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Journal : JURNAL BIOLOGI INDONESIA

Kajian Pakan Bersumber Energi Tinggi pada Pembentukkan Monyet Obes Oktarina, Ria; Mansjoer, Sri Supraptini; Astuti, Dewi Apri; Suparto, Irma Herawati; Sajuthi, Dondin
JURNAL BIOLOGI INDONESIA Vol 6, No 3 (2010): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.126 KB) | DOI: 10.14203/jbi.v6i3.3145

Abstract

ABSTRACTHigh Energy Diet to Develop Obese Animal Model in Cynomolgus Monkeys (Macacafascicularis). Obesity is a primary predisposition for diseases such as metabolic syndrome(insulin resistance, blood lipid abnormality, and hypertension), type 2 diabetes, andcardiovascular disease. The effort to overcome obesity is needed by understanding thedevelopment of obesity. Therefore, it is urgent to carry out preclinical trials by using an obeseanimal model however it is still limited. The objective of this research was to study the effect ofhigh energy diet with animal fat and soluble carbohydrate to produce obese cynomolgusmonkeys (Macaca fascicularis). Animals used in this study were 15 adult males dividedequally into three treatment groups and were given diets for 4 months. The 3 groups were 1)receiving diet A consists of beef tallow without egg yolk; 2) receiving diet B consists of beeftallow and egg yolk, (energy 4,207 cal/g, fat 19.62%, and starch 60.34% in both first two diet) 3)receiving diet C consists of monkey chow as control (energy 4,330 cal/g, fat 5.55%, and starch51.38%). Measurement were taken every four weeks for body weight, crown rump length, hipdiameter, abdominal skin thickness, body mass index (BMI), nutrient consumption anddigestibility. Results showed that animals received diet B had significant increase in bodyweight and BMI at week 4 and 8. Hip diameter and abdominal skin thickness were significantstarting at week 4 in animals receiving diet with egg yolk (p<0.05) compared to the other twogroups. Protein consumption and digestibility in group with diet A and B was lower (p<0.05)compared to control animals. However, digestibility for dry matter, fat, starch and energy wereabout 90%, meaning that the rations were considered adequate in developing obese monkey.The diet formula containing tallow and egg yolk increased body weight based on BMI criteriaabove 25 kg/m2.Key words: obesity, cynomolgus, egg yolk, body mass index, digestibility
KAJIAN PAKAN BERSUMBER ENERGI TINGGI PADA PEMBENTUKKAN MONYET OBES Oktarina, Ria; Mansjoer, Sri Supraptini; Astuti, Dewi Apri; Suparto, Irma Herawati; Sajuthi, Dondin
JURNAL BIOLOGI INDONESIA Vol 6, No 3 (2010): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v6i3.3145

Abstract

ABSTRACTHigh Energy Diet to Develop Obese Animal Model in Cynomolgus Monkeys (Macacafascicularis). Obesity is a primary predisposition for diseases such as metabolic syndrome(insulin resistance, blood lipid abnormality, and hypertension), type 2 diabetes, andcardiovascular disease. The effort to overcome obesity is needed by understanding thedevelopment of obesity. Therefore, it is urgent to carry out preclinical trials by using an obeseanimal model however it is still limited. The objective of this research was to study the effect ofhigh energy diet with animal fat and soluble carbohydrate to produce obese cynomolgusmonkeys (Macaca fascicularis). Animals used in this study were 15 adult males dividedequally into three treatment groups and were given diets for 4 months. The 3 groups were 1)receiving diet A consists of beef tallow without egg yolk; 2) receiving diet B consists of beeftallow and egg yolk, (energy 4,207 cal/g, fat 19.62%, and starch 60.34% in both first two diet) 3)receiving diet C consists of monkey chow as control (energy 4,330 cal/g, fat 5.55%, and starch51.38%). Measurement were taken every four weeks for body weight, crown rump length, hipdiameter, abdominal skin thickness, body mass index (BMI), nutrient consumption anddigestibility. Results showed that animals received diet B had significant increase in bodyweight and BMI at week 4 and 8. Hip diameter and abdominal skin thickness were significantstarting at week 4 in animals receiving diet with egg yolk (p<0.05) compared to the other twogroups. Protein consumption and digestibility in group with diet A and B was lower (p<0.05)compared to control animals. However, digestibility for dry matter, fat, starch and energy wereabout 90%, meaning that the rations were considered adequate in developing obese monkey.The diet formula containing tallow and egg yolk increased body weight based on BMI criteriaabove 25 kg/m2.Key words: obesity, cynomolgus, egg yolk, body mass index, digestibility
Co-Authors - Hernawati . Sumiati A Setiyono Achmad - Taher ACHMAD FARAJALLAH Achmad Taher Achmad Taher Achmad, Taher Agik Suprayogi Agita Rakhmawati Agus Buono Ainia Herminiati Akeme Cyril Njume Alma Agnia Alusyanti Primawati Anar, Muhammad Agung Firdhawansyah Andi Tarigan Andri Cahya Irawan Andri Cahya Irawan Anja Meryandini Anneke Anggraeni Anneke Anggraeni Annisa Annisa Annisa Annisa Anuraga Jayanegara Aris Purwanto Arismayanti Eka Armaji, Yone Asep Gunawan Asep Sudarman Aulia Evi Susanti Aulia Nurul Saputri Budi Setiawan Cece Sumantri Chairrusyuhur Arman Chusnul Choliq D Diapari D M Suci Daeli, Fanny Rahmasari Daulay, Kausar Didid Diapari Djokowoerjo Sastradipradja Dondin Sajuthi dortiana sijung, maria Dwierra Evvyernie DYAH PERWITASARI -FARAJALLAH Ekowati Handharyani Elizabeth Wina Elizabeth Wina Elmy mariana Elmy Mariana Elok Budi Retnani Endah Yuniarti Entang Iskandar Erika B. Laconi Evy Damayanthi f, Dilla Mareistia Fahmi, Melta Rini Fery Dwi Riptianingsih Firdus . Firkani, Rahmatiana Widi Fitriana, Eko Lela Hairani, Atikah Hanny Hafiar Harlystiarini Harlystiarini Harnowo Permadi Harry Dhika, Harry Heri Ahmad Sukria Hernawati Hernawati I Gusti Bagus Wiksuana I Komang Gede Wiryawan I NENGAH BUDIARSA I wayan Teguh Wibawan Ida Wiryanti Imas Sukaesih Sitanggang Irawan Sugoro Irawan Sugoro Irawan Sugoro Irma Herawati Suparto Jakaria Jakaria Janah, Fatiah Finanur Jean-Baptise Menassol K Komalasari Kevin Alexander, Kevin Klaus Becker Kokom Komalasari Komang G. Wiryawan Kurnia Bagus Ariyanto L Khotijah Lilis Khotijah Linar Zalinar Udin Lucia Cyrilla Eko Nugrohowati Luki Abdullah Mareistia Fassah, Dilla Marlina, Dwi Mohamad Yamin Mohamad Yamin Mohamad Yamin Mohammad Yamin Muhammad Agung Firdhawansyah Anar MUHAMMAD RIZAL Muladno - nabawi, Soviro Nurul Lisa Nahid Ritcher Nahrowi Nahrowi Nanda Nadhifa Nuraini Nanis Nurhidayah Natsir Sandiah NE Maharani Nella Nurhazizah Novita Anggraeni Nur Bambang Priyo Utomo Nurina Rahmawati Pamungkas, Joko Panca Dewi Manu Hara Karti PASETHA, ANDRE Pijoh, Deyv Pipih Suptijah Pursani paridjo Putri Sri Rahayu Qomariah, Indira Nurul R. Iis Arifiantini Rangkuti, Farhan Ananda Rangkuti, Farhan Ananda Rangkuti Razak Achmad Hamzah Retno Wulansari Ria Oktarina Ridwan Raafi'udin Ridwan, Habibi Rima Shidqiyya Hidayati Martin Rimbawan , Rini Herlina Mulyono Riptianingsih, Fery Dwi Rita Mutia Rizki Palupi Ronnie Permana Ronny Rachman Noor Rudy Priyanto Shelvie Nidya Neyman Sitanggang, Imas S. Siti Aslimah Siti Zubaidah Slamet Widodo Slamet Widodo sri murtini . SRI RAHAYU Sri Rahayu Sri Rahmatul Laila Sri Supraptini Mansjoer Suharti, Sri Sukarman Sukarman SULISTIYANI SULISTIYANI Sulistiyani Sulistiyani SULISTIYANI SULISTIYANI Sulistiyani, Sulistiyani Sumiati . Sumiati . Sumiati . . Sumiati Sumiati SYAHRIAL SYAHRIAL Syamsul Arifin Taher, Achmad Taniasari, Mila TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN Teguh Wahyono Tiurma Pasaribu Triansyah, Irvan Walberto Sinaga Wasmen Manalu Waterman, James O. Widya Hermana Wirdateti . Yuli Retnani