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Journal : Science and Technology Indonesia

Anti-Inflammatory Activity and Phytochemical Profile from the Leaves of the Mangrove Sonneratia caseolaris (L.) Engl. for Future Drug Discovery Rozirwan; Ade Siswanto; Nadila Nur Khotimah; Redho Yoga Nugroho; Wike Ayu Eka Putri; Fauziyah; Rezi Apri; Hartoni
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.502-516

Abstract

The increasing demand for effective and natural anti-inflammatory agents prompts an investigation into the properties of Sonneratia caseolaris (L.) Engl., a plant traditionally used in medicine. This study aimed to explore the ability of S. caseolaris leaves extract to inhibit inflammation and accelerate wound healing. S. caseolaris leaves were collected from Tanjung Api-Api area, Banyuasin, South Sumatra. The method involved carrageenan induction in rat paws as an inflammatory model. The results showed that the most effective dose was found in the group with a dose of 150 mg/kg BW measured using a digital caliper and plethysmometer. The qualitative phytochemical test contain alkaloids, steroids, flavonoids, and phenols. The results GC-MS analysis were thought to contain aldehydes, glucosinolates, coumarins, esters, terpenoids, alcohols, lipids, tocopherols, and steroids. Due to their diverse range of mechanisms of action, coumarins show significant promise in mitigating inflammation and hold potential for treating inflammatory conditions. This study provides new insights related to the potential of S. caseolaris as a source of natural anti-inflammatory agents, supporting public comprehension regarding the utilization of traditional herbal remedies.
Copper and Lead Contamination in Sediment and Benthic Ecosystems of Sembilang National Park’s Coastal Region, South Sumatra Rozirwan; Ananta, Dio Alif; Khotimah, Nadila Nur; Putri, Wike Ayu Eka; Fauziyah; Dianysah, Gusti; Siregar, Yusni Ikhwan; Ramses; Isnaini; Melki; Aryawati, Riris; Agustriani, Fitri; Nugroho, Redho Yoga
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.866-876

Abstract

Littoral zone often face environmental pressure due to anthropogenic activities, which can impact the quality of their ecosystem. This study analyzes the concentrations of copper (Cu) and lead (Pb) in sediments and benthic (Anadara granosa and Cerithidea cingulata). Sampling procedures were implemented during September 2022 across the aquatic habitats of Sembilang National Park, in South Sumatra Province, using the purposive sampling method. Sediment grain size and substrate type were analyzed using Shepard’s triangle. Metal detection using a spectrophotometric method based on atomic absorption. The results showed that the sediment fraction mostly consisted of clay, ranging from 92.03% to 94%. Cu concentrations in the sediment ranged from 5.01±0.017 to 5.71±0 mg/kg, while Pb concentrations ranged from 10.5±0.195 to 11.51±0.395 mg/kg. In the benthic, Cu concentrations ranged from 0.0037±0.00005773 to 0.0147±0.00000346 mg/kg, and Pb concentrations ranged from 0.0001±0.000227 to 0.005±0 mg/kg. According to the statistical evaluation testing via independent sample t-test showed that heavy metals differed significantly (p <0.05) between sediment and benthic compartments. These results show that the environmental quality in Sembilang National Park is still comparatively well maintained and within current quality requirements, despite certain activities that have the potential to pollute the environment. To guarantee the long-term viability of this area, it is advised that environmental quality be frequently monitored as a mitigation action.
Co-Authors Achmad Bahul Achmad Bahul Ade Siswanto Adelia Putri Suyatno Afifah, Imania Aidha Nofita Sari Ainun Barakah Akhmad Naruli Akhmad Tri Prasetyo Alexius Ulan Bani Alief Rakhman setyanto Amanda Astri Pratiwi Febrianti Amiwarti, Amiwarti Ananta, Dio Alif Bagas Dwi Janarko Bisma Arianto Chijaya, Ridwan Christina Menuk Sri Handayani Dahlia Daimon Matulessy, Helmy Deni Firmansyah Deny Rahmawati Dianysah, Gusti Dwi Lestari Dwigothammy, Rahmadella E, Agusta Dian Edy Sulistiyawan, Edy Elisa Wildayana Eni Srihastuti Estiasih, Soffia Pudji Fachrudy Asj'ari Fadia Dwi Agustin Fatima, Nuzhat Fatimura, Muhrinsyah Ferry Hariawan Fitri Agustriani Fitria Magdalena Suprapto Galih Whendasmoro, Raditya Gunawan Sudarsono, Bernadus Hartoni Ian Kurniawan Ida Ayu Putu Sri Widnyani Imami, Reza Imarotus Suaida Indra Yustian Indranata Indranata Intan Sari Rufiana Ira Yusmita Yulanda Iskandar Zulkarnain Iskhaq Iskandar Isnaini Istikhoroh, Siti Izzatun Maghfirah Joseph Juwita Sari, Amelia K, Hayumas Nurlita F Khasanah Sahara Khotimah, Nadila Nur Lisa Avita Liyan Habibty, Hamda M Halilurrahman Madkan Marhamah Marhamah Masruha Mehnaz Meisa, Ade Melki Mochammad Hilmy Moh. Ishaq Moh. Jufriyadi Sholeh Mohammad Nabil Almunawar Muhammad Abel Nabila Aprianti Nadia Hanim Nadila Nur Khotimah Nashrudin Latif Ningsih, Ellis Nurjuliasti Nita Nurdiana Noviandri, Fajar Nuha, Achmad Arifulin Nur Rahmanti Ratih Nur, Muhamad` Nurjuliasti Ningsih, Ellis Praka, Areta Bhanuwati Widya Prasasty Ramadhani, Septya Prima Noermaning Punang Amaripuja Putri Awalina Putri, Karladian Radeni Sukma Indra Dewi Rahel, Muhammad Ramses Ratih Wijayanti, Ratih Redho Yoga Nugroho Rezi Apri Rina Fariana Riris Aryawati Rozirwan . Rully Masriatini SADIYAH, HALIMATUS Sasi Kirani Mukti Handayani Sayyidah Mistun Andriani Setiawan, Yugi Sherly Widya Mei Sigit Prihanto Utomo Siska Siti Diyah Handayani Siti Maimunah Siti Samsiyah Siti Suwaibatul Aslamiyah, Siti Suwaibatul Sri Luayyi Srikalimah Subakir Sutama Wisnu Dyatmika Talysa Uliatyl Banat TAUDLIKHUL AFKAR Teguh Purwanto Tengku Riza Zarzani N TioAqzha, Raymirzhad Tri Ariprabowo Tri Darmaningrum, Khaerunnisa Ubaidillah, Lutfian Umi Mahiroh Umiyah Yayang Komang Utari Wardani, Amellia Whinarko Juliprijanto Widiar Onny Kurniawan Wike Ayu Eka Putri Wildatul , Hasanah Wiyati, Eni Rohma Yun Suryotomo Yun Suryotomo Yusmita Yusni Ikhwan Siregar Z, Kholila Indana Zamzam, Muhammad Yani