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All Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Medika Cendikia (e-Journal) Jurnal Informasi dan Teknologi Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Sains dan Teknologi Laboratorium Medik International Journal of Engineering, Science and Information Technology Jurnal Kolaboratif Sains Journal Of Human And Education (JAHE) Jurnal Pengabdian Masyarakat DEDIKASI Journal of Community Dedication Innovative: Journal Of Social Science Research Jurnal Kemitraan Responsif untuk Aksi Inovatif dan Pengabdian Masyarakat Journal of World Future Medicine, Health and Nursing Jurnal Medika Farmaka Journal of Pharmacopoeia Research of Scientia Naturalis Journal of Pharmacopoeia Jurnal Sipakatau
Dadang Muhammad Hasyim
STIKes Karsa Husada Garut
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Inorganic Nanoparticles for Drug Delivery Systems: Design and Challenges Hasyim, Dadang Muhammad; Fujita, Miku; Vandika, Arnes Yuli
Research of Scientia Naturalis Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v1i4.1578

Abstract

Inorganic nanoparticles have gained attention in drug delivery systems due to their unique properties, including high surface area, biocompatibility, and the ability to encapsulate therapeutic agents. These characteristics make them promising candidates for enhancing drug efficacy and targeting. This research aims to explore the design parameters and challenges associated with inorganic nanoparticles in drug delivery applications. The focus is on understanding how modifications in nanoparticle design can optimize performance and address existing limitations. A comprehensive literature review was conducted alongside experimental assessments of various inorganic nanoparticle formulations. Key parameters such as size, surface charge, and drug loading capacity were evaluated to assess their impact on drug delivery efficiency. In vitro studies were performed to analyze drug release profiles and cellular uptake.The findings indicate that specific design modifications significantly influence drug delivery performance. For example, smaller nanoparticles with positive surface charges exhibited enhanced cellular uptake and higher drug loading capacities. However, challenges such as stability, scalability, and regulatory hurdles remain prevalent in the field. Inorganic nanoparticles hold great potential for advancing drug delivery systems, but addressing associated design challenges is crucial. Continued research in this area will facilitate the development of more effective and safer drug delivery solutions, ultimately improving therapeutic outcomes for patients.  
The Role of Applied Statistics in Drug Development and Clinical Trials Rahmah, Sitti; Fawait, Aldi Bastiatul; Hasyim, Dadang Muhammad
Research of Scientia Naturalis Vol. 1 No. 6 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v1i6.1584

Abstract

Background: The integration of applied statistics in drug development and clinical trials is essential for ensuring the efficacy and safety of new pharmaceuticals. Statistical methods play a critical role in designing studies, analyzing data, and interpreting results, thereby influencing regulatory decisions and clinical practices. Objective: This study aims to examine the role of applied statistics in the drug development process, particularly within clinical trials. The focus is on identifying key statistical techniques and their impact on trial outcomes and decision-making. Methodology: A comprehensive review of literature was conducted, analyzing various statistical methods employed in clinical trials, including sample size determination, randomization techniques, and data analysis methods. Case studies were included to illustrate the application of these methods in real-world scenarios. Results: Findings indicate that robust statistical methodologies significantly improve the reliability of clinical trial results. Proper sample size calculations ensure adequate power to detect treatment effects, while randomization techniques minimize bias. Additionally, advanced data analysis methods enhance the interpretation of trial outcomes, leading to more informed regulatory approvals. Conclusion: This research highlights the indispensable role of applied statistics in drug development and clinical trials. Emphasizing the importance of sound statistical practices not only improves trial integrity but also contributes to the overall success of new drug therapies. Continued advancements in statistical methods will further enhance the efficiency and effectiveness of clinical research.
The Immunomodulatory Potential of Hesperidin from Garut Orange Peel (Citrus nobilis var. chrysocarpha) Against Human Metapneumovirus (HMPV) Infection: Based on In Vivo Mouse Model Study sugiah, sugiah; Dadang Muhammad Hasyim, Dadang Muhammad Hasyim; Marsha Yulianti, Marsha Yulianti; Akbar Nurjamil, Akbar Nurjamil; N. Ai Erlinawati, N. Ai Erlinawati
Jurnal Medika Cendikia Vol 12 No 02 (2025): Jurnal Medika Cendikia
Publisher : Karsa Husada Health Institute Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmc.v12i02.371

Abstract

Acute respiratory infections (ARIs), including those caused by Human Metapneumovirus (HMPV), remain a global health concern, and no specific therapy or vaccine is currently available. Hesperidin, the main flavonoid in Garut orange peel (Citrus nobilis var. chrysocarpha), is known for its anti-inflammatory, antiviral, and immunomodulatory activities. This study was an in vivo pilot study using 35 male Balb/c mice divided into seven groups: normal control, negative control (5% imiquimod), positive control (levamisole), and hesperidin-treated groups at 50, 100, and 150 mg/kg body weight, either alone or in combination with imiquimod. Observed parameters included total leukocytes, lymphocytes, neutrophil-to-lymphocyte ratio (NLR), body weight, organ weight, and lung histology. Hesperidin was extracted using 70% ethanol and identified by thin-layer chromatography (TLC).Results showed that body weight data were normally distributed, with no significant differences between groups (p > 0.05), indicating that hesperidin was safe at the tested doses. Hematological analysis revealed significant differences in leukocyte counts (p = 0.001), lymphocytes (p = 0.002), and NLR (p = 0.001). Imiquimod induced systemic inflammation, as evidenced by increased leukocytes, lymphocytes, NLR, and lung inflammation scores. Hesperidin exhibited dose-dependent immunomodulatory effects; the 100 mg/kgBW dose combined with imiquimod produced the most optimal results, characterized by low NLR and a histology score of 0, reflecting controlled inflammation and effective adaptive immune activation. In contrast, the 150 mg/kgBW dose triggered excessive inflammatory responses.
Pharmaceutical involvement in Infectious Disease control: Strategies, Challenge and Solutions Norma Winata; Dadang Muhammad Hasyim; Brevmana Anugrah Primulyanto
Journal of Pharmacopoeia Vol. 1 No. 2 (2024): SEPTEMBER-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/rtag4g06

Abstract

This study aims to explore the role of the pharmaceutical sector in controlling infectious diseases, focusing on strategies, challenges, and solutions that can be implemented. The research method used is Systematic Literature Review (SLR) to collect and analyze data from related literature. Inclusion criteria include articles published in the last ten years, using English or Indonesian, and discussing pharmaceutical strategies in controlling infectious diseases. The literature search process was carried out through scientific databases such as PubMed, Scopus, and Google Scholar. The results of this study are Infectious disease control strategies involve the development of new vaccines and drugs, efficient drug distribution, and public education. The pharmaceutical sector plays an important role in creating medical solutions and implementing vaccination campaigns. The main challenge is antimicrobial resistance, which is caused by the unwise use of antibiotics. To overcome this challenge, public education, strict supervision in health facilities, and the development of new drugs are needed. The application of digital technology, such as AI-based applications, can also help monitor drug use and provide early warnings about the spread of disease. The role of pharmacists is vital in providing information and education about disease prevention, correct drug use, and the importance of vaccination. With innovative solutions such as the development of emergency pharmaceutical packages, the implementation of e-prescription, and technology-based training for pharmacists, it is hoped that the global health system can be more resilient in dealing with infectious disease outbreaks. Collaboration between the pharmaceutical sector, governments, and international organizations is essential in strengthening infectious disease control efforts and improving the readiness of the global health system.
Evidence-Based Pharmacy: Integration of Data and Research in the Development of more Effective and Safer Drugs Dadang Muhammad Hasyim; Liza Rastiti
Journal of Pharmacopoeia Vol. 1 No. 2 (2024): SEPTEMBER-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/29d66p06

Abstract

The main objective of this study was to collect, evaluate, and synthesize findings from relevant studies on the use of evidence-based data in drug development. The method used was a Qualitative Systematic Literature Review (SLR), which focused on understanding in-depth how the integration of data from clinical trials, big data, and laboratory studies can improve drug efficacy and safety. Through this approach, the study identified experiences, perceptions, and findings in the literature on drug development, and how this evidence supports decisions in drug selection and testing. The results showed that evidence-based pharmacy has great potential to improve the efficacy and safety of therapies by leveraging the integration of data from various sources and advanced analytical technologies. This approach can address key challenges in modern pharmacy, such as drug resistance and patient response variability, and result in more personalized and effective therapies. However, the implementation of evidence-based pharmacy requires support from various stakeholders, including academia, industry, and policy makers. Challenges such as data interoperability and privacy protection need to be addressed to ensure wider adoption. With a strategic and collaborative approach, evidence-based pharmacy can be the foundation for better precision medicine in the future, providing significant benefits to patients worldwide.
Organic Farming Innovation: Building Public Awareness of the Health and Environmental Benefits of Organic Farming Dadang Muhammad Hasyim; Patriandi Nuswantoro; Syamsu Rijal; Syamsul Anwar; Azhariah Rachman
Jurnal Sipakatau: Inovasi Pengabdian Masyarakat Vol. 2 No. 2 (2025): Jurnal Sipakatau
Publisher : PT. Global Research Collaboration

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Abstract

Farmers in Kelompok Tani Sukawargi 2, Sukawargi Village, Cisurupan District, Garut Regency face challenges related to their dependence on conventional farming that uses chemicals, which impact health and environmental sustainability. A community service program was then implemented to enhance the knowledge, skills, and awareness of the community regarding the benefits of organic farming. The training provided covered the basic principles of organic farming, organic fertilizer production, natural soil management, and pest control using natural ingredients. The training also educated farmers on the importance of transitioning from chemical-based farming to organic farming for the sake of health and environmental sustainability. The results of the community service showed a significant improvement in farmers' understanding of organic farming and organic product marketing. Farmers showed a high interest in applying the techniques learned and implementing broader product marketing strategies. Awareness of the impact of chemicals on health and the environment also increased. Furthermore, training on organic product marketing opened up better economic opportunities for farmers.
Socialization of Healthcare Service Innovation: Developing a Pharmacy Information System to Improve Access and Service Quality Dadang Muhammad Hasyim; Arief Budi Pratomo; Abdul Rosid; Novycha Auliafendri; Ramson Rikson Maruwahal Sijabat
Jurnal Sipakatau: Inovasi Pengabdian Masyarakat Vol. 2 No. 2 (2025): Jurnal Sipakatau
Publisher : PT. Global Research Collaboration

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Abstract

Effective pharmacy management is essential in ensuring drug availability in health facilities. This study aims to analyze the pharmaceutical management system in Garut Regency, focusing on aspects of recording, infrastructure, readiness of health workers, and local government policies. The research method used was a qualitative approach with interview and observation techniques in several health facilities. The results showed that many health facilities still use a manual recording system, which risks causing errors and delays in drug procurement. In addition, limited infrastructure and the readiness of health workers in adopting pharmaceutical information systems are the main obstacles in digitizing pharmaceutical management. In terms of policy, the absence of strong regulations and limited budget hamper the optimal implementation of digital systems. Therefore, it is necessary to improve infrastructure, train health workers, and support clearer policies to encourage the digitalization of the pharmaceutical system in Garut Regency.
Education and Counseling on Adolescent Reproductive Health in High School Dadang Muhammad Hasyim; Elvina Triana Putri; Desty Endrawati Subroto; Sulaeman Sulaeman; Habibi Habibi
Jurnal Sipakatau: Inovasi Pengabdian Masyarakat Vol. 1 No. 6 (2024): Jurnal Sipakatau
Publisher : PT. Global Research Collaboration

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Abstract

Reproductive health is an important aspect that adolescents need to understand to maintain their physical and mental well-being. This community service program aims to provide education and counseling about reproductive health to students of IT As-Syakur High School, targeting students aged 16-18 years. The methods used include face-to-face counseling, interactive discussions, simulations, and utilizing digital platforms for self-study. The material presented covers reproductive anatomy, the risks of sexually transmitted diseases (STDs), early pregnancy, contraception, and psychosocial aspects related to relationships and decision-making. The implementation results showed a significant increase in students' understanding after the counseling, with an average improvement from 60% to 85% in the post-test. A total of 90% of students understood reproductive anatomy, while 85% understood the risks of STDs, and 80% mastered the material on contraception. The use of digital media by 65% of students for self-study also demonstrated the program's effectiveness. This program successfully addressed the stigma among students regarding reproductive health and encouraged their active involvement in learning. This success provides a strong foundation for implementing similar programs in the future with a broader scope, involving parents and teachers, and supporting the sustainability of the program through a technology-based approach.
Healthy Kids Program Improving Children's Nutritional Awareness Through Interactive Learning Desty Endrawati Subroto; Dadang Muhammad Hasyim; Abiyasa Eka Saputra
Jurnal Sipakatau: Inovasi Pengabdian Masyarakat Vol. 2 No. 5 (2025): Jurnal Sipakatau
Publisher : PT. Global Research Collaboration

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Abstract

Malnutrition and low nutrition literacy among school-aged children remain significant public health challenges in Indonesia, including in Rangkasbitung, Banten. This community service initiative, the Healthy Kids Program: Improving Children's Nutritional Awareness Through Interactive Learning, aimed to enhance children's understanding of balanced nutrition and foster healthy eating behaviors through engaging, interactive methods. The program employed educational games, simulations, and discussions to encourage active participation, complemented by the involvement of parents and teachers to reinforce learning outcomes at home and in the school environment. A pre-test and post-test were conducted to measure changes in children's knowledge, with results indicating a substantial increase in understanding of balanced nutrition and healthy food choices, rising from an average of 47% to 83%. Additionally, the program provided educational materials to schools, supporting the sustainability of nutrition education initiatives in the community. The findings align with evidence highlighting the effectiveness of interactive and community-based approaches in improving nutrition literacy and promoting healthy dietary practices among children. By building local capacity and aligning with public health goals, the Healthy Kids Program demonstrates its potential as a scalable and replicable model for addressing malnutrition challenges in similar contexts. This initiative underscores the importance of integrating interactive learning with family and community engagement to support the development of healthy lifestyles among school-aged children, contributing to broader efforts to achieve Sustainable Development Goals related to child health and education.
Co-Authors Abdul Rosid Abdul Rosid Abiyasa Eka Saputra Ahmad Izuddin Akbar Nurjamil, Akbar Nurjamil Aldi Bastiatul Fawait Fawait Andy Rachman ansori ansori Ardi, Abdullah Arief Budi Pratomo Arief Budi Pratomo Arnes Yuli Vandika Asmaret, Desi Astuti, Aldiana Azhariah Rachman Baiq Ayu Aprilia Mustariani Bansaleng, Yessikah Feiby Brevmana Anugrah Primulyanto Cecep Hilman Dani Sujana Dede Suharta Desty Endrawati Subroto Desty Endrawati Subroto Devi Rahmah Sope Dhaniswara, Erwin Diah Wardani Dina Nirwana Suwinda, Dina Nirwana Suwinda Dito Anurogo, Dito Eka Selvi Handayani Eka Selvi Handayani, Eka Selvi Elang Mohamad Atoilah Elvina Triana Putri Elvina Triana Putri Eny Retna Ambarwati Erlinawati, Noor Diah Euis Kusumarini Firman Muharam Fitriah Handayani Fujita, Miku Gina Nafsa Mutmainna, Gina Nafsa Mutmainna Habibi Habibi Habibi Hafid, Hendra Hamzah Puadi Ilyas, Hamzah Puadi Hendra Nusa Putra Hesti Renggana Hiola, Siti Fatmah Irma Muti Irmanida Batubara Iwan Aprianto Izuddin, Ahmad Judijanto, Loso Kusumarini, Euis La Ode Maksar Muhuruna Legito Liza Rastiti Marsha Yulianti, Marsha Yulianti Melinda Arismawati Mena Sari Mina Pertiwi Moh. Imron Rosidi Muntasir, Muntasir Muslimin Muslimin N. Ai Erlinawati, N. Ai Erlinawati Najamuddin Petta Solong Natalia Lisma Br Sembiring Nazaruddin Ahmad Norma Winata Novelti, Novelti Novycha Auliafendri Novycha Auliafendri Nuralfin Anripa Nurul Oktafian Farhan Ramdani, Hasbi Taobah Ramson Rikson Maruwahal Sijabat Ramson Rikson Maruwahal Sijabat Rian Novita Ridayani, Ridayani Riniati, Wa Ode Rukhmana, Trisna S. Sumihatul Ummah MS, S. Sumihatul Ummah Salma Nurin Fadilah Santi Yuliasari Saputra, Abiyasa Eka Siti Aisyah Hanim, Siti Aisyah Sitti Rahmah Solehuddin, Moh. STIKES Karsa Husada Garut Subroto, Desty Endrawati Sugiah, Sugiah Sulaeman Sulaeman Sulaeman Sulaeman Sulaminingsih, Sulaminingsih Sumerli A, Chevi Herli Supriatnini, Ai Susatyo Adhi Pramono, Susatyo Adhi Sutrisno Sutrisno Sutrisno Sutrisno Syamsu Rijal Syamsul Anwar Syamsul Anwar Syamsul Anwar, Syamsul Tarru, Harni Eirene Tarru, Reni Oktaviani Wiwid Suryono Yogi Rahman Nugraha Zahara Farhan Zakka, Umar Zani, Benny Novico