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Antihyperuricemia of A Combination of Eleutherine bulbosa and Annona muricata Extracts on Reducing Uric Acid Levels in Hyperuricemia Mice Azizah, Sarah; Hujjatusnaini, Noor; Indahsari, Lilin Ika Nur
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1634

Abstract

Increased uric acid levels in the blood have the potential to cause kidney problems and the formation of urate crystals in soft tissue if not treated properly. Standard treatments involving synthetic drugs, such as allopurinol, often cause side effects, making safer alternatives a necessity. This study aimed to investigate the effect of a combination of Eleutherine bulbosa and Annona muricataextracts on uric acid levels in hyperuricemic mice. This study used a posttest-only control-group design, with 28 male Balb/c mice induced with a high-purine diet, then given single and combination treatments at doses of 100, 200, and 300 mg/kg BW at a ratio of 1:2. Analysis using the Kruskal-Wallis and Mann-Whitney tests showed that the combination dose of 100 mg/kg body weight was most effective in reducing uric acid levels, with an average value of 2,7 mg/dL, while the single extract had no significant effect. At the cellular level, this combination works by inhibiting xantin oksidase (XO) enzyme activity, accelerating uric acid excretion through a diuretic mechanism, and reducing oxidative stress, which in turn helps protect kidney tissue from damage. Therefore, this combination has the potential to be a safe and effective natural antihyperuricemic agent.
Co-Authors Aín, Latifah Nur Adiansyah, Romi Afriliani, Hesti Agriana, Brenda Mila ahmad yani Ahmad, Dony Ajiza, Pratisa Defiera Ajiza, Pratisa Deifirera Alia, Rahmah Alya Meiana, Nurma Amelia Fitriani, Amelia Amin, Astuti Muh Anggraeni, Cici Ramadhan Artani Hasbi Astina Astina Astina Astina, Astina astuti muh amin Awaluddin, Annisa Maharani Ayatusa'adah, Ayatusa'adah Ayu Handayani Ayu Tiara Putri, Ayu Tiara Azizah, Sarah Azzahra, Jahida Bismillah, Alif Bunga Nur Siammukaromah, Jamalika Dalila, Aupi Damayanti, Annisa Darma, Rizki Novia Dina Nur Khalisa Dwi Rini Kurnia Fitri Erawaty, Yenny Fatimah Febrianty, Riafany Hadi Kusuma, Muhammad Prayoga Hamid, Nasim HAMIDAH Hidayati, Maulidia Ihsan, Afifi Raima Indahsari, Lilin Ika Nur Indriani, Amanda Jamalika Bunga Nur Siammukaromah Jarkani, Muhammad Jubaidah, Jubaidah Jumrodah Jumrodah Jumrodah Jumrodah, Jumrodah Karlina, Siti Karmila, Fitriyah Kartika, Cindy Khotimah, Ayu Husnul LINTAL MUNA M, Mila Maisyarah, Annisa Maradona, Maradona Marshanda, Utin Tria Marsiah Marsiah, Marsiah Maulana, Muhammad Akmal Maulida Maulida, Elyami Mega Selfia Mila Mila mila Mila, Nor Mufaddilah, Fira Muh Amin , Astuti Muh.Amin, Astuti Muhammad Nor Muhammad Ridho Muhammad Syaiful Anwar Muhammad Taufiq Muhammad Yusuf Mukhlis Rohmadi Nada, Ara Aulia Nadi, Nadi Najwa, Fatri Nasution, Aulia Fajrurramadhina Nirmalasari, Ridha Nisa, Zahratun Noor, Muhammad Arifin Nur Annisa Nur Indah Sari, Lilin Ika Nur Siammukaromah, Jamalika Bunga Nurindahsari, Lilin Ika Nurohman, Farkhan Nursalina, Nursalina Nurul Septiana, Nurul Nurul Wahdah Penia Penia Pitria, Pitria Purwanti, Devi Yuni Purwita Sari, Purwita Puteri Maharani, Septia Rahmadini, Lika Rahmadiyah, Novia Rahman, Luthfi Aulia Ramadhan, Ahmad Ananda Ramadhanti, Noor Raniah, Nor Reski Saputra, Reski Respi, Respi Rita Sukaesih Rita, Ambar Sari, Lilin Ika Nur Indah SARI, MITA Sasmita Sasmita Sa’adah, Ayatus Septianingrum, Dwi Dian Setyowati, Ais Rantauni Siti Maysaroh Sonia Sukmawati, Erviana Swestyani, Sondra Tenani, Miya Tuanfareena, Tuanfareena Tumini Tumini, Tumini Uswatun Khasanah, Purnama Wati, Helda Widya Ningsih, Sri Indah Widyadana, Rafif Ibnu Winanto, Aldi Wulandari, Noor Sari Yantiah Yantiah Yuliyana, Via Ziya, Kholida