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Journal : HAYATI Journal of Biosciences

The Effect of Stevia (Stevia rebaudiana Bertoni) Leaf Extract Cream on Transforming Growth Factor-β1 Levels and Collagen Amount in the Skin of Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Febrina, Jessica; Muliarta, I Made; Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Linawati, Ni Made; Artini, I Gusti Ayu
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.435-444

Abstract

Ultraviolet B (UVB) exposure is a major cause of skin aging, leading to collagen degradation and wrinkles due to free radical damage. Stevia (Stevia rebaudiana Bertoni) has antioxidant properties that may counteract this by preserving Transforming Growth Factor-β1 (TGF-β1), essential for collagen synthesis. This study evaluated the effects of stevia leaf extract cream on TGF-β1 and collagen levels in male Wistar rats. Thirty rats were divided into five groups: K0 (no UVB, no cream), K1 (base cream), P1 (2.5% stevia cream), P2 (5% stevia cream), and P3 (10% stevia cream). Groups K1, P1, P2, and P3 were exposed to a cumulative UVB exposure of 840 mJ/cm2 over four weeks. The TGF-β1 levels measured by ELISA did not differ significantly among groups (p>0.05). However, collagen levels, assessed using Picro Sirius Red staining, varied significantly (p<0.05). The K1 exhibited significantly lower collagen compared to K0 (p=0.003), whereas the P2 group effectively prevented collagen degradation compared to K1 (K1: 65.87% vs. P2: 77.92%; p = 0.005). While stevia leaf extract cream did not prevent TGF-β1 reduction, it demonstrated a clear protective effect against UVB-induced collagen loss. Among the tested concentrations, 5% stevia leaf extract cream was the most effective in preserving dermal Collagen, highlighting its potential as a topical agent for preventing photoaging and maintaining skin structural integrity.
Co-Authors A.A.Istri Firasti Widyaratni A.A.Ngurah Wisnu Nayaka Putra AA Lanang Dananjaya Putra Dewa WA adiartha g Agha Bhargah Agus Suarjaya Putra Alex Pangkahilla Ali Imron Anak Agung Ayu Ngurah Susraini Anak Agung Fridami Dewi Andreany Kusumowardani Andriana, Laily Mita Andy Sirada annie minerva datui Arfian Hamzah Ari Wibawa Ari Wibawa Asshiddiqie Chirac Sepakat Purba Ayunindya, Dewa Ayu Agung Megaretha Bagus Komang Satriyasa Bella Noviantika Bertha Melyana Boki Jaleha Catherina . D A inten Dahlan Abdullah Damayanti, Ni Kadek Ayu Maya Daryono . . Deny Sutrisna Wiatma Desak Made Wihandani Dewa Ayu Eka Wahyuni Dewa Gede Putra Angga Pradnyana Dewa Putu Gde Samatra Dewi, Anak Ayu Nyoman Trisna Narta Diahningrum, Sylvi Dio Septiyan Helmi Dionisius Wora Dw P. Sutjana Dwi Halim Kevin Gautama Dyno Aryo Christanto Enny Wulandari Febrina, Jessica Felicia Holil Gabriela Queensanya Lienardy Ganesa Puput Dinda Kurniawan Gde Ngurah Idraguna Pinatih Gusti Agung Gede Rama Wintara Gusti Made Agung Mega Utama Hairudin - Hendrata, Winona May Herman Saputra Herman Saputra I Dewa Ayu Agung Diah Sutarini I Dewa Ayu Inten Dwi Primayanti I Dewa Ayu Inten Dwi Primayanti I Dewa Putu Sutjana I Gede Bagus Bhaskara Wijaksana I Gede Bayu Utama Putra I Gede Donny Hendrawan I Gede Koko Gustrawan I Gede Widyatmika Pratama I Gusti Agung Ayu Narita Savitri I Gusti Ayu Artini I Gusti Ayu Putu Armayanthi I Gusti Ayu Sri Mahendra Dewi I Ketut Suada I Komang Suciptha Gago I Made Adi Widiantara I Made Ady Wirawan I Made Ari Samudera I Made Astika Yasa I Made Dhita Prianthara I Made Dwi Ariyuda I Made Gotra I Made Jawi I Made Krisna Dinata I Made Niko Winaya I Made Wahyu Palguna I Made Winarsa Ruma I Made Wirya Sastra I Made Wisnu Saputra I Nengah Sandi I Nyoman Adi Putra I Nyoman Mangku Karmaya I P G. Adiatmika I Putu Adiartha Griadhi I Putu Gde Surya Adhitya I Putu Gede Andyka Yasa I Putu Gede Windhu Saputra I Putu Prisa Jaya . I Putu Putra Suarsana I Putu Sutha Nurmawan I Wayan Bandem Adnyana I Wayan Juli Sumadi I Wayan Sugiritama I Wayan Surata I Wayan Weta I.A. Pascha Paramurthi Ida Ayu Dyah Yusa Dhammayanthi Ida Ayu Ika Wahyuniari Ida Ayu Intan Kartika Dewi Ida Ayu Made Pradnyanini Ida Bagus A. Swamardika Ida Bagus Adnyana Manuaba Ida Bagus Ngurah Ida Bagus Ngurah Ihsan, Muammar Ika Fitri Wulan Dhari Iman Santoso indah adiputra Indira Vidiari J Indra Lesmana Indrasuari, A.A Istri Diah Ivana Juliarty Sitanggang J. A. Pangkahila Jasmine Kartiko Pertiwi Jhon Roby Purba K Tirtayasa K Tirtayasa K tirtayasa K. Tirtayasa Kadek Kristina Harum Lasmi Katrin Rotua Simbolon Ketut Laksmi Puspa Dewi Ketut Tirtayasa Ketut Trisandy Khaerul Anam Komang Tri Adi Suparwati Kunjung Ashadi Kusumaningrum, Cornelia Ayu Liza Ariani Luh Ayu Widayanti Luh Made Indah S.H. Adiputra Luh Made Indah Sri H.A Luh Made Indah Sri Handari Adiputra Luh Made Indah Sri Handari Adiputra Luh Made Indah Sri Handari Adiputra Luh Made Indah Sri Handari Adiputra Luh Made Indah Sri Handari Adiputra Luh Putu Iin Indrayani Maker Luh Putu Ratna Sundari Luh Putu Ratna Sundari M Widnyana M. Ali Imron M.Ali Imron Made Adhi Dharma Setiawan Made Aditya Yogi Guntara Made Hendra Satria Nugraha Made Rania Deviyanti Made Sudarma Maghfirotul Iffah Makbullah - Maker, Luh Putu Iin Indrayani Manuela Serrano, Christina Zita Maria Imaculata Date Masrum Syam Meiza Anniza Meryl Pulcheria Moh. Ali Imron, Moh. Mohammad Syahroni Muh. Irfan Muh. Irfan Muhammad Ali Imron Muhammad Irfan Muhammad Irfan Muhammad Irfan Muthia Munawaroh Muthiah Munawaroh N. Adiputra N. Adiputra N. Adiputra Ni Eka Dewi Ambarawati Ni Kadek Ayu Maya Damayanti Ni Kadek Citra Patmala Ni Kadek Vindy Aprilyanti Ni Ketut Dewi Irwanti Ni Komang Ari Sepriyanti Ni Komang Dewi Semariasih Ni Luh Gede Puji Andini Ni Luh Made Reny Wahyu Sari Ni Luh Nopi Andayani Ni Luh Tu Pertiwi Ni Made Ida Kristina Dewi Ni Made Indah Pratiwi Ni Made Ista Prestiyanti Ni Made Linawati Ni Made Mahastuti Ni Made Rininta Adi Putri Ni Nengah Nita Sulistyawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Suratmiti Ni Putu Dita Kristinayanti Ni Putu Dwi Larashati Ni Putu Haryska Wulan Ni Putu Purnamawati Ni Putu Ruspata Bhyantari Ni Putu Sriwidyani Ni Wayan Rusni Ni Wayan Sintyabudi Kumalapatni Ni Wayan Tianing Ni Wayan Winarti Nila Wahyuni Nur Basuki Nurdianto, Arif Rahman Nyoman Kabella Cinthya Devi Oktovianus Fufu Popi Imelda Margareth Sitompul Purnawati, Susy Purnawati Putu Astawa Putu Ayu Sita Saraswati Putu Dede Asta Wiguna R. A.T. Kuswardhani Rina Mayangsari S Indra Lesmana S. Indra Lesmana S. Indra Lesmana S. Indra Lesmana S. P. Dedy Darma Yasa Santi Bery Hastuti Santoso Santoso Sawitri, Anak Agung Sagung Soeyanto, Milka Ivenna Sri Mahendra Dewi, I Gusti Ayu Suadnyana, Ida Ayu Astiti Sugijanto - Sugijanto - Sugijanto - Sulfandi Sulfandi Susy Purnamawati Susy Purnawati Sutha Nurmawan Swarmadika, Ida Bagus Alit Syahmirza Indra Lesmana Tjokorda Gde Bagus Mahadewa Tri Juniari, Ni Komang Trisna Damayanti Tyas, Ni Luh Putu Larasati Prabawaning Utomo Wicaksono Volman Tampubolon Wahyuddin, Wahyuddin Wahyudin - Wahyuni Novianti, I Gusti Ayu Sri Yohanes Seran Yuliana Yuliana