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Farida Ariani
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Journal : GANEC SWARA

 1 
PROTEIN RAS-LIKE PROTEINS FROM RAT BRAIN SEBAGAI TARGET PENGHAMBATAN PERKEMBANGAN SEL KANKER SUKANTY, NI MADE WIASTY; SAPUTRA, I PUTU BAYU AGUS; ARIANI, FARIDA; YUNITA, LINA; DEWI, NOVIANTI TYSMALA
GANEC SWARA Vol 17, No 4 (2023): Desember 2023
Publisher : Universitas Mahasaraswati K. Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35327/gara.v17i4.661

Abstract

Ras-like proteins from rat brain (Rab) is one of the crucial proteins in the process of intracellular transport. Rab plays a role in delivering vesicles from the donor membrane to the acceptor membrane. Vesicles contain various molecules that are important in cell growth and development. These molecules are generally involved in some signaling pathways. In carrying out its functions, Rab needs to be activated first. The activation process of Rab involves various proteins. Thus, Rab activation and deactivation control are critical to regulating the movement of the transferred molecules. In cancer, there is an uncontrolled activation and deactivation of Rab. Rab's involvement in various signaling pathways by providing molecules needed for growth and development is a basis for increasing the speed of growth and development of cancer cells. Although Rab is not the main factor causing cancer, it can help the development of cancer. So, it can be one of the keys to controlling the transfer of molecules involved in the growth and development of cancer cells. There are several methods related to the activation of Rab for molecular transport. Rab activation inhibition by Rab inhibitors and inhibitors of Rab activating proteins and the use of miRNAs can prevent molecule transport. Thus, control of Rab activation can be an alternative to suppress the growth and development of cancer cells.
Co-Authors Alfian Hamsi Almi Syafroza Amlys, Amlys Syahputra Silalahi Anisah Bayu Bresman P Siboro Bustami Syam Dahlan Tanjung Dardanila, Dardanila Darlan, Lalu Ahmad Dedy Suhendra Desimal, Iwan Dewi, Novianti Tysmala Dewi, Novianty Tysmala Dian M. Nasution Dwi Widayati, Dwi Eddy Sutadji Elisabeth Ginting Erin Ryantin Gunawan Eva Sartini Eva Sartini Bayu Eva, Eva Sartini Bayu Fahmi Bakrie Ananda Saragih Farel H. Napitupulu Ginting, Elizabeth Hariadi , Hariadi Susilo Hasdari, Hasdari Helmi Rangkuti I Putu Bayu Agus Saputra Ikhsan Siregar Ikhwansyah Isranuri Indra N. T. Jauhari, M. Thontowi Juanda, Rizky Juanda Junendri Ardian Khalida Syahputri Laksmi Nur Fajriani Lina Yunita Lina Yunita M Tafsin M. Sabri Ma'ruf, Ma'ruf Tafsin Mahadi Marragi M. Muhammad Ramadhan Muhsin, Lalu Busyairi MULYADI Ni Made Wiasty Sukanty Ni Made Wiasty Sukanty Ninsix, Retti Novia Zuriatun Solehah Nur Cholis Nur’ainun Pakpahan, Dion Peni Patriani Pulungan, Bgd. Sinomba Pebi Nanda Raden Mohamad Herdian Bhakti Rahmi M Sari Ramadan, Prima Ramadhan, Muhammad Ramadhan Reflianto, Reflianto Retti Ninsix Rosliana Lubis Rozitawati, Mona Saib Suwilo Sarjana Sembiring, Ferry Sembiring, Ferry Silalahi, Amlys Syahputra Suci N. Sandi Sukanty, Ni Made Wiasty Suprianto Suprianto Susanti, Baiq Indah Susilo, Hariadi Syahrul Abda Syarif, Abdul Azis Tafsih, Ma'Ruf Tafsin, Ma’ruf Terang UHS Ginting Tri Septian M. Tugiman Tugiman Tugiman Tulus Tulus B Sitorus Tulus Burhanuddin Sitorus Tulus Tulus Wahyuni, Dian Eka Mayasari Sri Widani Darma Isasih Yunita, Lina Yunus Nasution, Ahmad Zulhendri Zen Zulkifli Lubis