. Formula ini juga memenuhi kriteria fisik sediaan krim topikal. Dengan demikian, kombinasi ekstrak daun binahong dan beras berpotensi sebagai alternatif pengobatan topikal luka infeksi diabetes.
Analisis Cost-Benefit Terapi Simvastatin dengan Atorvastatin pada Pasien Dislipidemia di Apotek 71 Kota Kediri dengan Pendekatan Human Capital Method Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Fadel, Muhammad Nurul; Besan, Emma Jayanti; Astutik, Widhi; Arifin, Chandra; Rofiq, Abd; Rhomah, Eka Hayati
Business and Economic Publication Vol. 3 No. 2 (2025): Business and Economic Publication
Publisher : Fakultas Ekonomi Universitas KH. A. Wahab Hasbullah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32764/bep.v3i2.1571

Abstract

This study aims to analyze the cost-benefit of simvastatin therapy compared to atorvastatin in dyslipidemia patients at Apotek 71 Kediri City using the Human Capital Method. Using a cross-sectional study design, this study analyzed 60 patients (30 simvastatin users, 30 atorvastatin users). Productivity loss data was collected through a patient self-report questionnaire and valued monetarily using the assumption of a uniform daily wage. Results showed that direct costs of simvastatin were lower (IDR 75,000/month) than atorvastatin (IDR 210,000/month), but lost productivity in the simvastatin group was higher (IDR 384,000) than atorvastatin (IDR 180,000). The Net Benefit value of simvastatin therapy was -Rp 39,000 with a Benefit Cost Ratio (BCR) of 0.91, while atorvastatin produced a Net Benefit of +Rp 210,000 with a BCR of 1.54. The difference in Net Benefit was statistically significant based on an independent t-test (p=0.002). Thus, atorvastatin is more economically efficient than simvastatin because it provides higher productivity benefits despite higher direct costs.
AKTIVITAS ANTIBAKTERI DAN UJI KARAKTERISTIK FISIK CLAY MASK EKSTRAK BUAH PARIJOTO (Medinilla speciosa Blume) Terhadap Bakteri Staphylococcus aureus Alya Narulita; Muhammad Nurul Fadel; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1594

Abstract

Natural ingredients are used as an alternative to the use of synthetic drugs and antibiotics, due to the small side effects caused compared to synthetic drugs. Parijoto fruit (Medinilla speciosa Blume) has many benefits, one of which is as an acne-causing antibacterial with the content of flavonoid compounds, tannins, and saponins. The use of natural ingredients of parijoto fruit in the form of clay mask preparations was chosen because it has advantages and is popular among teenagers compared to other types of masks. This study aims to determine the effectiveness of clay mask preparation with 70% ethanol extract of parijoto fruit in inhibiting the activity of Staphylococus aaureus bacteria using the disc diffusion method. Parijoto fruit is extracted using the maceration method with 70% ethanol solvent to obtain a thick extract, then physical characteristics tests and antibacterial tests are carried out on clay mask preparations. Antibacterial testing of parijoto fruit extract used disc diffusion method with concentrations of 10%, 15%, and 20%. The results of the study showed that 70% ethanol extract clay mask preparations of parijoto fruit had moderate to strong antibacterial effectiveness against S. aureus in formulas F1 (10%), F2 (15%), and F3 (20%) with consecutive inhibition zones of 6.3 mm, 14.1 mm, 15.3 mm. The concentration of F3 (20%) showed the most optimal activity in inhibiting acne-causing S.aureus bacteria.
FORMULASI MASKER GEL LIDAH BUAYA (Aloe Vera) UNTUK PENGENDALIAN BAKTERI Propionibacterium acnes Irvan Shahrul Hidayat; Muhammad Nurul Fadel; Intan Adevia Rosnarita
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1662

Abstract

Acne (Acne vulgaris) is a common skin problem, especially among adolescents, with a prevalence reaching 80-85% in Indonesia. One of the main causes of acne is the bacteria Propionibacterium acnes. Acne treatment usually uses synthetic antibiotics, but long-term use can cause side effects and bacterial resistance. Alternative natural treatments are needed to address this problem. Aloe vera is known to have antibacterial, anti-inflammatory, and cell regeneration-accelerating properties, making it potentially useful in skin care products. The active ingredients of aloe vera, such as anthraquinones, saponins, and flavonoids, are effective in inhibiting the growth of Propionibacterium acnes. Peel-off gel masks were chosen as topical preparations because they are practical, have a cooling effect, and can increase the penetration of active ingredients. This study aims to develop a gel mask formulation with aloe vera extract and test its effectiveness in inhibiting the growth of Propionibacterium acnes bacteria. This study used a laboratory experimental method with a post-test only control group design. The formulas used included various concentrations of aloe vera extract (5%, 10%, and 15%) and a positive control using 1% clindamycin. Evaluation of the preparations included organoleptic tests, homogeneity, pH, viscosity, spreadability, adhesion, drying time, and antibacterial activity testing using the disc diffusion method. Antibacterial effectiveness testing was divided into 5 treatment groups. The inhibition zone test against Propionibacterium acnes was conducted to assess the effectiveness of each formulation. The test data were analyzed using the One Way ANOVA statistical method with SPSS 25 software to determine significant differences between groups. Antibacterial testing was conducted by disc diffusion. The results of the study on the aloe vera extract peel-off gel mask formulation showed good organoleptic physical quality, homogeneity, adhesiveness, and drying time of the preparation, while the viscosity and spreadability tests did not meet the requirements, and the pH test on formula F3 did not meet the pH requirements for mouthwash preparations. In the antibacterial activity test of the peel-off gel mask preparation, the inhibition zone values ​​were obtained at F0 2.23 mm; F1 4.8 mm; F2 6 mm; F3 7.2 mm; and the positive control 33.5 mm.
Co-Authors Abd Rofiq ABDUL ROKHMAN Adhimi, Cici Sayyidatul Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Arif Fahrudin Arif, Fahrudin Astutik, Widhi Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Eko Retnowati Ema Jayanti Besan Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Fransisca Dita Mayangsari Galih Kurniawan Gempita Hutami Dameria Hamzah, Hasyrul Hardiyani Presticasari Hasriyani Hasriyani Ika Mulyasari Ilhawa Zahra Imtiyaaz, Moh Thaariq Zelda Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Izda Rahmawati Julia Megawati Djamal Kadir, Mujtahid Bin And Khudzaifi, Muhamad Lailatul Farikah Lathifatun Nida Noor M. Wahyu Ariawan Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Khudzaifi Muhammad Lathoiful Minan Muhammad Ridwanto Muhammad Zielal Askari Mustaanah, Aulia Nur Nanda Ardianto Negara, Sri Bintang Sahara Mahaputra Kusuma Nihayatus Sholekhah Nirmala Manik Nura Ali Dahbul Nurin, Eka Filza Nurul Huda Oktadiana, Isma Rahma, Siti Sofia Ratna Mildawati Rhomah, Eka Hayati Rika Wahyu Pujiastini Rofiq, Abd Rosnarita, Intan Adevia Sabaan, Wahid Sabila Febrianisa Safitri Ayuningsih Sakti, Aditya Sindu Salmasfattah, Novyananda Salsabila Khairunnisa savitri, Lisa Setianingsih, Elfrida Rosselly Siti Mutamimah, Siti Ulviani Yulia Husna Ummi Nurus Salamah Viren Ramadhan Wijaya, Nadela Wahyu Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zuhri, Mukhammad Syaifuddin