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RASIONALITAS PENGGUNAAN ANTIPSIKOTIK PADA PASIEN GANGGUAN BIPOLAR DISORDER DI RSUD DR. LOEKMONO HADI KUDUS PERIODE JANUARI-JUNI 2024 Nila Khumaela Sofwatussuba; Endang Setyowati; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1586

Abstract

Mental disorders around the world according to WHO (World Health Organization) data have the highest number of bipolar sufferers as many as 60 million people. The Indonesian Association of Psychiatric Specialists (PDSKJI) revealed that Bipolar disorder in Indonesia covers around 0.3% to 1.5%. Antipsychotics can have a major effect on overcoming manic episodes, preventing recurrence and treating major depressive disorders. The purpose of this study is to determine the rationality of the use of antipsychotics in bipolar disorder patients at dr. Loekmono Hadi Kudus Hospital. The data analysis method used a non-experimental design with retrospective descriptive analysis with research materials in the form of patient medical records. The results of data collection were 95 selected patients, the majority of bipolar patients were women (76.8%), vulnerable 25-34 years old (27.4%), high school education/equivalent (36.8%), had other jobs (33.7%), used BPJS payment type (96.8%), used single antipsychotic drugs (73.7%), antipsychotics that were often used were quetiapine (24.2%). The results of the evaluation were indicated, the patient was right, the drug was 100% right, and the dose was 98.9% right. The use of antipsychotic drugs in patients with bipolar disorder at dr. Loekmono Hadi Kudus Hospital for the period January – June 2024 can be said to be rational because it is in accordance with the pharmacotherapy handbook 9 th edition and the VA/DoD Clinical Practice Guideline for Management of Bipolar Disorder.
HUBUNGAN KUALITAS PELAYANAN APOTEK DENGAN TINGKAT KEPUASAN KONSUMEN DI APOTEK BLUNYAH FARMA YOGYAKARTA Adel Meisita Putri; Endang Setyowati; Galih Kurniawan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1618

Abstract

Pharmaceutical services play an important role in the healthcare system, not only in drug dispensing but also in providing information and education. Suboptimal pharmacy service quality may affect customer satisfaction. This study aimed to determine the relationship between pharmacy service quality and customer satisfaction at Blunyah Farma Pharmacy Yogyakarta. This study used a quantitative approach with a cross-sectional design. A total of 300 respondents were selected using purposive sampling. Data were collected through closed-ended questionnaires consisting of 20 items for each variable: service quality and customer satisfaction. Data were analyzed using univariate and bivariate methods with the Pearson correlation test. The quality of pharmacy services was in the good to very good category, with the highest score in the prescription review aspect 90.84% and the lowest in drug information service/PIO 60.04%. Customer satisfaction was in the very satisfied category, with the highest score in the empathy dimension (91.97%) and the lowest in the responsiveness dimension 81.73%. The Pearson test results indicated a positive and significant relationship between service quality and customer satisfaction r = 0.342; p = 0.000 with a moderate correlation strength. There is a positive and significant relationship between pharmacy service quality and customer satisfaction at Blunyah Farma Pharmacy Yogyakarta. The better the service quality, the higher the customer satisfaction tends to be.
FORMULASI SEDIAAN LIP BALM KULIT MANGGIS (Garcinia mangostana L.) SEBAGAI ANTIOKSIDAN Sakna Binta Munaya; Endang Setyowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1624

Abstract

Lip balm is a cosmetic preparation designed to help protect, nourish, and moisturize the lips. This study utilizes mangosteen peel extract (Garcinia mangostana L.), which is rich in antioxidants, as the active ingredient in lip balm formulations. The aim of the study is to evaluate the physical quality and antioxidant activity of five lip balm formulas containing varying concentrations of mangosteen peel extract (10%, 15%, 20%, 25%) and one comparison formula containing 10% vitamin C. Physical quality tests included organoleptic evaluation, homogeneity test, and pH measurement. In addition, antioxidant activity was assessed using the DPPH method, along with skin irritation and user preference tests. The results showed that all lip balm formulas exhibited good organoleptic characteristics and homogeneity, with pH values ranging from (4.5 to 6.5). Irritation tests revealed no negative skin reactions. User preference tests indicated that Formulas F3 and F4 were the most favored in terms of texture, aroma, and comfort of use. The highest antioxidant activity was observed in Formula F5 (IC₅₀ = 46.6 µg/mL), followed by F4 (64.3 µg/mL), F3 (101 µg/mL), F2 (112 µg/mL), and F1 (113 µg/mL). These findings demonstrate that mangosteen peel extract can be successfully formulated into lip balm products that meet physical quality standards and exhibit significant antioxidant activity. The formula containing 25% extract (F4) showed the most optimal overall performance among the tested formulations.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BIJI KAPUK RANDU (Ceiba pentandra (L) Gaertn) DENGAN METODE DPPH Ariyanis Salma; Endang Setyowati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1626

Abstract

Kapuk randu (Ceiba pentandra (L). Gaertn) is a plant that is widely found in Indonesia and has long been used in traditional medicine. The seeds of this plant are known to contain various secondary metabolite compounds such as alkaloids, flavonoids, saponins, tannins and phenolics that have the potential to be antioxidants. This study aims to identify the compounds contained in randu kapok seeds and evaluate their potential antioxidant activity. The research method involves the extraction of kapuk seeds using maceration with 70% ethanol solvent. Furthermore, qualitative phytochemical screening is carried out to identify groups of compounds such as alkaloids, saponins, flavonoids, tannins, and phenolics. The antioxidant activity test was carried out using the DPPH method with concentration variations of 40, 80, 120, 160, and 200 ppm. The results of phytochemical screening showed that randu kapok seed extract was positive for alkaloid and flavonoid compounds. Antioxidant activity testing yielded an average IC50 value of 276.5 μg/mL. Based on categorization, the IC50 value indicates that randu kapuk seed extract has very weak antioxidant activity.
EVALUASI PENGGUNAAN OBAT ANTI HIPERTENSI TERHADAP PASIEN DI KLINIK TELAGA MEDIKA GUBUG Kadamsih, Kadamsih; Endang Setyowati; Ulviani Yulia Husna
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1628

Abstract

Hypertension is a condition of blood pressure that is higher than normal, which can damage vital organs such as the heart, blood vessels, and kidneys. If left untreated, this condition increases the risk of heart attack, stroke, kidney failure, and death. The effectiveness of antihypertensive drugs is determined by their ability to lower blood pressure, generally 7–13 mmHg systole and 4–8 mmHg diastole to achieve blood pressure targets. This study aims to determine the rationality of anti-hypertension which is assessed in terms of the right dosage, indications, patients, and drugs at Telaga Medika Gubug Clinic. This study is a type of observational research (non-experimental) with a descriptive research design using the retrospective cohort method. The approach was carried out retrospectively with a research time of June 1, 2025 The research location was carried out at the Telaga Medika Gubug Clinic, with a total sampling of 155 respondents according to the inclusion and exclusion criteria. For data analysis using frequency distribution. Based on the results of the research on the characteristics of hypertension patients at Telaga Medika Gubug Clinic, the majority age frequency was 51-60 years, namely 81 respondents (52.3%), the gender of the respondent was mostly female, 110 respondents (71.0%), the education of the majority of respondents was high school, namely 54 respondents (34.8%) and the majority of respondents were farmers, 60 respondents (38.7%), the pattern of use of amlodipin as the most antihypertensive drugs (46.36%) and metformin as the most comorbidities (45.97%). All patients are right, namely the right indication, the right patient, and the right dose, but the accuracy of the drug is only 76.8%. The use of antihypertensive drugs at Telaga Medika Gubug Clinic was declared rational, for the accuracy of indications, patients, and dosages while for the accuracy of drugs was only 76.8%.
PENGARUH VARIASI FORMULASI TEH CELUP DAUN TEH HIJAU (Camellia sinensis) KOMBINASI SERAI (Cymbopogon nardus) DAN JAHE (Zingiber officinale) TERHADAP KADAR FLAVONOID Haq, Athifa Afra Aulia; Endang Setyowati; Bintari Tri Sukoharjanti
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1642

Abstract

Excess free radicals can trigger oxidative stress and contribute to degenerative diseases. Flavonoids, as natural antioxidants, neutralize free radicals and are therefore important in the development of functional beverages. This study aimed to evaluate sensory characteristics, panelist preference, and flavonoid content, and to determine the optimal formulation of tea bags containing green tea leaves (Camellia sinensis), lemongrass (Cymbopogon nardus), and ginger (Zingiber officinale). Four formulations were prepared: F1 (100% green tea), F2 (70:15:15), F3 (50:25:25), and F4 (30:35:35). Flavonoid content was determined by UV-Vis spectrophotometry, while sensory properties were assessed through organoleptic and hedonic tests. Panelists were aged 18–59 years, regular tea drinkers, with normal sensory ability, while exclusion criteria included pregnancy, breastfeeding, allergies, medication use. Results showed that F4 had the highest flavonoid content (49.397 ± 3.258 mg QE/L), followed by F3 (32.677 ± 3.703 mg QE/L), F2 (13.877 ± 1.960 mg QE/L), and F1 (11.117 ± 1.502 mg QE/L). Statistical analysis confirmed significant effects of formulation on flavonoid content and sensory attributes of color, aroma, and taste (p < 0.05). F4 was identified as the optimal formulation with superior flavonoid content and panelist acceptance.
Analisis Kemometrika Kandungan Fitokimia dan Uji Anti Acne Ekstrak Etanol 70% dan Etil Asetat Daun Alpukat : (Persea Americana Mill) Pramesti Anggun Asyifa; Endang Setyowati; Fahrudin Arif
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7566

Abstract

Human skin requires care to prevent and treat acne caused by Propinobacterium acnes bacteria. Researchers are exploring the use of avocado leaves as a natural therapy to treat acne. Avocado leaves contain antibacterial and anti-inflammatory compounds such as flavonoids, saponins, and alkaloids. This study aims to measure the total flavonoid and phenolic content in extracts obtained with 70% ethanol and avocado ethyl acetate and analyze their anti-acne activity. Total flavonoids were determined using a reagent consisting of 10% AlCl3 and 5% acetic acid. Total phenolic determination was carried out using the Folin-Ciocalteu reagent with gallic acid as a reference standard. Measurement of phytochemical levels used the UV-Vis spectrophotometry method. Antibacterial testing was carried out using Staphylococcus aureus bacteria with concentrations of 12%, 14%, and 16%. The positive control used clindamycin. The negative control used 10% DMSO. The disc diffusion method was used to observe the inhibition zone in this study. The results of this study will be processed using chemometrics to analyze complex chemical data. The data results showed that 70% ethanol extract produced total flavonoid levels of 8.6954% mgEK/mL and total phenolics of 15.4385% mgEAG/mL, higher than ethyl acetate extract with total flavonoid results of 3.418% mgEK/mL and total phenolics of 4.6052% mgEAG/mL. The results of antibacterial activity at concentrations of 12%, 14%, 16%, 70% ethanol extract were 10.5±0.70 mm; 12.1±0.28 mm; 14.3±0.57 mm, respectively, which had higher activity than ethyl acetate extract with results of 9.1±0.28 mm; 10.5±0.5 mm; 12.3±0.57 mm, the highest antibacterial activity at a concentration of 16%. Chemometric analysis using Principal Component Analysis (PCA) showed a strong positive correlation between phytochemical content and antibacterial activity. The highest antibacterial activity was found in the 70% ethanol extract at a concentration of 16%.
Restorative Justice Policy in Law Enforcement Against Perpetrators of Spreading Hoaxes Related to Elections on Social Media Dian Rosita; Endang Setyowati; Suwandoko Suwandoko
International Journal of Sociology and Law Vol. 1 No. 2 (2024): May : International Journal of Sociology and Law
Publisher : Asosiasi Penelitian dan Pengajar Ilmu Hukum Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijsl.v1i2.104

Abstract

General elections (elections) are a benchmark for the success of democracy for countries that adhere to democratic principles such as Indonesia. The large number of hoax issues surrounding the election that are spread via social media are often considered cybercrime or cybercrime. Meanwhile, criminal law is currently developing discussions about Restorative Justice, which offers forms of settlement with the aim of fulfilling the wishes of the parties with a win-win solution. The legal issue analyzed in this research is how restorative justice policies apply in enforcing the law against perpetrators of spreading fake news (hoaxes) related to elections on social media to see the possibility of using alternative dispute resolution for election violations, especially at the police level. The method used in this research is normative juridical, using literature study and a statutory and regulatory approach related to the legal issue being discussed. This research shows that the Restorative Justice Policy against perpetrators of spreading fake news (hoaxes) taken by the Police is carried out to create a clean, healthy and productive Indonesian digital space so as not to give rise to diversity in investigative administration and differences in interpretations of investigators and irregularities must be carried out in a persuasive, educational manner. so that there is no suspicion of criminalization in the criminal act of spreading fake news (hoax) against the perpetrator or in other words the person being reported. 
PENINGKATAN PEMAHAMAN MASYARAKAT DESA WONOSALAM KABUPATEN DEMAK MENGENAI DASAR HUKUM DAN PENYELESAIAN SENGKETA KOPERASI SYARIAH Dian Rosita; Endang Setyowati
Jurnal Padamu Negeri Vol. 1 No. 2 (2024): April : Jurnal Padamu Negeri (JPN)
Publisher : CV. Denasya Smart Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69714/rekryp02

Abstract

Sharia Cooperatives are a form of cooperative that has principles, objectives and business activities based on Islamic Sharia, namely the Al-Qur'an and Assunah. The legal basis for establishing a sharia cooperative itself includes the following: Law of the Republic of Indonesia No. 25 of 1992 concerning Cooperatives, PP No. 9 of 1995 concerning the Implementation of Savings and Loans Business Activities by Cooperatives, Minister of Cooperatives and SMEs Regulation No. 11/M.KUKM/XII/2017 concerning Implementation of Savings and Loans and Sharia Financing Business Activities by Cooperatives, Minister of Cooperatives and SMEs Regulation No. 35.2/Per/M.KUKM/X/2007 Concerning Guidelines. Cooperative Management Operational Standards. The problem that often arises in the practice of sharia cooperatives is the emergence of problematic financing or bad credit. Dispute resolution can be resolved in two ways, namely dispute resolution in court or outside court. Due to the negative impact of the emergence of problematic financing, it is necessary for the Community Service Team (PkM) to organize outreach and counseling with the theme "Increasing Community Understanding  Wonosalam Demak Regarding the Legal Basis and Sharia Cooperative Dispute Resolution”. This activity uses methods, namely, counseling, question and answer and discussion methods.
KELAS LITERASI GEMBIRA: PENGEMBANGAN MINAT BACA SISWA SD MELALUI BUKU CERITA INTERAKTIF Endang Setyowati; Kingkin Puput Kinanti; Ari Nugrahani; Harry Surahman
Kreativitas Pada Pengabdian Masyarakat (Krepa) Vol. 5 No. 3 (2025): Kreativitas Pada Pengabdian Masyarakat (Krepa)
Publisher : CV SWA Anugerah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.8765/krepa.v5i3.13694

Abstract

The reading interest of elementary school students in Indonesia is still relatively low. Many students have not yet developed an independent reading habit due to the limited availability of engaging and age-appropriate media. To address this issue, the “Joyful Literacy Class” program was developed as an initiative to foster reading interest through the use of interactive storybooks equipped with appealing illustrations and simple activities designed to encourage active student participation. The implementation method of this program employed a participatory approach, consisting of observation, media development, literacy class implementation, and evaluation. The results indicate an increase in students’ reading interest, reflected in higher reading frequency, enthusiasm during activities, and improved comprehension of story content. This program has proven effective in cultivating early reading habits and can serve as a model for enjoyable and easily applicable literacy learning in elementary schools.