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All Journal Journal of Food and Pharmaceutical Science Jurnal Farmasi Klinik Indonesia Profesi Pendidikan Dasar INDONESIAN JOURNAL OF PHARMACY Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Edukasi : Jurnal Penelitian dan Artikel Pendidikan Jurnal Skala Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research JFIOnline UNTAG Law Review Jurnal Ilmiah Medicamento Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Proceedings Series on Social Sciences & Humanities Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Journal of Food and Pharmaceutical Sciences Usadha Journal of Pharmacy Indonesian Journal of Pharmacology and Therapy EDUKASI : Jurnal Penelitian dan Artikel Pendidikan
Fita Rahmawati
Faculty of Pharmacy, Universitas Gajdah Mada. Yogyakarta, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Digitalization of HYPOGLYRISK and Evaluation of Its Utility for Pharmacist-Led Hypoglycemia Risk Assessment in Type 2 Diabetes Mellitus Jaya, Made Krisna Adi; Ikawati, Zullies; Rahmawati, Fita; Yasin, Nanang Munif; Putra, I Gusti Ngurah Anom Cahyadi
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13619

Abstract

Background: We developed a tool for pharmacists to facilitate screening of medication-related hypoglycemia risk in patients with type 2 diabetes mellitus (T2DM), called HYPOGLYRISK. Although this instrument has been validated and proven reliable, the paper-based version was considered inefficient and prone to human error during routine screening.Objective: This study aimed to digitalize HYPOGLYRISK and evaluate its utility compared with the printed version.Methods: A mixed-method study design combining software development and a quasi-experimental trial was used. In the development stage, the application was created using Android Studio and validated through Black Box Testing and User Acceptance Testing (UAT). In the trial stage, 46 pharmacists participated and were divided into two groups using either the digital or paper-based HYPOGLYRISK to assess simulated ambulatory T2DM patients representing different hypoglycemia risk categories. The primary outcome was assessment time efficiency, while the secondary outcome was the potential for human error. Data were analyzed using the Mann-Whitney U test, chi-square test, and relative risk analysis.Results: The digital HYPOGLYRISK demonstrated significantly shorter assessment time compared with the conventional version (p<0.05) and reduced the probability of scoring errors by 3.3 times (p<0.05). The digital application also provided additional advantages, including efficiency, scalability, ease of use, rapid data access, and simplified data management.Conclusion: These findings suggest that digital HYPOGLYRISK can enhance pharmacist-led hypoglycemia risk assessment among ambulatory patients with T2DM.
Drug-Related Problems Leading to Hospitalization: A Literature Review Kharisma, Annisa Nur; Rahmawati, Fita; Siswanto, Soni
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.107839

Abstract

Background: Drug-related problems (DRPs) are described as problems associated with medications that can lead to treatment failure and may also cause hospital admissions. The novelty of this study is that it supplements previous research data with the latest data on DRPs leading to hospital stays, specifically articles published between 2021 and 2025. Objective: This study aims to identify the prevalence of hospitalization due to DRPs, the types of DRPs that lead to hospital admissions, the medications involved, and the risk factors for DRPs. Methods: A literature search was conducted across the PubMed, ScienceDirect, and Scopus databases, limiting publication years to 2021-2025. Results: In the 12 studies reviewed, the frequency of hospitalization due to DRP varied between 5,0% to 57,9%. Adverse drug reactions (ADRs), non-compliance, drug interactions, dosing errors, and incomplete therapy indication were the most common types of DRPs that lead to hospitalization. The drugs most commonly involved in DRPs were antidiabetic agents, cardiovascular agents, diuretics, and antineoplastic agents. Age, polypharmacy, and the number and severity of comorbidities were identified as primary risk factors for hospitalization caused by DRPs. Conclusion: The frequency of hospitalization due to DRP varied between 5,0% to 57,9%. Factors such as age, number of medications, and comorbidities influence the frequency of DRPs.
Safety Assessment of Proton-Pump Inhibitors: Study of Cardiovascular Adverse Events Using Global Pharmacovigilance Data Azzahra, Salma Nur Azizah; Rahmawati, Fita; Nugroho, Agung Endro
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.107840

Abstract

Proton-pump inhibitors (PPIs) have been associated with adverse cardiovascular events, underscoring the need for comprehensive safety evaluation, yet systematic consolidation of data on PPI-related adverse drug reactions (ADRs) leading to cardiovascular events remains lacking. This study aims to descriptively analyze cardiovascular events related to PPI use to summarize their safety profile. A quantitative descriptive analysis was performed on cardiovascular ADRs associated with PPIs using global pharmacovigilance data. The top 25 reported cardiovascular ADRs for each PPI were identified from VigiAccess launched by World Health Organization (WHO) global database. We selected the same 20 set potential ADRs using Venny 2.1.0 to enhance the comparability of data and we summarized by frequency and percentage. A total of 15,263 cardiovascular ADR cases were identified. Omeprazole showed the highest reports, mainly palpitations (1,675 cases; 28.5%), cardiac flutter (759 cases; 12.91%), tachycardia (549 cases; 9.34%), and myocardial infarction (498 cases; 8.47%). Pantoprazole reported palpitations (893 cases; 27.43%), tachycardia (332 cases; 10.20%), and cardiac flutter (326 cases; 10.01%), while lansoprazole (1,782 cases; 11.7%) reported palpitations (451 cases; 25.3%), tachycardia (166 cases; 9.3%), and cardiac flutter (153 cases; 8.6%). Esomeprazole was most associated with myocardial infarction (951 cases; 21.88%), palpitations (621 cases; 14.29%), and cardiac failure congestive (380 cases; 8.74%). PPIs are associated with cardiovascular ADRs such as palpitations and myocardial infarction, emphasizing the importance of careful risk assessment during therapy.
Co-Authors Abdullah, Ramez Agung Endro Nugroho Almira, Deta Anggriani, A. Anna Wahyuni Widayanti Annafiatuzakiah Annafiatuzakiah Arief Nurrochmad Arini, Yovita Dwi Astri Herawati, Astri Astuti Astuti Mahardika Astuti, Surya Yuli Aulia Fitri, Aulia Azhar Syed Sulaiman, Syed Azni, Meicella Azzahra, Salma Nur Azizah Bathari, Anggraini Citra Ryshang Chairun Wiedyaningsih Dewi Wulandari Djoko Wahyono Dwiningrum, Arissa Ejaz, Sundas Ejaz Ellykusuma, Nany Yusuf Ellykusuma, Nany Yusuf Endang Yuniarti Fitri Wulandari Gunarsih, Vidiya Haqoiroh Hidayah, Astika Nurul I Dewa Putu Pramantara I Gede Ketut Sajinadiyasa I Gusti Ngurah Anom Cahyadi Putra Ihsan, Mawardi Ika Puspita Sari Irnayanti, Irnayanti Ismayati, Dwi Jatiningsih, Setiyati Kartika Widayati Taroeno Hariadi Kharisma, Annisa Nur Kurniawati, Fivy Lily Annisa, Lily Lukman Hakim Lupitaningrum, Dita Marina Made Krisna Adi Jaya Mahmuda, Hartati Marlyn Dian Laksitorini, Marlyn Dian Maya Arfania Mayasari, Gita Medisusyanti, Amalia Suci Megawati, Sefi Mpila, Deby Afriani Mukrinin, Walit Uhkri Mulyani, Tuty Mustafidah, Nasikhatul Nanang Munif Yasin Neneng Ratnasari NSH, Maria Caecilia Nurcahya, Bekti Meilani Nurcahya, Bekti Meilani Nurlena Ikawati, Nurlena Oktasari, Sholikhah Rosvita PALUPI, Poppy Diah Parwatininghati, Ni Putu Pinasti Utami, Pinasti Presticasari, Hardiyani Probosuseno Probosuseno, Probosuseno Purwaningsih, Avianti Eka Dewi Aditya Puspitasari, Winda Dwi Putra, Aditya Maulana Perdana R.A. Oetari, R.A. Radiyanti, Radiyanti Rahayu, Asri Rahmawati, Reza Retno Murwanti Riana Mashar Rina Mutiara, Rina Robosuseno, Robosuseno Rukminingsih, Fef Salamah, Ardhanarishwari Umi Sammulia, Suci Fitriani Sapriati, Aisyah Nur Sari, Ernika Sari, Laras Ratna Sari, Ratih Pratiwi Septiani, Ana Maulida Siradjuddin, Ammar Siswanto, Soni Solihat, Citra Kurnia Syed Azhar Syed Sulaiman, Syed Azhar Syed Tista Ayu Fortuna Titik Nuryastuti Tri Murti Andayani Triananingsih, Novi Udhiyati, Aida Wahab, Izyan Abdul Willi Wahyu Timur Yoga, Bambang Hastha Yuditha Astarina, Davinda Yulia Maftuhah Hidayati