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All Journal Bionatura Sosiohumaniora Majalah Kedokteran Bandung Dentika Dental Journal Journal of Dentistry Indonesia Journal of Mathematical and Fundamental Sciences MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Padjadjaran Journal of Dental Researchers and Students Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Odonto dental journal

Irna Sufiawati

Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran Bandung, Jawa Barat

Author-ID : 388455

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Energy Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Serum IL-6 levels of atopic patients with recurrent aphthous stomatitis (RAS) Nur'aeny, Nanan; Sufiawati, Irna; Suwarsa, Oki; Gurnida, Dida Akhmad
Padjadjaran Journal of Dentistry Vol 31, No 1 (2019): March 2019
Publisher : Universitas Padjadjaran

Introduction: Atopy is a genetic tendency of allergic condition with specific clinical manifestations such as atopic dermatitis (AD), allergic rhinitis (AR), and bronchial asthma (BA). Atopic individuals might experience other health problems that coincide with atopic manifestations, including the appearance of recurrent aphthous stomatitis (RAS) which is an oral mucosal disease that can also be influenced by allergies. This study was aimed to be the preliminary study regarding the level of IL-6 serum in atopic patients who were also having RAS. Methods: Thirty subjects were recruited and grouped into three groups with ten subjects each were group of atopic (dermatitis, allergic rhinitis, or bronchial asthma) with RAS, atopic without RAS, and control. Blood specimens were obtained with an approved institutional board review protocol. This research was cross-sectional research with consecutive sampling method conducted at Dr Hasan Sadikin Hospital Bandung. Results: There were significant differences in IL-6 log levels in all three groups (p < 0.001). The higher IL-6 levels in the group of atopic with RAS might be due to the influence of atopy because this condition can increase the acute inflammation of RAS. IL-6 is a pro-inflammatory marker found in the circulation of atopic and RAS patients. Conclusion: Serum IL-6 levels in the group of atopic patients with RAS is higher than in other groups. Keywords: Serum, IL-6, atopic, recurrent aphthous stomatitis

Correlation between mandibular bone density with CD4-T cells and duration of HAART in HIV-infected children Maulani, Intan; Primarti, Risti Saptarini; Sufiawati, Irna; Indriyanti, Ratna; Andiesta, Niekla Survia; Riyanti, Eriska
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.15894

Introduction: Perinatal HIV infection has decreased adverse bone health effects and mineral accrual. HIV-infected patients have a multifactorial origin, including HIV bone cell infections, inflammatory cytokine effects on osteoblast and osteoclast activity, and HAART. The research objective was to analyze the correlation between the mandibular bone density with CD4 T-cells and duration of HAART in HIV-infected children. Methods: The mandibular bone density in the HIV-infected pediatric population was evaluated using a panoramic radiograph. The research design was a cross-sectional and univariate regression analysis for the sampling method. Mandibular density analysis using Spearman and Pearson correlation and HAART duration using Kendall correlation. Thirty-five HIV-infected children and seventeen non-HIV-infected children were recruited. Results: This study showed the significant correlation between Mandibular cortical shape index of HIV-infected and non-HIV children and there is a significant correlation between fractal dimension of HIV-infected and non-HIV children (p<0.05). There is no significant correlation between mandibular bone density and the CD4 level(p<0.05). Mandibular bone density and duration HAART and have a significant correlation (p<0.001). This research showed correlations between mandibular bone density CD4 T-cells and duration of HAART in HIV-infected children. Conclusion: There is no correlation between the mandibular bone density and CD4 T-cells count, however, there is a correlation between the mandibular bone density and duration of HAART in HIV-infected children.

The prevalence of Stevens Johnson Syndrome caused by antiretroviral in hospitalized patients at Dr. Hasan Sadikin General Hospital Bandung Maelani, Nurmilah; Sufiawati, Irna; Darmadji, Hartati Purbo
Padjadjaran Journal of Dentistry Vol 21, No 3 (2009): November 2009
Publisher : Universitas Padjadjaran

Stevens-Johnson Syndrome is a mucocutaneous disease caused by allergic drug eruption. Antiretroviral (ARV) therapy for HIV/AIDS patient may cause allergic drug eruption such as Stevens-Johnson Syndrome.The aim of this research was to find out the prevalence of Stevens-Johnson Syndrome caused by ARV in hospitalize patient at Dr.Hasan Sadikin General Hospital Bandung from January to December 2008.It was a descriptive research by taking the secondary data from patient’s medical record. The result of this research showed that from 20 Stevens-Johnson Syndrome patients, 12 persons of them (60%) are men.Most of the patients were between the age of 20-29 (45%).Oral manifestation of Stevens-Johnson Syndrome seen in 100% patients.Prevalence of Stevens-Johnson Syndrome caused by ARV was 28.6% which seen in 8 HIV/AIDS patients.ARV combination consists of nevirapine, lamivudine, and zidovudine was the most (50.0%) ARV which suspected causing Stevens-Johnson Syndrome.The conclusion of this research showed that the prevalence of Stevens-Johnson Syndrome caused by ARV in hospitalize patient at Dr.Hasan Sadikin General Hospital Bandung 2008 was 28.6% seen in 8 HIV/AIDS patients.

Correlation between saliva IgA level and T cell CD4+ in HIV/AIDS patients Sufiawati, Irna; Sasanti, Harum; Djauzi, Samsuridjal
Padjadjaran Journal of Dentistry Vol 19, No 2 (2007): July 2007
Publisher : Universitas Padjadjaran

Background: HIV infection appears to have direct effects on oral mucosal immunity, cellular and humoral. Antibody secretion, especially salivary immunoglobulin A (IgA), is a useful indicator of mucosal immune function. This immune system component is recognized as an important first-line of defence against pathogens which colonize and invade mucosal surfaces in the oral cavity. Objectives: The purpose of this study was to investigate salivary IgA levels and to determine its correlation with CD4+ T-cell counts among HIV-infected patients in Pokdisus AIDS Cipto Mangunkusomo Hospital Jakarta. Methods: The design study was using a cross-sectional study. Whole paraffin-wax-stimulated saliva was collected from 103 HIV-infected patients and 30 healthy individuals. Saliva was collected using the spitting method. Salivary IgA levels were determined by the immunoturbidimetry method using the Behring Turbitimer Analyser. CD4+ T-cell counts were analyzed by flow cytometry. Results: Salivary IgA levels were 141.55 ± 83.23 (HIV group) and 97.24 ± 38.25 (healthy individuals). The Mann-Whitney U test showed salivary IgA levels were significantly higher in HIV/AIDS subjects compared with healthy individuals (p<0.1). Most of the subject has severe immunosuppression with CD4+ T-cell counts <200 cell/mm.3 Pearson’s correlation test between CD4+ T-cell counts and salivary IgA levels showed no significant correlation (r= 0.06, p>0.1). Conclusion: This study indicates that total salivary IgA levels were significantly higher in the HIV-infected patients compared to control, and salivary IgA level seems not to be related significantly to CD4+ T-cell counts.

Herpes Labialis and Oral Candidiasis in HIV-infected intravenous drug users with poor hematologic status Sufiawati, Irna; Sasanti, Harum
Padjadjaran Journal of Dentistry Vol 20, No 3 (2008): November 2008
Publisher : Universitas Padjadjaran

Hematologic abnormalities are common in HIV-infected patient, particularly in individuals with more advanced HIV disease. Hematologic abnormalities and their association with HIV-associated oral lesions had been reported. Intravenous drug use has been associated with increased oral lesions too. We reported a case of oral lesions in a 24 years old man HIV-infected intravenous drug users. Poor hematologic status is a risk factor of Oral Candidiasis in HIV-infected person with clinical features appear generally. But the clinical feature of Herpes Labialis is not usually because of his poor hematologic status. It’s concluded that poor hematologic status and transmission of HIV through contaminated needlestick are the high-risk factors of oral lesions and appear not usually clinical features in ODHA. Correction of these hematologic abnormalities and appropriately management of oral lesions can minimize the severity and increase the better quality of life patient.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Noerkhaerin Putra Adi Ahmad Yusuf Adji Kusumadjati Aga Satria Nurrachman Agnes Rengga Rendati Alamsyah Piliang Alongsyah Zulkarnaen Ramadhan Amalia, Riezki An Nisaa Mardhatillah Ananda Sagita Andiesta, Niekla Survia Arny E. Muryah Arny E. Muryah, Arny E. Asri Arum Sari Budi Setiabudiawan Dani R. Firman Dani R. Firman Dendi Sandiono Dewi - Dewi Kania Intan Permatasari Dewi Marhaeni Diah Herawati Dewi Oktafia Traktama Dewi Puspasari Dewi Puspasari Dewi Zakiawati Dewi Zakiawati Dewi Zakiawati Dida Akhmad Gurnida Dudi Aripin Eliza Kristina M. Munthe Eriska Riyanti Etis Duhita Rahayuningtyas Farhani Azizah Farina Pramanik Hapid, M. Hasan Harry Galuh Nugraha Hartati Purbo Darmadji, Hartati Purbo Harum Sasanti, Harum Husnul Mahfaza Ibnu Suryatmojo Ignatius Setiawan Indah Suasani Wahyuni Indra Gunawan Isabellina Dwades Tampubolon Larasati Dyah Utami Lusi Epsilawati Maulani, Intan Merry Annisa Mieke Hemiawati Satari Munthe, Eliza Kristina M Nanan Nur'aeny Nanan Nurâ€™aeny Nanan Nurâ€™aeny Nanan Nur’aeny Nur'aeny, Nanan Nuri Fitriasari Nurmilah Maelani, Nurmilah Oki Suwarsa Radzuan, Maryam Rahmat Gunadi Rahmi Harmiyati Ratna Indriyanti, Ratna Revi Nelonda Revi Nelonda Ria N.Firman Ria Noerianingsih Firman, Ria Noerianingsih Riani Setiadhi Riezki Amalia Risti Saptarini Risti Saptarini Primarti Rita Wardhani Rudi Wisaksana S. Suniti Samsuridjal Djauzi Sarifah, Norlaila Siti Aliyah Pradono Sri Tjahajawati Sunardhi Widyaputra Sunardhi Widyaputra Sunardhi Widyaputra Syarifah Fatimah, Syarifah Tenny Setiani Tenny Setiani Dewi Tony S. Djajakusumah Tony S. Djajakusumah Vatchala Rani Ramamoorthy Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Wicaksono, Imme Kris Wijaya, Indra

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