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Journal : Journal Of World Science

Exploration and Antimicrobial Activity Test of Secondary Metabolites from Endophytic Fungi of Curcuma Zedoaria from West Nusa Tenggara Mario, Mario; Rizky Prima, Sylvia; Primahana, Gian
Journal of World Science Vol. 4 No. 9 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i9.1505

Abstract

Antibiotic resistance has become a significant public health issue in Indonesia, prompting the search for alternative antimicrobial agents from natural sources. Endophytic fungi symbiotically living inside medicinal plants such as Curcuma zedoaria (temu putih) have the potential to produce bioactive secondary metabolites that could serve as new antibacterial agents. This study aimed to isolate endophytic fungi from the rhizome of temu putih originating from West Nusa Tenggara (NTB), evaluate the antibacterial activity of isolates grown on Potato Dextrose Broth (PDB) and Yeast Malt Broth (YMB), and identify as well as elucidate the structure of the secondary metabolite compounds produced. This experimental comparative study involved isolation of endophytic fungi by surface sterilization, culturing on PDB and YMB media, extraction with ethyl acetate, and antibacterial testing against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 8739 using the microdilution method. Metabolite profiling was performed using HPLC-DAD, preparative HPLC for fractionation, LC-HRMS for molecular mass identification, and NMR spectroscopy for structural elucidation. Five endophytic fungal isolates were successfully obtained from the temu putih rhizome. Antibacterial activity was stronger in isolates cultured on PDB compared to YMB. From isolate TP 3 cultured in PDB, several secondary metabolite fractions were isolated, with fraction 4 (F4) containing linoleic acid as the pure compound. F4 demonstrated a Minimum Inhibitory Concentration (MIC) of 200 µg/mL against S. aureus, comparable to the TP 3 PDB isolate, while against E. coli, F4 showed MIC > 200 µg/mL and TP 3 PDB isolate showed an MIC of 100 µg/mL.
Co-Authors A.A. Ketut Agung Cahyawan W Adharamadinka, Muhammad Adistia, Firly Afriyani, Dhea Agung Danur Widyaputra, I Gusti Ahdi, Muhammad Aufil Ahmad Rusdi Aldrino, Aldrino Alvina Alvina Amirullah -, Amirullah Amsal, Bahrul Ananda, Ahmad Rafi Hanif Anggar Erdhina Adi Anggaraksa Wiprahutama, Farrel Anniza K, Nur Alia Ariandi, Syafina Zaskia Ariq, Muhammad Aris Rahmansyah Avidy, Robbyan Azhari, Irfan Azroy, Muhammat Banuaji, Salsabil Zharfa Barata, Muhammad Wibhysono Putra Bayuaji, Lalu Drasca Binekas, Nauval Boni Pahlanop Lapanporo Defritama, Rafly Deryanto, Deryanto Dwi Rahadianto, Irfan Falatehan, Falatehan Fauziyyah, Fakhirah Ferina, Mutiara Fida Oktavia, Alya Hadian Satria Utama Hairunisa, Nany Handini, Delvi Poppy Hani Dewi Ariessanti Hanifa Humaira, Amanda Hara Wikrama, Anak Agung Gde Hargiani, Fransisca Xaveria Haris, Andi Muhammad Arif HASNAWI HARIS, HASNAWI Idrus, Idham Irwansyah Ilmy, Miftahul Imran Siswadi, Imran Irawan, Musfira Putri Irfan Dwi Rahadianto Ismail, Ashari Jumadi Jumadi Jusnawati, Jusnawati Kalandaraputra Keswani, Heykhal Kamaruddin, Syamsu A. Khalipty Shauma, Nakita Khayyira, Salsabila Winra Laksmi Maharani Lie Tanu Merijanti, Lie Tanu Mandra, Mohammad Ahsan S. Mashabi, Yasmine Muh Nasrullah, Muh Muh Rijal, Muh Muhammad Aksha Wahda Muhammad Guntur, Muhammad Muhammad Luthfi Muhammad Rafiq Novalisa, Yoan Melliana Nurwijayanti Kusumaningrum Okolie, Ugo Chuks PB, Notopuro Permadi, Jibril Satrio Pratama, Muhammad Rifki Prima, Sylvia Rizky Primadi, Albert Yudi Primahana, Gian Pusparini Pusparini Putra Wansa, Rafif Rajendra Putri Manik, Angelina Putri, Septiana Yusnita Qatrunnada, Sekardilla Nur Aisyah Rahandito, Irfan Dwi Rahim, Hariashari Rahman, Luthfi Nur Ramadhani, Viana Nurwidi Ras, Atma Riri Amandaria Riska Damayanti, Riska Rully Ayu Nirmalasari, Rully Ayu Rully Sumarlin Saifuddin Saifuddin Salwia, Salwia Samatha, Felisca Sandra, Evita Satrio, Annisa Salsabilla Azharia Sheng, Mao Sihombing, Stephanie Jessie Margaret Sri Wahyuni Suedi, Reski Sukma, Dinny Sunaniah Surjadi, Lily Marliany Suseno, Tri Joko Tampubolon, Naomi Oktavia Tamrin, Sopian Tiara Radinska Deanda Ulfa Utami Mappe Usman, Musrayani Utami, Ayu Puspita Jurnalis W. Suhaeb, Firdaus Wachyu, Kyra Labiqa Wibisono Prayitno, Baihaqi Yohanes, Jonathan