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All Journal Journal of Food and Pharmaceutical Science Jurnal Farmasi Klinik Indonesia Profesi Pendidikan Dasar INDONESIAN JOURNAL OF PHARMACY Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Edukasi : Jurnal Penelitian dan Artikel Pendidikan Jurnal Skala Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline UNTAG Law Review Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Proceedings Series on Social Sciences & Humanities Media Farmasi Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences Usadha Journal of Pharmacy Indonesian Journal of Pharmacology and Therapy EDUKASI : Jurnal Penelitian dan Artikel Pendidikan
Fita Rahmawati
Faculty of Pharmacy, Universitas Gajdah Mada. Yogyakarta, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Impact of platinum-based and non-platinum chemotherapy on quality of life in non-small cell lung cancer: A narrative review Yuditha Astarina, Davinda; Rahmawati, Fita; Murti Andayani, Tri
Indonesian Journal of Pharmacology and Therapy Vol 7 No 1 (2026)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.27318

Abstract

Chemotherapy remains one of the main therapeutic options for patients with advanced non-small cell lung cancer (NSCLC), a disease that continues to contribute significantly to global cancer-related mortality. The selection of platinum-based or non-platinum chemotherapy regimens has important clinical implications, as these approaches differ not only in antitumor efficacy but also in their impact on patients’ health-related quality of life (HRQoL). This narrative review aimed to synthesize recent evidence regarding the effects of platinum-based and non-platinum chemotherapy on HRQoL among patients with NSCLC. Relevant studies published between 2020 and 2025 were identified through systematic searches of major scientific databases, including PubMed, Scopus, and Web of Science. The findings were narratively synthesized across commonly reported HRQoL domains using validated assessment instruments, such as the Functional Assessment of Cancer Therapy–Lung (FACT-L), the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Lung Cancer Module (QLQ-LC13), as well as the EQ-5D-5L. Overall, platinum-based chemotherapy was associated with better disease control but also with greater toxicity-related deterioration in physical and emotional functioning. In contrast, non-platinum regimens demonstrated improved tolerability and more stable HRQoL outcomes. These differences have important implications for shared clinical decision-making, particularly in patients with advanced disease for whom symptom relief and quality of life often represent primary treatment goals. This review highlights the need to integrate HRQoL considerations alongside clinical efficacy when individualizing chemotherapy strategies for patients with advanced NSCLC.
Co-Authors Abdullah, Ramez Agung Endro Nugroho Almira, Deta Anggriani, A. Anna Wahyuni Widayanti Annafiatuzakiah Annafiatuzakiah Arief Nurrochmad Arini, Yovita Dwi Astri Herawati, Astri Astuti Astuti Mahardika Astuti, Surya Yuli Aulia Fitri, Aulia Azhar Syed Sulaiman, Syed Azni, Meicella Bathari, Anggraini Citra Ryshang Chairun Wiedyaningsih Dewi Wulandari Djoko Wahyono Dwiningrum, Arissa Ejaz, Sundas Ejaz Ellykusuma, Nany Yusuf Ellykusuma, Nany Yusuf Endang Lukitaningsih Endang Yuniarti Erna Prasetya Ningrum Fitri Wulandari Fortuna, Tista Ayu Gunarsih, Vidiya Haqoiroh Hidayah, Astika Nurul I Dewa Putu Pramantara I Gede Ketut Sajinadiyasa Ihsan, Mawardi Ika Puspita Sari Irnayanti, Irnayanti Ismayati, Dwi Jatiningsih, Setiyati Kartika Widayati Taroeno Hariadi Kurniawati, Fivy Lily Annisa, Lily Lukman Hakim Lupitaningrum, Dita Marina Mahmuda, Hartati Marlyn Dian Laksitorini Marlyn Dian Laksitorini, Marlyn Dian Maya Arfania Mayasari, Gita Medisusyanti, Amalia Suci Megawati, Sefi Mpila, Deby Afriani Mukrinin, Walit Uhkri Mulyani, Tuty Mustafidah, Nasikhatul Nanang Munif Yasin Neneng Ratnasari NSH, Maria Caecilia Nurcahya, Bekti Meilani Nurcahya, Bekti Meilani Nurlena Ikawati, Nurlena Oktasari, Sholikhah Rosvita PALUPI, Poppy Diah Parwatininghati, Ni Putu Pinasti Utami, Pinasti Presticasari, Hardiyani Probosuseno Probosuseno, Probosuseno Purwaningsih, Avianti Eka Dewi Aditya Puspitasari, Winda Dwi Putra, Aditya Maulana Perdana R.A. Oetari, R.A. Radiyanti, Radiyanti Rahayu, Asri Rahmawati, Reza Retno Murwanti Riana Mashar Rina Mutiara, Rina Robosuseno, Robosuseno Rukminingsih, Fef Salamah, Ardhanarishwari Umi Sammulia, Suci Fitriani Sapriati, Aisyah Nur Sari, Ernika Sari, Laras Ratna Sari, Ratih Pratiwi Septiani, Ana Maulida Siradjuddin, Ammar Siswanto, Soni Solihat, Citra Kurnia Syed Azhar Syed Sulaiman, Syed Azhar Syed Titik Nuryastuti Tri Murti Andayani Triananingsih, Novi Udhiyati, Aida Wahab, Izyan Abdul Willi Wahyu Timur Yoga, Bambang Hastha Yuditha Astarina, Davinda Yulia Maftuhah Hidayati