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All Journal Bionatura Sosiohumaniora Majalah Kedokteran Bandung Dentika Dental Journal Journal of Dentistry Indonesia Journal of Mathematical and Fundamental Sciences MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Padjadjaran Journal of Dental Researchers and Students Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Odonto dental journal
Irna Sufiawati
Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran Bandung, Jawa Barat
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Energy Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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THE ROLE OF MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS AND STAGING OF ORAL SQUAMOUS CELL CARCINOMA: CASE REPORTS Rahmi Harmiyati; Irna Sufiawati; Harry Galuh Nugraha
ODONTO : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.0.24-32

Abstract

LINEAR MEASUREMENT OF THE CONDYLE POSITION IN HIV-INFECTED CHILDREN AND ADOLESCENTS Lusi Epsilawati; Ria N.Firman; Irna Sufiawati; Norlaila Sarifah; Indra Gunawan
Dentino : Jurnal Kedokteran Gigi Vol 5, No 1 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i1.8128

Abstract

Background: The incidence of HIV had recently increased rapidly. People infected with HIV were required to take anti-viral drugs. The severity of HIV also contributes to a decrease in bone mineral density due to taking antiviral drugs. Decreased bone density in people with HIV was a chronic disease due to the long-term use of drugs. TMD in people with HIV was often associated with several factors including emotional states such as depression. Patient infected HIV was vulnerable to TMD because it triggers physical and psychological changes. TMD and decreased bone density are common in people with HIV. Researchers hope that later there will be the latest findings that can make patients infected with HIV felt safe to take drugs without worrying about the decline in bone quality. Objective: This study aimed to investigate the value of linear measurement of the condyle position in HIV- infected children and adolescents based on panoramic radiographs in Dental Hospital Padjadjaran University. Methods: This descriptive and cross-sectional method was conducted on panoramic radiographs of HIV-infected children and adolescents since was born. Condyle position was defined by linear measurement using a protractor that divides the condyle 45° of anterior, 90° of superior, and 135° of posterior joint space from a horizontal line. The distance was then measured using a digital caliper. Results: According to linear measurements of the condyle position, all samples had abnormal linear distances in children and adolescents in all gender. The standard range of anterior joint space (Ajs) was 1.3 mm, superior joint space (Sjs) was 2.1 mm, and the posterior joint space (Pjs) was 1.8 mm. The result of this research, the right women condyle sample, the standard distance of the AJS was 0%, SJS was 16%, Pjs was 18%. While the left condyle, the usual range of the AJS was 4%, SJS was 12%, Pjs was 24%. The right men condyle sample, the standard distance of the Ajs was 0%, Sjs was 17.65%, Pjs was 11.76%. While the left condyle, the usual range of the Ajs was 0%, Sjs was 11.76%, Pjs was 5.88%. Conclusions: The abnormal distance measured was found in the condyle position of children and adolescents infected with HIV.
MANDIBULAR BONE QUALITY OF PANORAMIC RADIOGRAPHS IN HIV-INFECTED CHILDREN Ria Noerianingsih Firman; Irna Sufiawati; Risti Saptarini Primarti; Aga Satria Nurrachman; Merry Annisa Damayanti
Dentino : Jurnal Kedokteran Gigi Vol 5, No 1 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i1.8129

Abstract

Background: People living with HIV may have several pathologic conditions in its body and bone is one of the organs affected by HIV infection. HIV-infected patients have been associated frequently with osteoporosis and lower bone mineral density (BMD) which may lead to the increasing risk of bone fracture. This situation may become more complicated in children and young age as it will affect the long-term bone quality and development later in life until the peak BMD is reached. Objectives: The aim of this study was to measure the mandibular bone quality using the mandibular cortical index (MCI) and panoramic mandibular index (PMI) in panoramic radiographs of HIV-infected children. Method: This study used descriptive cross sectional research design which analyzed panoramic radiographs of HIV-infected children and measured its mandibular bone quality. Total 43 panoramic radiographs of HIV-infected children were observed and analyzed qualitatively using mandibular cortical index (MCI) and panoramic mandibular index (PMI) were used for the quantitave measurement, as it have been widely used for assesing mandibular bone quality in previous studies. Mandibular cortical index (MCI) has 3 categories of cortical bone quality: C1 (normal cortex), C2 (mildly to moderately eroded cortex), and C3 (severely eroded cortex), while the normal ratio of mental foramen-inferior border of mandible to mandibular cortical length in panoramic mandibuIar index is about 0.3. Result: Mandibular cortical index (MCI) of 43 HIV-infected children consist of 4 samples in C1, 38 in  C2, 1 in C3, while the panoramic mandibular index (PMI) of 43 HIV-infected children consist of 23 less than normal, 5 normal, 15 more than normal. Conclusions: The most number of mandibular cortical index (MCI) was C2 (mildly to moderately eroded cortex) and the most number of panoramic mandibular index (PMI) was less than normal of HIV-infected children.
ORAL SECONDARY INFECTION IN STEVENS-JOHNSON SYNDROME PATIENT WITH ORAL INVOLVEMENT: A CASE REPORT Etis Duhita Rahayuningtyas; Indah Suasani Wahyuni; Irna Sufiawati
Dentino : Jurnal Kedokteran Gigi Vol 6, No 1 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i1.10645

Abstract

ABSTRACTBackground: Stevens-Johnson syndrome (SSJ) is a hypersensitivity reaction that is often triggered by drugs but this case is rare. These reactions result in uncontrolled keratinocyte damage to the skin and mucosa throughout the body, including the oral mucosa, and are often life-threatening. The use of high doses of corticosteroids is a treatment that is often given but it can trigger secondary infections of fungal and viral in the oral cavity. Purpose: This case report discusses the management of oral manifestations and secondary infections in SSJ patients, and becomes guidance for health professionals. Case: A-42-years-old male patient was consulted from the Department of Dermatology and Venereology (DV) due to oral pain and eating difficulties. The severity-of-illness-score for toxic-epidermal-necrolysis (SCORTEN) was 1. Erosive serosanguinous crusts, tend to bleed were found on the lips. Intraoral clinically presented wide erosive lesions and multiple ulcers, accompanied by a pseudomembranous plaque, and teeth decay. Hematologic examination showed an increase in leukocytes, neutrophil segments, monocytes, SGOT, urea, and creatinine as well as decreased hemoglobin, hematocrit, erythrocytes, MCHC, protein, and albumin. Anti-HSV1 IgG increased almost 6 times than normal values. The patient was diagnosed with SJS with oral involvement, secondary infections of pseudomembranous candidiasis, and herpetic stomatitis. Case Management: Systemic therapy given were intravenous dexamethasone, ranitidine, calcium, and cetirizine, from the DV Department, while hydrocortisone lip ointment, Chlorhexidine digluconate 0.12%, and Nystatin oral suspension for oral problems. The lesions progressed in 24 days. Conclusion: Oral secondary infections may occur in SJS patients due to high-dose corticosteroid therapy.Keywords: Herpetic Stomatitis, Oral Manifestation, Oral Secondary Infection, Pseudomembranous Candidiasis, Stevens-Johnson Syndrome.
Oral Manifestations of Systemic Lupus Erythematous and Its Comprehensive Management: Two Case Reports Rita Wardhani; Irna Sufiawati
Majalah Kedokteran Bandung Vol 50, No 1 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.551 KB) | DOI: 10.15395/mkb.v50n1.1234

Abstract

Systemic lupus erythematous (SLE) is an autoimmune collagen-vascular disease involving mucocutaneous and musculoskeletal systems as well as blood vessels that is characterized by diverse clinical manifestations, making it necessary to use a comprehensive multidisciplinary approach. Oral manifestations of SLE include oral ulcer, discoid lesions, oral lichen planus-like-lesion, oral candidiasis, and xerostomia. This study reports two cases of 19-year-old and 41-year-old female patients visiting the Oral Medicine Department Dr. Hasan Sadikin General Hospital in October 2016. These patients were referred by the Internal Medicine Department with SLE diagnosis, involving hematological, musculoskeletal and mucocutaneous systems. Extraoral examination revealed moon face in the first patient and malar rash and lips exfoliations in the second  patient. Intraoral examination revealed oral ulcers on buccal and labial mucosa as well palate in both patients. Both patients were given methyl prednisolone, calcium, and folic acid by the Internal Medicine Department. Oral ulcers were treated with prednisone mouthwash, nystatin oral suspension, and vitamin B12. The oral ulcer on palate was considered very difficult to resolve so that topical corticosteroid was required. Prednisone mouthwash was chosen as drug of choice due to its efficacy on oral mucosa and its ability to minimize the systemic adverse effects which were resolved in 6 week after starting treatment. Comprehensive multidisciplinary approach associated with oral manifestation of SLE has significant effects in decreasing disease severity and improving the quality of life in patients with SLE.Key words: Oral ulcers, prednisone mouthwash, systemic lupus erythematosus Manifestasi Oral Lupus Eritematosus Sistemik dan Manajemen Komprehensifnya: Dua Laporan KasusSistemik lupus eritematosus (SLE) adalah penyakit kolagen-vaskular autoimun, yang melibatkan sistem mukokutan, muskuloskeletal, dan pembuluh darah yang ditandai dengan manifestasi klinis yang bervariasi, sehingga diperlukan pendekatan multidisiplin yang komprehensif. Manifestasi oral SLE meliputi ulkus mulut lesi diskoid, lichen planus-like lesion, kandidiasis oral, dan serostomia. Pasien wanita berusia 19 tahun dan 41 tahun yang dirujuk dari departemen Penyakit Dalam pada Oktober 2016 dengan diagnosis SLE yang melibatkan hematologis, muskuloskeletal, dan mukokutan. Pemeriksaan ekstraoral menunjukkan moon face pada pasien pertama, dan malar rash serta pengelupasan bibir pada pasien kedua. Pemeriksaan intra oral mengungkapkan ulkus oral, mukosa labial, dan palatum pada kedua pasien. Kedua pasien diberikan metil prednisolone, kalsium, dan asam folat dari departemen Penyakit Dalam. Ulkus oral diobati dengan obat kumur prednison, suspensi oral Nistatin, dan vitamin B12 yang diberikan dalam 6 minggu pengobatan. Ulkus oral adalah salah satu manifestasi oral yang umum pada pasien SLE. Ulkus oral pada palatum dianggap sangat sulit diatasi sehingga dibutuhkan kortikosteroid topikal. Prednisone mouth wash dipilih sebagai obat pilihan sebagai anti-inflamasi pada mukosa oral dan meminimalkan efek samping sistemik. Pendekatan multidisiplin komprehensif yang terkait dengan manifestasi oral SLE memiliki efek signifikan dalam menurunkan tingkat keparahan penyakit dan meningkatkan kualitas hidup pada pasien SLE.Kata kunci: Lupus eritematosus sistemik, ulser oral, obat kumur prednison
Seroprevalence of Herpes Simplex virus types 1 and 2 and their association with CD4 count among HIV-positive patients Irna Sufiawati; Sunardhi Widyaputra; Tony S. Djajakusumah
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 2 (2012): June 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.67 KB) | DOI: 10.20473/j.djmkg.v45.i2.p114-120

Abstract

Background: Herpes simplex virus (HSV) is a common cause of viral opportunistic infections among HIV-positive patients. Frequent, more severe and prolonged episodes of recurrent HSV infection can be a source of significant morbidity and mortality among HIV-positive patients with advanced immunosuppression, reflected by low CD4 count. However, conflicting results have also been reported. Purpose: The aim of this study was to investigate the seroprevalence of HSV type 1 (HSV-1) and type 2 (HSV-2) in HIV-positive patients compare with the rate in HIV-negative patients, and to evaluate their association with CD4 count. Methods: A cross sectional study was conducted among 145 subjects consisting of 80 HIV-positive and 65 HIV-negative patients attending the top referral hospital in Bandung, West Java, Indonesia. The serum obtained was assayed for the presence of HSV-1 and HSV-2 IgG antibodies using ELISA kits. Data were analyzed using a Chi-square test, t-tests and analysis of variance (ANOVA). Results: There were no significant differences in HSV-1 seroprevalence between HIV-positive patients (71%) and HIV-negative patients (66%). HSV-2 seroprevalence was significantly higher in HIV-positive patients (30%) than HIV-negative patients (5%). The titers of HSV-1 IgG antibodies in HIV-positive patients (mean 24.63 ± 19.06 IDU) were significantly lower than those of HIV-negative patients (mean 44.62 ± 33.22 IDU). In contrast, HSV-2 IgG antibody titers in HIV-positive patients (mean 13.31 ± 20.28 IDU) were significantly higher than HIV-negative patients (mean 4.42 ± 10.99 IDU). There was no significant correlation between HSV-1 and HSV-2 seropositivity and CD4 count among HIV-positive patients. However, most of HSV-2 seropositive patients had CD4 count < 200 cells/mm3. Conclusion: Seroprevalence of HSV-1 and HSV-2 among HIV-positive patients was high with no correlation with CD4 count.Latar belakang: Herpes simplex virus (HSV) adalah penyebab infeksi virus oportunistik yang paling umum pada pasien HIVpositif. Infeksi HSV rekuren yang sering terjadi, lebih berat, dan episode yang berkepanjangan dapat menjadi penyebab morbiditas dan mortalitas yang signifikan pada pasien HIV-positif dengan imunosupresi lanjut, ditandai dengan jumlah CD4 yang rendah. Namun, hasil yang bertentangan juga telah dilaporkan. Tujuan: Penelitian ini bertujuan untuk mengetahui seroprevalensi HSV tipe 1 (HSV-1) dan tipe 2 (HSV-2) pada pasien HIV-positif dibandingkan dengan pasien HIV-negatif, dan untuk mengevaluasi hubungannya dengan jumlah CD4. Metode: Penelitian potong lintang ini dilakukan pada 145 subjek yang terdiri dari 80 pasien HIV-positif dan 65 pasien HIV-negatif yang berkunjung ke rumah sakit pusat rujukan di Bandung, Jawa Barat, Indonesia. Antibodi IgG HSV-1 dan HSV-2 di dalam serum diperiksa dengan menggunakan ELISA. Data dianalisis dengan uji Chi-square, t-test dan ANOVA, nilai p < 0.05 dianggap signifikan secara statistik. Hasil: Seroprevalensi antibodi IgG HSV-1 pada pasien HIV-positif (71%) tidak berbeda secara signifikan dengan pasien HIV-negatif (66%). Namun, seroprevalensi HSV-2 secara signifikan lebih tinggi pada pasien HIV-positif (30%) dibandingkan dengan pasien HIV-negatif (5%). Titer antibodi IgG HSV-1 pada pasien HIV-positif (mean 24.63 ± 19.06 IDU) secara signifikan lebih rendah dibandingkan pasien HV-negatif (mean 44.62 ± 33.22 IDU). Sedangkan, titer antibodi IgG HSV-2 pada pasien HIV-positif (mean 13.31 ± 20.28 IDU) secara signifikan lebih tinggi dibandingkan pasien HIV-negatif (mean 4.42 ± 10.99 IDU). Tidak ada hubungan yang signifikan antara seropositivitas HSV-1 dan -2 dengan jumlah CD4. Namun, sebagian besar pasien seropositif HSV-2 memiliki jumlah CD4 < 200 sel/mm3. Kesimpulan: Seroprevalensi HSV-1 dan HSV-2 pada pasien HIV-positif adalah tinggi, tetapi tidak berkorelasi dengan jumlah CD4.
Noma management in a child with systemic lupus erythematosus Irna Sufiawati; Asri Arum Sari; Budi Setiabudiawan; Rahmat Gunadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.055 KB) | DOI: 10.20473/j.djmkg.v43.i1.p6-10

Abstract

Background: Noma, also known as cancrum oris, is an orofacial gangrene, which during its fulminating stage causes progressive and mutilating destruction of the infected tissues. The disease occurs mainly in children with malnutrition, poor oral hygiene and debilitating concurrent illness. Purpose: The aim of this paper was to report a unique case of noma associated with systemic lupus erythematosus in an 8-year-old boy. Case: An 8-year-old boy referred to Oral Medicine Department complaining about an ulcer at the left corner of his mouth for 1 month, painful and difficulty in opening the mouth. The patient was diagnosed systemic lupus erythematosus since 14 months before and had been given immunosuppressive therapy. The patient was also diagnosed severe malnutrition. Haematologic investigations revealed anemia. Case management: Panoramic radiography was performed to check for dental or periodontal foci of infection, but no abnormalities were present. The microbiology examination revelaed Fusobacterium necrophorum, Staphylococcus aureus, and Klabsiella. The patient has been treated with oral irrigation using hydrogen peroxide, saline and 0.2% chlorhexidine, thus helped to slough the necrotic tissue. Oral antibiotics and analgesics were prescribed. The patient was admitted to hospital under the care of a pediatrician, allergy and immunology specialist, and a nutritionist. The result of the comprehensive disease management showed that the lesion healed completely, but leaving a scar on his corner of the mouth. Its physical effects are permanent and may require reconstructive surgery to be repaired by oral surgeon. Conclusion: Noma is not a primary disease, there are various predisposing factors usually precede its occurrence. The management of noma requires a multidisciplinary approach.Latar Belakang: Noma, dikenal sebagai cancrum oris, adalah gangren pada daerah orofasial, yang menyebabkan kerusakan progresif dari jaringan yang terinfeksi. Penyakit ini terjadi terutama pada anak dengan gizi buruk, kesehatan mulut yang buruk dan penyakit yang melemahkan. Tujuan: Makalah ini bertujuan untuk melaporkan sebuah kasus noma yang unikpada seorang anak laki-laki berusia 8 tahun yang menderita lupus eritematosus sistemik. Kasus: Seorang anak laki-laki 8 tahun dirujuk ke Bagian Ilmu Penyakit Mulut, mengeluh adanya luka di sudut mulut sebelah kiri yang telah diderita selama 1 bulan, terasa sangat sakit dan sulit membuka mulut. Pasien didiagnosis lupus eritematosus sistemik sejak 14 bulan sebelumnya dan telah diberikan terapi imunosupresif. Pasien juga didiagnosis menderita malnutrisi yang berat. Pemeriksaan hematologi menunjukkan pasien menderita anemia. Tatalaksana kasus: Radiografipanoramik dilakukan untuk memeriksa fokus infeksi dental atau periodontal, tetapi tidak ditemukan adanya kelainan. Pada pemeriksaan mikrobiologi ditemukan adanya Fusobacterium necrophorum, Staphylococcus aureus, dan Klabsiella. Perawatan pada pasien meliputi irigasi pada daerah gangren dengan hidrogen peroksida, larutan salin dan klorheksidin 0,2% untuk membersihkan jaringan nekrotik. Pasien juga diberikan antibiotik dan analgesik. Pasien dirawat di rumah sakit di bawah perawatan dokter spesialis anak, dokter spesialis alergi imunologi, dan ahli gizi. Hasil penatalaksanaan penyakit secara komprehensif memperlihatkan adanya penyembuhan, tetapi meninggalkan jaringan parut pada sudut mulutnya. Kelainan fisik tersebut bersifat permanen dan memerlukan pembedahan rekonstruktifoleh dokter gigi spesialis bedah mulut. Kesimpulan: Noma bukanlah penyakit primer, terdapat berbagai faktor predisposisi yang biasanya mendahului terjadinya penyakit tersebut. Pengelolaan noma memerlukan pendekatan multidisiplin.
Oral lesions as a clinical sign of systemic lupus erythematosus Eliza Kristina M. Munthe; Irna Sufiawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 3 (2018): September 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (710.541 KB) | DOI: 10.20473/j.djmkg.v51.i3.p147-152

Abstract

Background: Oral lesions represent one of the most important clinical symptoms of systemic lupus erythematosus (SLE), an autoimmune disease with a high degree of clinical variability rendering it difficult to arrive at a prompt and accurate diagnosis. There are many unknown causes and multiple organ systems involved, with the result that permanent organ damage may occur before treatment commences. Purpose: The purpose of this case report is to discuss the importance of recognizing the lesions related to SLE which may help dentists to make an early diagnosis. Case: A 17-year-old female patient was referred by the Internal Medicine Department with a suspected case of SLE. Prior to admittance to the hospital, the patient was diagnosed with tuberculosis. A subsequent extraoral examination revealed ulceration with a blackish crust on the upper lip. An intraoral examination showed similar ulceration covered with a blackish crust on the labial mucosa accompanied by central erythema in the hard palate. Blood tests indicated decreased levels of hemoglobin, hematocrit and platelets, but increased levels of leukocytes. A diagnosis of oral lesions associated with SLE and angioedema was formulated. Case management: The patient was given 1% hydrocortisone and vaseline album for extraoral lesions, while 0.2% chlorhexidine gluconate and 0.1% triamcinolone acetonide was used to treat intraoral lesions. An improvement in the oral lesions manifested itself after two weeks of treatment. Conclusion: Early detection of oral lesions plays a significant role in diagnosing SLE. It is important for the dentist to recognize the presentation of diseases that may be preceded by oral lesions. A multidisciplinary approach and appropriate referrals are necessary to ensure comprehensive medical and dental management of patients with SLE.
Herbal-induced Stevens-Johnson syndrome with oral involvement and management in an HIV patient S. Suniti; Irna Sufiawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 3 (2018): September 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.31 KB) | DOI: 10.20473/j.djmkg.v51.i3.p153-157

Abstract

Background: Stevens-Johnson syndrome (SJS) is an immune complex-mediated hypersensitivity reaction affecting the skin and mucous membranes. Patients infected with human immunodeficiency virus (HIV) are at increased risk of developing SJS which is predominantly caused by an adverse reaction to medications, including herbal varieties. In recent years, the consumption of herbal medicines has increased, while their safety remains a matter for investigation. Purpose: The purpose of this case report is to explain the occurrence of SJS caused by herbal medicine. Case: A 43-year-old male patient with body-wide skin erosion was referred to the Department of Oral Medicine and subsequently diagnosed with Stevens-Johnson syndrome due to his consumption of a herbal medicine containing zingiber rhizoma, coboti rhizoma, asari herbal and epimedi. The patient’s chief complaints included difficulty when opening the mouth, dysphagia and excessive production of saliva continuously contaminated with blood and sputum. Extraoral examination showed a sanguinolenta crust on the lips. Intra oral examination of oral mucous showed erosive lesions with bleeding and pain. A HIV test performed at a Clinical Pathology Laboratory was positive for antibodies against HIV with a CD4 cell count of 11 cells/ml. Case management: Treatment consisted of the administering of NaCl 0.9 %, hydrocortisone 0.1% and Chlorhexidine digluconate 0.12% for 12  days. Conclusion: SJS can be caused by herbal medicine and it is essential to be aware of the latter’s potential adverse effects, especially in immunocompromised patients. Symptomatic management of oral lesions should be planned as an early intervention in order to decrease morbidity and mortality in SJS patients.
Analysis of the relationship between human cytomegalovirus DNA and gB-1 genotype in the saliva of HIV/AIDS patients with xerostomia and salivary flow rate Irna Sufiawati; S. Suniti; Revi Nelonda; Rudi Wisaksana; Agnes Rengga Rendati; Riezki Amalia; Isabellina Dwades Tampubolon
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 4 (2019): December 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p197-203

Abstract

Background: Human immunodeficiency virus (HIV) infection increases vulnerability to opportunistic viral infection, including Human cytomegalovirus (HCMV) infection, that has been detected in saliva. The HCMV envelope glycoprotein B (gB) is highly immunogenic and has been associated with HCMV-related diseases. Purpose: The purpose of this study is to assess the prevalence of HCMV and gB-1 genotype in the saliva of HIV/AIDS patients and to analyse their relationship with xerostomia and salivary flow rate (SFR). Methods: This cross-sectional study involved 34 HIV/AIDS patients. Saliva was tested for the presence of HCMV DNA using PCR microarrays, and nested PCR for gB-1 genotype detection. Xerostomia was measured using a Fox’s questionnaire. Unstimulated whole saliva flow rate was measured by means of the spitting method. Results: The composition of the research population consisting of 73.5% males and 26.5% females with HIV/AIDS. HCMV was found in 64.7% of HIV/AIDS patients, while gB-1 genotype was detected in 59.1%. Xerostomia was closely associated with the presence of HCMV in saliva (p<0.05), but not with gB-1. There was no significant relationship between xerostomia and SFR rates in the research subjects with HCMV positive saliva (p> 0.05). Conclusion: The presence of xerostomia-associated HCMV in saliva was elevated among HIV/AIDS patients. Further investigation is required to identify other gB genotypes that may be responsible for xerostomia and SFR changes in HIV/AIDS patients.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Noerkhaerin Putra Adi Ahmad Yusuf Adji Kusumadjati Aga Satria Nurrachman Agnes Rengga Rendati Alamsyah Piliang Alongsyah Zulkarnaen Ramadhan Amalia, Riezki An Nisaa Mardhatillah Ananda Sagita Andiesta, Niekla Survia Arny E. Muryah Arny E. Muryah, Arny E. Asri Arum Sari Budi Setiabudiawan Dani R. Firman Dani R. Firman Dendi Sandiono Dewi - Dewi Kania Intan Permatasari Dewi Marhaeni Diah Herawati Dewi Oktafia Traktama Dewi Puspasari Dewi Puspasari Dewi Zakiawati Dewi Zakiawati Dewi Zakiawati Dida Akhmad Gurnida Dida Akhmad Gurnida Dudi Aripin Eliza Kristina M. Munthe Eriska Riyanti Etis Duhita Rahayuningtyas Farhani Azizah Farina Pramanik Hapid, M. Hasan Harry Galuh Nugraha Hartati Purbo Darmadji, Hartati Purbo Harum Sasanti, Harum Husnul Mahfaza Ibnu Suryatmojo Ignatius Setiawan Indah Suasani Wahyuni Indra Gunawan Isabellina Dwades Tampubolon Larasati Dyah Utami Lusi Epsilawati Maulani, Intan Merry Annisa Mieke Hemiawati Satari Munthe, Eliza Kristina M Nanan Nur'aeny Nanan Nur’aeny Nanan Nur’aeny Nanan Nur’aeny Nur'aeny, Nanan Nuri Fitriasari Nurmilah Maelani, Nurmilah Oki Suwarsa Radzuan, Maryam Rahmat Gunadi Rahmi Harmiyati Ratna Indriyanti, Ratna Revi Nelonda Revi Nelonda Ria N.Firman Ria Noerianingsih Firman, Ria Noerianingsih Riani Setiadhi Riezki Amalia Risti Saptarini Risti Saptarini Primarti Rita Wardhani Rudi Wisaksana S. Suniti Samsuridjal Djauzi Sarifah, Norlaila Siti Aliyah Pradono Sri Tjahajawati Sunardhi Widyaputra Sunardhi Widyaputra Sunardhi Widyaputra Syarifah Fatimah, Syarifah Tenny Setiani Tenny Setiani Dewi Tony S. Djajakusumah Tony S. Djajakusumah Vatchala Rani Ramamoorthy Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Wicaksono, Imme Kris Wijaya, Indra