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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan MNJ (Malang Neurology Journal) Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Jurnal Kesehatan Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Surya Medika Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Acta Biochimica Indonesiana Oceana Biomedicina Journal SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Best Journal (Biology Education, Sains and Technology) Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Conferences of Medical Sciences Dies Natalis Jurnal Keperawatan Molekul: Jurnal Ilmiah Kimia
Zen Hafy
Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Karakteristik Umur dan Histopatologi pada Subtipe Karsinoma Payudara Tripel Negatif . Suly Auline Rusminan, Heni Maulani, Fifie Julianita, Zen Hafy
Majalah Patologi Indonesia Vol 21 No 3 (2012): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAK Latar belakang Karsinoma payudara tripel negatif (KPTN) adalah karsinoma payudara yang tidak mengekspresikan reseptor esterogen, progesteron dan HER-2. Proporsi kejadian KPTN adalah 10-17% dari seluruh karsinoma payudara. KPTN memiliki perjalanan klinis agresif, prognosis yang buruk dan karakteristik klinikohistopatologi serta molekular yang unik. Penelitian ini dirancang untuk mengetahui hal-hal yang terkait dengan karakteristik dan faktor-faktor yang diduga berhubungan dengan subtipe KPTN basal-like dan nonbasal-like berdasarkan tripanel petanda (CK14, EGFR dan 34βE12). Bahan dan cara kerja Penelitian observasi analitik ini menggunakan sampel 39 kasus KPTN dari Laboratorium Patologi Anatomik RSUP dr. Mohammad Hoesin Palembang (periode Juli 2009-Juli 2011). Pulasan imunohistokimia CK14, EGFR dan 34βE12 dilakukan untuk membedakan subtipe KPTN basal-like atau nonbasal-like, kemudian dianalisis hubungan antara karakteristik umur dan histopatologinya. Hasil KasusKPTN terbanyak didapatkan pada kelompok umur 45-49 tahun (33,3%), dengan rerata usia 55 tahun, umumnya adalah jenis karsinoma duktal invasif derajat keganasan tinggi (79,5%). Proporsi KPTN subtipe basal-like dijumpai pada 41% KPTN. Pada penelitian ini tidak dijumpai adanya hubungan statistik bermakna (p>0,05) antara umur dan karakteristik histopatologi yang meliputi ukuran tumor, pleomorfisme inti, jumlah kelenjar, jumlah mitosis, derajat keganasan, subtipe histologi, komponen DCIS, invasi limfovaskular, status limfonodus, tepi tumor dan area nekrosis dengan subtipe KPTN. Kesimpulan Berdasarkantripanel petanda imunohistokimia (CK14, EGFR dan 34βE12) didapatkan 41% kasus termasuk KPTN tipe basal-like. Tidak ada hubungan bermakna antara karakteristik umur dan histopatologi dengan subtipe karsinoma payudara tripel negatif. Kata kunci : Karsinoma payudara tripel negatif, basal-like, CK14, EGFR, 34βE12, umur, karakteristik histopatologi. ABSTRACT Background Triple negative breast cancer (TNBC) is defined as a subtype of breast cancer which is negative for estrogen receptor, progesterone receptor and HER-2. Accounts for 10-70% of all breast cancer.TNBC have aggressive behavior, poor prognosis, unique clinicohistopathologic characteristic and molecular profiles. This study designed to identified characteristics and related with TNBC subtype using tripanels CK14, EGFR and 34βE12. Methods This study was an analytical observasional study based on thirty nine cases of TNBC at the Anatomic Pathology Laboratory of Dr.Mohammad Hoesin General Hospital, Palembang since July 2009-July 2011 period, immunohistchemical staining for CK14, EGFR and 34βE12 were use to distinguish the TNBC basal-like and nonbasal-like subtype, and correlated with age and histopathologic characteristics. Results Most ofTNBC patients were 45-49 years old (33.3%), with mean 55 years old. Most of TNBC (79,5%) were high grade invasive ductal carcinoma (79,5%). Proportion of the basal-like TNBC subtype was 41%. No statistical correlation (p>0,05%) between age, and histopathologic characteristics including tumor size, nuclear pleomorphism, mitotic score, tubule formation score, histologic grade, DCIS component, lymphovascular invasion, lymph node status, margin, and necrosis area with TNBC subtype. Conclusion Based on thetripanel immunohistochemical marker (CK14, EGFR and 34βE12 determine 41% of cases as TNBC basal-like. No statistical correlation between age and histopathological characteristics with TNBC subtype. Key words: Triple negative breast cancer, basal-like, CK14, EGFR and 34βE12, age, histopathologic characteristic.
Akurasi Potong Beku, Sitologi Imprint dan Scraping Intraoperatif dalam Mendiagnosis Tumor Ovarium . Elda Rusnita, Henny Sulastri, Jusuf Fantoni, Zen Hafy
Majalah Patologi Indonesia Vol 21 No 3 (2012): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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ABSTRAK Latar belakang Teknik potong beku maupun sitologi imprint dan scraping sudah digunakan sebagai konsultasi patologi intraoperatif dalam mendiagnosis tumor ovarium. Penelitian mengenai keakuratan diagnosis potong beku intraoperatif pada tumor ovarium pernah dilakukan namun terhadap sitologi imprint dan scraping belum pernah dilakukan di RSUP. Dr. Moh. Hoesin Palembang. Tujuan dari penelitian ini adalah untuk mengetahui akurasi potong beku, sitologi imprint dan scraping dalam mendiagnosis tumor ovarium dibandingkan histopatologi sebagai baku emasnya. Bahan dan cara kerja Penelitian ini merupakan uji diagnostik pada 105 sampel arsip tumor ovarium dari bulan Januari 2009 sampai Desember 2010. Hasil pemeriksaan potong beku, sitologi imprint dan scraping serta histopatologinya dibaca ulang oleh dua orang Spesialis Patologi Anatomik. Data dianalisis untuk menghitung nilai akurasi pemeriksaan potong beku serta sitologi imprint dan scraping. Hasil Didapatkan nilai akurasi potong beku sebesar 99% dan akurasi sitologi imprint dan scraping sebesar 97,14%. Kesimpulan Pemeriksaan potong beku serta sitologi imprint dan scraping merupakan pemeriksaan dengan nilai akurasi yang tinggi. Pemeriksaan sitologi imprint dan scraping dapat menjadi alternatif pemeriksaan intraoperatif untuk rumah sakit yang tidak mempunyai fasilitas potong beku. Kata kunci: Tumor ovarium, potong beku, sitologi imprint dan scraping, akurasi. ABSTRACT Background Frozen section or imprint and scrape cytology technics have been used as an intraoperative consultation measure for ovarian tumor diagnosis. Study about the accuracy of frozen section diagnosis for ovarian tumor had already been done in Dr. mohammad Hoesin General Hospital Palembang but not for imprint and scrape cytology. The aim of this study is to evaluate the accuracy of frozen section, imprint and scrape cytology in ovarian tumor diagnosis compared with histopathology as a gold standard. Methods This study was a diagnostic tes of one hundred and five samples from the archives of ovarian tumors from January 2009 to December 2010. The frozen section, imprint, scrape cytology and histopathological results were evaluated by two pathologists. The data were analized for the determination of the accuracy of frozen section and imprint and scrape cytology. Results The overall accuracy rate for frozen section, imprint and scrape cytology is 99% and 97,14% respectively. Conclusion Frozen section and imprint and scrape cytological examination revealed high accuracy, therefore imprint and scrape cytology are strongly recommended as an alternative measure for intraoperative consultation instead of frozen section mainly for hospitals that do not have facility of frozen section. Key words : Ovarian tumor, frozen section, imprint and scrape cytology, accuracy
Hubungan antara Ekspresi Ki-67 dengan Stadium Klinis dan Derajat Histopatologis Karsinoma Sel Skuamosa Serviks Nita Hertati; Heni Maulani; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Cervical cancer is the third most common type and the fourth most deadly cancerian women which remains a significant health problem worldwide especially in developing coumtry. Ki-67 is a prototype protein in nuclear which influence cell proliferation rate, hence it can be used as one of parameter to evaluate progressivity of tumor cells in carcinoma cases as the cervical squamous cell carcinoma (SCC). This study aims to determine the relationship between clinical staging of cervical SCC and histopatological grading of the cervical SCC with the expression of Ki-67. Methods This was an observational study with a cross sectional design. Sixty cervical squamousa cell carcinoma archive histopathological slide samples (45 biopsy specimens and 15 radical hysterectomy tissues) were collected for this study from the Anatomical Pathology Department of RSUP dr. Mohammad Hoesin Palembang (January 2008 to July 2013). The samples were stained with Ki-67 antibody and analyzed with respect to patient’s clinical stage and histopatological grade. Results The positivity of Ki-67 expressions were more common in the age of ≤ 50 year-old group, in the non-keratinizing type, in the late clinical staging (stage IIIB) and in the moderatelly differentiated histopathological grade. High scores of the Ki-67 expressions (Ki-67>20%) was predominantly found in the late clinical stage and moderatelly differentiated histopathological grade cases. Statistically, there was a significant relationship (p=0.034) with a strong correlation (r=0.714) between the Ki-67 ecpression and the clinical stage of cervical SCC, but not histopathological grade. Conclusion The higher clinical staging of cervical SCC, the higher expression of Ki-67. Key words: cervical squamous cell carcinoma, clinical staging, histophatological grade, Ki-67.
Hubungan Ekpresi E-Cadherin dengan Invasi Limfovaskular dan Status KGB pada Karsinoma Payudara Tripel Negatif Citra Dewi; Henny Sulastri; Jusuf Fantoni; Zen Hafy
Majalah Patologi Indonesia Vol 22 No 1 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

ABSTRAK Latar belakang Karsinoma payudara tripel negatif (KPTN) memiliki karakteristik, prognosis dan terapi yang khas dan dengan angka kematian yang tinggi. Seiring dengan berkembangnya ilmu pengetahuan biomolekuler mengenai penanda tumor, telah banyak penanda prognosis yang diteliti dan salah satunya adalah E-cadherin. Penelitian ini bertujuan untuk melihat hubungan ekspresi E-cadherin dengan invasi limfovaskular dan status kelenjar getah bening (KGB) serta ekspresi E-CD berdasarkan ukuran tumor, morfologi tumor dan derajat histologi pada KPTN. Metode Penelitian ini adalah penelitian retrospektif cross sectional. Tiga puluh sampel jaringan hasil biopsi, lumpektomi dan mastektomi diambil secara acak dari arsip di Bagian Patologi Anatomik Rumah Sakit Mohammad Hoesin (RSMH) Palembang, dilakukan pulasan dengan antibodi E-cadherin dan diteliti hubungannya dengan invasi limfovaskular serta sebaran ekspresinya berdasarkan usia, morfologi tumor dan derajat histologi. Dua puluh dua sampel jaringan hasil mastektomi diteliti untuk menilai hubungan antara ekspresi E-cadherin dengan status KGB dan sebarannya berdasarkan ukuran tumor. Hasil Sebaran ekspresi E-cadherin positif terbanyak pada KPTN dengan ukuran massa tumor >2 cm, jenis karsinoma duktal invasif, derajat histologi tinggi (43,3%). Rasio prevalens hubungan ekspresi E-cadherin dengan invasi limfovaskular dan status KGB masing-masing 1,14 (Interval Kepercayaan 0,19-0,39;p>0,01) dan 1,65 (Interval Kepercayaan-0,143-0,663; p>0,05). Kesimpulan Hasil penelitian ini menunjukkan bahwa E-cadherin belum bisa digunakan sebagai bahan pertimbangan untuk menentukan invasi limfovaskular dan status KGB pada kasus KPTN sehingga E-cadherin kurang dapat memberikan informasi mengenai prognosis penderita KPTN khususnya bagi klinisi dan penderita sendiri. Kata kunci : Karsinoma payudara tripel negatif, E-cadherin, invasi limfovaskular, status KGB. ABSTRACT Background Triple negative breast carcinoma (TNBC) has some unique characteristics, prognosis and treatment, and also a high mortality rate. Prognostic markers have been widely studied and one of them is Epithelial-Cadherin (E-cadherin). This study aims to look the relationship between E-cadherin expression with lymph vascular invasion, lymph node status, tumor size, morphology and histologic grade in TNBC. Methods This was a retrospective cross sectional study. Thirty samples of biopsy, lumpectomy and mastectomy specimens were taken randomly from the archives of the Anatomical Pathology Department of Mohammad Hoesin Hospital Palembang, stained with E-cadherin antibody, were used to investigate the relationship between the expression of E-cadherin with lymph vascular invasion, age, tumor morphology and histologic grade. Twenty-two tissue samples of mastectomy specimens were used to investigate the relationship between E-cadherin expression with lymph node status and tumor size. Results Mostly, positive expression of E-cadherin was expressed in tumor mass >2cm, in invasive ductal carcinoma type (40%) and in a high histologic grade tumor (43,3%). The prevalence ratio (PR) of E-cadherin expression of lymph vascular invasion was 1.14 (Convidence Interval 0.19-0.39; p> 0.05) and the PR of E-cadherin expression of the lymph nodes status was 1.65 (Convidence Interval -0.143-0.663; p> 0.05). Conclusion This study demonstrates that E-cadherin could’nt provide information on prognosis of TNBC as E-cadherin can’t be used as indicator for lympho-vascular invasion and lymphnode status. Key words: TNBC, E-cadherin, lymph vascular invasion, lymph node status
Ekspresi HPV16 Onkoprotein E7 pada Lesi Prakanker dan Karsinoma Sel Skuamosa Serviks Verli Saniba; Wresnindyatsih; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.581 KB) | DOI: 10.55816/mpi.v29i2.409

Abstract

BackgroundCervical cancer is the secondmost common malignancy in women worldwide.The vast majority of cervical cancersare associatedwith high risk HPV16 infection. The persistence of HPV16 and integration of viral DNA into cell genome are necessary for thedevelopment of precancerous lesion and squamous cell carcinoma (SCC) of the cervix. The integration of viral DNA in the host cellgenome resulted in the regulation of oncoprotein E7 leading to detection of HPV16 E7 expression in precancerous lesions and SCCof the cervix.The aim of this study was to evaluate differences of HPV16 E7 expression in precancerous lesions and cervical SCC.MethodsAn observational study with cross-sectional design was performedat Department of Anatomical Pathology Faculty of MedicineUniversity of Sriwijaya/dr. Mohammad Hoesin General Hospital Palembang, from 1st July 2014 to 30st Juni 2017. The selectedsamples consisted of 25 precancerous cases lesions (13 cases of LSIL and 12 samples of HSIL) and SCC (25 cases).Immuhistochemical stained was conducted using HPV16 E7 antibody. Fisher exact’s test was used to analyze differences inexpression of HPV16 E7 among precancerous lesions and cervical SCC.ResultsThe pracancerous lesions occurred mostly between the ages of 30-40 years, while SCC were those between the ages of 51-60years. All SCC cases (100%) and 91.6% of HSIL showed weak to strong HPV16 E7 expression, and 84.6% cases of LSIL showedimmunonegative.ConclusionThe positivity of HPV16 E7 increased in HSIL and KSS lesions.
Hubungan Kepadatan Infiltrasi Sel Radang Limfosit dengan Klinikopatologik Karsinoma Kolorektal di RSUP Dr. Mohammad Hoesin Palembang Calvin Ienawi; Suly Auline Rusminan; Zen Hafy
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (719.439 KB) | DOI: 10.55816/mpi.v29i3.447

Abstract

BackgroundColorectal carcinoma has become one of primary problem that caused mortality and morbidity around the world. This malignancyhas contributed almost more than 9% of all cancer incidence. Lymphocyte infiltration density (TILs) is one of prognostic factors toevaluate colorectal cancer. Although some studies have found that there still have variations in sassociation lymphocyte density withclinicopathology of colorectal carcinoma which related to patient prognosis. This study was aimed to identify and analyze theassociation of lymphocyte density with clinicopathological colorectal carcinoma patients in Dr. Mohammad Hoesin General HospitalPalembang.MethodsA total of 41 HE stained slides which were diagnosed as colorectal carcinoma were observed under the light microscope.Lymphocytes were counted in five different areas that showed the highest lymphocytes density. The mean values of the lymphocytewere received from those five different areas. Determination of cutoff point was counted from the median of all mean value of thelymphocytes and being classified to become two categories, high-density lymphocytes and low-density lymphocytes.ResultsOut of 41 subjects, most patients have tumor size more than/or equal to 5 cm (63.4%), the tumors are often found in the left-sided ofcolon (39.0%), have moderate differentiated degree (65.9%), are included into T3 in tumor staging (48.8%), and no regional lymphnodes metastasis (39.0%). The most histopathological classification is adenocarcinoma (41.5%). Bivariate analysis showed thatlymphocyte density has correlation with tumor differentiation degree (p=0.021) and histopathological classification (p=0.004).ConclusionLymphocyte infiltration density has correlation with degree differentiation and histopathological classification of colorectal carcinomain Dr. Mohammad. Hoesin General Hospital-Palembang
Hubungan Kadar Komponen Besi Darah Pendonor terhadap Kualitas Packed Red Cells (PRC) di UDD PMI Provinsi Sumatera Selatan Rahmi Widiyawati; Zen Hafy; Phey Liana
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2303

Abstract

Iron is the essential component of our body especially used to make Hemoglobin. If the intake of iron enters from our food less than issued, it makes our reserve iron will be used, and it can cause iron deficiency. There are three pathogenesis stages of iron deficiency, first marked by reduced iron reserve or the absence of iron reserved, ferritin levels decreased, while other parameters to determinate the presence of iron deficiency( Serum Iron, TIBC, Hb, Transferrin Saturation) are still normal. The purpose of this study was to analyze the relationship level of donor iron components and quality of Packed Red Cells (PRC) in UDD PMI Provinsi Sumatera Selatan. This research is an analytic observational study with a cross-sectional design. The result of the research was conducted in April 2021, using 86 blood samples from donors. It showed there were 15 samples with iron deficiency. Consisted of 9 samples with iron deficiency in the first stage and 6 samples in the second stage. It is known that there are 6 samples with poor PRC quality; all of them are iron deficiency in the second stage. In conclusion, there is a significant relationship iron component level of the donor and the quality of PRC p<0,05.
Perbandingan Proporsi Antibodi Ireguler pada Pasien Multitransfusi dan Pasien Non Multitransfusi di UTD RSUP Dr. Mohammad Hoesin Palembang Amalia Amalia; Zen Hafy; Phey Liana
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2630

Abstract

Irregular antibodies or "unexpected antibodies" are antibodies other than antibody A and antibody B that can occur due to pregnancy and blood transfusions. Patients who frequently perform transfusions (multitransfusions) are more at risk of forming irregular antibodies because the frequency of exposure to donor red blood cell antigens is more frequent. Irregular antibodies are clinically significant because they can cause hemolysis (erythrocyte alloantibodies), febrile non-hemolytic transfusion reactions (leukocyte alloantibodies), or refractory platelet transfusions (platelet alloantibodies). This research aims to compare the proportion of irregular antibodies in multitransfusion patients and non-multi transfused patients at UTD Dr. Mohammad Hoesin Palembang. This research is an analytic observational study with a cross-sectional design conducted on 2 groups of subjects, 45 each sample. Antibody identification in each group was carried out. Chi-Square analyzed the proportion of irregular antibodies. An analysis of the types of antibodies found and the accompanying clinical diagnoses were carried out. This study showed a significant difference in the proportion of irregular antibodies between the multitransfusion and non-multitransfusion groups with a p-value of 0.001. The types of irregular antibodies found anti-c, Fya, Lea, M, Kpa, LubkKpb, and the clinical diagnoses that found irregular antibodies were anemia, thalassemia, and AIHA.
THE EXPRESSION OF NFATC1 IS MORE PREDOMINANT IN TRIPLE NEGATIVE BREAST CARCINOMA PATIENTS Riana Sari Puspita Rasyid; Krisna Murti; Zen Hafy
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.14137

Abstract

Breast carcinoma is the most common malignancy among women in developed and developing countries. Invasive breast carcinomas are classified into 4 subtypes i.e. luminal A and B, human epidermal growth factor receptor 2 (HER2)-enriched and triple negative, the latter has the worst prognosis. Nuclear factor of activated T cell (NFATc)1 is an important transcription factor in malignant transformation and progression. Therefore, NFATc1 expression may determine prognosis of breast carcinoma. This study aimed to determine the roles of NFATc1 inbreast carcinoma progression. Materials and Methods  Fifty-two paraffin blocks were selected and prepared to assess NFATc1 expression by immunohistochemistry. These data were taken from medical records: i.e. molecular classification, patient age, tumor size, lymphovascular invasion and grade of tumor were recorded. Results: Positive NFATc1 expression was observed in 4 samples i.e. in the nuclei of luminal A (1 out of 12; 8.8%), luminal B (1 out of 15; 6.7%), and triple negative (2 out of 12; 16.7%), but no NFATc1 expression was detected in HER2-enriched samples. Clinicopathologically, more of these patients were in the fifth decade (38.5%), with larger tumor size (?2 cm; 90%), lymphovascular invasion positive (80.8%), and high degree (3; 59.6%). Conclusion: NFATc1 expression is more predominant in triple negative breast carcinoma.
PEMBERIAN N-ASETYLSISTEIN TERHADAP KADAR IFN-GAMMA PADA PENDERITA HIV/AIDS YANG MENJALANI PENGOBATAN ANTIRETROVIRAL Sri Sulpha Siregar; Eddy Mart Salim; Zen Hafy; Nova Kurniati; Harun Hudari; Erial Bahar; Agustian Dwi Putra; Afriyana Siregar
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I2.13269

Abstract

HIV merupakan penyakit infeksi yang masih menjadi masalah besar kesehatan di Indonesia maupun dunia. Berbagai macam bentuk infeksi yang disebabkan oleh HIV, salah satunya ditandai dengan turunnya jumlah sel limfosit T CD4+ dan juga penurunan kadar IFN-GAMMA yang dapat menyebabkan percepatan replikasi virus hingga terjadi kegagalan sistem imun. NAC yang merupakan antioksidan diharapkan dapat memperbaiki kondisi tersebut. Penelitian ini bertujuan untuk mengetahui efek pemberian NAC terhadap perubahan kadar IFN-GAMMA  pada penderita HIV/AIDS di RSUP dr. Mohammad Hoesin Palembang. Penelitian ini merupakan uji klinik acak tersamar ganda. Sampel yang digunakan dalam penelitian ini sebanyak 32 pasien HIV/AIDS yang menjalani pengobatan ARV di RSUP dr. Mohammad Hoesin Palembang dibagi secara acak ke dalam 2 kelompok, yaitu kelompok Plasebo dan NAC. Pada kelompok Plasebo, pasien diberi kapsul yang berisi laktosa dengan dosis 3x1 kapsul/hari, sedangkan kelompok NAC, diberi NAC dengan dosis 3x 200 mg/hari. Setiap kelompok diberi perlakuan sama selama 12 minggu. Darah pasien diambil sebelum dan setelah perlakuan untuk diperiksa kadar IFN-GAMMA . Hasil penelitian menunjukkan bahwa kelompok uji yang diberikan NAC maupun placebo tidak menunjukkan perubahan kadar IFN-GAMMA yang bermakna setelah 12 minggu perlakuan. Kesimpulan penelitian, pemberian NAC tidak mempengaruhi kadar IFN-GAMMA pada penderita HIV/AIDS yang menjalani pengobatan ARV.HIV is an infectious disease that becomes a major health problem in Indonesia and the world. There are various forms of infection caused by HIV, one of which is marked by a decrease in the number of CD4 + T lymphocytes and a decrease in IFN-GAMMA level which can accelerate viral replication to the point of immune system failure. NAC, an antioxidant, is expected to improve this condition. This research aimed to determine the effect of NAC on IFN-GAMMA levels in HIV / AIDS patients in Dr. Mohammad HoesinCentral Hospital, Palembang. This research was a randomized double blind clinical trial. The samples were 32 HIV / AIDS patients who were undergoing ARV treatment at Dr. Mohammad Hoesin Central Hospital, Palembang, which were randomly divided into 2 groups; the placebo and the NAC groups. In the placebo group, patients were given capsules containing lactose at a dose of 3x1 capsules / day, while patients in the NAC group were given NAC at a dose of 3 x 200 mg / day. Each group was given the same treatment for 12 weeks. The patients’ blood were taken before and after treatment to check their IFN-GAMMA levels. The results showed that both groups did not show any significant changes in IFN-GAMMA levels after 12 weeks of treatment. The conclusion of this researchis that NAC administration did not affect IFN-GAMMA levels in HIV / AIDS patients who were undergoing ARV treatment. 
Co-Authors A, Rafdi A, Rafdi Abdullah Fikri Abdullah Sahab Afriyana Siregar Afriyana Siregar Agnes Felicia Lubis Agnes Felicia Lubis Agustian Dwi Putra Agustian Dwi Putra Agustina Br Haloho Ahmad, Zen Amalia Amalia Anisah Nida'ul Haq Argentina, Fiva aryani, Inda astri Aulia Annisa Rizki Bastian Bastian Bayu Winata Putera Calvin Ienawi Chairil Anwar Citra Dewi Desi Arlindia Didit Pramudhito Dwi Handayani Dwi Handayani Dwiana Ocviyanti Dwirini Retno Gunarti Dya Anggraeni Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim, Eddy Mart Efrieni Erial Bahar Erial Bahar Erial Bahar Erial Bahar, Erial Ernawati Sinaga Fachmi Idris Ferry Yusrizal Ferry Yusrizal Fitri Octaviana Francisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Fransisca Srioetami Tanoerahardjo Gita Dwi Prasasty Hadi Nugraha Mustofa Haekal M Handayani, Sri Hartati Harun Hudari Harun Hudari Harun, Yusril Heni Maulani Heni Pujiastuti Henny Sulastri Hermansyah Hermansyah Hu, Owen Iche Andriyani Liberty, Iche Andriyani Indra Franajayakk Inggarsih, Rara Irsan Saleh Jayawarsa, A.A. Ketut Jusak Nugraha Jusak Nugraha Jusak Nugraha Jusak Nugraha Jusuf Fantoni Kemas Ya'kub Rahadiyanto Kemas Ya'kub Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Yusuf Effendi Kms Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kms. Yusuf Effendi Kodrati, Adika Krisna Murti Krisna Murti kurniati, nova Laida Neti Mulyani Larasati, Veny Legiran Legiran Legiran Legiran Lidya Ramadhayanti Lubis, Fadhyl Zuhry M, Haekal M, Haekal M. Irsan Saleh Masagus Irsan Saleh Hasani Maya Eka Apriyanti Meiliza Indriani Mgs. Irsan Saleh Mgs. Irsan Saleh Mohamad Sadikin Muhammad Irsan Saleh Nita Hertati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Kurniati Nova Lestari Novizar S Nurmalia Purnama Sari Ocktariyana, Ocktariyana Oktariana, Desi Pancarani, Muftia Phey Liana Prihantika S., Sabrina Purnamasari, Septi Puspita, Riana Sari Puspita, Riana Sari R, Sentani R, Sentani Radiyati Umi Partan Radiyati Umi Partan, Radiyati Umi Rafdi A Rafika Novianti Rahadiyanto, Kemas Ya'Kub Rahmi Widiyawati Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Ray Suga Aulia Ray Suga Aulia Sentani Riana Sari Puspita Riana Sari Puspita Rasyid Rikka Wijaya Rini Nindela, Rini Rizal Sanif S, Novizar S, Novizar Sabri Prihantika Sabrina Prihantika Saleh, M Irsan Saleh, Mgs. M. Irsan Salutondok, Welly Sari, Nurmalia Purnama Selvy Apriani Sentani R SEPTI WULANDARI Soilia Fertilita Sri Sulpha Siregar Sri Sulpha Siregar Subandrate Sudarto Sudarto Suly Auline Rusminan Susiwati, Susiwati Syifa Alkaf Tanoerahardjo, Francisca Srioetami Tungki Pratama Umar Venny Larasati Venny Larasati Verli Saniba Wresnindyatsih Ya’kub Rahadiyanto Yudianita Kesuma, Yudianita Yunni Diansari Yusuf Effendi Yusuf Effendi Yusuf Effendi Yusuf Effendi Zen Ahmad Ziske Maritska Zulkarnain Musa