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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin JURNAL PENGABDIAN KEPADA MASYARAKAT The Indonesian Biomedical Journal Collaborative Medical Journal (CMJ) Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Andalas obstetrics and gynecology journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Kesehatan Masyarakat Indonesia (JKMI) Jurnal Riset Ilmiah Seroja Husada: Jurnal Kesehatan Masyarakat
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Journal : Jurnal Ilmu Kedokteran (Journal of Medical Science)

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Malignant Peripheral Nerve Sheath Tumor di Regio Bahu yang menyerupai Undifferentiated Carcinoma: Tantangan Diagnostik Handriyani, Fitri Nur; Tofrizal, Tofrizal; Mayorita, Pamelia
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.90-95

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare and aggressive group of neoplasms arising from the peripheral nervous system sheath cells (Schwann cells or perineurial cells). Malignant peripheral nerve sheath tumors are typically seen in patients aged 20–50 years, and the most common sites are the trunk and extremities. This case highlights the diagnostic complexity and distinguishes MPNST from undifferentiated carcinoma. We present a case report of a 59-year-old male patient who presented with a rapidly growing mass in the right shoulder for six months. Clinical examination on his shoulder showed a solid mass, lobulated and ulcerated, and an irregular margin measuring 16x12x5 cm. A thoracic MRI revealed a large mass, fusiform and lobulated, with dimensions of 15.02 x 15.81 x 12.65 cm. The patient underwent surgical incision biopsy of the mass. Histopathological and immunohistochemical examinations with S100 and cytokeratin (CK) markers were performed on this patient with MPNST results. The immunoprofile of MPNST showed focal positive staining for S100 marker and negative staining for CK marker. The diagnosis of malignant peripheral nerve sheath tumor can be more challenging if the histopathological examination resembles a feature of undifferentiated carcinoma, like lobulated pattern and clustering of cells with round-oval nuclei. The role of immunohistochemical examination is very important to rule out differential diagnoses.
Co-Authors Abdiana Abdiana, Abdiana Afdal Afdal Afriani Afriani, Nita Aini, Julpa Nurul Aizah, Havina Nurul Aljassri, Resti Karunia Alvarino Alvarino Amel Yanis Aqilah, Giffary Zahida Ariani, Novita Ariani, Yuliza Arnofyan, Budi Pratama Asri, Ennesta Aswiyanti Asri Aswiyanti Asri Athika Rahmawati Avit Suchitra Azmal, Nita Afriani Cimi Ilmiawati, Cimi Daan Khambri Deddy Saputra Deddy Satriya Putra Desmawati Desmawati Dessy Arisanty Devianti, Loli Djong Hon Tjong Dwi Yanti Fioni Putri Dwisari Dillasamola Elli Firdamila Elmatris Elmatris Elmatris, Elmatris Endrinaldi Ennesta Asri Erkadius Erkadius Eryati Darwin Eryati Darwin Eti Yerizel Fadhilah, Maisarah Fadil Oenzil Fadillah Fadillah Fajriza Yona Fesdia Sari Firdamila, Elli Gardenia Akhyar Gusti Revilla Hafni Bachtiar Handriyani, Fitri Nur Hasmiwati Henny Mulyani henny Mulyani Hera Novianti Hirowati Ali, Hirowati Husna Yetti Husna Yetti Intan, Shinta Ayu Khotimah, Rifqoh Kusumardani, Dini Lubis M Mahata, Liganda Endo Maliza, Rita Mayorita, Pamelia Miftah Irramah Muhammad Idris Muhammad Nazri Janra Mustika Sari Naqia, Masyithah Nelzima, Maisyah Nita Afriani Nofrita Nofrita Novianti, Hera Novita Ariani Noza Hilbertina Noza Hilbertina, Noza Nur Afrinin Syah Nuzulia Irawati O ktora, Meta Zulyati Oktora, Meta Zulyati Putra Santoso Putri Amran, Fajriana Anggun Putri, Biomechy Oktomalio Putri, Nabila Priscilla R. Zuryati Nizar Rahmi Ramadhani Rauza Sukma Rita Restu Susanti Ria Oktavia Ria Oktavia Rina Gustia Rio Hendra Robby Jannatan Rony Rustam Runky Pebranka Rusnita, Dewi RZ Nizar Safnita, Dewi Salmiah Agus Salmiah Agus Salmiah Agus Selfi Renita Rusjdi, Selfi Selly Alinta Syukri Setiawatu, Yessy Sisca Dwi Yarni Siti Nurhajjah SRI LESTARI Sri Lestari Sri Wahyuni Handayani Sri Wahyuni Handayani, Sri Wahyuni Suci Rahmadhani Sukri Rahman Syamel Muhammad Tiffany, Begum Utama, Bobby Indra Yarni, Sisca Dwi Yenita . Yenita Yenita Yenny Raflis Yessy Setiawati Yessy Setiawati Zehan Afifa Yusran Zulfadli Syahrul, Muhammad