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All Journal Pharmasipha Jurnal Delima Harapan Jurnal Farmasi Indonesia Jurnal Analis Farmasi Jurnal Riset Kefarmasian Indonesia PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma JAF (Jurnal Analis Farmasi) Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) Sehat Rakyat: Jurnal Kesehatan Masyarakat JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal Ilmiah Kesehatan Jurnal Ilmiah Research and Development Student Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Pengabdian Masyarakat dan Riset Pendidikan Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Science and Community Pharmacy Journal Jurnal Ilmiah Farmasi Indonesia (JIFIN) Green Health: Journal of Health Sciences, Nursing and Nutrition Jurnal Pengabdian Ilmu Kesehatan Borneo Nursing Journal MURAKES
Listyani, Tiara Ajeng
Universitas Duta Bangsa Surakarta
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Uji Stabilitas dan Kelembapan Lip balm Ekstrak Rosella (Hibiscus sabdariffa L.) dengan Variasi Rasio Candelilla dan Carnauba Wax Anis Kurnia Sukmawati; Tiara Ajeng Listyani; Tatiana Siska Wardani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i6.2534

Abstract

Dry and chapped lips occur because the epidermis of the lips lacks a natural moisturizing mechanism, resulting in an increased rate of transepidermal water loss (TEWL) and creating a need for effective lip care products. Roselle flower petals (Hibiscus sabdariffa L.) contain anthocyanins, flavonoids, and vitamin C, which have potential antioxidant and moisturizing properties. The physical quality and stability of lip balm are influenced by the wax base, particularly the ratio of candelilla wax to carnauba wax. This study aimed to determine the effect of varying the ratio of candelilla wax to carnauba wax on the physical quality, physical stability, and moisturizing effectiveness of roselle extract lip balm, as well as to determine the optimum formula. This laboratory experimental study used four formulas: F0 (blank), F1 (10%:6%), F2 (8%:8%), and F3 (6%:10%), with 8% roselle extract in F1–F3. Evaluations included organoleptic properties, homogeneity, pH, spreadability, adhesion, application properties, irritation, and hedonic testing, as well as a six-cycle cycling test and moisturizing effectiveness assessment in 30 panelists over seven days using a skin analyzer. Data were analyzed using the Shapiro–Wilk, paired samples t-test, Friedman, and Wilcoxon tests. All formulas met the physical quality requirements and caused no irritation. F3 showed the best pH stability, while F2 demonstrated the highest moisturizing effect and panelist acceptance. Formula F2 (8%:8%) was determined to be the optimum formula because it provided the best balance of physical quality, stability, moisturizing effectiveness, and panelist acceptance.
Evaluasi Stabilitas Fisik dan Karakteristik Kelembapan Kulit dari Claystick Ekstrak Etanol Limbah Kulit Bawang Merah (Allium Ascalonicum L) Kelvin Putra Kurniawan; Tiara Ajeng Listyani; Bangkit Riska Permata
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i6.2542

Abstract

Indonesia has a tropical climate with high levels of sun exposure, which can cause dry skin. This condition can be addressed with cosmetic products containing moisturizing ingredients, such as flavonoids and antioxidants derived from natural sources. Red onion (Allium ascalonicum L.) peel has potential as a moisturizer because it is rich in flavonoids and antioxidants. The extract was formulated into a clay stick—a practical product that helps remove dead skin cells and is easy to wash off. To assess the impact of red onion peel extract on a clay stick formulation, three extract concentrations—8% (F1), 12% (F2), and 16% (F3)—were formulated. The resulting products were then evaluated for their physical properties, formulation stability, and skin-moisturizing activity. Formulations were evaluated for pH, physical properties, moisture, hedonic profile, and irritation using a cycling test. Extract concentration affected pH, viscosity, and spreadability.. Differences in the concentration of the red onion skin ethanol extract also influenced the moisturizing activity on the skin. Formula III (16% extract) showed the highest moisturizing activity. Extract concentration affected viscosity stability after the cycling test, while all formulations met physical stability and skin moisture requirements.
Formulasi Sediaan Nanoemulsi Face mist Ekstrak Etanol Herba Bayam Merah (Amaranthus tricolor L) sebagai Pelembab Alami Fernandita Dylea Fasya; Tiara Ajeng Listyani; Danang Raharjo
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i6.2549

Abstract

Air pollution is a serious global public health concern that may negatively affect skin health. Red spinach herb (Amaranthus tricolor L.) contains flavonoids and tannins that have potential benefits in maintaining skin moisture. This study aimed to develop a nanoemulsion face mist containing red spinach herb extract and determine the best formulation based on physical quality and skin moisturizing activity. The extract was obtained through maceration using 96% ethanol and formulated into four nanoemulsion face mist preparations: F0 without extract, F1 with 1.5% extract, F2 with 2% extract, and F3 with 2.5% extract. Evaluation parameters included particle size, organoleptic properties, pH, homogeneity, viscosity, spreadability, drying time, irritation test, hedonic acceptability, and skin moisture measurement using a digital skin tester. Data were analyzed using Microsoft Excel and SPSS. Phytochemical screening confirmed the presence of flavonoids and tannins in the extract. All formulations demonstrated good physical quality. Formula F3 showed the highest skin moisture value at 45.5%, compared with F0 (38.6%), F1 (40.2%), and F2 (42.6%). Thus, red spinach herb extract can be formulated into a nanoemulsion face mist, with F3 identified as the optimal formulation.
Uji Efektivitas Nanoemulsi Ekstrak Daun Melinjo (Gnetum gnemon L.) Sebagai Tabir Surya dengan Metode Spektrofotometri UV-Vis Faizah Ariqoh Nariswari; Tatiana Siska Wardani; Tiara Ajeng Listyani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i6.2584

Abstract

Excessive ultraviolet (UV) exposure can cause skin damage, including melanoma. In 2020, the World Health Organization reported 1,609 melanoma cases in Indonesia with 699 deaths. Melinjo leaves (Gnetum gnemon L.) contain flavonoids, tannins, saponins, and phenolic compounds with antioxidant and photoprotective potential. This study aimed to evaluate the sunscreen activity of melinjo leaf extract, its formulation into nanoemulsions, and the highest Sun Protection Factor (SPF) achieved. Methods: Extracts were standardized and formulated into nanoemulsions with concentrations of 0.20% (F1), 0.25% (F2), and 0.30% (F3). Physical properties including particle size, transmittance, pH, viscosity, emulsion type, irritation, and hedonic characteristics were assessed. Sunscreen efficacy was tested in vitro using UV-Vis spectrophotometry (290–320 nm), and SPF values were calculated with the Mansur equation. Results: Extract concentrations of 100–300 ppm produced SPF values of 5.07–9.97. Nanoemulsions F0–F3 showed SPF values of 4.67–13.93, with all formulations meeting quality standards. Conclusion: Melinjo leaf extract demonstrated sunscreen activity and was successfully formulated into nanoemulsions. The highest protection was observed in F3, with an SPF of 13.93, categorized as maximum protection.
Uji Stabilitas dan Antioksidan Sediaan Bedak Tabur Ekstrak Etanol Daun Jati (Tectona grandis L.f.) dengan Metode DPPH Belin Isnani Fitriati; Tiara Ajeng Listyani; Tatiana Siska Wardani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 6 (2026): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ultraviolet radiation and exposure to environmental pollution can contribute to premature aging and skin cell damage. Teak leaves (Tectona grandis L.f.) are known to contain secondary metabolites, particularly flavonoids and phenolic compounds, which have the potential to exhibit antioxidant activity. This study aims to develop a loose powder formulation containing teak leaf ethanol extract and to evaluate its physical stability and antioxidant activity. The experimental study was conducted by formulating the extract at concentrations F0 (0%), F1 (15%), F2 (20%), and F3 (25%), followed by evaluations of physical quality, a cycling test, an irritation test, a hedonic test involving 30 panelists, and antioxidant testing using the DPPH method. The extract tested negative for ethanol and heavy metals but tested positive for alkaloids, flavonoids, tannins, and terpenoids. The extract’s antioxidant activity yielded an IC50 value of 69.02 ppm, which is classified as strong. All formulations met the requirements for physical quality, safety, and stability during the cycling test. The IC50 values for F0, F1, F2, and F3 were 253.75 ppm (weak), 107.90 ppm (moderate), 90.55 ppm (strong), and 75.64 ppm (strong), respectively, while the positive control (product X) was 69.80 ppm (strong). F3 (25%) was the formulation with the best antioxidant activity. The results of this study indicate that teak leaf ethanol extract has the potential to be used as an active ingredient in an antioxidant-active loose powder formulation.
Uji Stabilitas dan Aktivitas Antioksidan Sediaan Face Toner Ekstrak Etanol Daun Jambu Biji (Psidium Guajava L.) dengan Metode DPPH Delita Brytha Dos Santos; Tatiana Siska Wardani; Tiara Ajeng Listyani
Borneo Nursing Journal (BNJ) Vol. 8 No. 2b (2026)
Publisher : Akademi Keperawatan Yarsi Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61878/bnj.v8i2b.1960

Abstract

Kulit wajah terpapar radiasi ultraviolet dan polusi yang dapat meningkatkan pembentukan radikal bebas dan berkontribusi terhadap kerusakan kulit. Daun jambu biji (Psidium Guajava L.) mengandung metabolit sekunder, terutama flavonoid dan senyawa fenolik, yang berpotensi sebagai antioksidan. Penelitian ini bertujuan mengetahui aktivitas antioksidan ekstrak etanol daun jambu biji serta memperoleh sediaan Face Toner dengan mutu fisik dan stabilitas yang baik. Penelitian eksperimen dilakukan dengan ekstraksi maserasi menggunakan etanol 70% dan formulasi F0 (0%), F1 (10%), F2 (15%), dan F3 (20%). Evaluasi meliputi organoleptik, homogenitas, pH, viskositas, kejernihan, uji iritasi, uji hedonik, serta stabilitas Cycling Test enam siklus. Aktivitas antioksidan ditentukan dengan metode DPPH berdasarkan nilai IC₅₀. Ekstrak memiliki rendemen 11,67%, kadar air 8,53%, dan positif mengandung flavonoid, alkaloid, saponin, dan tanin. Nilai IC₅₀ ekstrak sebesar 73,68 ppm. Nilai IC₅₀ F0, F1, F2, dan F3 berturut−turut 84,53; 86,32; 75,70; dan 77,55 ppm. Seluruh formula homogen, tidak menimbulkan iritasi, dan menunjukkan stabilitas fisik selama enam siklus. F2 merupakan formula dengan aktivitas antioksidan terbaik karena memiliki nilai IC₅₀ terendah, yaitu 75,70 ppm.
FORMULASI SEDIAAN GEL EKSTRAK DAUN SUKUN (Artocarpus altilis) SEBAGAI TERAPI LUKA SAYAT PADA KELINCI NEW ZEALAND WHITE Danang Raharjo; Ika Dwi Ningrum; Tiara Ajeng Listyani
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 3 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i3.443

Abstract

Breadfruit leaf (Artocarpus altilis) is a type of plant that has a single to oval leaf from the Moraceae family. There are secondary metabolites in breadfruit leaves (Artocarpus altilis), namely flavonoids, tannins, and saponins which are efficacious as a treatment for the wound healing process. This study aims to determine whether breadfruit leaf extract (Artocarpus altilis) can be formulated into a gel preparation and to determine the maximum concentration of breadfruit leaf extract (Artocarpus altilis) in wound healing. This study was an experimental study to determine the maximum concentration in healing cuts with varying concentrations of 6.25%, 12.5%, and 25% tested on 5 male rabbits with 3 treatment groups. Wound healing data were analyzed using One Way ANOVA (Analysis of Varian) and the physical evaluation of the gel preparation was analyzed descriptively. The results showed that breadfruit leaf extract (Artocarpus altilis) could be formulated into gel preparations and fulfilled the physical evaluation test for gel preparations. Statistical test results had a significant effect on wound healing in rabbits p=0.001 (p<0.05) and the maximum concentration in wound healing was a concentration of 25% with a healing time of 11 days.        
ANALISIS DOCKING MOLEKULER BESERTA PREDIKSI ADME DERIVAT FLAVONOID SENYAWA KOMPOSISI KIMIA EKSTRAK BUNGA ROSELA (Hisbiscus Sabdariffa L.) SEBAGAI ANTIOBESITAS Tiara Ajeng Listyani; Dinar Azizah
Duta Pharma Journal Vol. 5 No. 2 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/pbz5mq71

Abstract

Latar Belakang: Pemanfaatan bunga rosela dapat mengobati salah satunya yaitu obesitas. Tujuan: Penelitian ini bertujuan untuk mengetahui senyawa berkhasiat antiobesitas yang terkandung dalam bunga rosela melalui ekstraknya dengan melihat nilai binding affinity dan interaksi asam amino dari komposisi ekstrak bunga rosela. Metode: Senyawa uji digambar lalu diubah ke 3D menggunakan software ChemOffice dan target uji yang telah dipreparasi menggunakan aplikasi Biovia Discovery Studio selanjutnya dipreparasi menggunakan aplikasi VegaZZ. Target yang telah dipreparasi ditambatkan dengan ligan native menggunakan software Pyrx-Phyton 0.8 Autodock Vina untuk melakukan validasi metode docking selanjutnya dilakukan analisis docking terhadap semua ligan uji dan dilihat interaksi asam amino melalui aplikasi Biovia Discovery Studio. Seluruh ligan uji dilakukan prediksi ADME menggunakan progam SwissADME . Hasil: docking 11 struktur senyawa ekstrak bunga rosela (Hibiscus sabdariffa L.) derivat flavonoid ditemukan dua senyawa yang berpotensi sebagai antiobesitas berdasarkan nilai binding affinity dan asam amino yang berkontribusi terhadap interkasi dengan ikatan hydrogen asam amino dimana interaksi tersebut mirip senyawa NAG yang merupakan ligan asli protein target yaitu Kaempferol-3-rutinosid dan Quercetin-3-rutinosid. Kesimpulan: Prediksi ADME semua struktur senyawa memenuhi persyaratan Lipinski’s rule of five sehingga dapat diprediksi memiliki peluang untuk menjadi obat oral.
Analysis of Stability and Skin Hydration Activity of Body Lo-tion Preparations of Guava Leaf Ethanol Extract (Psidium guajava L.) Alfina Putri Aisyah; Tiara Ajeng Listyani; Tatiana Siska Wardani
Green Health International Journal of Health Sciences Nursing and Nutrition Vol. 3 No. 4 (2026): October: Green Health: Journal of Health Sciences, Nursing and Nutrition
Publisher : International Forum of Researchers and Lecturers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70062/greenhealth.v3i4.347

Abstract

Based on a Taylor Nelson Sofres (TNS) survey of 1,800 women aged 20–39 years in five Asian countries, it is known that the average signs of aging in Asian women begin to appear around the age of 25. Dry skin is one of the indicators of premature aging triggered by increased transepidermal water loss (TEWL). Guava leaves (Psidium guajavaL.) contain flavonoids and phenolic compounds which have potential as natural moisturizing active ingredients. This study aims to formulate guava leaf ethanol extract into a body lotion, determine the best formula for skin hydration activity, and evaluate its stability. Laboratory experimental research. The extract was obtained by maceration using 70% ethanol and formulated at a concentration of 6% with three propylene glycol:glycerin ratios, namely F1 (8:10), F2 (8:8), and F3 (10:8), compared with the base (F0) and positive control (K+). Evalua-tions included physical quality, hedonic test, irritation test, accelerated stability test (6-cycle cycling test), and skin hydration test on 30 respondents using a digital skin analyzer. Hydration data were analyzed using the Friedman and Wilcoxon tests. All formulas met the requirements for pH, viscosity, spreadability, and oil-in-water emulsion type, and did not cause irritation. F1 provided the highest moisture increase (19.14%), which was not significantly different from K+ (20.75%; p = 0.304), while F2 (15.27%) and F3 (13.82%) were lower. F2 and F3 were less homo-geneous during testing. Guava leaf ethanol extract has the potential to be used as a natural moisturizing active ingredient in body lotion, with F1 as the optimal formula.
Co-Authors Achsantya, Raden Roro Karyna Cindy Addawiyyah, Muniroh Ade Surya Kusumawati Agung Eru Wibowo Aini, Riszki Nur Aisyah Rabitha Alisi Alfina Putri Aisyah Anis Kurnia Sukmawati Anita Dwi Septiarini Anna Fitriawati Anna Fitriawati Aprilia Rika Alvita Apriliawan, Hidayah Aqila Widya Sari Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Bagas Ardiyantoro Bagas Ardiyantoro Bangkit Riska Permata Belin Isnani Fitriati Danang Raharjo Delita Brytha Dos Santos Deniessa, Ardelea Desy Ayu Irma Permatasari Dinar Azizah Diza Aulia Ramadhani Dwi Bagus Pambudi Effendi Nursalim Ekarani, Meisyah Litang Endang Suciati Erick Ferdian Fadila, Vera Nurhidayatul Faizah Ariqoh Nariswari Fajar Aditya Pratama Fazlin Fauzi Ferlinda Ayu Astuti Fernandita Dylea Fasya Galuh Puspitasari Guterres, Agostinha Hafalika, Aviv Ifalahma, Darah Ika Dwi Ningrum Jihannaz Firdamaya Kelvin Putra Kurniawan KHABIB ALIA AKHMAD Kharisma, Putri Nur Khilda Hilyatul 'Ulya Krisnantari, Ni Luh Novelia Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Kusumaningtyas Siwi Artini Kusumasedya, Willyana Pratiwi Lathifah Nur Khasanah Lende, Yulianus Erman Masruroh, Sururul Kamalin Muniroh Addawiyyah Mutiara Marzalina Wardhani Nabillah Sirli Okta Maharani Niken Luthfiyanti ningsih, endang wahyu Nissa Syahraningtyas Putri Nugraha, Novanda Satria Nur Azmi, Tasya Nabila Oktaviana, Aptika Pang Jyh Chyang Pratama, Kharisma Jayak Puguh Ika Listyorini Puspitasari, Rara Ayu Rafidah Hanifah Rahmasari, Ikrima Rahmat Hidayat Rahmat Hidayat Ratna Safitri Rezky Ardika Pamungkas Rina Herowati Rohmana, Vivin Marwiyati Sari, Cantyka Eka Viemala Sejati, Siti Laila Utari Septian Maulid Wicahyo Septiarini, Anita Dwi Silvia Devi Silvia Mawardani Sindi Anita Pratiwi Siregar, sherina Sarifitri Suwardi, Nisa Aura Rizky Tanoyo, William Tatiana Siska Wardani Tatiana, Siska Wardani Ucik Susilowati Urip, Sri Khanti Veranita, Weri Wahdah Sri Rahayu Wahyu Budi Utomo Wardani, Tatiana Siska Wargani, Rizki Nugraha Yoga Pratama Yosua Christabel Natanael Yuliana, Ana Yuliana, Silvia Zanjabila, Chanida Zavitra, Mei Nanda