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All Journal JURNAL PENELITIAN SAINTIKA Science and Technology Indonesia Sinkron : Jurnal dan Penelitian Teknik Informatika Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research Jurnal Indah Sains dan Klinis Journal of Fundamental and Applied Pharmaceutical Science FORTE JOURNAL Mejuajua JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Miracle Journal Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam (JURRIMIPA) Jurnal Natural Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Journal of Innovative and Creativity Jurnal Indah Sains dan Klinis

Nilsya Febrika Zebua, Nilsya Febrika

Faculty Of Pharmacy, Universitas Tjut Nyak Dhien, Medan, 20123, Indonesia

Author-ID : 3915091

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Literatur Review: Tumbuhan Penghasil Asap Cair Tari Putri Utami Rizki; Nilsya Febrika Zebua
INSOLOGI: Jurnal Sains dan Teknologi Vol. 2 No. 3 (2023): Juni 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v2i3.1783

Liquid smoke is the dispersion of smoke vapor in water. One of the systems for the formation of liquid smoke by condensing the smoke from incomplete combustion of wood. During combustion, compounds from wood include cellulose, helmicellulose and lignin to obtain pyrolysis to produce several compounds such as phenols, carbonyls, acids, furans, alcohols, lactones, polycyclic hydrocarbons, these compounds function as antioxidants, antibacterials and form color and taste. typical. Pyrolysis is a method of breaking down lignocellulosic by limited heat and oxygen and forming gas, liquid or charcoal, the amount of which depends on the types of materials, methods and conditions of pyrolysis. The liquid smoke formation method is carried out through a number of stages starting from pyrolysis, condensation and redistillation. Plants that have been used to produce liquid smoke include coconut shells, nutmeg shells, areca nut shells, bamboo, durian bark, corn cobs, mangrove bark, oil palm and rice husks. The purpose of writing this journal is to find out which plants produce the most liquid smoke.

Analisis Kadar Kafein Biji Kopi Arabika Dengan Variasi Temperatur Sangrai Yang Tumbuh Di Aek Sabaon Tapanuli Selatan Mey Linda Hasibuan; Sumardi Sumardi; Nilsya Febrika Zebua; Nurmala Sari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Roasting can change the physical properties and chemical properties of coffee beans such as the composition of the chemical compounds contained in them, namely caffeine compounds. Caffeine is one of the compounds contained in coffee beans. It is necessary to analyze the differences in the roasting profile in the roasting process of coffee beans to find out if there is a difference in caffeine levels in coffee based on variations in roasting temperature. This study was conducted to determine the caffeine content in arabica coffee grown in Aek Sabaon Village, Marancar District, South Tapanuli Regency with variations in roasting temperatures. The roasting method is carried out in a modern way using a coffee roasting device equipped with a thermometer. The extraction method used is liquid-liquid extraction using chloroform as the solvent. The determination of arabica coffee caffeine levels with variations in roasting temperatures was carried out using the UV-vis spectrophotometry method using HCl 0.1 N as solvent. The results showed caffeine content in arabica coffee samples with variations in roasting temperatures with temperatures of 180°C, 200°C and 210°C respectively; 11.23%, 11.30% and 13.92%. Statistically, the test using ANOVA showed a difference in caffeine levels in the variation in roasting temperature which was not very significant because the significance of p > 0.05 and in the t Test it met the requirements of the significance value p < 0.05 so that it showed a free variable positive and significant effect on the bound variable.

Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form Nerdy Nerdy; Linda Margata; Nilsya Febrika Zebua; Puji Lestari; Tedy Kurniawan Bakri; Faisal Yusuf; Vonna Aulianshah
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.344-352

The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenicol in the capsule dosage form. The sample analysis showed that all analyzed thiamphenicol in capsule dosage form showed good results both qualitatively and quantitatively. Qualitatively all the samples analyzed showed a specific peak at specific positions and specific wavenumbers. These results meet the requirements for containing thiamphenicol in the dosage form. Quantitatively all the samples analyzed ranged from 97.97% to 102.24% by peak height and peak area. These results meet the requirements for active substance levels in general preparations within 90.0% to 110.0%. The method validation for peak height and peak area showed that the accuracy parameter had a recovery percentage of 100.28% and 100.41% (between 98.0% to 102.0%), the precision parameter with a relative standard deviation of 0.31% and 0.37% (not more than 2.0%), and the linearity parameter with a correlation coefficient of 0.9999 and 0.9997 (not less than 0.99). The limit of detection value was 0.2971 mg/mL and 0.5338 mg/mL, the limit of quantitation value was 0.9004 mg/mL and 1.6176 mg/mL, the range for both was 80% to 120%, and the specificity for both met the requirement. The Fourier Transform Infrared method has been successfully developed, applied, and validated for qualitative analysis and quantitative analysis of thiamphenicol in capsule dosage form.

Pembuatan Sediaan Gel Anti Acne dari Asap Cair Tempurung Kelapa Berbasis Galaktomanan dengan Bakteri Staphylococcus aureus Nilsya Febrika Zebua; Rahma Yulia; Nia Zulkarnain
Journal of Pharmaceutical and Health Research Vol 4 No 3 (2023): October 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i3.4219

Liquid smoke is a condensate liquid resulting from coconut shell pyrolysis which contains the main constituents of acids, phenols and carbonyls, so it is widely applied as a natural preservative in food and as an anti-bacterial. Gel preparations are preferred because when used they leave a translucent, elastic layer, good drug release and an attractive appearance. This study aims to determine whether liquid smoke can be formulated into an acne gel dosage form on a galactomannan basis which at certain concentrations has antimicrobial activity againstStaphylococcus aureus and does not cause skin irritation. This research was conducted using experimental and descriptive methods. Beginning with collecting literature information related to the content of liquid smoke from coconut shells, then making a galactomannan base, formulation of acne gel preparations from liquid smoke, making microbiological media, methods of testing antimicrobial activity, examining the physical quality of preparations including preparation homogeneity, testing the preparation's pH, testing preparation stability, and irritation test on volunteers. Based on the results of the study, it was shown that liquid smoke can be formulated into an acne gel dosage form based on galactomannan. Homogeneity test results on gel preparations remained homogeneous, the pH obtained remained stable, skin irritation test results did not cause irritation, preparation viscosity test results obtained between 4520-9990 mPas, gel preparation test on growthStaphylococcus aureus at a concentration of 5% gives an inhibition of 15.3 mm and the results of the antibacterial activity test on liquid smoke can inhibit growthStaphylococcus aureus in the minimum range of 12.5 mg/ml gives an inhibitory diameter of 7.0 mm which is included in the medium category.

Development of Fourier transform infrared spectrophotometric method for identification and determination of marketed metamizole tablet preparation NERDY NERDY; EFFENDY DE LUX PUTRA; NILSYA FEBRIKA ZEBUA; CHRISTICA ILSANNA SURBAKTI; JIHAN SAFIRA
Jurnal Natural Volume 21 Number 1, February 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v21i1.18318

Metamizole is a nonsteroidal antiinflammatory drug (NSAID) that functions as an analgesic, antipyretic, and antiinflammatory. Examination of active substance contents is a requirement that must be met to ensure the quality of drug preparations. The aims of this study were to develop and validate the Fourier Transform Infrared spectrophotometric method for the quantitation of metamizole content in marketed tablet preparation. Identification and determination of metamizole contents by Fourier Transform Infrared spectrophotometric method used methanol solvent in the wavenumber range 4000 cm–1 to 650 cm–1. The results showed that the specific wavenumbers of metamizole were 1649.3 cm–1; 1623.3 cm–1; and 1589.7 cm–1; and the contents metamizole in marketed tablet preparation ranged from (97.954 ± 0.121)% to (104.541 ± 0.257)%. From the validation method, the recovery result is 100.129%; the relative standard deviation is 0.057%; the limit of detection is 2.09526 mg/mL; the limit of quantitation is 6.34928 mg/mL; and the range 40 mg/mL to 60 mg/mL. The quantitation of metamizole contents can be carried out by Fourier Transform Infrared spectrophotometric method with accurate and precise quantitation results.

Formulasi dan Uji Aktivitas Antioksidan dengan Metode DPPH dari Minuman Sari Buah Cempedak (Artocarpus Integer) Menggunakan Spektrofotometri UV-Vis Sumardi, Sumardi; Zebua, Nilsya Febrika; Ulpah, Ulpah
Journal of Pharmaceutical and Health Research Vol 5 No 1 (2024): February 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i1.4966

As chempedak fruit is only used fresh in the community, it is easily affected by mechanical, chemical, and microbiological factors and decays quickly. Therefore, fruit processing becomes very important to extend the shelf life of the fruit. Making juices, syrups, and juice products with a long shelf life is one of the selected ways of fruit utilization. The preparation of cempedak fruit juice as an antioxidant is the objective of this study. This is a summary of the article to help the reader quickly ascertain the purpose of the study according to the research needs. Fruit juice is a drinkable liquid obtained by squeezing or filtering the pulp. Cempedak juice drink formulas were tested for antioxidant activity in water, sugar, and CMC as part of the formula optimization process using SLD (simple lattice design) and respondent polling. Seven cempedak juice drink formulas with concentrations of 80 µg/mL, 60 µg/mL, 40 µg/mL, and 20 µg/mL were shown to have antioxidant capacity based on the results. The IC50 readings of the seven cempedak juice drink formulas are as follows: 7.948 µg/mL, 2.048 µg/mL, 3.085 µg/mL, 0.435 µg/mL, 11.057 µg/mL, 3.388 µg/mL, and 2.726 µg/mL, all of which were considered very strong. The audience found high popularity in the optimal formula made with a mixture of water, sugar, and CMC addition in the hedonic test, which measured responses to taste, aroma, and color. The highest pH of 4 was achieved in the pH 7 test of the Cempedak juice drink recipe. The homogeneity and cycling test results showed that the beverage formulation could be integrated into the drink.

LITERATUR REVIEW: BEBERAPA FORMULASI DARI ASAP CAIR Zebua, Nilsya Febrika; Nadia, Syarifah; Elviana, Elviana
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1253

Liquid smoke is the result of condensation or direct combustion produced from materials containing lignin, cellulose, hemicellulose and other carbon compounds. Based on the literature read, it turns out that there are many contents of liquid smoke, one of which is as a preservative. The method used in this research is the literature review method where this method can help in terms of inputting data in detail and clearly. The results of this study state that liquid smoke can be used in preservative, antibacterial and deodorizing latex preparations. The purpose of this research is to find out how many uses for liquid smoke so that it can be used in everyday life. The conclusion in this study is that liquid smoke is most widely used in preservatives which distinguishes the method used in the form of a literature review.

Antibacterial, antioxidant and total flavonoid of Adenostemma lavenia (L.) ZEBUA, NILSYA FEBRIKA; FUJIKO, MUFLIHAH; DACHI, KANNE; NERDY, NERDY; SEPTAMA, ABDI WIRA
Jurnal Natural Volume 24 Number 2, June 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i2.36396

Adenostemma lavenia (L.) is one of the medicinal plants on Nias Island that is used to treat many symptoms including cough, fever and diarrhea. Empirical data of this plant suggests that these medicinal benefits can be attributed to its antibacterial and antioxidant properties, as well as the total flavonoids contained within it, but research on this is still limited. Adenostemma lavenia (L.) was extracted with ethanol, while the antibacterial properties were measured using the disc method. Antioxidant testing was conducted with the DPPH (1,1-diphenyl-2-2picrihydrazyl) inhibition method. Total flavonoids were assessed using a modified AlCl3 method with a quercetin standard. Antibacterial test results of Staphylococcus aureus, Klebsiela pneumoniae, Propionibacterium acnes, Escherichia coli, Salmonella typhi, Bacillus cereus and Shigella sonnei with mean inhibition were 8.76 0.44, 8.13 0.72, 8.77 0.45, 6.47 0.54, 7.77 0.60, 7.33 0.44, 12.06 0.60 respectively. IC50 was 59.844 3.36 ppm. Total flavonoids were 13.566 0.021 mcg/g. The results of the antibacterial test of the ethanolic extract of Adenostemma lavenia (L.) were classified as moderate. The antioxidant activity and total flavonoids were in the high category, which can be attributed to the capture of free radicals to overcome disease.

UJI AKTIVITAS ANTIOKSIDAN DAN PENENTUAN NILAI SPF EKSTRAK DAUN BANGUN-BANGUN (Plectranthus amboinicus (Lour.) Spreng) PADA SEDIAAN SERUM WAJAH Anggraeini, Dea; Febrika Zebua, Nilsya; Hidayat, Supran; Rahmi Ningrum, Siti; Nadia, Syarifah; Yanti , Fekbri
Miracle Journal Vol. 4 No. 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/mj.v4i2.1280

Bangun-bangun (Plectranthus amboinicus (Lour.) Spreng) adalah tanaman berasal dari famili Lamiaceae dan memiliki kandungan antioksidan yang diformulasi dalam sediaan serum yang mengandung tabir surya untuk menangkal paparan sinar matahari. Tujuan penelitian ini adalah menentukan aktivitas antioksidan dan nilai SPF. Penelitian ini menggunakan metode eksperimental pada uji aktivitas antioksidan dan nilai SPF. Pengolahan simplisia menggunakan metode maserasi dengan pelarut etanol p.a yang diformulasi dalam bentuk serum wajah dengan konsentrasi oxybenzone : octyl methoxycinnamate : ekstrak yaitu F0 (0:0:0), F1 (2:3:5), F2 (1:1,5:7,5), F3 (0:0:10), dan F4 (4:6:0). Pemeriksaan mutu fisik sediaan meliputi homogenitas, pH, viskositas, stabilitas, iritasi, kesukaan, uji aktivitas antioksidan, dan pengukuran nilai SPF. Berdasarkan hasil penelitian bahwa ekstrak daun bangun-bangun dapat diformulasikan dalam sediaan serum yang homogen, rentang pH sesaat dibuat 5,84-6,29 dan setelah cycling test 5,55-6,26, rentang viskositas 1230-1620 mPa.s, sediaan serum yang stabil, tidak mengiritasi kulit, dan F3 (10%) yaitu sediaan paling disukai. Aktivitas antioksidan ekstrak dengan nilai IC₅₀ 58,06 ppm termasuk kategori “kuat”, pada F0 (532,26 ppm), dan pada sediaan serum terbaik pada F3 (63,88 ppm). Hasil pengukuran nilai SPF sediaan serum F0 (0,68), pada sediaan serum terbaik pada F1 (29,2). Formulasi serum ekstrak daun bangun-bangun mempunyai aktivitas antioksidan kategori kuat dan nilai SPF >8 (lebih dari kategori proteksi ekstra).

Uji Efektivitas Ekstrak Etanol Daun Ketapang (Terminalia cattapa L.) Terhadap Bakteri Patogen Saputri, Muharni; Mierza, Vriezka; Zebua, Nilsya Febrika; Panjaitan, M Ridho Pangestu
Journal of Pharmaceutical and Health Research Vol 5 No 3 (2024): October 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i3.6139

Antiba Antibacterials work by preventing and managing the growth of pathogenic bacteria. The goal of controlling bacterial growth is to stop the spread of infection. Basically, people use synthetic drugs in antibacterial prevention but often there is a lot of resistance in the human body that can cause adverse effects. The active ingredients in ketapang leaves have the potential to act as natural antibiotics and antibacterials to combat antibiotic resistance. To determine the antibacterial effectiveness of these chemical compounds against bacteria Pseudomonas aeruginosa, Demacoccus nishinomiyaensi, Stapylococcus epidermidis and Micrococcus luteus, a study was conducted with the aim of knowing the content of chemical compounds contained in ketapang leaves based on maceration results. This study uses an experimental descriptive method with Ketapang leaf test material (Terminalia cattapa L.) This research stage includes making simplisia, maceration extraction using ethanol solvent, antibacterial activity test agar well diffusion method and analysis of chemical compound components by phytochemical screening.The results of drying fresh ketapang leaves produce as much as 1.6 kg of simplisia, and when 300 grams of ketapang leaf simplisia is macerated using ethanol pro analysis, 1.5 kg of simplisia is obtained. The ethanol extract from the maceration of ketapang leaves has antibacterial activity as shown by the inhibition of Pseudomonas aeruginosa bacteria by 18.38 mm, Dermacoccus nishinomiyaensis bacteria by 23.05 mm, Staphylococcus epidermidis bacteria by 18.71 mm, and Micrococcus luteus bacteria by 20.71 mm. After screening the ethanol extract of ketapang leaves, triterpenoid components, anthraquinone glycosides, saponins, and tannins were found. Flavonoid compounds were also found.

Co-Authors Abdi Wira Septama Afni Saufa Yarda Akmil Hidayah Alizha Aisyah Andre Aditya Andrian, Dedek Anggraeini, Dea Anggraini, Dea Anna Juniar Ari Usman Ari Usman, Ari Asih, Fivi Nur Aulia Milda Ayu Lestari, Eka BAKRI, TEDY KURNIAWAN Dacci, Kanne Dachi, Kanne dafitri salsabila Dahra, Aminatun Dea Amelia Adiatma Dea Anggraini Dessy Natalia Siahaan Desy Natalia Siahaan Desyandri Desyandri Dewi Hariman, Annisa Dikxi Putri Mulyana Effendy De Lux Putra, Effendy De Lux Elviana Elviana, Elviana Ernawaty Ginting Ernawaty Ginting Eva Sartika Dasopang Faisal Yusuf Fanny Rizki Sembiring Fathur Raihan Amri Febrianti, Yessi Fekbri Yanti Fujiko, Muflihah Furqaan Ali Kusuma Ginting, Ernawaty Hafizatun Suardi Hafizurrahman Hafizurrahman Hasri, Najwa Miladi Hidayat, Supran Ika Julianti Tambunan Ika Julianti Tambunan Imanuel Damanik Ira Eka Fahira Ira Nofriani JIHAN SAFIRA Julianti, Ika Kanne Dachi Khalisa Khalisa Khoiriyah Khairul Lidia Muliani Linda Margata Lubis, Salmah Handayani Marcella Maran Gabean Masrina Prihatini Meutia Indriana Mey Linda Hasibuan Mierza, Vriezka Miska Raihana Miswati Furqani Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nabila Aini Nabilah Dinda Ramadani Nadia, Syarifah Nerdy Nerdy Nerdy, Nerdy Nia Zulkarnain Ningrum, Siti Rahmi Novriansyah, Reza Nurmala Sari Nurmala Sari Nurul Amalia Nurul Anggraini Nurul karima Nurul Karimah Panjaitan, M Ridho Pangestu Pasaribu, Indah Peri Aisyah Zubaidi Pinanga, Yangie Dwi Marga Prasetyo, Bayu Eko Pravil Mistryanto Tambunan Puji Lestari Putri, Ghera Fakhira Qalbiah Nurmilad B Rahma Yulia Rahma Yulia Rahmi Ningrum, Siti Razali, Mariany Rijalul Ihsan Rina Ridara Rini Karlina Putri Zega Riska Julia Safriana Risma Yeni Rosniwaty Br. Bangun Said Haikal Alfajar salmah handayani Lubis Salman Salman Saputri, Muharni Saputri, Muharni Sara Ariska Purba Shadiq Suwailim Shahira Yasmin Shelva Filiana Sari Shofian Syarifuddin Siahaan, Ririyen Dessy N Siti Aisyah Siti Arum Widiyanti siti muliani julianty Siti Rahmi Ningrum Siti Raudah Siti Salmiyah Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sulika Hati Sumardi Sumardi Sumardi . Sumardi Sumardi Supran Hidayat Supran Hidayat Supran Hidayat Suprianto Suprianto SURBAKTI, CHRISTICA ILSANNA Suryaningsih, Evi Syadzna Malika Maimun Syafitri, Yuni Syarifah Lisa Andriati Syarifah Nadia Tandra Alexandro Tari Putri Utami Rizki Tedy Kurniawan Bakri Tedy Kurniawan Bakri Ulpah, Ulpah Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Winny Wastika Syahfitri Yanti , Fekbri Yessi Febriani Yuliasmi, Sri

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