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Annisa Fitria
Bogor Agricultural University
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Journal : Majalah Farmaseutik

 1 
Evaluasi Aktivitas Sitotoksik Ekstrak Paku Tanduk Rusa [Platycerium coronarium (J.Koenig ex O.F.Müll.)] Desv. Terhadap Sel Kanker Payudara MCF-7 Jumaryatno, Pinus; Wardhani, Kristy Tri; Fitria, Annisa
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.85592

Abstract

ABSTRAK Platycerium coronarium (J.Koenig ex O.F.Müll.) Desv. atau dikenal dengan Paku Tanduk Rusa merupakan tanaman yang secara tradisional biasa digunakan untuk mengobati penyakit kanker di Sumatera Utara. Namun, kemampuannya dalam melawan kanker payudara masih belum diketahui. Oleh karena itu, penelitian ini bertujuan untuk mengevaluasi sitotoksisitas ekstrak P. coronarium terhadap sel kanker payudara MCF-7. Selain itu, skrining fitokimia terhadap ekstrak aktif juga dilakukan untuk mengidentifikasi golongan senyawa yang terkandung didalamnya. Evaluasi sitotoksisitas dilakukan terhadap akar serabut, spora, daun fertil dan daun steril P. coronarium dan ekstraknya diperoleh dengan cara maserasi yang dibantu gelombang gelombang ultrasonik menggunakan pelarut etanol 70%. Sitotoksisitas masing-masing ekstrak terhadap sel kanker payudara MCF-7 ditentukan dengan menggunakan MTT-assay. Hasil penelitian menunjukkan bahwa hanya ekstrak akar serabut yang menunjukkan aktivitas sitotoksik dengan nilai IC50 sebesar 427,76 ppm, sedangkan ekstrak lainnya tidak aktif. Selanjutnya senyawa alkaloid, flavonoid, triterpenoid/steroid, saponin dan fenolik teridentifikasi pada skrining fitokimia terhadap ekstrak akar serabut. Berdasarkan penelitian ini, ekstrak akar serabut P. coronarium memiliki aktivitas sitotoksik yang lemah terhadap sel kanker payudara MCF-7 dan penelitian lebih lanjut diperlukan untuk mencari metabolit sekunder bioaktif yang bertanggung jawab atas aktivitas sitotoksik. Kata Kunci: Kanker payudara; MCF-7; MTT-assay; Platycerium coronarium; sitotoksik  ABSTRACT Platycerium coronarium (J.Koenig ex O.F.Müll.) Desv. or known as Paku Tanduk Rusa is a plant commonly used traditionally to treat cancer in North Sumatera. However, its capability against breast cancer remains unknown. Therefore, this study aimed to evaluate the cytotoxicity of P. coronarium extract against breast cancer cell line MCF-7. In addition, the phytochemical profile of the active extract was also screened. The cytotoxicity evaluation was conducted to the fibrous roots, spores, fertile leaves and sterile leaves of P. coronarium and the extracts of which were obtained by ultrasound-assisted maceration using ethanol 70%. Their cytotoxicity against MCF-7 cell line was determined using MTT assay. The results showed that only the fibrous roots extract exhibited cytotoxic activity with an IC50 value of 427.76 ppm, while other extracts were inactive. Furthermore alkaloids, flavonoids, triterpenoids/steroid, saponins and phenolic compounds were identified on the phytochemical screening of fibrous roots extract. Based on this study, the fibrous root extract of P. coronarium has weak cytotoxic activity against MCF-7 cell line and warrants further investigation for the search of the bioactive secondary metabolites that responsible for the cytotoxic activity. Keywords: breast cancer; cytotoxic; MCF-7; MTT-assay; Platycerium coronarium
Co-Authors Aang Munawar Achmad Edi Subiyanto ACHMAD FAUZAN Ade Hari Siswanto Adi Nur Rohman , Adi Nur Rohman Adriana, Hannura Ahmad, Ahluddin Saiful Akbar, Resti Alfiana, Rita Ali Rakhman Hakim Almasuri, Indah Ambya, Ambya Amelia Fitri Aminulloh, Ali Anatomi Muliawan Anifah, Siti Anissa, mutiara Anna Triningsih, Anna Antara, Nyoman Putra Apipah , Nur Arba Pramundita Ramadani Ari Wibowo Aulia Rahmah Ayatika, Aqhila Fadilla Aziz, Rizka Amelia Azzahra , Nisa Kamila Bariklana, Muhammad Bastomi, Selam Binastya Anggara Sekti Budi Asri, Dyah Permata Damayanti, Siska Dwi Darman, Melani Deni Hermawan Devi, Luh Ari Kamala Dharma, Agus Surya Dior Manta Tambunan DWI SURYANTO Ecica, Ecica Elawati, Tuti Endang Ruswanti Fairana, Vinanti Aesca Fariani Syahrul Fauzan, Rizky Feriza, Gousta Fitriani, Hannie Freddy Harris, Freddy Ganjar Fadillah, Ganjar Ginting, Henndy H Z, M Robith Hakim, Sherina Nabila Putri Hapsari, Nia Puspita Harahap, Pardamean Hariyanto, Ario Yudo Helvis, Helvis Hikmawati, Elok I Gede Hartadi Kurniawan Isnatin Miladiyah Jr., Andre Cardenas Juanda Juanda Jumaryatno, Pinus Juwita, Silvia Ratna Kantikha, I Made Khantika, I Made Kurniawati, Darini Lee, Bonita Lisasih, Nin Yasmine Mahaludin, Agus Wafa Mari’ah, Siti Indriani MASITA DWI MANDINI MANESSA, MASITA DWI MANDINI Maulana, Faid Muhammad Firdaus Murti, Sri Musayadah, Binti Mustaqimah Mustaqimah Nazah, Farida Nurun Nixon Erzed Noorrahman, Moh. Fajar Noorsy, Muhammad Ichsanudin Nurhayani nurhayani Nurida, Luthfiyah Shofi Panggabean, Marshanda Vennesa Pratama, Pebi Paisal Puapitasari, Ruliana Putri, Mela Antika Rahma, Syifa Zakia Rahmahani, Adhining Prabawati Rahman, Agenia Rina Saputri Rohman, Adi Nur Rojak Samsudin, Agus Samuel, Alexander Satinem Sembiring, Malemna Sura Anabertha Sibarani, Paulus Ramotan Siti Zulaikha Sugeng Sugeng Sukma, Putri Patrina SULISTIOWATI Suprajogi, Agus Syaifudin, Ramadhan Syahril Tambunan, Rudy Parluhutan Thaher, Irmanjaya Trapsilo, Alex Wahyudi, Endik Wardhani, Kristy Tri Wasahua, Idris Wasis Susetio Widiatno, Men Wih Widiawati Widiawati, Widiawati Wiraguna, Sidi Ahyar Yandi Syukri Yustian, Alifira Adhany Zulfikar Judge Zulfikar Zulfikar