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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin JURNAL PENGABDIAN KEPADA MASYARAKAT The Indonesian Biomedical Journal Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Majalah Patologi Indonesia Health and Medical Journal Andalas obstetrics and gynecology journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Kesehatan Masyarakat Indonesia (JKMI) Jurnal Riset Ilmiah Seroja Husada: Jurnal Kesehatan Masyarakat Frontiers on Healthcare Research
Tofrizal
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UPAYA PENINGKATAN PENGETAHUAN ORANG TUA TERHADAP ZINC DAN PEMBERIAN ZINC KEPADA SISWA SD BUSTANUL ULUM PADANG Siti Nurhajjah; Nur Afrinin Syah; Afdal Afdal; Dewi Rusnita; Tofrizal Tofrizal; Dwisari Dillasamola; Desmawati Desmawati
BULETIN ILMIAH NAGARI MEMBANGUN Vol 4 No 1 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i1.288

Abstract

Zinc is an essential micronutrient in the human body as a cofactor of about 300 enzymes. Zinc is very instrumental in the growth process, including maintaining the thymus so that atrophy is not fast. Zinc deficiency can affect the immune system. Zinc deficiency can be caused due to a lack of zinc intake. In theory, many factors affect zinc intake, among others, community knowledge, education, economy, diet, habits, and customs. Lambung Bukit Village is a fostered village of Andalas University. Most people in this village are classified as economically deficient because the community generally farms. The level of public knowledge about zinc is still lacking. This service aims to increase public knowledge of the importance of zinc on body health and the provision of zinc supplements to prevent zinc deficiency and is expected to reduce morbidity and mortality due to infection in children. This activity has been carried out at Bustanul Ulum Elementary School in Batu Busuk Village, Lambung Bukit Village, Pauh District, Padang City. Counseling conducted to 48 people (parents of students and teachers). Almost all parents' knowledge is lacking about zinc, the role, source of zinc, and its relation to several diseases. We hope this counseling can increase public knowledge about the importance of zinc on the body, mainly to prevent susceptibility to infections and any food sources that contain zinc. The results of a health examination by pediatricians found two students suffering from Congenital Heart Disease (CHD), poor oral hygiene, and many teeth carious students. Giving zinc syrup to children aged 7-10 years is expected to prevent zinc deficiency in children.
Correlation between Oxidative Stress with Cartilage Thickness and Catalase Activity in Osteoarthritis Model Rat after MSC-WJ Treatment Endrinaldi Endrinaldi; Rauza Sukma Rita; Tofrizal Tofrizal; Sisca Dwi Yarni
Majalah Kedokteran Andalas Vol 44, No 3 (2021): Online August 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i3.p%p.2021

Abstract

Objective: This study was conducted to investigate the involvement of oxidative damage in rat model of osteoarthritis treated with Mesenchymal Stem Cell Wharton Jelly and to elucidate whether oxidative stress indicators correlate with cartilage damage and catalase activity. Methods: This research is an experimental research with Posttest-Only Control Group Design. The sample consisted of 30 OA rat divided into 5 groups. Group I was the OA rat control group, group II was the OA rat group after 4 weeks, group III was the OA rat group after 8 weeks, group IV was the OA rat group after 4 weeks of treatment with MSC-WJ and group V is the OA rat group after 8 weeks treated with MSC-WJ. Malondialdehyde were measured by Ohkawa method, Cartilage Thickness were measured by using the Betaview program and catalase activity were measured by modification of Shinha.Results: The results showed that the analysis of the Correlation between MDA with Cartilage Thickness (r= – 0.665) and CAT activity (r= – 0.666) in osteoarthritis Model Rat after Mesenchymal Stem Cell Wharton’s Jelly Treatment.Conclusion: This study demonstrated a strong negative correlation between oxidative stress and knee cartilage thickness and catalase activity of MSC-WJ treated OA rats.
PELATIHAN PEMBUATAN KAIN ECOPRINT BAGI KELOMPOK PKK KAMPUNG WISATA BUKIT NOBITA, SUMATRA BARAT Rita Maliza; Tofrizal Tofrizal; Muhammad Nazri Janra; Robby Jannatan; Putra Santoso; Muhammad Idris; Nofrita Nofrita; Fadillah Fadillah
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 29, No 2 (2023): APRIL-JUNI
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkm.v29i2.40929

Abstract

Kain ecoprint pada saat sekarang mengalami masa populer dan memiliki harga ekonomis yang tinggi, bahkan sampai menembus pasar internasional. Pembuatan kain ecoprint dengan mengembangkan keterampilan kain kreatif yang melibatkan pewarna alami dari alam seperti daun, ranting dan bunga merupakan salah satu produk yang mencerminkan karya yang kreatif dan berkarakter cinta lingkungan (ecofriendly). Kegiatan pengabdian ini bertujuan untuk meningkatkan keterampilan dan wawasan Ibu-Ibu PKK kampung wisata Bukit Nobita, Kelurahan Kampung Jua, Padang, dalam memanfaatkan potensi lingkungan yang ada disekitarnya untuk menghasilkan suatu produk/barang yang memiliki potensi ekonomis dan dijadikan salah satu produk kreatif dari kampung wisata bukit nobita nantinya. Metode pelaksanaan pengabdian meliputi beberapa tahap yaitu tahap observasi dan koordinasi, tahap persiapan, tahap pelaksanaan yang terdiri dari empat kegiatan dan tahap evaluasi. Hasil yang didapatkan dari pelatihan, Mitra telah bisa membuat kain batik ecoprint dan sudah memahami tahapan-tahapan pembuatan kain ecoprint. Kegiatan pengabdian ini meningkatkan keberdayaan mitra pada pengetahuan dan keterampilan, kreatifitas yang nantinya bisa digunakan untuk menjadi salah satu usaha atau kegiatan Ibu-Ibu PKK di kampung wisata Bukit Nobita.
Efek Pemberian Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) terhadap Gambaran Histologi Pankreas Hewan Model Diabetes Melitus Tipe 1 Endrinaldi Endrinaldi; Tofrizal Tofrizal; Elmatris Elmatris; Sisca Dwi Yarni
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1704-1711.2024

Abstract

Objective: This study was conducted to determine the effect of administering Mesenchymal Stem Cell Wharton Jelly (MSC-WJ) on the histological appearance of the pancreas of rat in a type 1 diabetes mellitus model. Methods: This research is an experimental research with a Posttest-Only Control Group Design. The sample consisted of 3 groups (Normal, T1DM, T1DM + MSC-WJ). The treatment group was treated with MSC-WJ for 4 weeks. Data analysis used One Way ANOVA and Post Hoc Bonferroni tests. Results: WJ-MSC can increase the mean diameter and area of the islets of Langerhans in the T1DM rat group from 98.08 mm – 126.85 mm and from 4911.95 mm2 – 8995.35 mm2, but this difference is not yet significant (p > 0.05). Conclusion This research shows that there is improvement in pancreatic damage by administering WJ-MSC to diabetic rat due to alloxan induction.
Deteksi crypstosporidium sp. pada pasien dengan kanker kolorektal Sri Wahyuni Handayani; Nuzulia Irawati; Djong Hon Tjong; Tofrizal Tofrizal; Elli Firdamila
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p%p.2023

Abstract

Cryptosporidium sp. adalah parasit obligat intraseluler yang menyerang sel epitel usus. Infeksinya mengakibatkan diare, malnutrisi, dehidrasi dan cedera usus terutama pada orang dengan gangguan imunitas. Tingginya infeksi Cryptosporidium pada pasien HIV-AIDS pada penelitian  sebelumnya menandakan sumber infeksi yang tinggi di lingkungan. Cryptosporidium dilaporkan memiliki hubungan dengan kanker kolorektal baru-baru ini. Tujuan: tujuan penelitian ini adalah untuk mengetahui prevalensi infeksi Cryptosporidium pada pasien dengan kanker kolorektal. Metode: metode yang digunakan observasional dengan desain cross-sectional study pada 43 pasien kanker kolorektal yang sesuai dengan kriteria yaitu pasien yang baru didiagnosis dan belum mendapatkan terapi onkologis. Pengumpulan sampel feses dilakukan dari bulan April hingga Agustus 2023. Pemeriksaan ookista dilakukan secara mikroskopik dengan pewarnaan tahan asam modifikasi ziehl neelsen. Hasil: hasil penelitian didapatkan 46,5% (20/43) pasien positif terinfeksi Cryptosporidium. Kesimpulan: kesimpulan hasil penelitian, infeksi Cryptosporidium tinggi pada pasien kanker kolorektal, terutama pada lokasi kanker rektum. Penelitian lebih lanjut untuk mengetahui spesies Cryptosporidium diperlukan untuk mengetahui  rute penularan dan sumber infeksi.
Hubungan antara Ekspresi Epidermal Growth Factor Receptor (EGFR) dengan Derajat Histopatologik dan Invasi Perineural pada Adenokarsinoma Prostat Ria Oktavia; R. Zuryati Nizar; Yenita; Tofrizal
Majalah Patologi Indonesia Vol. 30 No. 1, Januari 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i1.458

Abstract

ABSTRAKLatar belakangEpidermal Growth Factor Receptor (EGFR) berperan penting pada karsinogenesis beberapa karsinoma termasuk karsinoma prostat.Overekspresi EGFR pada adenokarsinoma menyebabkan sel tumor menjadi resisten terhadap terapi hormonal. Tujuan penelitian iniuntuk mengetahui hubungan antara ekspresi EGFR dengan derajat histopatologik dan invasi perineural pada adenokarsinomaprostat.MetodePenelitian ini merupakan penelitian observasional dengan desain cross sectional dengan sampel penelitian sebanyak 60 kasusadenokarsinoma prostat yang telah didiagnosis di 5 Laboratorium Patologi Anatomik di Sumatera Barat periode Januari 2015 sampaiDesember 2017. Sampel diperoleh dari blok parafin yang berasal dari jaringan hasil operasi transuretral resection of prostat (TURP)dan prostatektomi kemudian dilakukan reevaluasi terhadap derajat histopatologik dan invasi perineural. Ekspresi EGFR pada seltumor dilihat dengan pewarnaan imunohistokimia. Analisis statistik menggunakan uji Chi-Square.HasilEkspresi EGFR positif ditemukan pada 38 kasus (63,33%) dan kasus terbanyak dengan EGFR positif adalah poorly differentiated(57,9%). Kasus adenokarsinoma prostat dengan invasi perineural paling banyak ditemukan dengan ekspresi EGFR positif (42,1%).Analisis statistik menunjukkan terdapat hubungan bermakna antara ekspresi EGFR dengan derajat histopatologik (p=0,003) dan tidakterdapat hubungan yang bermakna antara ekspresi EGFR dengan invasi perineural (p=0,129).KesimpulanTerdapat hubungan yang bermakna antara ekspresi EGFR dengan derajat histopatologik pada adenokarsinoma prostat dan tidakterdapat hubungan antara ekspresi EGFR dengan invasi perineural.
Profil Pasien Lupus Eritematosus Kutaneus di Rumah Sakit Umum Pusat Dr M Djamil Padang Periode 2015 - 2020 Tiffany, Begum; Akhyar, Gardenia; Revilla, Gusti; Asri, Ennesta; Tofrizal, Tofrizal; Afriani, Nita
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 6 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lupus eritematosus kutaneus (LEK) merupakan salah satu dari jenis penyakit lupus eritematosus (LE) yang merupakan penyakit autoimun dengan variasi klinis luas. Walaupun penyebab lupus jenis manapun belum jelas diketahui, salah satu faktor pencetus yang mungkin jadi penyebab penyakit ini adalah faktor hormon, paparan sinar matahari, dan faktor lainnya. Sama seperti lupus eritematosus lainnya, LEK lebih sering terjadi pada wanita usia subur dibandingkan dengan laki laki dengan manifestasi klinis yang muncul di kulit yang dapat dipicu karena paparan sinar matahari. Hal ini ditambah dengan manifestasi klinis lain selain manifestasi pada kulit yang juga muncul, dapat menimbulkan masalah yang mempengaruhi kualitas hidup penderitanya.Tujuan dari penelitian ini adalah untuk mengetahui profil klinis pasien LEK di RSUP Dr M Djamil Padang periode 2015-2020. Populasi dalam penelitian ini adalah seluruh pasien LEK di RSUP Dr M Djamil Padang periode 2015-2020, dengan total 20 data. Data sekunder berupa rekam medis pasien LEK digunakan dalam penelitian ini, dan disajikan dalam bentuk narasi dan tabel distribusi frekuensi.Hasil penelitian ini diperoleh jumlah penderita LEK di Rumah Sakit Umum Pusat Dr M Djamil Padang tahun 2015 - 2020 adalah sebanyak 17 orang penderita LES dan LEK, dan 3 orang penderita LEK saja dari 354 orang penderita LE. Jumlah pasien LEK perempuan jauh lebih banyak dari pasien laki laki. Distribusi kelompok umur terbanyak adalah berusia 15-24 tahun.
Ekspresi Protein Sitoplasmik SOCs2 pada Adenokarsinoma Kolorektal: Studi Imunohistokimia Azmal, Nita Afriani; Intan, Shinta Ayu; Tofrizal, Tofrizal
Jurnal Kesehatan Andalas Vol. 11 No. 1 (2022): Online March 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i1.1982

Abstract

 Inflammatory cytokines have a role in triggering cell signals in colorectal cancer. They increase signaling pathways into cells via the Janus kinase pathway (JAK) - signal transducer and activator of transcription (STAT) -suppressor of cytokine signaling (SOCs) JAK-STAT. SOCs2 protein is a cytoplasmic protein that can inhibit activation of JAK-STAT pathway so that it prevents cascade of signals into the nucleus. This protein is thought to have decreased in adenocarcinoma colorectal. Objectives: To reveal the expression of SOCs2 protein in 37 paraffin block samples in Anatomy Pathology Department Medical Faculty Andalas University. Methods: Data were taken from medical records and histopathology was assessed by HE. SOCs2 expression was evaluated by immunohistochemistry using SOCs2 polyclonal antibody (bs-1896R). Cytoplasmic expression was counted using Image J software. Results: The average of age was 56.57 years, 21 samples (55.8%) were male, depth of invasion was mostly in the tunica muscularis (T3), and 7 cases of malignancy (18.9%) were poorly differentiated. SOCs2 expression was  5 cases (13.5%).   Conclusion: There was SOCs2 expression in a small proportion of colorectal adenocarcinoma.Keywords:  SOCs2 protein, cytoplasmic inhibitor, JAK-STAT, cell signaling
Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer Aizah, Havina Nurul; Yanis, Amel; Ali, Hirowati; Tofrizal, Tofrizal; Ilmiawati, Cimi; Arisanty, Dessy
Jurnal Kesehatan Andalas Vol. 12 No. 1 (2023): Online March 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i1.2140

Abstract

Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability to suppress Amyloid-beta (Aβ) plaques formation. It is found that people with Alzheimer's disease have a lower expression of Sirtuin-1 because of the oxidative stress that was produced by Aβ plaques. Objective: To observe the Sirtuin-1 gene in Alzheimer's disease rat models that AlCl3 was inducing after being given MSC-WJ. Methods: This was an experimental study with a post-test-only control group design, including three groups with a total sample of 18 samples of Alzheimer RNA rat models. Group-1without AlCl3 and MSC-WJ; Group-2 with AlCl3; Group-3 AlCl3 and MSC-WJ. Mean value of the Sirtuin-1 gene was obtained by the Image-J application using a semiquantitative method which was then tested using the One Way ANOVA test. The study was significant if the p-value < 0,05. Results: This study found that the mean ± standard error value of the Sirtuin-1 gene in three groups were 0.18±0.04; 0.16±0.03; and 0.36±0.06 respectively. The statistical test showed a significant difference between the three groups (p = 0.014). Conclusion: There was an increased Sirtuin 1 gene expression in Alzheimer’s rat Model after being given Mesenchymal Stem Cells Wharton’s Jelly.Keywords:  Alzheimer, MSC-WJ, Sirtuin-1
Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer Putri, Nabila Priscilla; Ali, Hirowati; Tofrizal, Tofrizal; Darwin, Eryati; Susanti, Restu; Hasmiwati, Hasmiwati
Jurnal Kesehatan Andalas Vol. 12 No. 2 (2023): Online July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v12i2.2142

Abstract

The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease. Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) is expected to increase the PPAR-γ Gene expression. Objective:  To observed the PPAR-γ Gene expression in Alzheimer's Mice. Methods: The mice are induced using AlCl3 and were given MSC-WJ. This study was an experimental study with a post-test-only control group design on 18 samples of RNA from Alzheimer's mice that were divided into 3 groups. Negative control group (K-), positive control group (K+), and experimented group (P). The mean of PPAR-γ gene expression was obtained by comparing the PPAR-γ gene with the GAPDH gene. This study used semiquantitative methods using ImageJ. Data analysis was used with the Kruskal-Wallis test. It is significant if the value is <0,05. Results: The mean ratio of PPAR-γ gene expression that was obtained in K-, K+, and P were 0.12, 0.06, and 0.08, respectively. There were significant differences between each group, with a p-value of 0,023 (p<0,05). Conclusion: Giving MSC-WJ could increase the PPAR-γ gene expression. Further study using real-time PCR is highly needed to increase the MSC-WJ treatment in patients with Alzheimer's disease.Keywords:  Alzheimer disease, MSC-WJ, PPAR- γ
Co-Authors Abdiana Abdiana, Abdiana Afdal Afdal Afriani Afriani, Nita Aini, Julpa Nurul Aizah, Havina Nurul Aljassri, Resti Karunia Alvarino Alvarino Amel Yanis Aqilah, Giffary Zahida Ariani, Novita Arnofyan, Budi Pratama Asri, Ennesta Aswiyanti Asri Aswiyanti Asri Athika Rahmawati Avit Suchitra Azmal, Nita Afriani Cimi Ilmiawati, Cimi Daan Khambri Daan, Khambri Deddy Saputra Deddy Satriya Putra Desmawati Desmawati Dessy Arisanty Djong Hon Tjong Dolly Irfandy Dwisari Dillasamola Elli Firdamila Elmatris Sy Endrinaldi Ennesta Asri Erkadius Erkadius Eryati Darwin Eryati Darwin Eti Yerizel Fachry Abda El Rahman Fadhilah, Maisarah Fadil Oenzil Fadila, Srigunda Arisya Fadillah Fadillah Fesdia Sari Firdamila, Elli Gardenia Akhyar Gusti Revilla Hafni Bachtiar Handriyani, Fitri Nur Hasmiwati henny Mulyani Henny Mulyani Hera Novianti Hirowati Ali, Hirowati Husna Yetti Intan, Shinta Ayu Kamelia, Muthia Kusumardani, Dini Lubis M Mahata, Liganda Endo Maliza, Rita Mayorita, Pamelia Miftah Irramah Muhammad Idris Muhammad Nazri Janra Mustika Sari Naqia, Masyithah Nita Afriani Nofrita Nofrita Novita Ariani Noza Hilbertina Noza Hilbertina, Noza Noza, Hilbertina Nur Afrinin Syah Nuzulia Irawati Perisnawati, Pemi Putra Santoso Putri Amran, Fajriana Anggun Putri, Biomechy Oktomalio Putri, Nabila Priscilla R. Zuryati Nizar Rahmadian, Rizki Rauza Sukma Rita Raymond, Benni Restu Susanti Ria Oktavia Ria Oktavia Rifqoh Khotimah Rina Gustia Rio Hendra Robby Jannatan Runky Pebranka Rusnita, Dewi RZ Nizar Safnita, Dewi Salmiah Agus Salmiah Agus Salmiah Agus Sari, Rini Purnama Selfi Renita Rusjdi, Selfi Selly Alinta Syukri Sisca Dwi Yarni Siti Nurhajjah Sri Lestari SRI LESTARI Sri Wahyuni Handayani Sri Wahyuni Handayani, Sri Wahyuni Suci Rahmadhani Sukri Rahman Syahrul, Muhammad Zulfadli Syamel Muhammad Tiffany, Begum Utama, Bobby Indra Yarni, Sisca Dwi Yenita . Yenita Yenita Yenny Raflis Yerizal, Eti Yessy Setiawati Yessy Setiawati Zehan Afifa Yusran