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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Global Medical and Health Communication Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Medical Laboratory Technology Journal Indonesian Journal for Health Sciences (IJHS) SRIWIJAYA JOURNAL OF MEDICINE Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Indonesian Journal of Anesthesiology and Reanimation (IJAR) JK Unila (Jurnal Kedokteran Universitas Lampung) Eureka Herba Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Indonesian Community Empowerment Journal Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Arkus Wal'afiat Hospital Journal International Journal of Islamic and Complementary Medicine Conferences of Medical Sciences Dies Natalis Sriwijaya Journal of Dentistry WAL'AFIAT HOSPITAL JOURNAL Biomedika Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Jamu Journal of Medicine and Health
Nita Parisa
Department Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The Effectiveness of Cinnamon extract (Cinnamomum burmannii) to reducing ureum level in male Rattus norvegicus Unilateral Ureteral Obstruction (UUO) model Evi Lusiana; Theodorus Theodorus; Nita Parisa; Fatmawati Fatmawati; M. Ivan Pratama
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.112

Abstract

Cinnamon extract's effectiveness as a renoprotective has not been previously investigated due to its widespread use in daily life, either as a cooking ingredient or as a herb. The aim of this study is to determine the effectiveness extract of cinnamon (Cinnamomum burmannii) as a renoprotective in lowering urea levels in the kidneys. An in vivo experimental study with a pre-post test and control group design was conducted at the Faculty of Medicine's Animal House and Biotechnology Laboratories. Male white rats (Rattus norvegicus) were used as the research subjects. Thirty rat were divided into five groups: negative control, positive control, cinnamon extract at 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW. The data were processed using SPSS 22.0. Cinnamon extract doses of 100 mg/kgBW and 200 mg/kgBW were the most effective in reducing urea levels and suspending the progression of the renal fibrosis process in Wistar male white rats with unilateral ureteral obstruction (UUO) model.
Utilization of Kersen Leaves as Antihyperuricemia Nita Parisa; Aprilia Paskah Samosir; Fatmawati Fatmawati; Rachmat Hidayat; Marlyani Tamara; Karina Nurul Fahira; Alfiyah Munawwaroh Abdullah; Rischka Salsabila Maulini; Rohaya Rohaya
Sriwijaya Journal of Medicine Vol. 5 No. 2 (2022): Vol 5, No. 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i2.145

Abstract

Kersen (Muntingia calabura), a tropical plant originating from Latin America, is a wild plant that has many benefits. Kersen contains flavonoid compounds, tannins, triterpenes, saponins, alkaloids that are useful as anti-inflammatory, anti-tumor, and anti-uric acid. Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood which precipitates uric acid crystals in the kidneys and joints. Most patients with hyperuricemia do not require medical therapy, but lifestyle modifications can be made such as regular eating, adequate exercise, and avoiding foods and drinks high in protein and purines. This study aims to investigate the benefits of Kersen Leaf as an anti-uric acid. The method used in this study is a literature study based on library sources excavated through national and international sites such as Google, Google Scholar, and PubMed.
Genetic Factors Affecting Neuroplasticity Ziske Maritska; Muhammad Fakhri Altyan; Ardy Oktaviandi; Muhammad Barkah; Amirah Dhia Nabila Sinum; Emelda Emelda; Hawari Martanusa; Rini Nindela; Nita Parisa; Bintang Arroyantri Prananjaya; Puji Rizki Suryani; Eka Febri Zulissetiana
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.152

Abstract

Neuroplasticity pertains to the brain's ability to adjust functions or structure in response to events and is an important factor for skill-learning development as well as functional recovery from a neurological disorder. Numerous factors could influence neuroplasticity processes. This literature review aims to discuss the roles of genetic factors in neuroplasticity. The literature search was conducted using the keywords “neuroplasticity”, genetics”, “genes”, and polymorphism” in search engines like google scholar and PubMed, covering original articles, reviews, and text book both in Bahasa Indonesia and English for the last ten years. Genetic variation including gene polymorphism was responsible for the impact of BDNF, ApoE, and dopamine on the functional neural repair of the brain. Certain processes might directly influence neuroplasticity; others might interfere indirectly through the process. A deeper insight into genetic influence regarding neuroplasticity could lead to a better understanding and potential improvement of treatment.
Genetic Conditions Associated with Intellectual Disability in Indonesian Population: A Review Ziske Maritska; Atikah M. Ihsan; Ina Rahmawati; Perawati Perawati; Mohammad Hilal Atthariq Ramadhan; Bintang Arroyantri Prananjaya; Nita Parisa
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.220

Abstract

Intellectual disability (ID) brings challenges to the affected individuals, their families, and the community at large. It is a multifactorial condition with many contributing factors, namely genetics. This review aims to briefly provide several related genetic conditions for ID in the Indonesian population. Literature studies search relevant articles using PubMed and Google Scholar using the terms ‘intellectual disability’, ‘genetics', ‘Indonesian population’. In Indonesia, the prevalence of children with ID is 1–3%, with 62,011 school-aged children affected with Intellectual Disability. Genetics plays a role in around 25–50% of cases. ID in the Indonesian population is associated with several genetic disorders, namely Duchenne muscular dystrophy (DMD), autism spectrum disorder (ASD), fragile X syndrome (FXS), Down syndrome (DS), Apert syndrome, and subtelomeric chromosomal rearrangements. There is limited research on genetics related to intellectual disability in Indonesia, implying further research is needed.
Affinity of Chlorogenic Acid as COVID-19 Antiviral with Molecular Docking Method Bagaskara, Surya; Parisa, Nita; Pasaribu, Rouly Pola; Tamzil, Nia Savitri; Kamaluddin, Muhammad Totong
Biomedika Vol 16, No 1 (2024): Biomedika Februari 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i1.4622

Abstract

Due to the continued presence of and impact of COVID-19 on our modern world, the benefit and necessity of alternative treatment options and effective antiviral compounds is readily apparent. This study seeks to explore the utility of chlorogenic acid as a COVID-19 antiviral. The in-silico experimental study was conducted using a laptop and publicly-available freeware. Key compounds used in this study are the comparative drugs favipiravir (CID 492405), oseltamivir (CID 65028), nafamostat (CID 4413), and spironolactone (CID 5833), to be tested against our subject, chlorogenic acid (CID 1794427). Compunds used in this study were docked with specific target proteins, such as ACE2, TMPRSS2, RdRp, dan 3Clpro, using AutoDock Vina. The visualization of molecular interactions was performed with Discovery Studio v21. Our results showed that chlorogenic acid has one Lipinski’s Rule of Five violation in H-bond Donor parameter. Chlorogenic acid had a higher affinity towards ACE2 and 3CLpro and lower affinity towards TMPRSS2 and RdRp, if compared to competing drugs, with a binding energy of -7.8, -6.9, -7.0, and -7.4 kcal/mol respectively, for ACE2, TMPRSS2, RdRp, and 3CLpro. We conclude that chlorogenic acid shows promise as oral drug candidate based on these results, and that further studies into the realm of molecular dynamics, in-vitro, or in-vivo studies are warranted in order to explore this underutalized compound and possibly bring it to human trials.
Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin in a Rat Model of High Fructose Corn Syrup Induced Hyperuricemia Tahany, Hanifah; Parisa, Nita; Nugraha, M Daffa; Harahap, Debby Handayati; Theodorus, Theodorus
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.200

Abstract

An increase in the blood level of uric acid, or hyperuricemia, is a disorder that can cause damage to the kidneys and gout among other health problems. Worldwide, the incidence of hyperuricemia has been rising, in part because of dietary factors such the use of HFCS, a prevalent sweetener found in processed foods. Thus, research into natural substances with anti-inflammatory and anti-hyperuricemia attributes, such as chrysin, is critical to the fields of therapeutic and preventive medicine. This study investigates the anti-inflammatory and anti-hyperuricemic effects of chrysin in a rat model of hyperuricemia induced by high-fructose corn syrup. The research reveals that chrysin exerts its therapeutic effects through antioxidant activity and the inhibition of inflammatory signaling pathways, resulting in a decrease in oxidative stress and the expression of the pro-inflammatory cytokine IL-1β. Treatment with chrysin leads to a significant increase in tissue weight, tissue index, and kidney histology, indicating its potential in mitigating kidney damage associated with hyperuricemia. The study demonstrates a dose-dependent reduction in IL-1β levels and inflammation activation with chrysin treatment, surpassing the anti-inflammatory effects of the comparison group. Furthermore, chrysin treatment reduces malondialdehyde concentration and mitigates the activation of inflammasome-related protein induced by high-fructose corn syrup. These findings highlight the promising therapeutic potential of chrysin in managing hyperuricemia and related metabolic disorders.
Edukasi swamedikasi obat herbal yang rasional pada kelompok ibu rumah tangga di Kelurahan Karya Baru Rosdah, Ayeshah Augusta; Adenina, Masayu Syarinta; Parisa, Nita; Harahap, Debby Handayati; Lusiana, Evi; Fatmawati, Fatmawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.169

Abstract

Indonesian Health Survey reported that more than half of the population in South Sumatera utilizes herbal medicine to alleviate disease symptoms. The survey also indicated that factors such as lower-middle income levels and the female gender are relatively more likely to utilize medicinal plants compared to higher-income levels and the male gender. The findings from this health survey strongly support the characteristics of the target audience for this community service, specifically the residents of Karya Baru Village represented by the women in Majelis Taklim Al-Kahfi. Initial interviews with several members of this group revealed a tendency to self-treat sick family members, particularly using herbal remedies, as they are perceived to have no side effects compared to modern medications (synthetic drugs). These findings indicate a potential irrational use of herbal medicine in self-medication practices. Self-medication refers to the efforts made by individuals to determine treatments for their disease symptoms. For self-medication practices to be safe and effective, it is essential for the community to be equipped with adequate knowledge about the rational use of herbal medicines. Therefore, a community service initiative is necessary to enhance public knowledge regarding the types of herbal medicines and promote rational behaviors on self-medication practice of herbal medicines within the community.
SPECIAL MONTH FOR SPECIAL NEEDS CHILDREN Maritska, Ziske; Arroyantri Prananjaya, Bintang; Parisa, Nita
International Journal of Islamic and Complementary Medicine Vol. 3 No. 1 (2022): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V3I1.32

Abstract

Down Syndrome is one of the most commonly found genetic conditions, a chromosomal abnormality that is. It is caused by an extra chromosome 21 in their body. The extra chromosome itself can be a total chromosome 21, or just part of it. Whatever the form is, it leads to distinct physical features along with associated medical conditions. One of the symptoms of people with Down Syndrome is the cognitive problem where all of them would have various levels of intelligence, making the learning and comprehension process challenging. For Muslims all around the world, Ramadhan is the one special month of the year where everyone would fast. Learning about Ramadhan and conducting fasting during Ramadhan could be challenging for children with Down Syndrome. There is no known absolute contraindication for them to fast, but several comorbidities related to the condition might hinder them from doing fasting.
POTENTIAL OF DUTCH TEAK LEAVES (Guazuma ulmifolia) AS ANTIOXIDANTS AND ANTI-INFLAMMATORIES AGENT Smaradhna, Safira; Az Zahra, Zaviera; Maria Sidabutar, Carolina; Eskalatin, Khaira; Tamzil, Nia Savitri; Lusiana, Evi; Oktariana, Desi; Dwi Prasasty, Gita; Parisa, Nita
International Journal of Islamic and Complementary Medicine Vol. 4 No. 1 (2023): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V4I1.57

Abstract

Oxidative stress is an imbalance in the quantity of reactive species and antioxidant activity that is often associated with inflammatory diseases. Inflammation is the main cause of morbidity in most of the world's population. Inflammation occurs when there is an invasion of foreign bodies and pathogenic agents such as bacteria, parasites, and viruses that cause activation of the immune system. The protective effect of the inflammatory process is actually very good under normal circumstances. However, in chronic inflammation, tissue damage becomes uncontrollable and can lead to various diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, psoriasis and neoplastic transformation. For inflammatory therapy, steroids and non-steroidal drugs (NSAIDs) are usually used, but the use of these drugs can have serious long-term effects. Therefore, the development of anti-inflammatory agents from natural sources such as certain plant species that are safe, efficacious, biocompatible and cost-effective is a rational strategy that can be used to treat inflammatory diseases. One of its species, Guazuma ulmifolia or Dutch teak plant, is widely used in traditional medicine because it contains bioactive compounds, especially proanthocyanidins and flavonoids which have anti-oxidant and anti- microbial properties. The leaves and flowers of Guazuma ulmifolia can be used in fever, gastrointestinal disease, kidney disease and diabetes. Guazuma ulmifolia can protect the gastric mucosa against the harmful effects of NSAIDs through anti-inflammatory and anti-oxidant mechanisms. The extract of Dutch teak leaves (Guazuma ulmifolia) was also effective in reducing the expression of myeloperoxidase in the pulmonary tissue of Wistar white rats with pulmonary contusions .
Socialization of Occupational Health and Safety to the Construction Worker Community Parisa, Nita
Indonesian Community Empowerment Journal Vol. 1 No. 1 (2021): Indonesian Community Empowerment Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/icejournal.v1i1.4

Abstract

Hazards related to working at heights include falling from height, falling objects, electrical hazards and weather conditions. Labor Law No. 1 of 1970 concerning occupational safety regulates the prevention of worker accidents in Indonesia. This study aimed to describe the socialization activities of occupational safety and health among construction workers in Palembang. Occupational safety and health socialization activities are carried out online using Google Meet every week during June 2020. Four meetings were held, each meeting duration of 2 hours. This activity was attended by around 164 members of the construction community of South Sumatra, Indonesia. The socialization activities were carried out by presenting material, questions and answers and mini demonstrations of occupational safety and health. In conclusion, Occupational safety and health socialization activities increase the knowledge and awareness of workers in applying work safety principles.
Co-Authors ., Mariana Abdulwahab Hakimi Adenina, Masayu S Agustina Septi Hijir Aini, Nurlutfiyyah Aisyah Fristania Ditamor Alfiyah Munawwaroh Abdullah Alwi Shahab Amira Azra Arisa Putri Amirah Dhia Nabila Sinum Anisah Nida'ul Haq Aprilia Paskah Samosir Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardy Oktaviandi Arroyantri Prananjaya, Bintang Athiah, Medina Atikah M. Ihsan Ayeshah A Rosdah Az Zahra, Zaviera Azizah, Aida Nur Bagaskara, Surya Bintang Arroyantri Bintang Arroyantri P Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Carissa Delania Chris Alberto Amin Citra Yuliana Clara Alverina Dara Prameswari Debby Handayati Harahap Desi Oktariana Diah Andini Diba, Msy. Farah Diyaz Syauki Ikhsan Dwi Tantri Marylin Eka Febri Zulissetiana Ella Amalia, Ella Emelda Emelda Eskalatin, Khaira Evi Lusiana Fakhri Abdurrahman Fakhri Abdurrahman Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Febryana Ramadhani Machyar Gita Dwi Prasasty Gita Dwi Prasasty Haq, Anisah Nida'ul Hawari Martanusa Ina Rahmawati Indri Seta Septadina Inggarsih, Rara Irga, Muhammad Islami, Arya Putera Izzah, Puspita Nurul Jayawarsa, A.A. Ketut Joko Marwoto Kamaluddin, Muhammad Totong Karina Nurul Fahira Karina, Mathius Kemas Muhammad Deky Berryl Ananta Putra Larasati, Veny Leonardo Satria Lusia Hayati Lusia Hayati, Lusia M. Ivan Pratama M. Khairul Kahfi Pasaribu M. T. Kamaluddin M. T. Kamaluddin M. Totong Kamaluddin Manurung, Maya Rina Santara Maria Sidabutar, Carolina Marlyani Tamara Mayasari Mayasari Mgs Irsan Saleh Mgs Irsan Saleh Mgs. Irsan Saleh Mgs. Irsan Saleh, Mgs. Irsan Mohammad Hilal Atthariq Ramadhan MT Kamaluddin Muhammad Barkah Muhammad Fakhri Altyan Muhammad Irsan Saleh Muhammad Reagen Muhammad Totong Kamaluddin Muhammad Totong Kamaluddin Muhammad Yusuf Wijahaska Nabila, Safa Putri Nadhila Apriadhanti Nafrah Ardita Nashif, Arkan Abdullah Nia Savitri Tamzil Noviyanti Eliska, Noviyanti Nugraha, M Daffa Oktariana, Desi pariyana, Pariyana Pasaribu, Rouly Pola Perawati Perawati Perryanis Perryanis Perryanis, Perryanis Prananjaya, Bintang A Prananjaya, Bintang Arroyantri Puji Rizki Suryani Purnamasari, Septi Putra, Marco Manza R.A. Alda Adelia RACHMAT HIDAYAT Rachmat Hidayat Rachmat Taufan Radiyati Umi Partan Rahma Nur Islami Rahmat Hidayat Rahmat Hidayat Rahmi Isman Rasyid, Riana Sari Puspita Rini Nindela Rini Nindela Rio Dwi Arliansyah Rischka Salsabila Maulini Rohaya Rohaya Rosdah, Ayesha Augusta Rovania Yantinez Quardetta Rovania Yantinez Quardetta Rulan Adnindya Safira Azahra Saleh, M. Irsan Saleh, Masagus I Salni Salni Salni Salni Salni Samantha Ferlin Boentara Samantha Ferlin Boentara Saputra, Andre Sativandi Riza Sindy Bintang Permata Siti Rusdiana Puspa Siti Rusdiana Puspa Dewi Smaradhna, Safira Sri Nita Sri Nita Subandrate Sutandar, Vivi Hendra Syarinta Adenina Syifa Syifa Syifa Tahany, Hanifah Tantoro, Valyn T Theodorus Theodorus Theodorus Parulian Theodorus Parulian Theodorus Theodorus Theodorus Theodorus Theodorus Theodorus Tiara Fatrin tri wahyuni Tri Wahyuni Triwani Triwani Triwani Triwani Triwani Triwani Triwani Triwani Try Merdeka Puri Tryvanie R Putra Uswati Uswati Valentino, Albert Amadeus Venny Larasati Vincensius Hans Kristian Pratama Wicaksono, Bonanza Abi Wildan Dwi Putra Widodo Yeni Agustin Yeni Agustin Yeni Agustin Yuliana, Citra Yuliarni Yuliarni Yuliarni Yuliarni Zabila Adwie Prilishia Ziske Maritska