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All Journal Pythagoras: Jurnal Matematika dan Pendidikan Matematika Jurnal Periodic Jurusan Kimia UNP KALAM CENDEKIA PGSD KEBUMEN Jurnal Penelitian Fisika dan Aplikasinya (JPFA) Jurnal Pengajaran MIPA Jurnal Teknik Elektro Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam Folia Medica Indonesiana Telaah Science and Technology Indonesia Health Notions Spektra: Jurnal Fisika dan Aplikasinya Communications in Science and Technology Journal of Physics and Its Applications JURNAL PENDIDIKAN TAMBUSAI Hearty : Jurnal Kesehatan Masyarakat Jurnal Kreativitas PKM Manuju : Malahayati Nursing Journal Jurnal Notariil Edumaspul: Jurnal Pendidikan Jurnal Pengabdian Masyarakat Sains Indonesia (Indonesian Journal Of Science Community Services) INSPIRASI: Jurnal Kajian dan Penelitian Pendidikan Islam Klasikal: Journal of Education, Language Teaching and Science Jurnal Ners Jurnal Dedikasi MAHESA : Malahayati Health Student Journal ARRUS Journal of Social Sciences and Humanities Berkala Ilmiah Kimia Farmasi Wen Chuang: Journal of Foreign Language Studies, Linguistics, Education, Literatures, Cultures, and Sinology Jurnal Ilmiah Mahasiswa Manajemen, Bisnis dan Akuntansi Jurnal Riset Kesehatan Masyarakat Makara Journal of Science Journal of Halal Science and Research Jurnal Masyarakat Madani Indonesia Jurnal el-Huda: Jurnal Pendidikan, Sosial, dan Keagamaan PEDAMAS (Pengabdian Kepada Masyarakat) Camellia Usadha Journal of Pharmacy JGuruku: Jurnal Penelitian Guru Jurnal Kefarmasian Indonesia Jurnal Wicara Desa
Isnaeni Isnaeni
Universitas Negeri Semarang
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Journal : Berkala Ilmiah Kimia Farmasi

 1 
Identification of Paracetamol and Caffeine in Jamu Powders Simultaneously Using TLC-Densitometry Wahyuningsih, Etik; Isnaeni, Isnaeni; Asri Darmawati; Annisa Kartika Sari
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i1.44242

Abstract

Paracetamol and caffeine were chemical compounds suspected to be illegally added to traditional herbs claimed as rheumatics drugs. Identification of paracetamol and caffeine was conducted on five samples of jamu powder obtained from the Depot Jamu in Surabaya. This study aimed to simultaneously identify paracetamol and caffeine commonly found in traditional medicine, one of which was jamu powder, using thin-layer chromatography densitometry (TLC-Densitometry). Evaluation of the presence of paracetamol and caffeine in the product of jamu was performed by thin-layer chromatography with silica gel GF254 and chloroform-ethyl acetate (1:1) as the stationary and mobile phases, respectively. The spots on the TLC plate were detected using a UV light at 254 nm, and the areas were measured by a Camag TLC scanner. The TLC profile demonstrated good separation of paracetamol, caffeine, and other substances contained in the products. The retardation factors (Rf) of paracetamol and caffeine were 0,42 and 0,26, with detection limits of 0,0125 µg/spot and 0,05 µg/spot, respectively. The simultaneous identification of caffeine and paracetamol using thin-layer chromatography densitometry revealed that none of the five samples were detected to contain paracetamol and caffeine. Keywords:  Simultaneously, Identification, Paracetamol, Caffeine, Jamu Powder, TLC- Densitometry
Color Stability and Antioxidant Activity of Red Roselle (Hibiscus Sabdariffa L.) Calyx Infuse Sholika Sari, Trisiyana; Kusumawati, Idha; Isnaeni, Isnaeni
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.51706

Abstract

The roselle flower (Hibiscus sabdariffa L.), was known as a potential functional food source because of its antioxidant and antibacterial properties. Apart from that, it was also used as a natural dye because of its red color. Antioxidant compounds in roselle flowers included neo-chlorogenic acid, chlorogenic acid, crypto- chlorogenic acid, routine, and isoquercitrin. The high content of these antioxidant compounds often causes color instability. For this reason, this research would analyzed the effect of temperature and long storage on color changes and the antioxidant activity of a red roselle flower infusion. Storage conditions were carried out with three temperature variations, namely cold temperature (2–8℃), cool temperature (8–15℃), and room temperature (15–30℃), with a long storage of 8 days. The stability parameters used were color changes and activity as an antioxidant. Color changes were measured using a chromameter, while the antioxidant activity was measured by the IC50 value using the DPPH method. The principle of this method was based on a purple color change reaction, which faded, and then the inhibitory intensity against DPPH was measured using UV-Vis spectrophotometer. It was found that the color values had significant differences visible from the first day storage at the room temperature (30℃), cool temperature (11℃), and cold temperature (6℃). Thus, there was an influence of temperature and long storage on the color change of boiled red roselle flower calyx. A significant decrease in activity was seen on the first day storage at room temperature (30℃) and third day storage at cool temperature (11℃). Meanwhile, at cold temperatures (6℃), there was no significant effect on the reduction in activity from boiling red roselle flower calyx for up to 8 days of storage. Keywords:  Red Rosela, Stability, Infuse, Color, Antioxidant
The Effectiveness of Vitamin E Soft Capsules as an Antioxidant Putri, Syakirah Yasmin; Isadiartuti, Dewi; Isnaeni, Isnaeni; Aulya Farah Fahreza; Alvina Violita Mulyanto Putri; Zulfa Diana; Nafa Nazilatul Fatihah; I Gede Rekyadji Arimbawa; Alya Fakhirah; Talitha Nabilla Wijayanata; Muhammad Pramudya Pangestu; Azzalia Firdanthi; Oudrey Addriana; Umi Aida Rohma
Berkala Ilmiah Kimia Farmasi Vol. 11 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v11i1.51902

Abstract

Antioxidants inhibited the oxidation of other molecules and played an important role in maintaining a healthy body. Antioxidants were found in fruits, vegetables, all parts of plants, and were present in the body as enzymes or products of metabolism. Vitamin E referred to a large number of natural or synthetic compounds, with alpha-tocopherol being the most active and widely distributed form in nature. Alpha-tocopherol was the most active antioxidant form of vitamin E and served as the primary lipophilic antioxidant in plasma, membranes, and tissues. The most important function of vitamin E was its antioxidant capability, counteracting free radical attacks that could damage cells and cause various degenerative diseases. Additionally, antioxidants helped reduce the effects of photoaging on the skin, potentiated anti-aging and anti-inflammatory activity, increased the rate of wound healing, and helped maintain healthy eyes and the immune system. One form of vitamin E dosage form was a soft capsule, which had several advantages, including the ease of filling the Active Pharmaceutical Ingredient (API) in liquid form, higher production capacity, and formulation uniformity compared to gelatin tablets or hard capsules. Soft capsule preparations also had rapid API release, which could result in achieving therapeutic blood levels more quickly and achieving greater bioavailability. This study aimed to evaluate soft capsule dosage forms in enhancing the effectiveness of vitamin E as an antioxidant. The research utilized review articles sourced from national and international journals, as well as scientific journals. The results showed that vitamin E supplementation in soft capsules could increase its effectiveness as an antioxidant.Keywords:  Soft Capsule, Increase Effectiveness, α-tocopherol, Vitamin E, Antioxidant
Co-Authors Abdillah, Roby Abdul Hamid Achmad Basori, Achmad Achmad Toto Poernomo Adi Fadli Adillah, Rifda Ahmad, Faozan Akhiruddin Maddu Al As'ary, Muawwal Alaih, Akhmad Futukhillah Fataba Ali Amran Ali Imran Alvina Violita Mulyanto Putri Alya Fakhirah Andhika Prima Prasetyo Anida Zulfa, Baiq Annisa Kartika Sari Anwar, Nazwa Zahira Ardiana, Alma Dita Ari Asnani As'ary, Muawwal Al Asiandi Asiandi, Asiandi Asri Darmawati As’ary, Muawwal Al AT, Poernomo Aty Widyawaruyanti Aulya Farah Fahreza Ayumuyas, Nur Palestin Ayuni, Nur Azizah, Mir’ah Azka, Aril Danish Azmi, Vania Amelia Azzahra, Chofifatus Solecha Azzalia Firdanthi Basyaruddin, Muh Budi Utomo Calvina, Aisha Bella Cassia, Diva Cholisoh, Lilis Dadan Hermawan, Dadan Dahlang Tahir Debi Yustisia, Wa Ode Deni Shidqi Khaerudini Deski Beri Dessidianti, Rachma Dewi Isadiartuti Dinda Annisya, Sukma Diyah, Nuzul Wahyuning Djoko Agus Purwanto Eddy Bagus Wasito Elfinita, Revi Elly Arliani Esti Hendradi Etik Wahyuningsih Fajarli Apriani M, Baiq Faradillah Rusliana Febrianti, Suhaemi Firna, Firna Fitri, Andi Fitri Geminastiti Sakkir H Hasmawati Hadi Poerwono Hadi, M. Warisul Haerunisa, Haerunisa Hakimi, Ahmad Reza Hamid, Muhammadin Hanistya, Ria Hardhienata, Hendradi hasani, riadhatul Hendrawan Hendrawan Heri Retnawati Hidayat, Rabiyatun Hidayati, Shabrina Wahyu I Gede Rekyadji Arimbawa Ibrahim, Mohamad Thorik Idha Kusumawati Ikhza Wafiyah, Evelyna Ikmawati, Isna Ita Sarmita Samad, Ita Sarmita Iwan Sugihartono Iyon Titok Sugiarto Julham Hukom Juliansyah, Irgi Zaini Kamaruddin, Harni Sartika Kana Hidayati Kartuti Debora, Kartuti Khairunnisa, Ayu Kholis Amalia Nofianti Kristianti, Rayi Kurnijasanti, R Larasati, Rini Lestari Widiantika, Susi Lestari, Ismira Wahyu Lewa, Ismira Wahyu Lestari Lisdayanti, Nur Lucky Anugrah, Riska Mahmudah, Rifaatul Maria Margaretha Suliyanti Martila, Lenny Intan Masmira, Ade Meiliningtyas, Crysuci Miladya, Nanda Fadlilatul Mirzautika, Anggita Mohar, Rahmat Setiawan Muhammad Pramudya Pangestu Mulyawan, Reynaldi Gilang Nafa Nazilatul Fatihah Ni Made Mertaniasih Nisa, Asriatun Nurhasanah, Wahidatun Dewi Nurhayati Nurhayati Nurrosyidah, Iif Hanifa Nursidik Yulianto Nursidik Yulianto, Nursidik Oktaviany Irma Wiputri Oudrey Addriana Paramita, Diajeng Putri Paramitha, Pradnia Permono Adi Putro Putri, Syakirah Yasmin R., Mantasiah Ramdani, Dewi Rippi Maya Riyaningrum, Wahyu Rusita, Resi Sambudi, Nonny Soraya Samlan, Karima Santosa, Nadya Rachmania Sari, Dewi Lintang Shiddiq, Muhandis Sholihattri, Wina Sholika Sari, Trisiyana Sigit Wibawanto, Sigit Siti Fatimah Soewoto, Haswi Purwandanu SRY WAHYUNI, SRY Suaebah, Evi Sudjarwo, SA Sudrajat, Aji Ajat Sugiarto, Iyon Titok Sukmawati, Rosnanda Sulaeman, Uyi Suryadi Suryadi Suryadini, Aisha Suci Susanto, I Gede Arya Sutarno Sutarno Talitha Nabilla Wijayanata Taufik Taufik Tejo Faridh Waloyo Tiam, Tan Swee Tiana, Elia Marta Triyono, Djoko Tulus Ikhsan Nasution Tutiek Purwanti Umi Aida Rohma Utami, Mega Putri Nur Wahyudi Wahyudi Wahyudi, Muh.Diki Wijoyo, Hadi Wildan Panji Tresna Wiwied Ekasari Yin, Shu Yuliati Herbani ZAINUL ARIFIN IMAM SUPARDI Zaskya Wati, Wa Ode Zulfa Diana Zulfiana, Risa