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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Molecular and Cellular Biomedical Sciences (MCBS) Journal of Health Sciences JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan MEDIC MEdical Dedication Proceedings Series on Health & Medical Sciences Nursing Information Journal Jurnal Penyuuhan dan Pemberdayaan Masyarakat (JPPM) Conferences of Medical Sciences Dies Natalis Journal of Artificial Intelligence and Digital Business Journal of Medical Studies Prosiding Seminar Hukum Aktual Fakultas Hukum Universitas Islam Indonesia Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Imiah Pengabdian Pada Masyarakat (JIPM) Indonesian Journal of Biomedicine and Clinical Sciences Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Jurnal Hukum dan Pendidikan Kewarganegaraan

Citra Maharani

Universitas Jambi

Author-ID : 2916046

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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THE VARIATION OF THE NOS3 GENE RS1799983 IS NOT ASSOCIATED WITH PREECLAMPSIA IN MALAY POPULATION Citra Maharani; Herlambang Herlambang; Anggelia Puspasari
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 10 No. 3 (2022): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

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ABSTRACT Background: eNOS play role in preeclampsia pathophysiology due to disturbing spiral arteries re-modelling and enhanced maternal vasoconstriction. A genetic variant of NOS3 associated with eNOS level. In addition, the previous study reported a genetic variant of NOS3 rs1799983 as a risk of preeclampsia with conflicting results beyond the population. To the best of our literature search, this genetic variant as preeclampsia risk has never been reported in the Jambi Malay population. This study aims to determine the association of the NOS3 genetic variant with preeclampsia in the Jambi Malay population. Methods: This study was a cross-sectional study that involved 43 pregnant women suffering preeclampsia and 53 normotensive pregnant women. All the subject resides in Jambi Province and was Jambi Malays. Genotyping was performed with tetra ARMS-PCR. Bivariate statistically analysis was performed. Result: The frequency of GT genotype was lower in the preeclamptic group and GG genotype was higher in the preeclamptic group than the TT genotype, but the difference was not statistically different for NOS3 rs1799983. Conclusion: Our findings indicate that the genetic variant of NOS3 rs1799983 is not associated with preeclampsia in the Jambi Malay population. Keywords: NOS3, eNOS, rs1799983, genetic variant, preeclampsia, Malay population ABSTRAK Pendahuluan: eNOS berperan dalam patofisiologi preeklamsia karena mengganggu remodelling arteri spiralis dan meningkatkan vasokonstriksi maternal. Varian gen NOS3 berkaitan engan peningkatan kadar eNOS. Penelitian sebelumnya melaporkan hasil yang bertentangan pada berbagai populasi terkait hubungan antara varian gen NOS3 rs1799983 dengan risiko kejadian preeklamsia. Sejauh pencarian literatur, varian gen NOS3 rs1799983 sebagai risiko preeklamsia belum pernah dilaporkan pada populasi Melayu Jambi. Penelitian ini bertujuan mengetahui hubungan varian gen NOS3 dengan preeklamsia pada populasi Melayu Jambi. Metode: Penelitian ini menggunakan desain potong lintang, melibatkan 43 orang ibu hamil dengan preeklamsia dan 53 orang ibu hamil normotensif. Semua subjek berdomisili di Provinsi Jambi dan merupakan orang Melayu Jambi. Pemeriksaan genotip dilakukan dengan metode tetra ARMS-PCR. Analisis statistik dilakukan meggunakan uji bivariat. Hasil: Hasil analisis didapatkan frekuensi genotip GT lebih rendah pada kelompok preeklampsia dan genotip GG lebih tinggi pada kelompok preeklampsia dibandingkan genotip TT, namun perbedaan tersebut tidak berbeda bermakna secara statistik. Kesimpulan: Hasil penelitian ini mengesankan bahwa varian genetik NOS3 rs1799983 tidak meningkatkan risiko preeklampsia pada populasi Melayu Jambi. Kata kunci: NOS3, eNOS, rs1799983, varian genetik, preeklamsia, populasi Melayu

A GENETIC VARIANT OF ANGIOTENSIN RS699 ASSOCIATED WITH DIABETIC NEPHROPATHY IN PATIENTS OLDER THAN 50 YEARS OLD Anggelia Puspasari; Elfiani Elfiani; Citra Maharani; Susan Tarawifa
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 10 No. 3 (2022): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

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ABSTRACT Background: Beyond controlling blood pressure and blood glucose, a genetic factor may play role in diabetic nephropathy (DN) progression in Type II Diabetes Mellitus (T2DM). Previous studies reported a genetic variant of Angiotensin rs699 (M235T) associated with diabetic nephropathy, with conflicting results across populations worldwide. To the best of our knowledge association of this genetic variant has never been conducted in the Jambi Malay population. Aims The Aims of this study is to the reveal association of the genetic variant of Angiotensin rs699 with diabetic nephropathy in the Jambi Malay population. Methods: This study design was cross-sectional. Totally 70 T2DM patients aged 22-67 years old were participated, as many 41 patients have aged older than 50 years old. Genotyping was performed using tetra ARMS PCR specific for rs699. Result: Patients aged older than 50 who have CTTT genotype have lower risk for suffering DN than CC genotype (p-value 0.029; OR (95% CI) 0.233 (0.06-0.88)), the statistic significant persist in multivariate analysis (p-value 0.030; OR (95% CI) 0.19 (0.04-0.86)). Conclusion: CTTT genotype was protective for DN in patients older than 50 years old. Further study with larger sample size, multi-centre and measuring confounding factors was needed. Keyword: Genetic variant of Angiotensin, rs699, diabetic nephropathy, Type II Diabetes Mellitus, Malay population ABSTRAK Latar belakang: Kendali Tekanan darah dan glukosa darah saja tidak cukup untuk mencegah kejadian nefropati diabetik (DN) pada Diabetes Mellitus Tipe II (T2DM), faktor genetik juga berperan penting. Studi sebelumnya melaporkan varian genetik Angiotensin rs699 (M235T) yang terkait dengan DN, dengan hasil yang berbeda antar populasi. Sejauh studi literatur yang dilakukan, varian genetik ini belum pernah diteliti pada populasi Melayu Jambi. Tujuan dari penelitian ini adalah untuk mengetahui hubungan varian genetik Angiotensin rs699 dengan nefropati diabetik pada populasi Melayu Jambi. Metode: penelitian ini merupakan penelitian potong lintang. Sebanyak 70 pasien T2DM berusia 22-67 tahun berpartisipasi, 41 diantaranya berusia lebih dari 50 tahun. Genotyping dilakukan dengan menggunakan tetra arms PCR spesifik untuk rs699. Hasil: Pasien berusia lebih dari 50 tahun yang memiliki genotipe CTTT memiliki risiko lebih rendah untuk menderita DN daripada genotipe CC (nilai p 0,029; OR (95% CI) 0,233 (0,06-0,88)), analisis multivariat juga menunjukkan hasil serupa (nilai p 0,030; ATAU (95% CI) 0,19 (0,04-0,86)). Kesimpulan: CTTT genotipe adalah pelindung untuk DN pada pasien yang lebih tua dari 50 tahun. Studi lebih lanjut dengan ukuran sampel yang lebih besar, berbagai pusat studi dan mengukur faktor risiko genetik dan non-genetik lain perlu dilakukan. Kata kunci: Varian genetik angiotensin, rs699, nefropati diabetik, Diabetes Mellitus Tipe II, populasi Melayu

IDENTIFIKASI VARIABLE DETERMINAN DEFISIENSI DAN INSUFISIENSI KADAR PLASMA VITAMIN D PADA WANITA USIA SUBUR Anggelia Puspasari; Herlambang Herlambang; Nyimas Natasha Ayu Shafira; Amelia Dwi Fitri; Rita Halim; Dhea Assyifa; Esa Indah Ayudia; Erny Kusdiyah; Citra Maharani; Rina Nofri Enis
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 10 No. 4 (2022): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Introduction: Vitamin D have played role as nutrition for reproductive age healthy. Indonesia is tropicalcountry which got sunshine along the year but previous study reported high prevalence of deficiency and insufficiency of Vitamin D. Factor which influence Vitamin D level is complex and may specific for the population.Objective: This study aimed to determined Vitamin D plasma level and factors influenced in it.Methods: This cross-sectional study attended by 23 non pregnant women in reproductive age between 20-45 years old. Plasma level of Vitamin D measure with CLIA. Risk factor assessed with questionnaire.Results: This study reported all the women have deficient and insufficient. Factor which statisticallysignificant associated with higher Vitamin D plasma level were older age, higher sun exposure score, history for delivery the baby, not applied sunscreen and Vitamin D supplement intake.Conclusion: There are several factors influence plasma vitamin D level in women at reproductive age other than sun exposure.Key words: sun exposure, Vitamin D, women in reproductive age

HUBUNGAN EKSPRESI 8OH2DG SEBAGAI PENANDA STRES OKSIDATIF KERUSAKAN DNA DENGAN KEJADIAN PREEKLAMPSIA DAN LUARAN NEONATAL Citra Maharani; Herlambang Herlambang; Anggelia Puspasari; Ahmad Syauqy; Huntari Harahap; Betty Marlina
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 10 No. 4 (2022): Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Background: Hypoxic conditions in preeclampsia cause oxidative stress in the placenta. Oxidative stress triggers endothelial dysfunction resulting in changes in placental parenchyma and vasculature, turn leads to clinical manifestations in maternal and neonatal. Previous studies reported that preeclampsia placental tissue increased the expression of the oxidative stress marker 8OH2dG.Objective: This study aimed to observe the expression of the marker 8OH2dG on the incidence ofpreeclampsia and its association with neonatal outcome.Methods: This study design was case-control, a number of 44 pregnant women participated in this study. The case group was preeclampsia women based on American College of Obstetricians and Gynecologist (ACOG) 2013 criteria and normotensive women as control group. The immunohistochemical was perform in placental tissue for expression of 8OH2dG in trophoblast nuclei. The results were positive when the trophoblast cell nuclei were stained â‰¥5% with moderate and strong intensity; and negative if stained weakly <5%. Bivariate analysis was performed to determine the association of 8OH2dG expression with preeclampsia and neonatal outcome.Results: This study reported the frequency of trophoblast nuclei with 8OH2dG positive staining was higher in the preeclampsia group than the control group. Expression of 8OH2dG positive staining also increased the risk of low birth weight and asphyxia.Conclusion: The results of this study indicate that the marker 8OH2dG is associated with preeclampsia and adversely neonatal outcome.Keywords: 8OH2dG, preeclampsia, oxidative stress, neonatal outcome

Profile of Apoptotic Marker Genes and Histopathology of the Placenta in Pregnancies with Pre-Eclampsia Herlambang, Herlambang; Enis, Rina Nofri; Tarawifa, Susan; Harahap, Huntari; Puspasari, Anggelia; Maharani, Citra; Kusdiyah, Erny
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n2.3088

Background: Pre-eclampsia (PE) is a hypertensive disorder in pregnancy and a significant cause of maternal and perinatal mortality and morbidity. Failure of spiral artery remodeling due to abnormal apoptosis, triggers disturbances in the mother and the baby’s growth. This study aimed to identify the profile of apoptotic marker genes and histopathological features of the placenta in pregnancies with pre-eclampsia.Methods: This study had used case-control method. Samples were taken from normal pregnancies (n=25) and pregnant women with pre-eclampsia (n=25) using a purposive sampling method from several hospitals in Jambi. qRT-PCR was used to examine apoptotic gene expression from placental tissue and hematoxyline eosin staining to view the placenta’s microscopic appearance. The targeted genes were BCL2-associated X (BAX) and B-cell lymphoma 2 (BCL-2). Histopathological changes of the placenta observed were syncytial node, cytotrophoblast, villous edema, hypervascularization, fibrosis stroma, atherosis, infarction, and thrombosis.Results: Relative BAX genes expression were increased once in placenta pre-eclampsia compared to controls, but not statistically significant (p-value>0.05). There was no difference between the decline of BCL-2 gene expression in pre-eclampsia placenta compared to the control (p-value >0.05). Histopathological changes in the placenta were syncytial node and cytotrophoblast (25 of 25), villous edema (19 of 25), hypervascularization (24 of 25), fibrosis stroma (22 of 25), atherosis (12 of 25), infarction (17 of 25), and thrombosis (24 of 25).Conclusion: The expression of BAX genes in pre-eclampsia tends to increase compared to normal pregnancy, and the expression of BCL-2 decreases. The histopathological features of pre-eclampsia pregnancy placenta are mostly syncytial nodes, cytotrophoblasts, stromal fibrosis, and thrombosis.

Angiotensin-Converting Enzyme Genetic Polymorphism rs4343 as Risk of Diabetic Nephropathy in Jambi-Malay Population Elfiani, Elfiani; Puspasari, Anggelia; Arif, Cut Wulan; Maharani, Citra; Ali, Zulkhair; Suhaimi, Novadian; Effendi, Ian; Suprapti, Suprapti; Shafira, Nyimas Natasha Ayu
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.410

Background: Diabetic nephropathy (DN) is one of the frequent complications of type II diabetes mellitus (T2DM) in Jambi province. Controlling blood glucose and blood pressure does not guarantee DN prevention, since genetic factors may also contribute to this disease. Multi-ethnic studies showed that one of the strongest genetic factors associated with DN was single nucleotide polymorphism rs4343 of angiotensin-converting enzyme (ACE) gene. Study regarding phenotype-genotype association of ACE rs4343 and DN has not yet been performed in Jambi Province, which is dominated by Malay ethnicity. This study was conducted to reveal the association between ACE rs4343 and the risk of DN in the Jambi-Malay population.Materials and methods: This was a cross-sectional study involving 75 subjects (44 with DN and 31 without DN) who suffered from T2DM and hypertension. DN was defined as albumin to creatinine ratio (ACR) ≥30 mg/g. Genotyping was performed with one-step tetra amplification refractory mutation system-polymerase chain reaction (PCR) using specific primer for ACE rs4343. Bivariate and multivariate analyses were performed to analyze the genetic risk for DN.Results: The bivariate analysis showed the proportion of DN subjects was higher than non-DN within the AG genotype (11:1) than within the AA (33:30) genotype. This difference was statistically significant (p=0.012; OR (95% CI): 10.00 (1.22-82.15)). Multivariate analysis showed that AG genotype (p=0.047; OR (95% CI): 10.04 (1.03-97.31)) and uncontrolled blood pressure (p=0.001; OR (95% CI): 6.72 (2.08-21.71)) were the risk factors of DN in the Jambi-Malay population.Conclusion: Polymorphism of ACE rs4343 is a risk factor of DN in the Jambi-Malay Population.Keywords: rs4343, angiotensin-converting enzyme gene, diabetic nephropathy, Malay, Jambi

Sosialisasi dan Edukasi Literasi Keuangan pada Masyarakat Penerima Bantuan Sosial dalam Meningkatkan Kesejahteraan Masyarakat Miskin Supartono; Agus Anggiana; Arinda Triagita; Citra Maharani; Ellysa Shalsabella; Gian Mariana; Jamilatul Rizqiyah; Zita Andini Sabillah; Ilham Rizqi Ariyandi
Jurnal Imiah Pengabdian Pada Masyarakat (JIPM) Vol 2 No 1 (2024): Juli - September
Publisher : CV. ITTC INDONESIA

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The study aims to analyze how the financial literacy influence of the social welfare recipients of the village of Jatiwangi RT 01 can help improve the well-being of the community in the village. Increased public literacy on finance is essential to boosting the economy and improving the well-being of individuals and families. However, people still lack understanding of financial literacy, including people in Jatiwangi Village. Therefore, there is a need for a community service program that enhances financial literacy. If government efforts to reduce poverty through social assistance programmes are not offset by increased financial awareness for those who receive aid, the results will be less satisfactory. The research is conducted through surveys, observations, and financial education to the target community directly. The results of the research show that the community of beneficiaries of social assistance in Jatiwangi Village RT 01 can be more conscious in regulating family finances as well as can maximize the use of social aid funds obtained, with the provision of education and socialization of financial literacy carried out by dedication students. Therefore, this study aims to know and understand how the process or implementation of socialization and education of financial literature to recipients of social assistance funds in Jatiwangi Village RT 01.

EDUKASI KESEHATAN MATA DAN DETEKSI DINI PENURUNAN TAJAM PENGLIHATAN SEBAGAI UPAYA PENCEGAHAN KELAINAN REFRAKSI PADA ANAK USIA SEKOLAH DI MADRASAH TARBIYATUSSHOLATIYAH JAMBI Tarawifa, susan; Rina Nofri Enis; Nyimas Natasha Ayu Shafira; Anggelia Puspasari; Citra Maharani
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 2 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

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ABSTRACTEye health is a vital aspect in supporting the physical and cognitive development of children, especially at school age. Disruptions in eye health, or even blindness, can have negative impacts on their lives. This community service project aims to provide eye health education and vision examinations for children enrolled in the Al-Qur'an memorization program at Madrasah Tarbiyatussholatiyah Jambi, as an effort to maintain their visual health. The activity involved 40 tahfidz children, and data was collected regarding their vision conditions and reading habits. The examination results indicated that 62.5% of the children had normal vision (6/6), while 35% experienced significant vision impairment of varying degrees, and 2.5% were blind. The education provided included proper reading techniques and the importance of adequate lighting to raise awareness among both children and parents. This community service activity emphasizes the necessity of integrating eye health programs in tahfidz educational institutions, particularly at Madrasah Tarbiyatussholatiyah, to detect and prevent vision disorders early on, as well as to effectively support the learning and memorization of the Al-Qur'an.Keyword: Eye health, Visual impairment, Reading habits. ABSTRAKKesehatan mata merupakan aspek vital dalam mendukung perkembangan fisik dan kognitif anak, terutama pada usia sekolah. Pada saat terjadi gangguan pada kesehatan mata atau bahkan kebutaan akan berdampak negatif pada kehidupan. Pengabdian kepada masyrakat ini bertujuan untuk memberikan edukasi kesehatan mata dan pemeriksaan visus pada anak-anak tahfidz Al-Qur'an di Madrasah Tarbiyatussholatiyah Jambi sebagai Upaya untuk menjaga kesehatan penglihatan mereka. Kegiatan ini melibatkan 40 anak tahfidz, data dikumpulkan mengenai kondisi visus dan kebiasaan membaca. Hasil pemeriksaan menunjukkan bahwa62,5% anak memiliki visus normal (6/6), sementara 35% lainnya mengalami penurunan tajam penglihatan, dengan berbagai derajat dan 2,5% mengalami kebutaan. Edukasi yang diberikan terkait teknik membaca yang benar dan pentingnya pencahayaan yang dibutuhkan untuk meningkatkan kesadaran anak dan orang tua. Kegiatan peengabdian ini menekankan perlunya integrasi program kesehatan mata di lembaga pendidikan tahfidz khususnya di Madrasah Tarbiyatussholatiyah untuk mendeteksi dan mencegah gangguan penglihatan sejak dini, serta mendukung proses belajar dan menghafal Al-Qur'an secara efektif.Kata Kunci: Kesehatan mata, Gangguan Penglihatan, Kebiasaan membaca

Kedudukan Hukum Antara Bank Dan Nasabah Pada Akad Murabahah Di Bank Riau Kepri Syariah Nalanwal, Khayla; Maharani, Citra; Wulansari, Retno; Prabowo, Bagya Agung
Prosiding Seminar Hukum Aktual Fakultas Hukum Universitas Islam Indonesia Vol. 2 No. 4 JULI 2024
Publisher : Fakultas Hukum Universitas Islam Indonesia

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Penelitian ini bertujuan untuk meneliti terkait Bank Riau Kepri pasca konversi menjadi Bank Riau Kepri Syariah (BRK Syariah) yang mengkaji dua rumusan masalah: Pertama, bagaimana kedudukan debitor dan kreditor pada Bank Riau Kepri pasca konversi. Kedua, bagaimana keabsahan akad murabahah pada Bank Riau Kepri pasca konversi. Metode penelitian yang digunakan pada penelitian ini menggunakan metode Normatif, yang berdasar pada data-data penelitian dan sumber penelitian. Pendekatan yang digunakan adalah pendekatan konseptual dan pendekatan peraturan perundang-undangan (statute approach). Analisis data dilakukan secara kualitatif. Hasil penelitian ini dapat disimpulkan bahwa dalam BRK Syariah kedudukan kreditor dan debitor berubah menjadi Ba’i dan Musytari sehingga, telah menerapkan adanya prinsip syariah serta terjadinya perubahan perjanjian kredit menjadi akad Murabahah pasca berkonversi dari Bank Riau Kepri menjadi BRK Syariah. Keabsahan pada Bank Riau Kepri sudah terbilang sah karena BRK Syariah sudah memenuhi syarat subjektif dan objektif serta telah menerapkan adanya prinsip syariah yang terdapat dalam Undang-Undang No. 21 Tahun 2008 terkait Perbankan Syariah dimana hal ini menjadikan syarat utama dalam keabsahan akad terutama yang terjadi di Bank Riau Kepri Syariah.

Pengaruh Penyuluhan Tentang Kesehatan Reproduksi Remaja Terhadap Tingkat Pengetahuan Pada Siswa Di SMP 4 Satap Segeri Alamri, Fahrial; Maharani, Citra; Syamsuriyati, Syamsuriyati; Wilma, Wilma; Basir, Muhammad; Mustamin, Mustamin
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 1 (2024): MARET
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i1.2368

The most important health in adolescence is reproductive health, adolescent reproductive health programs are to help adolescents to have responsible and healthy reproductive knowledge, counseling for adolescents has special problems. Adolescent reproductive health materials cover aspects of adolescent life related to reproductive health knowledge. The purpose of this study was to determine the level of knowledge of adolescent reproductive health before and after being given counseling on adolescent reproductive health in VIII students of SMPN 4 Satap Segeri. This research method is a pre-experimental research with one group pre-post design. This research was conducted at SMPN 4 Satap Segeri in 2020. The sample taken was 42 students of class VIII using the proportional simple random sampling technique. The instrument used is a questionnaire on adolescent reproductive health knowledge using presentation media. The test to determine the data analysis used the Wilcoxon non-parametric test. The results of this study indicate that the average level of knowledge of class VIII students before being given health education about adolescent reproductive health is 16.7 and the average knowledge of class VIII students after being given health education is 90.5 with a significant value of 0.000 or p <0.05. The conclusion shows the effect of health education on the level of knowledge of adolescent reproductive health in class VIII SMPN 4 Satap Segeri

Co-Authors Agus Anggiana Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alamri, Fahrial Alhadi, Annisa Alya Dwiva Juhari Amatullah, Afifah Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amri, Fahrial Al An Aldia Asrial Andrea Zulius Anarta Anggelia Puspasari Annissa Delfira Arif, Cut Wulan Arinda Triagita Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap Azzahra Sarah Fatimah Ramadhanti Bachrudin Syaroni Bagya Agung Prabowo, Bagya Agung Bernhard Arianto Purba Betty Marlina Budi Justitia Budi Justitia Bulqis, Ratu Defriani Dwiyanti, Defriani Devy Afriyanti Dhea Assyifa Dhea Olivia Putri Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Elga Lauza Evelyna Ellysa Shalsabella Erny Kusdiyah Esa Indah Ayu, Esa Indah Eva Yuniritha, Eva Fanny Annisa Fazarrosy Fitriyanti Gian Mariana Hadi, Desta Asmara Hana Nurul Qur’ani Hasmita, Debby Hasneli, Hasneli Helfira Citra Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Herlambang Herlambang Herman, Sriyana Huntari Harahap Ika Setyawati Ilham Rizqi Ariyandi Irfannuddin Irfannuddin Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Jamilatul Rizqiyah Khairunnisa, Dhia Fairuz Kusumawati, Diana Maharani, Amrina Maulana Haikal An Nur Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muhamad Reza Muhammad Basir Muhammad Iqbal Fasa Mus, Rosdiana Mustamin Mustamin Nalanwal, Khayla Nurul Izza Nyimas Natasha Ayu Shafira Pramudji Hastuti Prasetyawan, Riyan Dwi Prio Wibowo Rahma, Syawalya Rara indah Oktaviani Renaldi Rizki Nugraha Retno Wulansari Rina Nofri Enis Rita Halim Rita Halim Rusli Shandra Khaerunissa Sri Darningsih Suhaimi, Novadian Supartono Suprapti Suprapti Syamsuriyati, Syamsuriyati Syarif Syifa Energi Maulana Syukur, Astian Nathaniel Tarawifa, Susan Tengku Arief Buana Perkasa Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Vivi Fadhilah Safitri Wahyu Indah Dewi Aurora Wilma Wilma, Wilma Winiesti Melani Putri Zita Andini Sabillah Zulkhair Ali

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