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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Akuntabilitas Manajemen Pendidikan Jurnal Sains dan Teknologi Farmasi E-Dimas: Jurnal Pengabdian kepada Masyarakat Empowerment : Jurnal Pengabdian Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal SOLMA JURNAL EKONOMI PENDIDIKAN DAN KEWIRAUSAHAAN Martabe : Jurnal Pengabdian Kepada Masyarakat PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Halal Research International Journal of Economics Development Research (IJEDR) BERNAS: Jurnal Pengabdian Kepada Masyarakat Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Entrepreneurship Bisnis Manajemen Akuntansi (E-BISMA) International Journal of Engineering, Science and Information Technology Jurnal Ekonomi Bisnis, Manajemen dan Akuntansi (JEBMA) INTERNATIONAL JOURNAL OF CULTURAL AND SOCIAL SCIENCE Jurnal Locus Penelitian dan Pengabdian Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Medical Chemistry and Bioinformatics Eduvest - Journal of Universal Studies E-JRM Amkop Management Accounting Review (AMAR) Jurnal Multidisiplin Indonesia Indonesian Journal of Community Empowerment Jurnal Pengabdian Farmasi dan Sains Jurnal Sains dan Kesehatan
Hadi Sunaryo
Fakultas Farmasi Dan Sains Universitas Muhammadiyah Prof. Dr. Hamka
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EFEK ANTIDIABETES DAN IDENTIFIKASI SENYAWA DOMINAN DALAM FRAKSI KLOROFORM HERBA CIPLUKAN (Physalis angulata L.) Sediarso, .; Sunaryo, Hadi; Amalia, Nurul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 2 (2008)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

To reveal the dominant substances contribute to antidiabetic effect of Physalis angulata herbs, an antidiabetic test had been done  on chloroform fraction of the herbs eluted with methanol-ammoniak. Identification of active substances was done by GC-MS.  Antidiabetic test was done using 30 male mice  (Mus musculus) strain ddY. The blood samples was taken on day-7 and day-14. Results showed that sugar blood level of the treated mice was significantly decreased, and reached normal level on day-14. Identification with GC-MS revealed that dominant substances in chloroform fraction of Physalis angulata herbs were unsaturated fatty acids, i.e. Hexanoic acid, Hexadecanoic acid methyl ester, 9-Octadecenoic acid methyl ester, Oleic acid butyl ester, 9-Octadecenoic acid, 1,2-Benzendicarboxylic acid, and Aplysterylacetate.. Beside fatty acids it was also found Nordextromethorphan, an alkaloid substance. In conclusion, chloroform fraction of  Physalis angulata herbs had antidiabetic avtivity and the dominant substances were unsaturated fatty acids and alkaloid Nordextromethorphan.   ABSTRAK Untuk mengetahui senyawa dominan dalam herba ciplukan yang mempunyai efek antidiabetes, maka dilakukan uji antidiabetes fraksi kloroform yang dieluasi dengan metanol-amoniak, selanjutnya diidentifikasi kandungannya dengan kromatografi gas spektrofotometri massa (KGC-MS). Pengujian dilakukan dengan menggunakan 30 ekor mencit putih jantan (Mus musculus) galur ddY. Masing-masing mencit diambil sampel darahnya pada hari ke-7 dan hari ke-14, untuk diuji kadar gula darahnya. Hasilnya ketiga dosis menunjukkan penurunan kadar gula darah secara signifikan pada hari ke-7, tetapi penurunannya belum mancapai kadar normal, sedangkan pada hari ke-14 seluruh perlakuan menunjukkan penurunan kadar gula darah secara signifikan dan penurunannya telah mencapai normal. Hasil identifikasi dengan KGC-MS menunjukkan kandungan dominan fraksi kloroform yang dieluasi dengan metanol-amoniak adalah golongan asam lemak tidak jenuh berantai panjang yaitu asam heksanoat, metil heksadekanoat, metil 9-oktadekanoat, butil oleat, asam 9-oktadekanoat, asam 1,2-benzendikarboksilat, dan Aplistearilasetat. Di samping asam lemak tidak jenuh, ditemukan pula senyawa alkaloid yaitu Nordextromethorphan. Dapat disimpulkan bahwa fraksi kloroform herba ciplukan mempunyai efek antidiabetes dan mempunyai kandungan senyawa golongan asam lemak tidak jenuh dan alkaloid Nordextromethorphan.
UJI EFEKTIVITAS KOMBINASI EKSTRAK KULIT KAYU MANIS (Cinnamomum verum J. Presl) DAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN DAN PAKAN Sunaryo, Hadi; Dwitiyanti, Dwitiyanti; Suriantika, Cipto
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.586

Abstract

Deficiency insulin results increased of lipid in people with diabetes. It happens because of the disruption of insulin function as a result complications of high blood fat levels, especially cholesterol and triglycerides. This research was conduct to determine effec of the combination of Cinnamomum verum extract (KM) and Phaleria macrocarpa extract (MD) on decreasing of total cholesterol and LDL in rat. The research divided into 8 treatment groups that is normal, negative, positive, dose combination 1 (KM 300 mg/kg BB+MD 1000 mg/kg BB), dose combination 2 (KM 300 mg/kg BB+MD 500 mg/kg BB), dose combination 3 (KM 300 mg/kg BB+MD 250 mg/kg BB), dose combination 4 (MD 1000 mg/kg BB+KM 150 mg/kg BB), dose combination 5 (MD 1000 mg/kg BB+KM 75 mg/kg BB). Tukey test results showed a decrease in the optimal combination 4 with a percentage decrease in total cholesterol and LDL by 42.83% and 35.01% but the decline is not comparable to the positive control (atorvastatin) amounted to 47.13% and 47.15%.
Co-Authors . Sediarso . Sediarso . Sediarso, . AA Sudharmawan, AA Adia Putra Wirman Adia Putra Wirman, Adia Putra Aggasy, Savira Yustinah Agustin, Faikotul Wulan Ajiningtyas, Rahtanaya Amin, Muhammad Sirojuddin Amrullah, Angkoso Ahmad Anisa Amalia Apriyanto, Guntur Ari Widayanti Arini Fitria Mustapita Bariroh, Tahyatul Chamid Alif, A’an Abdul Daram Heriansyah DIAN LESTARI Dwi Anita Suryandari Dwitiyanti Dwitiyanti Dwiyani Sudaryanti Efendi, Feriawan Ekafianti, Firdayani Elly Wardani, Elly Ema Dewanti Etin Diah Permanasari Fahrurrozi Rahman Farida, Eka Fatahillah, Mulki Fikriansyah, M. Firhan Azis Fith Khaira Nursal Fitri Hidayah, Ratna Fujianti, Fujianti Hariati, Wiwik Harijanto, Djony Hariyanti Hariyanti Hariyanti Hariyanti Hayati Hayati Hayati Hayati Hayati, Hayati Hidayah, Ratna Fitri Ika Resty Kania Ika Resty Kania, Ika Resty Imam Bushiri, Moh Irandi Putra Pratomo Isra, Rafiq Al Jamaliah Jamaliah Jeni Susyanti Kartika Sari, Devel Khaerunissa Anbar Istiadi Khalikussabir, Khalikussabir Khalishatunnada, Khalishatunnada Kristiana, Helda Ladeska, Vera Luluk Yunaini Lusi Putri Dwita M. Abi Rafdi M. Agus Salim Al Fathoni Mayangsari, Jihanning Yudha Mobaraq, Moh. Rizki Fajar Mohammad Rizal, Mohammad Muhammad Zaki Sopiani Muhammad Zaki Sopiani, Muhammad Zaki Mukti, Shinta Aulia Cahya Mulki Fatahillah Mulki Fatahillah, Mulki Ni Putu Ermi Hikmawanti Niadianti, Elivia Nikmatullah, Nurul Azmah Nining, Nining Nugroho, Satrio Ridho Numlil Khaira Rusdi, Numlil Khaira Nur Rizky, Syahrul Nur Wakhid Nurjanah, Desi Nurul Amalia Nurul Amalia Nurul Amalia Nurul Azmah Nikmatullah Nurul Azmah Nikmatullah Oktadio Erikardo Pardiman Pardiman Pardiman Permatasari, Indriani Detty Pramiswari, Galih Intan Prasetyo, Rachmad Eka Prasetyo, Rachmad Eka Primaning Tyas, Rischa Prisiska, Fahjar Puji Sari Purbasari, Euis Putri, Vera Eselia R, Rizky Arcinthya Rahmadini, Nuriza Rahmat, Amalia Retno Lia Sari Rini Prastiwi Riyanti, Hurip Budi Rizky Arcinthya R Rizky Arcinthya R RIZKY ARCINTHYA RAHMANIA Rizky Rafiqul Rizky, Syahrul Nur Safira, Easy Salim, M. Agus Samiratul Mufidah Saraswati, Ety Sari Nurlaily, Sari Sediarso Sediarso, Sediarso Sejati, Eling Rosa Septiana Tri Pamungkas Shoalihin Shoalihin Siska Siska siska siska Siska Siska siska, siska Siti Asiyah Sopiani, Muhammad Zaki Suharto, M. Khoirul Anwarudin Broto Suja’i, Ahmad Yusuf Imam Supriyanto Supriyanto Suriantika, Cipto Suwandini, Amelian Nisa Syahbandono, Tri Hutomo Syahputra, Hafiz Firdaus Taslim, M. Tri Hutomo Syahbandono Tri Hutomo Syahbandono Ulya, Naylia Fadhilatul Wahyu Hidayati wardani, teja kusuma Wati Sukmawati Wati Sukmawati Wati Sukmawati Wati, Ice Trisna Zamahsari, Mohammad Fikri