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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Berkala Perikanan Terubuk Alchemy : Journal of Chemistry The Journal of Pure and Applied Chemistry Research Jurnal Agroekoteknologi Pharmacon CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Teknologi Laboratorium Chimica et Natura Acta Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Gema Wiralodra Canrea Journal: Food Technology, Nutritions, and Culinary Journal Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Indonesia Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Hydrological and Environmental for Sustainability Makara Journal of Science Jurnal Farmasi Sains dan Praktis JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Sains dan Kesehatan JURNAL REKAYASA KIMIA & LINGKUNGAN DIVERSITAS HAYATI: Journal of Conservation and Biological Resources
Madyawati Latief
Prodi Kimia Fakultas Sains Dan Teknologi Universitas Jambi
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Journal : Pharmacon

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Aktivitas Antihiperurisemia Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Pada Mencit Putih Jantan Madyawati Latief; Indra Lasmana Tarigan; Putri Maya Sari; Fiolita Etsa Aurora
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.12880

Abstract

Hyperuricemia is a disease caused by an increase in uric acid levels in the blood. Currently, various treatments are developed by utilizing natural ingredients as an anti-hyperuricemia. Sungkai (Peronema canescens Jack) is one of the plants that contain a natural compound that can use as an anti-hyperuricemia treatment is the leaves of sungkai (Peronema canescens Jack.). The aim of this study to determine the anti-hyperuricemia activity of the ethanol extract of Sungkai leaves. The test animals used in this study were male white mice Wistar strain. This study used a completely randomized design (CRD) with 5 groups consisting of negative control (Na CMC 0.5%) positive control (allopurinol 10 mg / kg BW), treatment 1 (extract 125 mg / kg BW), treatment 2 (extract 250 mg / kg BW) and treatment 3 (extract 500 mg / kg BW). The parameters seen were uric acid levels measured using the POCT (Point of Care Test) method and analyzed using One Way Anova statistical analysis and Duncan's continued test. Our results showed that the treatment group with a dose of 125-500 mg / Kg BW reduce uric acid levels in mice. The best dose was a dose of 500 mg / Kg BW in reducing uric acid levels in mice with percent decline of 38.66%.
Co-Authors -, Maison Addion Nizori Ahmad Fadhil Alfi Khatib, Alfi Alrizal, Alrizal Amanda, Dwi Rahma Amanda, Hilda Anggi Ayunda Triani Anggun Tri Fisesa Ardhica, Jammes Arum, Dewi Azizah, Regina Wan Batubara, Ummi Mardhiah Bela, Anisa Betharia Juli Mas Tambunan Br Sembiring, Vera Lorensya Budiyanto Budiyanto Budiyati Ichwan Bulan, Catherine Putri Delviani, Delviani Dewi, Tribuana Tungga Dwi Wahyu Ramadhan Dyah Puspitasari, Ratih Elis Kartika Ermadani Ermadani Faizar Farid Farah, Farah Fauzan Azima Fikriansyah, Muhammad Fiolita Etsa Aurora Fisesa, Anggun Tri Fitrianingsih Fitrianingsih FITRY TAFZI Havizur Rahman Havizur Rahman Helmina Mandalahi Helmina Mandalahi, Helmina Hengky Irawan, Hengky Heriyanti Heriyanti Heriyanti Heriyanti, Heriyanti Humaryanto, Humaryanto Husna, Naimul Ilmavia Wilantika Indra Lasmana Tarigan Jamaludin Al-Anshori Kharisma, Tiara Kurnia Nastira Ningsih Lenny Marlinda Lince Muis Lince Muis Lizawati Lizawati Lucky Zaehir Maulana Maharani, Rizky Maharani, Viola Giary Rizkillah Mahya Ihsan Masruri Masruri Melani, Fitria Muhaimin Muhaimin Muhaimin Muhaimin Mursyid Djawas Nabila, Annisa Candra Nadia Rahmasari Natasya, Dian Nelson Nelson Nelson Nindita Clourisa Amaris Susanto Nurjannah, Sofia Nurul Huda Oktavioni, Marsella Pebralia, Jesi Prabawa, Satria Prahandika, Graha Puspitasari, Ratih Dyah Putri Maya Sari Putri Maya Sari Putri Maya Sari Putri, Silvi Ayudiah Putri, Yunika Eka qurrota aini Rahayu Sindy Ramadhan, Ilham Ifandi Ratih Dyah Puspitasari Razai, Tengku Said Resta, Ichy Lucya Restina Bemis Restina Bemis, Restina Riany, Hesti Rizki Ananda Rosi Rahayu Saharin, Siti Munirah Samsidar Samsidar Saputra, Muhammad Furqon Novryan Sarah Aknesia Marbun Sari, Tika Seow, Eng Keng Shadrina, Putri Nur Shindi Amanda Rizki Sholeha Annisa Martines Silaban, Desy Vania Silvi Leila Rahmi Sinurat, Julius Alvin Novensius Suci, Ulan Susanto, Nindita Clourisa Amaris Sutrisno Sutrisno, Sustrisno Sutrisno, Sutrisno Tarigan, Indra L. Uce Lestari Vitadella, Veronika Warni, Tri Wazzan, Huda Winda Dwi Setiawati Wulan Safitri, Wulan Yana Cahyana Yoza Fendriani Yulianti, Nike Desvi Yusnaidar Yusnaidar Yusnaidar, Yusnaidar Yusof, Yus Aniza Zulnita, Anis