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All Journal PROSIDING SEMINAR NASIONAL Jurnal Penelitian Saintek Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedika Jurnal Kesehatan Pharmacon Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Nutraceuticals and Herbal Medicine Martabe : Jurnal Pengabdian Kepada Masyarakat Indonesian Community Journal Jurnal Farmasi Sains dan Praktis Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Farmasi Klinik dan Sains Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Pharmacon: Jurnal Farmasi Indonesia
Andi Suhendi
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : PROSIDING SEMINAR NASIONAL

 1 
UJI TOKSISITAS SUBKRONIS EKSTRAK ETANOL DAUN TUMBUHAN SALA (Cynometra ramiflora Linn.) DENGAN PARAMETER KIMIA URIN DAN HISTOPATOLOGI ORGAN GINJAL PADA TIKUS GALUR WISTAR Haryoto -; Andi Suhendi; Eka Prasnaparamita W; Tanti Azizah Sujono; Muhtadi -
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Tumbuhan Sala (Cynometra ramiflorra Linn.) merupakan salah satu tumbuhan mangrove, yang memiliki beberapa manfaat antara lain antioksidan, antihiperglikemia, dan antiinflamasi. Uji toksisitas subkronis digunakan untuk mengetahui toksisitas suatu senyawa yang dilakukan selama 90 hari. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan ekstrak etanol daun Sala terhadap parameter kimia urin dan histopatologi ginjal. Penelitian ini merupakan penelitian eksperimental dengan rancangan Post Test Controlled Group Design, yaitu melihat perubahan yang terjadi pada tikus setelah diberi perlakuan. Sampel penelitian terdiri dari 20 ekor tikus putih jantan yang dibagi 4 kelompok dosis perlakuan. Kelompok pertama merupakan kelompok kontrol yang diberi CMC-Na (Sodium Carboxy Methyl Cellulose), kelompok kedua, ketiga, dan keempat diberi ekstrak etanol daun Sala dengan dosis 500, 1000, dan 1500 mg/kgBB. Parameter yang diamati yaitu kimia urin dan histopatologi ginjal. Parameter kimia urin dievaluasi menggunakan urin tampungan pagi hari pada hari ke-0, 45, dan 90 menggunakan reagen strip. Hasil parameter kimia urin tikus untuk kelompok kontrol dan perlakuan selama 90 hari memberikan pengaruh pada parameter protein, glukosa, keton, bilirubin, urobilinogen terhadap fungsi ginjal, namun tidak mempengaruhi pH dan nitrit. Hasil histopatologi menunjukkan terjadinya peradangan pada ginjal tikus yang diberi ekstrak etanol daun Sala dengan dosis 1000 dan 1500 mg/kgBB.Kata kunci: Cynometra ramiflora Linn., toksisitas subkronis, kimia urin
UJI TOKSISITAS AKUT DARI EKSTRAK KULIT BUAH RAMBUTAN (Nepheliumlappaceum L.) YANG BERPOTENSI SEBAGAI OBAT HERBAL ANTIDIABETES Muhtadi -; Haryoto -; Tanti Azizah Sujono; Andi Suhendi
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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The acutetoxicitytestinghave been conducted inthe male and female ratsSD strain oframbutan (Nepheliumlappaceum L.)fruitpeel extract. The testing had been doneby providingwitha doserankedasfollows: the firstdose; 0mg/kgBW, doseII; 400mg/kgBW, doseIII; 1,400mg/kgBW, IVdoses; 4,900mg/kgBW, and thedosage ofV; 17,150mg/ kgBW for 14days. Thenit had been observedclinical symptomsthat happened, changed in body weightperweekanddefect on vital organs, namely: the liver, kidneys, stomach, intestines, spleen, heartandlungs. Theresults ofthis study was concludedthat thehighest doseof up to17,150mg/kgBW ofthe extract, safety andproved to be not toxic to thefemaleandmaleratsSDstrain.Keywords : The acutetoxicitytesting; rambutanfruitpeel extract; thefemaleandmaleratsSDstrain.
PREDIKSI 3D-MOLEKULAR AKTIVITAS TURUNAN SENYAWA POLIHIDROKSI ZERUMBON TERHADAP GLIKOGEN SINTASE KINASE-3 BETA (GSK-3) MENGGUNAKAN DOCK6 Broto Santoso; Dedi Hanwar; Andi Suhendi
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Insulin resistance causes 90% of type 2 diabetes mellitus (DM) cases and this is due to an increase in the activity of glycogen synthase kinase-3 (GSK-3). Dephosphorylation and activation of glycogen synthase prevent type 2 diabetes by inhibiting the work of GSK-3 beta isoform primarily. The study was done in unix (mac and linux) operating system with the sequence of steps were optimization of geometry of ligand, ligand and protein preparation, validation of docking methods, molecular docking and analysis, and 3D modeling of ligand-protein interactions. Optimization of target ligand geometry using Gaussian showed that molecular docking score increased 62.5% compared with geometry optimization using MarvinSpace. Polyhydroxy compound zerumbon derivats: ZER04, ZER05 and ZER06 potential to be tested further in the laboratory as an anti- type 2 diabetes both in vitro and in vivo. This is based on the ability of the compounds in term of molecular interactions that better than the native ligand of target protein 4PTE, 4AFJ, 3ZRK, 3GB2, 3DU8 and 1Q3W (60% of the total protein targets tested) as an inhibitor of glycogen synthase kinase- 3 types of beta (GSK-3b).Keywords: polyhydroxyzerumbone, glycogen synthase kinase-3 beta, docking molecular, DOCK6
INTRODUKSI TEKNOLOGI TEPAT GUNA UNTUK PERBAIKAN PROSES PRODUKSI DAN PENGEMBANGAN USAHA JAMU HERBAL DI CV. ARBA’IN JAYA MANDIRI SURAKARTA Muhtadi -; Andi Suhendi; Agus Triyono; Agus Ulinuha
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang Teknik dan Rekayasa The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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Abstract

IPTEKDA LIPI XVIII activities in 2015 was intended to improve the quality and capacity of production in SMEs CV. Arba'in Jaya Mandiri Surakarta, through the introduction of some technology included medicinal herb powder mixer machines, mixer machines for honey, and semi-manual capsule filling. While in the second phase, will be introduced vacuum evaporator machine and application software for the development marketing online of herbal medicinal and honey products Arba'in. The results had been achieved in the first phase of IPTEKDA LIPI 2015, ie an increased in productivity and efficiency of production procesing as well as improving the quality of herbal medicine production. The mixing process of herbal ingredients were more efficient with the capacity of mixing up to 25 kg / process, from only 3-5 kg / process before. The process of mixing herbs-based honey, had showed a more homogeneous mixing and faster. Through the introduction and applications of technology production procesing, it was hoped will provide multifier effect for SMEs, employment, supplier partners and the communities.Keywords : SMEs CV. Arba'in Jaya Mandiri Surakarta, the introduction of efficient technology, production process improvement, business development of herbal medicine
Co-Authors 'Aina Fahrina Anwar . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Abdillah, Safira Mafaza Abdul Rohman Abidi, Subhan R Aflit Nuryulia Praswati Agus Triyono Agus Ulinuha Ahmad, Farhand Ainur Tri Hapsari Aisy, Inandrohatul Alida Rahmalia Damayanti Alvita Marshanda Purnama Puteri Amalinda Ayu Faroska Anifatussaa'dah, A Annissa, Yanis Nur Anwar, 'Aina Fahrina Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti, Dhinar Aulia Tassya Fadhilla Auliya, Dhiyahul Aurum, Mursalina Nanda Basusena, Rahardian Surya Broto Santoso Burhanudin Ichsan Cahyaningrum, Safira Citra, Tia Mella Citradewi, Lia Intan Da'i, Muhammad Dedi Hanwar Dewi, Triana Ariska Didik Setiawan Djoko Wahyono Dwi Lestari Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Erlya Ayusari Ramly Erna Herawati Erna Herawati, Erna Fadhilla, Aulia Tassya Fahriza Mei Trihatmoko Farah Salsabila Farid Adi Prasetya Faridita khoirun Nisa' Faroska, Amalinda Ayu Fauzi Ahmad Muda Fidhia Nur Rifaini Fitriani, Rizki Ainun Fortuna, Tista Ayu Frida Rosenova Gunawan Setyadi Hadi, Ismanurrahman Haliza Arzeti Nurseptiria Hamimatusalma Alkautsar Hamzah, Hasyrul Handayani, Vivi Resty Hapsari, Atikah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Heni Lutfiyati, Heni Hesti Pawarti HI, Marsilia Rosa Sinensis Hidajah Rachmawati Hidayah Karuniawati Hidayati, Ria Husna Amalia Halwa Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Jessica Rosalinda Joko Priyanto Wibowo Kasful Asra Sakika Keisya, Aulita Khairunnisa Azani Meilinasary, Khairunnisa Azani Kharisma Aulia Husna Khusnul Khotimah khusnul khotimah Kumalla, Novea Kusumastuti, Lina Ayu Laila Dzafira Lia Intan Citradewi Lina Ayu Kusumastuti Listiana Masyita Dewi M Muhtad Manggo, Tasya Faradillah Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania MAULANA, RIZA Muhammad Da'i Muhtad, M Muhtadi Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Nida’ Nur Jannah Nisa', Faridita khoirun Nur Muhammad Arrizky Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurseptiria, Haliza Arzeti Nurul Tri Anggraini Oktaviani, Ardalia Rinanda Pawarti, Hesti Pawarti, Hesti Peni Indaryudha Peni Indaryudha, Peni Puspa, Fajrina Eka Putri, Ega Annisa Raafika Studiviani Rahardian Surya Basusena Ranatri Puruhita Ria Utami, Primanitha Rifaini, Fidhia Nur Rizki Ainun Fitriani Rizky Ainun Fitriani Rosa Sayentina Amin Sabtanti Harimurti, Sabtanti Sari Haryanti Sayyidah Nurul Muslihah Selviana, S Siti Aisyah Siti Aisyah Studiviani, Raafika Subekti, Istiara Subhan R Abidi Tanti Azizah Sujono Tasysaningtyas, Thalia Fiandra Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Utama, Haya Nabilah Vitania Marsya Vivi Resty Handayani Wahyu Utami, Wahyu Widyastuti, Vera Yanis Nur Annissa