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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Primatologi Indonesia Jurnal Sain Veteriner VALENSI Majalah Kedokteran Bandung BIOTROPIA - The Southeast Asian Journal of Tropical Biology Proceeding International Conference on Global Resource Conservation Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat BERITA BIOLOGI Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) ARSHI Veterinary Letters JITPI : Jurnal Ilmu Dan Teknologi Peternakan Indonesia (Indonesian Journal of Animal Science and Technology) JURNAL KAJIAN VETERINER Narra J Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Borneo Journal of Pharmacy al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Veteriner Biodiversitas Journal of Biological Diversity
Agik Suprayogi
Department Of Physiology And Pharmacology, Faculty Of Veterinary Medicine, IPB University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Analysis of Amino Acid Profiles in Bone, Oil, and Muscle Tissue and Wound Healing Activity of Pangasius hypophthalmus Oil in Rattus norvegicus Hidayaturrahmah, Hidayaturrahmah; Suprayogi, Agik; Hanif, Novriyandi; Roosita, Katrin; Darusman, Huda Shalahudin; Aprilyana, Lia
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8182

Abstract

Patin (Pangasius hypophthalmus), a commercially important freshwater fish, is a rich source of protein containing both essential and non-essential amino acids, crucial for various biological functions. This study aimed to determine the amino acid composition of muscle tissue, oil, and bones of P. hypophthalmus and evaluate the wound healing potential of its oil extract in Rattus norvegicus. High-Performance Liquid Chromatography was employed to quantify the levels of essential and non-essential amino acids in each tissue. Results revealed that P. hypophthalmus oil exhibited the highest total amino acid content, particularly rich in histidine, arginine, and lysine. The wound healing activity of P. hypophthalmus oil extract was assessed in a rodent model, demonstrating a significant reduction in wound area (0.62-0.84 mm) and an impressive wound healing percentage (79-84.45%). These findings suggest that different parts of P. hypophthalmus possess valuable nutritional and therapeutic properties. Notably, the high amino acid content of P. hypophthalmus oil, particularly essential amino acids, highlights its potential as a promising source for developing pharmaceutical products, including amino acid supplements, wound healing agents, and formulations for metabolic support. Further research is warranted to fully explore the therapeutic potential of P. hypophthalmus oil and its bioactive components.
Effects of patin fish-based nutritional intervention on biochemical and physiological recovery in malnourished rats: An in vivo study and its implications for clinical nutrition Hidayaturrahmah, Hidayaturrahmah; Suprayogi, Agik; Darusman, Huda S.; Roosita, Katrin; Hanif, Novriyandi
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1811

Abstract

Malnutrition is a major global health concern, especially in developing countries. Although patin fish oil and protein offer benefits, their individual and combined effects on maternal physiology remain unclear, particularly during early pregnancy. The aim of this study was to assess the effect of patin-based nutritional intervention on total serum protein, albumin, hemoglobin levels, body weight during pregnancy, body weight during lactation, heart rate, respiratory rate, body temperature, external appearance, behavioral activity, and milk production in malnourished rats. An in vivo study was conducted using Rattus norvegicus rats. The rats were divided into six groups: (1) healthy control, receiving standard feed; (2) malnourished control, receiving an 8% low-protein diet; (3) malnourished group, receiving standard feed; (4) malnourished treated with patin oil; (5) malnourished treated with patin meat; and (6) malnourished treated with a combination of patin oil and meat. The treatment consisted of 21 days during pregnancy and 23 days during lactation, for a total of 44 days. Our data indicated that patin-based intervention significantly increased total protein (p=0.044), albumin (p=0.001), and hemoglobin levels (p=0.034) compared to malnourished control group. The malnourished animals treated with patin oil showed the highest increases in total protein (1.67%), albumin (17.75%), and hemoglobin (24.26%). Body weight gain improved significantly in patin-treated group in both pregnancy (p=0.032) and lactation (p<0.001) compared to the malnourished control, with the highest gains observed in the patin oil group. Milk production also increased significantly (p<0.05), reaching its peak in the patin oil and meat combination group (6.97 g). Physiological parameters, including heart rate (p=0.021), respiratory rate (p=0.025), and body temperature (p=0.023), were significantly different among groups, of which patin oil and meat groups had the most optimal parameters compared to malnourished control group. In conclusion, patin-based nutritional intervention effectively enhances protein metabolism, hematological parameters, and physiological health in malnourished maternal rats, with patin oil demonstrating the most pronounced effects.
Enhancement of α-Glucosidase Inhibitory Activity, Antioxidant Activity, and Antioxidant Compounds in Mulberry Leaves Under Salinity Stress Wulandari, Yasinta Ratna Esti; Sulistyaningsih, Yohana Caecilia; Suprayogi, Agik; Rahminiwati, Min; Triadiati, Triadiati
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.87-94

Abstract

Salinity stress disrupts redox homeostasis in plants, leading to notable changes in the levels of bioactive compounds. These compounds are recognized for their significant role in inhibiting the α-glucosidase enzyme, which is relevant in glycemic control. Detailed insights into how salinity stress modulates α-glucosidase inhibition in mulberry leaves remain scarce. This study aims to investigate the effects of salinity stress on α-glucosidase inhibitory activity in mulberry leaf extracts, and to identify accessions exhibiting the most potent inhibitory properties. In vitro assays were employed to conduct qualitative phytochemical analyses and to quantify total phenolic content, total flavonoid content, and α-glucosidase enzyme activity. The results demonstrate that high salinity stress enhances the inhibitory activity of mulberry leaf extracts against the α-glucosidase enzyme. Notably, the MB2-3 sample exhibited the most favorable IC50 value (0.59 µg/mL), coupled with a substantial phenolic content (141.9 mg GAE/g extract) and the highest content of flavonoid observed among all tested samples (619.56 mg QE/g extract). Collectively, these findings highlight the capacity of salinity stress to augment both the inhibitory potential of mulberry extracts against α-glucosidase and the accumulation of phenolic and flavonoid compounds, with sample MB2-3 displaying auspicious attributes.
Gambaran Histologis Tubulus Seminiferus Kambing Kacang Jantan Lokal Pascapemberian Suplemen Daun Katuk Ferasyi, Teuku Reza; Budiman, Hamdani; Akmal, Muslim; Melia, Juli; R, Razali; Novita, Andi; Barus, Rina Aulia; Suprayogi, Agik
Jurnal Kedokteran Hewan Vol 8, No 1 (2014): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v8i1.1261

Abstract

Penelitian ini mengetahui pengaruh pemberian tepung atau ekstrak alkohol daun katuk terhadap perubahan histologis testis kambing kacang lokal jantan. Dalam penelitian ini digunakan 15 ekor kambing dengan umur sekitar 1,5 tahun. Semua hewan penelitian terlebih dahulu diaklimatisasi selama 2 minggu terhadap lingkungan penelitian. Hewan-hewan tersebut dibagi menjadi 3 kelompok yang masing-masing terdiri atas 5 ekor kambing. Kelompok P0 (kontrol) telah hanya diberikan air distilasi. Pada kelompok P1, diberikan perlakuan berupa suplementasi tepung daun katuk dan untuk kelompok P2 diberikan ekstrak alkohol daun katuk. Semua perlakuan diberikan secara oral sebanyak dua kali per hari (pada pagi dan sore hari) selama 35 hari berturut-turut. Setiap kambing percobaan diberikan pakan yang terdiri atas daun-daunan dan rumput, serta disediakan akses untuk memperoleh air minum secara ad libitum. Pada akhir waktu penelitian, seluruh hewan dikastrasi dan bagian tubulus seminiferus dari testis diambil dan diproses lebih lanjut untuk evaluasi secara histologis. Hasil yang diperoleh menunjukkan bahwa terdapat indikasi peningkatan produksi spermatid dan spermatosit pada Kelompok P1 dan P2. Dengan demikian disimpulkan bahwa pemberian suplemen daun katuk dapat meningkatkan produksi spermatid dan spermatosit kambing kacang lokal jantan.
Pengetahuan, Sikap, dan Praktik Biosekuriti Pedagang Burung Terkait Pengendalian Flu Burung di Kota Bogor Ardilasunu Wicaksono; Indah Ratna Yutami; Agik Suprayogi
Jurnal Veteriner Vol. 26 No. 3 (2025)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2025.26.3.298

Abstract

Kota Bogor merupakan wilayah endemis avian influenza sehingga program pengendaliannya masih gencar dilakukan. Pasar burung memiliki potensi penyebaran avian influenza karena interaksi yang tinggi baik antara hewan maupun dari hewan ke manusia sehingga penerapan biosekuriti penting dilakukan oleh pedagang burung. Penelitian ini bertujuan untuk mengukur pengetahuan, sikap, dan praktik pedagang burung terkait praktik biosekuriti untuk mendukung program pengendalian avian influenza di Kota Bogor. Seluruh pedagang burung di Kota Bogor sebanyak 31 orang diambil sebagai sampel/responden. Metode pengambilan data menggunakan kuesioner yang telah disusun secara terstruktur. Data hasil penelitian kemudian diolah secara deskriptif dan dilakukan analisis korelasi menggunakan Uji Chi-Square dan Uji Korelasi Spearman. Hasil penelitian menunjukkan bahwa kebanyakan pedagang belum memahami pentingnya penggunaan alat pelindung diri dan peran pembatasan hewan lain (>80.0%), belum meyakini risiko menerima burung titipan dari pedagang lain (80.0%), belum selalu menggunakan sabun saat mencuci tangan dan membersihkan kandang (66.7%), tidak mengenakan APD (80.0%), dan masih membuang kotoran burung ke selokan (63.3%) serta membuang bangkai burung ke tempat sampah umum (93.3%). Hasil analisis terhadap peubah yang diamati memperlihatkan hubungan yang nyata antara umur (X2=14.403, p=0.000) dan pengalaman berdagang (X2=12.543, p=0.001) terhadap pengetahuan pedagang dengan kekuatan hubungan yang kuat dan positif (r=0.596-0.693). Selanjutnya, pengetahuan berhubungan nyata terhadap sikap (p= 0.001, r= 0.558) begitu juga sikap terhadap praktik biosekuriti (p= 0.001, r= 0.558).
Dampak Ekonomi Kejadian Avian Influenza di Kabupaten Pinrang pada Peternakan Ayam Petelur Ardilasunu Wicaksono; Sri Wahyuni; Agik Suprayogi
JURNAL KAJIAN VETERINER Vol 14 No 1 (2026): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v14i1.25165

Abstract

Avian influenza reduces egg production in layer chickens, leading to significant economic losses for farmers. Pinrang, one of the largest egg-producing regions in South Sulawesi, continues to face recurring cases of avian influenza. This study aimed to estimate the economic losses associated with avian influenza incidences in layer chicken farms in Pinrang District. The economic impact was assessed using partial analysis by calculating both direct and indirect costs of avian influenza at the district and farm levels on an annual basis. Input parameters included epidemiological and economic data obtained from the Department of Livestock and Plantation of Pinrang District, scientific literature, commodity and veterinary product records, and veterinary practitioners. Sensitivity analysis was performed to evaluate the effect of uncertain parameters on the estimated outcomes. The results indicated that the total economic loss reached IDR 12.4 billion/year at the district level and IDR 9 million/year at the farm level. The largest allocation of the losses was attributed to reduced egg production (38.1%), followed by vaccination costs (25.9%). The most influential parameters affecting the estimates were disease incidence and egg prices. In conclusion, avian influenza causes substantial economic losses in Pinrang District, highlighting the importance of preventive measures to minimize future costs.
Hematological Profile of Beef Cattle After Consuming Concentrate Feed Supplemented with Depolarized Katuk Leaf (Fedtugrow®) in Local Farmers Ronald Tarigan; Fadjar Satrija; Muladno; Afton Atabany; Yuliantoni Queen; Agik Suprayogi
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 1 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.1.146

Abstract

Fedtugrow® is a complete feed containing depolarized katuk (Sauropus androgynous) leaves and is beneficial for enhancing the productivity of both dairy and beef cattle. Depolarization technology in katuk leaves involves the removal of polar compounds from the leaf to eliminate the potential side effects resulting from katuk consumption, such as bronchiolitis obliterans and inhibition of calcium absorption. This technology could eliminate side effects without compromising the efficacy of katuk leaves in increasing milk production and body weight gain. This study aimed to evaluate the efficacy of Fedtugrow® in promoting the growth of beef cattle and its impact on the health status of the cattle raised on smallholder local farms with distinct characteristics compared to commercial farms. Ten Limousin male cattle entering the fattening phase were divided into a control group that consumed standard concentrate and a treatment group that consumed Fedtugrow® for three months. Blood was collected at the end of treatment for hematological analysis, including erythrocyte and leukocyte profiles. Cows consuming Fedtugrow® showed a significantly higher average daily gain and lower stress index than the control. Furthermore, no significant differences were observed in the hematological profile, such as total erythrocyte count, hemoglobin level, hematocrit, and total leukocytes. This study showed the ability of Fedtugrow® as a growth promoter without negatively affecting the physiological status of beef cattle raised on smallholder farms. Keywords: Beef cattle, Fedtugrow®, hematology, smallholder local farm
The Impact of Fedtugrow® Downstreaming with SPR Integration in Central Lampung Regency Using SROI Farida Ratna Dewi; Ronald Tarigan; Fadjar Satrija; Muladno Muladno; Afton Atabany; Indah Wijayanti; Agik Suprayogi
Jurnal Ilmu Pertanian Indonesia Vol. 30 No. 4 (2025): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.30.4.812

Abstract

The dissemination of research findings (innovation) in universities would have a social and economic impact on the larger community. IPB developed the depolarized katuk invention (known as Katulac), which was patented (P00201800110, Jan 5, 2018). IPB collaborated with the Local Government of Central Lampung Regency, PT Great Giant Livestock (GGL), and community farms named Hipermadani (downstreaming of university innovation for the community and farmers) in downstreaming Fedtugrow (innovation in combined livestock feed Katulac® and concentrate) to improve farmer welfare. Katulac®'s downstream innovation is the School for Smallholder Livestock Farming (Sekolah Peternakan Rakyat, SPR), an IPB innovation with copyright (EC00201987765, Nov 28, 2019). The Katulac® downstreaming initiative with SPR institutional integration resulted in a social investment of IDR 501,837,278 and a net social benefit of IDR1,488,959,391 for all stakeholders in the Hipermadani ecosystem. This program had a Social Return on Investment (SROI) of 2.97, which means that for every IDR 1 invested, it would deliver a social benefit of IDR 2.97, showing the program's success. Keywords: downstreaming, Hipermadani, innovation, Katulac, Social Return on Investment
Milk Production of Friesian Holstein Cows During the First Month Postpartum as Affected by Depolarized Katuk Supplement Afton Atabany; Agik Suprayogi; Muladno Muladno; Fadjar Satrija; Ronald Tarigan; Farida Ratna Dewi; Welly Sugiono; Yuliantony Queen; Tras Amboro
Jurnal Ilmu Pertanian Indonesia Vol. 31 No. 2 (2026): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.31.2.313

Abstract

This study included 21 recently calved FH cows divided into three treatment groups: control (P0), depolarized katuk (Sauropus androgynus) leaf powder (P1), and depolarized katuk leaf pellet (P2). The study found that the dry matter intake for treatment P0, P1, and P2 were 15.59 ± 0.91 kg, 15.14 ± 1.38 kg, and 16.27 ± 1.28 kg, respectively. Milk production in these three different treatments were 25.91±5.94 L, 23.80±3.42 L, and 32.11±4.75 L, respectively. The dry matter percentage of milk (total solid) in P0 was 21.75±11.67%, P1 was 21.7±0.99%, and P2 was 31.0±10.75%. Depolarized katuk leaves, particularly in pellet form, resulted in much higher milk production than the control group. These data suggest that feeding depolarized katuk leaves as a supplementary feed to FH dairy cows can improve milk supply and quality during the first month of lactation. The inclusion of depolarized katuk leaves, particularly in pellet form, may be a useful technique for increasing dairy cattle productivity and health. Keywords: friesian holstein, depolarized katuk leaves, milk quality, 1-month lactation, milk production
Short Communication: Phytochemistry and chemical fingerprint of katuk (Sauropus androgynus) leaves extract from four varieties FACHRUDDIN FACHRUDDIN; AGIK SUPRAYOGI; NOVRIYANDI HANIF
Biodiversitas Journal of Biological Diversity Vol. 26 No. 2 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260230

Abstract

Abstract. Fachruddin, Suprayogi A, Hanif N. 2025. Short Communication: Phytochemistry and chemical fingerprint of katuk (Sauropus androgynus) leaves extract from four varieties. Biodiversitas 26: 824-830. Katuk (Sauropus androgynus) is a medicinal plant known to consist of four varieties based on the presence and distribution of white spots on the leaf surface. These characteristic differences affect the content of active compounds and their biological activities. This study aimed to determine the phytochemical content of crude ethanol extracts and to analyze the chemical fingerprints of the n-hexane fractions from the leaves of four S. androgynus varieties. The extraction process was conducted using ethanol to obtain the crude extract, followed by partitioning with n-hexane to separate the non-polar fractions. Qualitative phytochemical tests were performed on the crude ethanol extract, while chemical fingerprint analysis was carried out on the n-hexane fraction using LC-MS instruments. The results showed that the crude ethanol extract contained flavonoids, saponins, tannins, and steroids. LC-MS analysis revealed that all S. androgynus varieties shared similarities in their chemical fingerprint patterns, particularly the Zanzibar-Bastar varieties (six peaks on the chromatogram had the same retention times). The major compound groups found in the n-hexane fractions included triterpenoid glycosides (Zanzibar), diterpenoids (Bastar and Paris), and steroids (Kebo). These similar fingerprints and slight variations in chemical composition provide insights that are likely to produce subtly different pharmacological effects, thereby sparking further intrigue and eagerness for future research in the field of medicinal plant studies.
Co-Authors - Hernawati . Prastowo . Priyanto . Yudi A.S. Satyaningtijas Achmad Tjahja Ahmad Tjahja Nugraha, Ahmad Tjahja Amrozi Andi Novita Aprilyana, Lia Ardiansyah Nurdin Ardilasunu Wicaksono Arifin B. Nugraha Arni Fitri Aryani Satyaningtijas Asep Yayan Ruhyana Asep Yayan Ruhyana Aswani, Tuti Atabany, Afton Damiana Rita Ekastuti Darwati, Sri Dede Sukandar Deni Noviana DEWI APRI ASTUTI Dewi Ratih Agungpriyono Edi Santosa Elsi Ramadhani Fachruddin Fachruddin Fachruddin Fachruddin Fadjar Satrija Farida Ratna Dewi Farida Ratna Dewi Ganjar Alaydrussani Gunanti . Hadri Latif Hajar Hajar Hamdani Budiman Hamdani Budiman Hera Maheshwari Hernawati Hernawati Herwin Pisestyani Hidayaturrahmah Hidayaturrahmah Huda Salahuddin Darusman Huda Shalahudin Darusman I Gusti Agung Ayu Suartini I Gusti Ngurah Kade Mahardika I Wayan Teguh Wibawan Ika Amalia, Ika Indah E Wijayanti, Indah E Indah Ratna Yutami Indrawati Sendow Iqbal Ngabdusani Ira Agustina Dewi Gandasari Irfan Nurhidayat Isdoni Bustaman Jannatun Delvia Juang Gema Kartika Juli Melia Juli Melia Katrin Roosita Khairul Ihsan Koekoeh Santoso Kudang Boro Seminar Kukuh Santoso L. M. Saniwu La Ode Sumarlin La Ode Sumarlin Linda Tjhin Lynette Ong Huey Maritrana Putri Megawati Iskandar Meyliana Wulandari Min Rahminiwati Mokhamad Fakhrul Ulum, Mokhamad Muhammad Ardiansyah Nurdin Muladno - Muslim Akmal Nastiti Kusumorini NASTITI KUSUMORINI Nelda Fliza Zora Ni Luh Putu Agustini Nofriyandi Hanif Novriyandi Hanif Pudji Achmadi Rahmat Hidayat Razali R Razali R Ridi Arif Ridzki M.F. Binol Rika Sudranto Riki Siswandi rina aulia barus Rina Aulia Barus Ritonga, Arya Widura Rivangga Yuda Hendika Ronald Tarigan Sattabongkoch Maneewong Saukhan, Ghiandra Naufal Syazily Sri Murtini Sri Supraptini Mansjoer Sri Wahyuni Sri Wahyuni Sumiaty Aiba Sumitro - Suryahadi (Suryahadi) Syaprianti Evi Dame Arita Tampubolon, Andre Rymma Teuku Reza Ferasyi Tras Amboro Triadiati Triadiati Tuti Aswani Umi Cahyaningsih Wasmen Manalu Welly Sugiono Welly Sugiono Welly Sugiono Yasinta Ratna Esti Wulandari Yohana Caecilia Sulistyaningsih Yuliantoni Queen Yuliantoni Yuliantoni Yuliantony Queen Yuliantony Queen Zulvia Maika Letis