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Manfaat Ekstrak Kunyit (Curcuma domestica Val.) Dalam Menghambat Pertumbuhan Staphylococcus aureus Putri, Putu Winna Deyanti; Rusyati, Luh Made Mas; Praharsini, I Gusti Agung; Sudarsa, Prima Sanjiwani Saraswati
E-Jurnal Medika Udayana Vol 12 No 3 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i03.P17

Abstract

Background: Staphylococcus aureus is an major human pathogen. Most individuals get Staphylococcus aureus infections with varying degrees of malignancy, such as superficial pyoderma, at some point in their lives. Antibiotics are often used to treat Staphylococcus aureus infections, however they may not be utilised or prescribed correctly, resulting in resistance. Alkaloids, flavonoids, tannins, essential oils, terpenoids, and curcuminoids are some of the active components in turmeric that have antibacterial properties. Objective: The goal of this study was to see how efficient the most effective turmeric extract (Curcuma domestica Val.) was in stopping Staphylococcus aureus from growing. Methods: This is an experimental research with a post-test control group. A maceration process employing 96 percent ethanol as a solvent was used to extract Singaraja turmeric. The extract concentrations employed in this research were 15%, 30%, 50%, 75%, and 100%; the positive control was vancomycin, and the negative control was 96 percent ethanol. Using the disc spreading approach, the test was conducted four times. The Kruskal-Wallis test was used to examine the findings of the research. Results: For the average, the inhibition zones were 7 mm, 7.25 mm, 7.5 mm, 7 mm, and 7 mm in diameter at each concentration. This research obtained significance figure by 0.001 (p<0.05). This suggests that the development of Staphylococcus aureus is influenced by varying amounts of turmeric ethanol extract. Conclusions: Turmeric extract (Curcuma domestica Val.) inhibits the growth of Staphylococcus aureus at all concentrations, with 50% of the extracts displaying the largest inhibition zone width.
Epidemiology of Leprosy in Indonesia: a Retrospective Study Lubis, Ramona Sari; Anum, Qaira; Argentina, Fifa; Menaldi, Sri Linuwih; Gunawan, Hendra; Yuniati, Renni; Mulianto, Nur Rachmat; Siswati, Agnes Sri; Widasmara, Dhelya; Rusyati, Luh Made Mas; Mamuaja, Enricco Hendra; Muchtar, Vitayani; Cita Rosita Sigit Prakoeswa; Agusni, Regitta Indira; Bagus Haryo Kusumaputra; Medhi Denisa Alinda; Listiawan, Muhammad Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.29-35

Abstract

Background: According to WHO data, the number of new cases of leprosy has decreased in 2019. However, Indonesia continues to provide a significant number of cases. According to statistics, India, Brazil, and Indonesia account for 79 percent of all instances. Purpose: This study aims to describe the profile of leprosy patients, and involves all Dermatology and Venereology Academic Hospitals in Indonesia. Methods: This study was a retrospective study of 2461 patients from Dermatology and Venereology Outpatient Clinic at 13 Academic Hospitals in Indonesia between January 2018 and December 2020. Result: Subjects in this study were dominated by males (66.8%) and aged > 14 years (95.3%). The most common type of leprosy was multibacillary (MB) (86.2%), and erythema nodosum leprosum (ENL) was the most leprosy reaction (20.3%). Majority of the subjects experienced disability in the hands (26.6%), in grade 1. Conclusion: Leprosy cases in Indonesia are mostly experienced by adult males. The most common type of leprosy is MB, with ENL being the most common leprosy reaction. Grade 1 disability is the most prevalent, therefore proper education is necessary to keep patients from progressing to grade 2 disability.
Characteristics of skin aging at the Dermatology and Venereology Outpatient Unit at Prof. dr. I Goesti Ngoerah Gde Ngoerah General Hospital, Denpasar from January to December 2019 Tiara Evangelista; Ni Made Dwi Puspawati; Luh Made Mas Rusyati; I Gusti Ayu Agung Praharsini
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v6i1.33

Abstract

Background: Skin aging is a complex biological process influenced by intrinsic and extrinsic factors. In addition, national data regarding skin aging is still scant. This research was carried out to learn the characteristics of skin aging at the Dermatology and Venereology outpatient unit of Prof. Dr. I G. N. G. Ngoerah General Hospital, Denpasar, in January-December 2019. Methods: This research is a quantitative descriptive study with a cross-sectional design. Sampling was carried out by total sampling with research subjects consisting of skin-aging patients at the Dermatology and Venereology Outpatient Unit of Prof. dr. I G. N. G. Ngoerah General Hospital in January-December 2019. The data collected consists of age, gender, smoking history, alcohol consumption history, body mass index, usage of sunscreen, duration of sun exposure, and Glogau scale classification. Descriptive analysis was carried out using SPSS ver. 23. Results: Twenty cases of skin aging were included. Most cases of skin aging were in the age group of 36-45 years old, all of whom were female, all of whom had no history of smoking, all of whom had no history of alcohol consumption, most body mass index classification was overweight, most do not use sunscreen, the duration of the sun exposure is mostly 30 minutes-6 hours, and the highest classification of the Glogau scale is group III. Conclusion: In this study, body mass index, usage of sunscreen, and duration of sun exposure are the main factors affecting skin aging.
Effect of Chicken Bile Application on Scar Healing Process limanda, Claudia Felicia; Intizam, Marwa Humaira; Jusuf, Pierre Joshua; Tanujaya, Monica Aprilia; Rusyati, Luh Made Mas
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 1 (June 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/6kq9ke38

Abstract

Type of scars varies from mild fine line scars to abnormal scars which treatment will differ according to its type, site, symptoms, and severity. Scars have a great impact of human life, namely physically, aesthetically, psychologically, and socially that make choosing the right treatment very important. Treatment for scars can be done conventionally in health care facilities and traditionally. Chinese traditional medicine has been known to have a major role in scar treatment. One of the examples is the use of chicken bile. "Chicken bile", "Chicken bile effect", "Wounds", and "Wound healing process" were the keywords applied to scientific online databases. Wound healing is composed of three initial stages, such as inflammatory, proliferative, and remodeling stage. Chicken bile is known to have a low but strong bilirubin level with little biliverdin. These agents can serve as antipyretic, antioxidant, anti-inflammatory, and anti-atherogenic that can aide wound healing. Bile also supports protein metabolism, fat metabolism, energy production, and synthesis of glycogen. Most importantly, bile contains matrix metalloproteinases (MMPs) that function to degrade type IV collagen which have an important role in wound reepithelization process, altering wound matrix, enabling cell to migrate, and tissue remodeling. Thus, it is certain that MMPs are essential in wound healing.
Cyclooxygenase-2 as potential intervention target of leprosy reactions: a systematic review Rusyati, Luh Made Mas; Sari, Luh Gede Melia Puspita; Winaya, Ketut Kwartantaya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/wf9qxd44

Abstract

Background: Leprosy reaction is an acute inflammatory of leprosy complication that potentially cause disability. Prompt and appropriate treatment is needed to prevent this permanent neurological complication. As inflammation of this reaction is mediated by cyclooxygenase-2 (COX-2), therefore targeting this substance may potential to prevent disability. This systematic review aimed to define COX-2 as a potential target of intervention in leprosy reaction. Method: Medline, Cochrane library, PubMed, and Google scholar databases were searched for articles published at any time. Observational study and clinical trial, comparative, prospective, retrospective, and descriptive study were extracted, analyzed, and discussed. Results: We found 6 studies that met the inclusion and exclusion criteria, with 104 participants with leprosy reactions and 143 comparators included in this review. In leprosy reactions, COX-2 expression was found in the vessels and nerves of the dermis and subcutis. Macrophages are cell mostly abundantly expressing COX-2. The COX-2 expression was found higher in the leprosy reaction compare to the non-leprosy reaction. Genetically, genes PTGS2 and TNFAIP6 encode COX-2 production also tend to increase especially in type 1 reaction. Conclusions: Preclinically and genetically, COX-2 is a potential target for intervention of leprosy reaction.
Effect of 8% Purple Sweet Potato Extract Cream on Wrinkle Reduction, Skin Moisture, and Elasticity Laksmi, I Gusti Ayu Agung Mini; Praharsini, I Gusti Ayu Agung; Karmila, I Gusti Ayu Agung Dwi; Rusyati, Luh Made Mas; Suryawati, Nyoman; Winaya, Ketut Kwartantaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.1-8

Abstract

Background: Purple sweet potato has been shown to contain anthocyanins, polyphenols, flavonoids, and tannins that act as antioxidants and have the potential to correct signs of aging in the skin, such as wrinkles, lack of hydration, and pigmentation. Purpose: to known the potential of 8% purple sweet potato extract for wrinkles, moisture, and elasticity. Methods: A one-group experimental study with pre and post-test assessment. The subject is women with photoaging aged 30-45 years. A pre-test was conducted by examining wrinkles using the Glogau scale and a simple A-one scanner, treatment with 8% purple sweet potato extract cream for 6 weeks, and then a post-test at the end of the 6th week to check wrinkles, moisture, and elasticity using a simple A-one scan. Statistical tests using the SPSS program, version 25.0. The analysis performed was descriptive statistical and comparative analysis using a paired T test.  Result: A total of 25 respondents with a mean age ± SD of 38.22 ± 4.23 years, the most Glogau scale in type 2 is 22 respondents (88%), the most sun exposure for 30 minutes per day is 14 respondents (56%). The degree of wrinkles decreased after treatment -4.960±1.353 [95% CI -7.681-(-2.239); P=0.001]. The degree of moisture increased after treatment 8.840±2.990% (95% CI 2.829-14.851; P=0.005. The degree of elasticity increased after treatment 14.840±4.623 (95% CI 5.544-24.136; P=0.002). Conclusion: 8% purple sweet potato extract can reduce the degree of wrinkles, improve the degree of skin moisture, and improve the degree of skin elasticity.
Gray Patch Tinea Capitis by Microsporum canis in a Child: A Case Report Highlighting Environmental Risk Factors and Diagnostic Nuances Mario Korwa; Luh Made Mas Rusyati; Handelia Phinari; Andrew Wicaksono; Nandya Dwizella
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 11 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i11.1429

Abstract

Background: Tinea capitis, a dermatophytosis of the scalp, is a leading cause of hair loss in children. Its successful management hinges on understanding its complex etiology, including host susceptibility and pathogen virulence. Microsporum canis, a zoophilic fungus, is a primary causative agent, yet its transmission pathways and diagnostic markers are not fully elucidated. Case presentation: A 3-year-old female presented with a two-week history of progressive, pruritic alopecia. Clinical history was notable for the absence of animal contact but revealed significant environmental exposure at a hair salon. Dermatological examination showed multiple, well-demarcated, alopecic patches with fine scaling, characteristic of gray patch tinea capitis. While Wood's lamp examination was negative, trichoscopy revealed comma hairs and Morse code-like hairs, suggesting fungal infection. Microscopic examination of hair shafts confirmed an ectothrix invasion pattern, and fungal culture definitively identified Microsporum canis. The patient achieved complete resolution following a six-week course of oral griseofulvin and adjuvant topical ketoconazole. Conclusion: This case demonstrates that indirect fomite transmission from environmental reservoirs like hair salons is a critical risk factor for zoophilic tinea capitis, independent of animal contact. It further establishes trichoscopy as an essential tool for accurate, rapid diagnosis when classic signs, such as Wood's lamp fluorescence, are absent, thereby optimizing patient management and public health outcomes.
Pencegahan Disabilitas pada Kusta Thiodorus, Robert; Rusyati, Luh Made Mas; Sadeli, Marrietta Sugiarti
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.216-223

Abstract

Leprosy, a chronic granulomatous infectious disease caused by Mycobacterium Leprae, presents a complex challenge with profound social, physical, and economic implications. The burden of leprosy is a persistent concern in many developing countries, despite substantial control efforts. The World Health Organization (WHO) initiated the "Global Leprosy Strategy 2016-2020" to combat this issue, focusing on reducing children diagnosed with leprosy, eliminating visible deformities, and enacting anti-discrimination laws. Disability in leprosy is multifaceted and preventing disability in leprosy is a critical endeavor, such as prophylaxis, early diagnosis, and comprehensive care strategies. Vaccination with the BCG vaccine provides moderate protection, and combining it with single-dose rifampicin (SDR) can enhance its effectiveness, particularly for lepromatous cases with delayed diagnoses. Improved training for healthcare providers can facilitate early detection, reducing the risk of disability. After effective leprosy treatment, longterm morbidity remains a concern. Continued education of healthcare workers and communities is pivotal in preventing damage to hands, feet, and eyes, especially in cases of peripheral neuropathy. Disability progression is a substantial risk, highlighting the need for ongoing medical assessments, even post-MDT treatment. Restructuring primary care services to ensure quality post-treatment care is essential. Stigma remains a significant obstacle in leprosy prevention. Community awareness and stigma reduction can motivate individuals to seek treatment. Epidemiological patterns transmission within households, play a crucial role in identifying new cases. Routine examinations of household contacts of leprosy patients can expedite early diagnosis. Nutrition also plays a role in leprosy prevention. Ensuring access to nutritious food is critical to reducing the risk of developing the disease. In conclusion, the prevention of disability in leprosy is a multifaceted endeavor that demands comprehensive strategies, early intervention, awareness, and community engagement. Addressing this issue is vital for improving the quality of life for individuals affected by leprosy and for achieving a leprosy-free world.
Kadar Transforming Growth Factor- Serum Berkorelasi Positif dengan Kadar Immunoglobulin M Anti-Phenolic Glycolipid-1 pada Narakontak Serumah Pasien Kusta Multibasiler Primasari, Putu Yunita; Rusyati, Luh Made Mas; Karmila, I Gusti Ayu Agung Dwi; Winaya, Ketut Kwartantaya; Suryawati, Nyoman; Karna, Ni Luh Putu Ratih Vibriyanti
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.146-157

Abstract

Background Leprosy is a chronic progressive infectious disease. Phenolic glycolipid-1 (PGL-1) is an antigen of Mycobacterium leprae, which can trigger the host’s antibody response. Transforming growth factorβ (TGF-β) plays an immunosuppressive role when the host is exposed to PGL-1 antigen or other M. leprae antigens. This study aims to determine the correlation of TGF-β levels with IgM anti-PGL-1 levels in patients with multibacillary leprosy household contacts. Methods Observational analytical study with a cross-sectional approach. The study subjects consisted of 48 household contact subjects and 24 non-household contact subjects aged 15-65 years old who were selected by consecutive sampling based on inclusion and exclusion criteria. 3 mL of venous blood samples were taken and then examined for IgM anti-PGL-1 and TGF-β with the ELISA kit. Data analysis was carried out using SPSS version 23, and a p-value <0.05 was significant. Results The mean level of IgM anti-PGL-1 in the household contact group was 685.46 ± 290.79 u/mL, while in the non-household contact group was 345.50 ± 206.58 u/mL. The mean TGF-β level in household contact groups was 256.69 ± 127.41 pg/mL, while in the non-household contact group was 144.85 ± 36.73 pg/mL (p<0.001). This study found a moderate positive relationship (r=0.450, p<0.001) between levels of TGF-β and IgM anti-PGL-1 household contacts and non-household contacts group. Conclusions The mean level of IgM anti-PGL-1 and TGF-β in household contacts is higher than in non-household contacts, with a significant difference. There is a moderate positive significant relationship between levels of TGF-β and IgM anti-PGL-1 household contacts and non-household contacts group.
The Role of Vitamins, Minerals, and Nutrition in Leprosy Patients: A Review Wijaya, Edward; Sutiajaya, Nikita Lestari; Rusyati, Luh Made Mas
Indonesian Journal of Global Health Research Vol 6 No S5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS5.4720

Abstract

Leprosy, is a chronic infectious disease caused by Mycobacterium leprae, an airborne intracellular bacillus and is considered a disease of poverty. Leprosy, with its associated physical and social morbidity, results in economic conditions that lead to malnutrition. The purpose of this study was to explore the role of vitamins, minerals, and nutrition in leprosy patients. The method used in this study was to explore articles and theories related to vitamins, minerals, nutrition and leprosy patients. The results of this study are that decreased antioxidant levels can lead to increased oxidative stress and complications of infectious diseases and leprosy. Because these nutrients have regulatory effects on innate and adaptive immune responses, a perfect balance in their concentrations is important to improve the immune response to pathogens.
Co-Authors A.A.N.B. Adhitya Wirakusuma Aanak Agung Gde Putra Wiraguna Adeline Santoso Agnes Sri Siswati Agung Bagus S. Satyarsa Anak Agung Bagus Putra Indrakusuma Anak Agung Gde Putra Wiraguna Andrew Wicaksono Angela Sandi Tagaroi Rahasia Antonio Orson Ongkowidjojo Anum, Qaira Arim Sadeva, I Gede Krisna Aurelia Stephanie Aurelia Stephanie Aurelia Stephanie Bagus Haryo Kusumaputra Cita Rosita Sigit Prakoeswa Desak Made Wihandani Desak Nyoman Trisepti Utami Dewa Made Rendy Sanjaya Dewi Gotama Dhelya Widasmara Dian Galih SIliwangi Edward Wijaya, Edward Elice Wijaya Elice Wijaya Febrina D Pratiwi Fifa Argentina Firly Clarissa Suyanto Gde Ngurah Arya Ariwangsa Gede Made Cahya Trisna Pratama Gede Mahadika Pradipta Atmaja GK Darmaputra Gotama, Dewi Haikal Hamas Putra Iqra Handelia Phinari Herman Saputra I Dewa Ayu Vanessa Vijayamurthy I Dewa Ayu Vanessa Vijayamurthy I Dewa Made Rendy Sanjaya I G. P. Supadmanaba I Gede Agus Bhakti Suputra I Gede Krisna Arim Sadeva I Gede Raditya Narayana I Gede Wahyu Toya Pratama I Gusti Amanda Jaya I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Ayu Tika Indriani I Gusti Ketut Darmada I Gusti Ketut Darmada I Gusti Nyoman Darmaputra I Gusti Nyoman Sri Wiryawan I Komang Arimbawa I Made Oka Adnyana I Made Swastika I Pt Agus Suryantara P I Putu Arie Sasmita I Putu Eka Widyadharma I Putu Gilang Iswara Wijaya I.G.A. Karmila I.G.K Darmada I.G.K. Darmada Ida Ayu Diah Purnama Sari Ida Ayu Uttari Priyadarshini Ida Ayu Widya Anjani IGK Darmada Indra Teguh Wiryo Indra Teguh Wiryo Indrakusuma, Anak Agung Bagus Putra Indry Salonika Sutiawan Intizam, Marwa Humaira Jason Jonathan Jayawarsa, A.A. Ketut Jusuf, Pierre Joshua Kadek Ayu Rima Mahadewi Kadek Yuda Sujana Karmila, I. G. A. A Dwi Karna, N. L. P Ratih Vibriyanti Ketut Kwartantaya Winaya Ketut Kwartantaya Winaya Ketut Wida Komalasari Komang Ayu Kristiana Dewi K Laksmi, I Gusti Ayu Agung Mini Limanda, Claudia Felicia Lisa Alverina Lubis, Ramona Sari Luciana Luciana M. Yulianto Listiawan Made Hermina Laksmi Made Martina Windari Made Swastika Adiguna Made Wardhana Mamuaja, Enricco Hendra Mario Korwa Marrietta Sugiarti Sadeli Martima W Medhi Denisa Alinda, Medhi Denisa Muchtar, Vitayani Nandya Dwizella Nevristia Pratama Ni Kadek Setyawati Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Ni Made Dwi Puspawati Ni Made Linawati Nyoman Raditya Adiprayoga Nyoman Suryawati Nyoman Suryawati Patricia Dian Putri Praharsini, I Gusti Agung Prima Saraswati Sanjiwani Sudarsa Prima Sudarsa Prima Sudarsa Prima Sudarsa Primasari, Putu Yunita Puspawati . Putri Ayu Wulandari Putri Ayu Wulandari, Putri Ayu Putri, Patricia Dian Putri, Putu Winna Deyanti Putu Ayu Saraswati Putu Diah Pratiwi Putu Gde Hari Wangsa Putu Raisha Vishkariana Dewi Ratih Vebrianti Ratih Vibriyanti Karna Regitta Indira Agusni Renni Yuniati Riyana Noor Oktaviyanti Sadeli, Marrietta Sugiarti Santoso, Adeline Saravanan Krishnan Sari, Luh Gede Melia Puspita Sari, Luh Putu Sustiana Kartika Sissy Sissy Sissy, Sissy Sofyan Faridi Sri L. Menaldi Stefanus Soewito Sutanto Stephanie, Aurelia Sudarsa, Prima Suharmono Hadi Suryawati . Sutiajaya, Nikita Lestari Tanujaya, Monica Aprilia Thiodorus, Robert Tiara Evangelista Trisna Yuliharti Tersinanda Vijayamurthy, I Dewa Ayu Vanessa Widya Anjani, Ida Ayu Winaya, Ketut Kwartantaya Wiryo, Indra Teguh Wisnu Triadi Nugroho Yara Egyptha Saraswati