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All Journal Jurnal Pendidikan Matematika Journal of Education and Learning (EduLearn) Pharmaciana: Jurnal Kefarmasian Jurnal Infinity AKSIOMA: Jurnal Program Studi Pendidikan Matematika Mutiara Medika: Jurnal Kedokteran dan Kesehatan Eduma : Mathematics Education Learning and Teaching Science and Technology Indonesia Union: Jurnal Ilmiah Pendidikan Matematika REiD (Research and Evaluation in Education) Jurnal Surya Medika Jurnal Berkala Kesehatan Journal of Mathematics and Mathematics Education (JMME) Media Ilmu Kesehatan Theorems (The Original Research of Mathematics) Malikussaleh Journal of Mathematics Learning (MJML) SJME (Supremum Journal of Mathematics Education) Manuju : Malahayati Nursing Journal Gammath : Jurnal Ilmiah Program Studi Pendidikan Matematika Jurnal Didactical Mathematics Jurnal Penelitian Pembelajaran Matematika Sekolah Jurnal Ners An-Nadaa: Jurnal Kesehatan Masyarakat Jurnal Educatio FKIP UNMA BERNAS: Jurnal Pengabdian Kepada Masyarakat Southeast Asian Mathematics Education Journal Community Empowerment Plusminus: Jurnal Pendidikan Matematika Jurnal Neuroanestesi Indonesia Makara Journal of Technology Progressive of Cognitive and Ability Journal of Research in Science and Mathematics Education INCOME: Indonesian Journal of Community Service and Engagement Indonesian journal of teaching and learning International Journal of Contemporary Studies in Education JNPM (Jurnal Nasional Pendidikan Matematika) International Journal of Mathematics and Mathematics Education (IJMME) Journal of Community Service (JCOS) Journal of Literature Language and Academic Studies (J-LLANS) JRAMathEdu (Journal of Research and Advances in Mathematics Education) Jurnal Infinity International Journal of Applied Learning and Research in Algebra International Journal of Geometry Research and Inventions in Education Jurnal Pendidikan MIPA Jurnal Pendidikan Progresif Mathematics Education Journal SJME (Supremum Journal of Mathematics Education)
Nia Kania
Department Of Mathematics Education, Universitas Majalengka, 45411
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Journal : Science and Technology Indonesia

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The Potential of Ethanol Extract of Pasak Bumi Roots (Eurycoma longifolia Jack) as an Anti-Prostate Cancer In Vitro Against PC-3 Cells Kania, Nia; Rahman, Eka Yudha; Priyandoko, Didik; Sabrina, Adilah Hafizha Nur; Widowati, Wahyu; Azis, Rizal; Annaba, Aziz; Hadiprasetyo, Dhanar Septyawan; Alexandro, Garry
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.452-466

Abstract

The prevalence of prostate cancer cases in men is expected to continue increase. In 2040, it is estimated that there will be 2.293.818 new cases and a 1.05% increase in the death rate due to prostate cancer. Eurycoma longifolia Jack roots extract (ELE) has potential as an alternative treatment. This study aims to analyze ELE potential as an anti-prostate cancer agent through in silico assay and in vitro assays on the prostate cancer cell line (PC-3). ELE compounds were docked against Casp-3, Casp-8, HAX-1, p27, and PTEN. In vitro assays on PC-3 cells were used, namely cell viability (WST-8), ROS levels; cell cycle; and cell apoptosis (flow cytometry), PC-3 cell senescence (μ-Galactosidase staining), Casp-3; Casp-8; HAX-1; p27; and PTEN gene expression (qRT-PCR). All proteins target were successfully docked with ELE compounds and presented binding interactions. ELE is known to reduce viability, intracellular ROS levels, live cells, necrosis, and reduce HAX-1 gene expression, and inhibit the cell cycle G0/G1 phase. ELE can also increase inhibition, senescence, late and early apoptosis, and Casp-3, Casp-8, p27, and PTEN gene expression. ELE 100 μg/mL is the most effective concentration. ELE has potential as an anti-prostate cancer agent through apoptosis, cell cycle, and antioxidant pathways
Co-Authors Aep Saepudin Aep Sunendar Agung Ary Wibowo, Agung Ary Agus Suhendar, Agus Alexandro, Garry Anggraini, Farida Anggun Apriliani Annaba, Aziz Anton Nasrullah, Anton Apriliani, Anggun Azis, Rizal Azma Rosida, Azma Azmiyannoor, Muhammad Bonyah, Ebenezer Budiwinata, Winardi Dadang Juandi Dadang Juandi Dede Eti Nurhasanah Devi, Wivina Riza Dewi Fitriyani Dian Ana Mutriqah Didi Suryadi Didik Priyandoko Edi Hartoyo Eka Yudha Rahman Eko Suhartono Elah Nurlaelah Elis Rosmawati Elsayed, Ebrahim E. Eriana, Nisa Nur Agistni Erik Santoso Erik Santoso Ermina Istiqomah, Ermina Esabilita, Monica Fahdyanoor, Fahdyanoor Faridayanti, Iva Fath, Tri Putra Nuur Fatharoni, Gusti Dicky Fitriani, Cut Florence M. Kyaruzi Fujiati ., Fujiati Gazali, Akhmad Gí¼rbí¼z, Ferit Gürbüz, Ferit Hadiprasetyo, Dhanar Septyawan Hani Hanipah Harapan Parlindungan Ringoringo, Harapan Parlindungan Hariri, Dewi Damayanti Hendriyanto, Agus Herawati , Herawati Herawati Herawati Hidayat, Amat Hidayati, Novita Huldani Huldani Husaini Husaini Ida Ayu Putu Sri Widnyani Iik Nurhikmayati Iik Nurhikmayati, Iik Ilham Muhammad Isa, Mohamad Istiqamah, Ermina Istiqamah Jarnawi Afgani Dahlan Julia, Rida Krida Singgih Kuncoro Kyaruzi, Florence Larsari, Vahid Norouzi Lenie Marlinae Lilis Marina Angraini M. Arif Hakim M. Gilar Jatisunda Mahmudah, Hilda Mardini, Heni Meitria Syahadatina Noor Mijani Rahman, Mijani Mohamad Gilar Jatisunda Mohammad Bakhriansyah Mohammad Rudiansyah Muhammad Abdan Shadiqi Muthia Elma Nelly Al Audhah Nila Nirmalasari, Nila Noor, M. Hafidhuddin Nunuy Ratnawulan Nunuy Ratnawulan Perdias, Antonio Poerwosusanta, Hery Pratama, Muhammad Noor Aditya Pratiwi, Amalia E. Rachman, M. Fathur Rahma, Aulia Rampun, Erdina L.A. Ratnawulan, Nunuy Risnawati Risnawati Roselina Panghiyangani Rosihan Adhani, Rosihan Sabrina, Adilah Hafizha Nur Sanyoto, Didik Dwi Silvia Kristanti Tri Febriana Silvia Kristanti Tri Febriana, Silvia Kristanti Skripsiana, Nika Sterina Sri Asnawati, Sri Sudianto Sudianto Sudianto Sudianto Suhana, Nono Sutapa, Hendra Tri Nopriana, Tri Triawanti Triawanti Triawanti Umar, Nasir Vahid Norouzi Larsari Vici Suciawati WAHYU WIDOWATI Wibawa, Fayza Sandya Yasir Yasir Yaya S. Kusumah Yulizar, Deddy Rasyidan Zaenal Arifin Zaenal Arifin Zaenal Arifin Zainal Abidin Zairin Noor