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All Journal Jurnal Ilmu Pertanian Indonesia FORUM STATISTIKA DAN KOMPUTASI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kimia (Journal of Chemistry) International Journal of Renewable Energy Development SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan The Journal of Pure and Applied Chemistry Research agriTECH INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemical Science Indonesian Journal of Chemistry Jurnal Agroqua: Media Informasi Agronomi dan Budidaya Perairan Jurnal Ilmiah Pesantren Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Media Agribisnis RESEARCH AND DEVELOPMENT JOURNAL OF EDUCATION (RDJE) Jurnal Pengabdian Polinema Kepada Masyarakat Prosiding Seminar Nasional Sasindo Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan

Mohamad Rafi

Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor

Author-ID : 2450722

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Development of Quality Control Method for Glucofarmaka Antidiabetic Jamu by HPLC Fingerprint Analysis Hanifullah Habibie; Rudi Heryanto; Mohamad Rafi; Latifah Kosim Darusman
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

Herbal medicines become increasingly popular all over the world for preventive and therapeutic purposes. Quality control of herbal medicines is important to make sure their safety and efficacy. Chromatographic fingerprinting has been accepted by the World Health Organization as one reliable strategy for quality control method in herbal medicines. In this study, high-performance liquid chromatography fingerprint analysis was developed as a quality control method for glucofarmaka antidiabetic jamu. The optimum fingerprint chromatogram were obtained using C18 as the stationary phase and linear gradient elution using 10–95% acetonitrile:water as the mobile phase within 60 minutes of elution and detection at 210 nm. About 20 peaks were detected and could be used as fingerprint of glucofarmaka jamu. To evaluate the analytical performance of the method, we determined the precision, reproducibility, and stability. The result of the analytical performance showed reliable results. The proposed method could be used as a quality control method for glucofarmaka antidiabetic jamu and also for its raw materials.

Separation of Inorganic Anions and Phenolic Compounds Using Tetraethylene Oxide-Bonded Stationary Phases in Capillary Liquid Chromatography Roza Linda; Mohamad Rafi; Lee Wah Lim; Toyohide Takeuchi
Indonesian Journal of Chemistry Vol 19, No 1 (2019)
Publisher : Universitas Gadjah Mada

Tetraethylene glycol monomethyl ether (TEGMM) and tetraethylene glycol (TEG) modified silica were synthesized and used in capillary liquid chromatography as stationary phases. The stationary phases were prepared by chemically bonding TEGMM or TEG on silica via reaction with 3-glycidyloxypropyltrimethoxysilane. The present stationary phases were successfully used for the separation of several inorganic anions and phenolic compounds. The TEG-modified silica stationary phase had a better selectivity and higher retention for five anions compared to TEGMM-modified silica stationary phase. The repeatability of retention time for the five anions was satisfactory on both stationary phases. By using 2 mM sodium chloride as eluent, the relative standard deviation values were in ranging from 0.68–3.21 and 2.00–2.16% for analytes in the TEG-and TEGMM-bonded stationary phase, respectively. It was found that the TEG-bonded stationary phase had hydrophilic properties due to the presence of the hydroxyl group at the end of the TEG chains.

Fast Analytical Method for Authentication of Chili Powder from Synthetic Dyes Using UV-Vis Spectroscopy in Combination with Chemometrics Eti Rohaeti; Khoirotul Muzayanah; Dewi Anggraeni Septaningsih; Mohamad Rafi
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

Chili is widely used in many food products, especially in Indonesia food. Sometimes a synthetic dye, i.e., rhodamine B or red textile dye were found in commercial chili powder. A fast, precise and accurate analytical method is necessary to authenticate chili powders from the two synthetics dye as they can cause a health problem. A combination of UV-Vis spectroscopy and chemometrics (multivariate analysis) were used in this study to detect rhodamine B and red textile dye present in chili powder samples. Authentication of chili powder from the two dyes by principal component analysis (PCA) with absorbance data from the UV-Vis spectra of samples was not able to classify all of the samples into each group (pure and adulterated chili powder). Fortunately, by using principal component analysis-discriminant analysis (PCA-DA), approximately 89 and 86% of chili samples mixed with rhodamine B and commercial red textile dye were successfully classified into their corresponding group respectively. The combination of UV-Vis spectroscopy with PCA-DA could be used for fast authentication of chili powder from rhodamine B and textile dye used in this study.

FTIR and HPLC-Based Metabolomics of Yacon Leaves Extracts (Smallanthus sonchifolius [Poepp & Endl.] H. Robinson) from Two Locations in Indonesia Zulhelmi Aziz; Nancy Dewi Yuliana; Partomuan Simanjuntak; Mohamad Rafi; Syamsudin Abdillah
Indonesian Journal of Chemistry Vol 20, No 3 (2020)
Publisher : Universitas Gadjah Mada

Smallanthus sonchifolius [Poepp. & Endl.] H. Robinson (Asteraceae) also known as Yacon or insulin plant, is traditionally used for treating diabetes. Varying geographical origins and postharvest handling, however, seem to affect quantitative and qualitative metabolites in the leaves of Smallanthus sonchifolius [Poepp. & Endl.] H. Robinson (Yacon). The study was conducted to compare and differentiate metabolites profile/fingerprint of Yacon leaves which were grown and obtained from different locations in Pulau Jawa i.e. Lembang (Jawa Barat) and Wonosobo (Jawa Tengah). Three different solvents (95% ethanol, 50% ethanol and water) were used to synthesize Yacon leaves extracts, in order to determine the suitable solvent to produce discernable differentiation through FTIR and HPLC-based metabolomics. Principal Component Analysis (PCA) of FTIR data (4000–400 cm1 wavenumber) indicated that Yacon leaves extracted with ethanol at 95%, had a distinctive FTIR fingerprint profile when compared to others. However, the FTIR-based PCA could not differentiate the extracts based on their geographical origins, although PCA analysis of HPLC-data successfully differentiated the extracts based on their geographical origins. Furthermore, the prominent peak for the leaves extract from Lembang and Wonosobo as regards retention time, was observed at 21.59–25.10 min and 20.69–21.695 min respectively. Notably, R2Y and Q2 value obtained by cross-validation and permutation tests showed all multivariate models were statistically reliable. Overall, there is the need to conduct further research using a more sophisticated tool such as LC-MS, to identify which metabolites represented by the aforementioned FTIR and HPLC data.

FTIR-based Fingerprinting and Chemometrics for Rapid Investigation of Antioxidant Activity from Syzygium polyanthum Extracts Eti Rohaeti; Fadila Karunina; Mohamad Rafi
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.54577

Syzygium polyanthum, known as salam in Indonesia, which is rich in phenolics compounds with high antioxidant activity. In this study, we performed the determination of total phenolics and characterization of the antioxidant activity of S. polyanthum leaves extracts using the FTIR-based fingerprinting technique. The extracts of S. polyanthum in water, ethanol, and ethanol-water (30, 50, and 70%) were measured for their antioxidant activity, total phenolics, and FTIR spectra. The antioxidant activity of S. polyanthum extract with different solvent extraction showed the highest antioxidant activity and total phenolic content is 70% and 50% ethanolic extract, respectively. The FTIR spectrum of each extract showed identical FTIR spectra patterns. According to their different solvent extraction, S. polyanthum extract could be grouped based on FTIR spectra using principal component analysis. Correlation between the functional group in the FTIR spectra with IC50 from S. polyanthum extract was analyzed using partial least square (PLS). The PLS analysis results showed that O–H, C–H sp3, C=O, C=C, C-O, and C–H aromatic are the main functional groups contributed to the antioxidant activity of S. polyanthum extract. FTIR-based fingerprinting combined with chemometrics could be used to classify different extracts of S. polyanthum and predicted functional groups having a significant contribution to antioxidant activity.

Data Fusion of UV-Vis and FTIR Spectra Combined with Principal Component Analysis for Distinguishing of Andrographis paniculata Extracts Based on Cultivation Ages and Solvent Extraction Antonio Kautsar; Wulan Tri Wahyuni; Utami Dyah Syafitri; Syifa Muflihah; Nursifa Mawadah; Eti Rohaeti; Zulhan Arif; Bambang Prajogo; Muhammad Bachri Amran; Abdul Rohman; Mohamad Rafi
Indonesian Journal of Chemistry Vol 21, No 3 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.60321

Andrographis paniculata is one of the medicinal plants used for the treatment of antidiabetic. Cultivation ages and solvent extraction affected metabolites' composition and concentration that directly cause the plant's efficacies. This research aimed to distinguish A. paniculata based on cultivation ages and solvent extraction using data fusion of UV-Vis and FTIR spectra combined with principal component analysis (PCA). A. paniculata with 2, 3, and 4 months post-planting were extracted by water, 50% ethanol, 70% ethanol, and ethanol. In each extract, we measured UV-Vis and FTIR spectra. Then, we used the data fusion from both spectra. We used UV-Vis and FTIR absorbance from 200–400 nm and 1800–400 cm–1, respectively. Each extract gives a similar pattern of UV-Vis and FTIR spectra, only differ in their intensities. PCA score plot in two and three-dimensional showed A. paniculata extracts could be distinguished based on cultivation ages and solvent extraction with a total variance of 86 and 92%, respectively. Furthermore, this study confirms the data fusion of UV-Vis and FTIR spectra could distinguished A. paniculata extracts combined with chemometrics based on cultivation ages and solvent extraction.

Phenolics Profiling and Free Radical Scavenging Activity of Annona muricata, Gynura procumbens, and Typhonium flagelliforme Leaves Extract Dewi Anggraini Septaningsih; Amalia Yunita; Cecep Abdurohman Putra; Irma Herawati Suparto; Suminar Setiati Achmadi; Rudi Heryanto; Mohamad Rafi
Indonesian Journal of Chemistry Vol 21, No 5 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.62124

The leaves of Annona muricata (sirsak), Gynura procumbens (sambung nyawa), and Typhonium flagelliforme (keladi tikus) have been used as traditional medicines in Indonesia. This study aims to determine the antioxidant capacity and putatively identified phenolics from the leaves of three medicinal plants forementioned above. We used the DPPH (2,2-diphenyl-1-picrylhydrazyl) method for measuring radical scavenging (antioxidant assay) while the phenolics profiling was determined using UHPLC-Q-Orbitrap HRMS. The results showed that the percentage of radical scavenging activity of G. procumbens leaves extract in ethanol was higher than the other two plants. Phenolics profiling of the three medicinal plants was identified with 38 compounds belonging to flavones and flavanols hydroxycinnamic acid, and several other groups. The number of metabolites identified putatively was 12, 31, and 19 metabolites in the extracts of A. muricata, G. procumbens, and T. flagelliforme, respectively. The results confirmed the correlation between the phenolics presence and the antioxidant capacity of three plants used in this study.

The Use of Chemometrics for Classification of Sidaguri (Sida rhombifolia) Based on FTIR Spectra and Antiradical Activities Abdul Rohman; Asefin Nurul Ikhtiarini; Widiastuti Setyaningsih; Mohamad Rafi; Nanik Siti Aminah; Muhamad Insanu; Irnawati Irnawati; Djoko Santosa
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64360

Sidaguri (Sida rhombifolia) is one of the herbal components used in traditional medicine. The application of chemometrics in the standardization of herbal medicine is common. The objective of this study was to classify Sidaguri from different regions based on FTIR spectra with chemometrics of principal component analysis (PCA) and to correlate the antioxidant activities with FTIR spectra using the multivariate calibration of partial least square regression (PLSR). The extraction of Sidaguri powder was performed using ultrasound-assisted extraction (UAE) at optimum conditions. The obtained extracts were subjected to antiradical scavenging activities using DPPH (2,2’-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) radicals. The PCA result shows that Sidaguri from different regions could be separated using 14 wavenumbers of FTIR spectra based on the PCA's loading plot. PLSR regression using the second derivative FTIR spectra at wavenumbers of 3662–659 cm–1 could predict radical scavenging activities (RSA) of Sidaguri with R2 values of 0.9636 and 0.9024 for calibration and validation models, with RMSEC and RMSEP values of 1.45% and 2.65%, respectively. It can be concluded that FTIR spectra treated by PCA were reliable for classifying Sidaguri from different regions. At the same time, PLSR was accurate and precise enough to predict the RSA of Sidaguri.

Pendampingan Pengelolaan Media Promosi Bagi UMKM Prima Laundry Malang Rizky Kurniawan Murtiyanto; Shinta Maharani Trivena; Lina Budiarti; Abdul Waris; Umi Khabibah
Jurnal Pengabdian Polinema Kepada Masyarakat Vol. 8 No. 2 (2021): Jurnal Pengabdian Polinema Kepada Masyarakat
Publisher : UPT Penelitian dan Pengabdian Kepada Masyarakat Politeknik Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33795/jppkm.v8i2.79

Pengabdian kepada Masyarakat ini bertujuan untuk memberikan pendampingan pengelolaan media promosi bagi UMKM Prima Laundry guna menjangkau lebih banyak lagi calon konsumen baru. Media promosi yang akan dibuat berupa media promosi online dan offline dikarenakan selama ini masih mengandalkan media promosi offline saja terutama Word of Mouth. Kegiatan pengabdian kepada masyarakat ini berupa pendampingan kepada UMKM Prima Laundry ini diharapkan dapat membantu bagi pelaku usaha UMKM yang masih memiliki kesulitan dalam hal promosi usaha. Metode pengabdian dilakukan dengan mengadakan pendampingan pelatihan pembuatan desain media promosi dan pengelolaan media sosial (instagram). Hasil akhir dari kegiatan ini adalah pemanfaatan media promosi secara berkesinambungan untuk meingkatkan jumlah customer Prima Laundry di Kota Malang, sehingga dapat mewujudkan program Pemerintah untuk membangkitkan UMKM.

Study of Pests and Diseases 10 Accessions of Sowthistle in Organic Cultivation Tatik Raisawati; Maya Melati; Sandra Arifin Aziz; Mohamad Rafi; Parwito Parwito
Jurnal Agroqua: Media Informasi Agronomi dan Budidaya Perairan Vol 20 No 1 (2022): Jurnal Agroqua
Publisher : University of Prof. Dr. Hazairin, SH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32663/ja.v20i1.2507

Tempuyung (Sonchus arvensis L.) is known in Indonesia as traditional medicine. This study was conducted to observe diseases that attack tempuyung in organic cultivation. Ten accessions of sowthistle were collected from Dramaga, Cibadak, Cicurug, Lembang, Matesih, Sekipan, Tawangmangu, Batu, Banjararum, and Sumbersekar, with altitudes between 186-1280 m above sea level and rainfall of 988-2573 mm. The research was carried out in the organic experimental field of Cikarawang, IPB, Bogor, with a geographical location of 6o30' - 6o45' SL and 106o30'-106o45´ EL and an altitude of 190 m above sea level. The research location is a lowland with 1618 mm of rainfall during the study. Pest identification was carried out in the Plant Clinic laboratory of the Plant Protection Department of IPB. Disease identification was carried out by taking symptomatic plants, then isolated and grown in PDA media and then identified. The results showed that the disease that attacked the sowthistle in this experiment was caused by the bacterium Pseudomonas sp and fungi Fusarium sp. The disease attack rate ranges from 32 to 60%. Disease attacks were controlled by removing the affected plants and then spraying with turmeric solution in a ratio of 1: 10. Pests that attacked sowthistle were snails, grasshoppers, fruit borer caterpillars, and panicle-sucking insects.

Co-Authors A. Wahyuningrum Abdul Rohman Abdul Rohman Abdul Waris Adi Novriansyah Agus Jatnika Effendi Agus Mohamad Soleh Alfi Hudatul Karomah Ali Miftahudin Allen Kurniawan Amalia Yunita Amrullah Amrullah Antonio Kautsar Aryo Tedjo Asefin Nurul Ikhtiarini Atang Sutandi Auliatifani, Reza Auliya Ilmiawati Baba Barus Bambang - Riyanto Bambang Prajogo Eko Wardoyo Cahya Septyanti Cecep Abdurohman Putra Derry Permana Dewi Anggraeni Septaningsih Dewi Pusparani Sinambela Dien Atin Boritnaban Djoko Santosa Dyan Fitri Nugraha E. Rohaeti Edy Djauhari Purwakusumah Edy Djauhari Purwakusumah Edy Djauhari Purwakusumah Esti Mumpuni Eti Rohaeti Fadila Karunina Fifi Gus Dwiyanti Hanifullah Habibie Henny Purwaningsih Herdiyanto Herdiyanto Heriyanto Syafutra Ikrar M. Saleh Indah Mutiara Ningtyas Razaad Irma Herawati Suparto Irmanida Batubara Irnawati Irnawati ISKANDAR ZULKARNAEN SIREGAR Khaydanur, Khaydanur Khoirotul Muzayanah L. K. Darusman Latifah K Darusman Latifah K Darusman Latifah K. Darusman Latifah K. Darusman Latifah Kosim Darusman Latifah Kosim Darusman Latifah Kosim Darusman Latifah Kosim Darusman Lee Wah Lim Liliek Nurhidayati Lisa Aprilia Indriyani Lusi Royani M. Agung Zaim Adzkiya Maeda Wahyuningrum Makmum Syafi’i Maya Melati Muhamad Insanu Muhamad Noor Azizu, Muhamad Noor Muhammad Bachri Amran Muhammad Fuad Zaini Muhammad Majiidu Nancy Dewi Yuliana Nanik Siti Aminah Neliwati Nengsih, Nunuk Kurniati Nita Hestiyana Nurameylia Rasaidi Nurhajawarsi Nurhajawarsi Nurmaida Nurmaida Nursifa Mawadah Partomuan Simanjuntak Parwito Purnomo, Tsania Firqin Putra Astaman Putri Vidiasari Darsono R. Heryanto Rifki Husnul Khuluk Rita K Sari Rizka Wildani Rizky Kurniawan Murtiyanto Rizna Azrianiningsari Roza Linda Roza Linda Roza Yusfiandayani Rudi Heryanto Sandra Arifin Aziz Septaningsih, Dewi Anggraini Setyaningsih, Widiastuti Shinta Maharani Trivena Sifa Awalul Fikriah Siti Norazian Ismail Slamet Ari Dwi Ratnanto SUMINAR SETIATI ACHMADI Suyanti Natalia Syamsudin Abdillah Syamsudin Abdillah Syifa Muflihah Taopik Ridwan Tatik Raisawati Toyohide Takeuchi Tun Tedja Irawadi Umi Khabibah Usman Ahmad Utami Dyah Safitri Utami Dyah Syafitri Waras Nurcholis Widia Citra Anggundari, Widia Citra Wina Yulianti Wisnu Ananta Kusuma Wulan Tri Wahyuni Wulansari, Laela Yanuar Chandra Wirasembada Yashinta Fitriani Yulita Suyatmika Zulhan Arief Zulhelmi Aziz Zulliati Zulliati

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