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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Majalah Obstetri dan Ginekologi Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Farmasi Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat YARSI Medical Journal Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Abdi Insani Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Jurnal Locus Penelitian dan Pengabdian Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Journal of Clinical Microbiology and Infectious Diseases Jurnal Widya Medika Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Folia Medica Indonesiana
Eko Budi Koendhori, Eko Budi
Departemen Mikrobiologi Fakultas Kedokteran Universitas Airlangga
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Edukasi Resistensi Antimikroba pada Siswa SMA: Upaya Membangun Kesadaran Penggunaan Antibiotik yang Bijak: Upaya Membangun Kesadaran Penggunaan Antibiotik yang Bijak Koendhori, Eko Budi; Dwi Endraswari, Pepy; Kusumaningrum, Deby; Mahmudatul Muna, Nafdzu; Juniastuti, Juniastuti; Wiqoyah, Nurul; Retno Wahyunitisari, Manik; J. Setiabudi, Rebekah; Wiwin Retnowati; Setiawan, Firman; Alimsardjono, Lindawati
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 10 No 3 (2025): Desember
Publisher : Politeknik Negeri Jember

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Abstract

Latar Belakang: Resistensi antimikroba merupakan salah satu ancaman kesehatan global yang dapat meningkatkan angka kesakitan, kematian, dan biaya pelayanan kesehatan. Edukasi tentang penggunaan antibiotik yang bijak perlu diberikan sejak usia sekolah agar siswa dapat menjadi agen perubahan di masyarakat.Tujuan: Meningkatkan pengetahuan siswa SMA mengenai antibiotik dan resistensi antimikroba melalui edukasi interaktif.Metode: Kegiatan dilaksanakan pada 97 siswa SMA Al-Uswah Surabaya dengan metode seminar, diskusi, dan lomba media edukasi (video/poster). Evaluasi dilakukan melalui kuesioner pre-test dan post-test dengan 10 pertanyaan terkait antibiotik dan resistensi antimikroba. Analisis dilakukan dengan menghitung persentase jawaban benar dan peningkatan pengetahuan.Hasil: Rata-rata skor post-test meningkat dibandingkan pre-test. Peningkatan tertinggi pada pertanyaan mekanisme resistensi antibiotik (34,5%), terendah pada pemahaman dasar antibiotik (3,9%). Normalized gain (g=0,44) menunjukkan kategori peningkatan sedang.Kesimpulan: Edukasi interaktif efektif meningkatkan pemahaman siswa tentang resistensi antimikroba. Kegiatan serupa perlu dilanjutkan secara berkelanjutan dan diperluas ke sekolah lain.
CLOVIBACTIN : STUDI LITERATUR ANTIBIOTIK BARU YANG DIHARAPKAN DAPAT MENGATASI RESISTENSI Wulida Nuril Fajriyah; Zamrotul Izzah; Eko Budi Koendhori; Afifah Listiadewi; Melisa Nur Diniah
Jurnal Farmasi Indonesia Vol 22 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v22i2.2717

Abstract

This review discusses about that Clovibactin is a new antibiotic isolated from soil samples in the state of North Carolina. Clovibactin contains eight depsipeptide residues consisting of a macrolactone ring and a linear tail. This antibiotic is active against gram-positive bacteria, including drug-resistant human pathogens such as Methicillin-resistant Staphylococcus aureus, Vancomycin-resistant enterococci, dan Mycobacterium.tuberculosis. This review aims to assess the activity of clovibactin against Mycobacterium tuberculosis. Clovibactin works by inhibiting all cell wall biosynthesis reactions that consume lipid I, lipid II, lipid IIIwall teichoic acid or undecaprenyl-pyrophosphate (C55PP). Clovibactin showed no cytotoxicity to National Institute of Health/3T3 and HepG2 cells in mammals at a dose of 100 µg/mL. Clovibactin has bactericidal properties on gram-positive bacteria. Clovibactin has an MIC of 0.5-1 µg/mL on M.tuberculosis so it has good bactericidal efficacy with low toxicity.
Effectiveness of Black Cumin (Nigella Sativa) Seed Extract as an Antibacterial Agent Against Mycobacterium Tuberculosis Using The Resazurin Microtiter Assay (REMA) Method Laura Freitas Silva Ferreira; Nurul Wiqoyah; Tutik Kusmiati; Eko Budi Koendhori
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 7 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i7.5941

Abstract

Tuberculosis remains a major global health problem caused by Mycobacterium tuberculosis. The rising prevalence of multidrug-resistant tuberculosis and the adverse effects associated with prolonged first-line therapy like rifampicin, highlight the need for alternative or adjunctive treatments. Nigella sativa, a medicinal plant rich in bioactive compounds, has attracted considerable attention because of its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties, which are primarily attributed to its major active compound, thymoquinone. This study aimed to determine the antimicrobial activity and minimum inhibitory concentration of Nigella sativa seed extract against Mycobacterium tuberculosis using the resazurin microtiter assay method. A true experimental study was conducted using the H37Rv strain of Mycobacterium tuberculosis. A methanolic extract of Nigella sativa seeds was prepared using the maceration method. Antibacterial activity was assessed using the resazurin microtiter assay (REMA) after 10 days of incubation. Bacterial growth inhibition was determined through visual observation of resazurin color change and confirmed using a microplate reader at 630 nm. Wells remaining blue indicated inhibition, whereas pink indicated growth. Rifampicin and sterile water were included as positive and negative controls respectively to validate experimental conditions and assay performance consistency throughout the study. Nigella sativa seed extract demonstrated antimicrobial activity with a minimum inhibitory concentration of approximately 0.125 mg/mL (31-62 µg/mL), indicated by the absence of color change and supported by lower absorbance values at 630 nm. Rifampicin showed inhibitory activity at significantly lower concentrations 0.125µg/mL, confirming its higher antimicrobial potency. Nigella sativa seed extract exhibits measurable antibacterial activity against Mycobacterium tuberculosis.
Co-Authors ACHMAD RIFAI Afifah Listiadewi Alimsardjono, Lindawati Alpha Fardah Athiyyah Anak Agung Putri Nadia Paramitha Andy Darma Andy Setiawan Ayu Lidya Paramitha Bagus Meurah Suropati Bambang Purwanto Betty Agustina Tambunan Catur Endra Arky, Catur Endra Cynthia Dwi Ramadhanie Deby Kusumaningrum Dewinta Enggar Pramesthi Dian Neni Naelasari Diani Dwi Indrasari Dimas Firman Hidayat Eddy Bagus Wasito Endraswari, Pepy Evy Ervianti Fikri Sasongko Widyatama Gatut Hardianto, Gatut Hanik Urifah, Hanik Happy, Terza Aflika Harsono, Setio Henky Mohammad Masteryanto Hermanto Tri Joewono Hidayat, Dimas Firman I Gusti Made Reza Gunadi Ranuh Ikhwani, Irfan Arif Imam Susilo Irfan Arif Ikhwani Ismi Masyithah Jayanti Putri, Jayanti Juita, Liza Puspa Senja Asmara Juniastuti Juniastuti Kadariswantiningsih, Ika Kawilarang, Arthur Pohan Khadijah Rizky Sumitro Kuntaman Kuntaman Kusmiati, Tutik Kusumaningrumm, Deby Laura Freitas Silva Ferreira Lestari, Aprilia Dwi Linda Dewanti Lindarto, Wira Widjaya M. Amin M. Amin Mahmudatul Muna, Nafdzu ManikRetno Wahyunitisari Melisa Nur Diniah Mia Rahardjo Muhammad Aafi Baharuddin Attamimi Muna, Nafdzu Mahmudatul Muna, Nafdzu Makhmudatul Ni Made Mertaniasib Ni Made Mertaniasih Ni Njoman Juliasih Nurul Wiqoyah Nurul Wiqoyah, Nurul Nuswantoro, Djohar Paramitha, Ayu Lidya Pepy Dwi Endraswari, Pepy Dwi Priyo Budi Purwono Putri, Naomi Lesmana Raihan Akbar Muhammad Rakhmatul Binti Sulistya Ratna Kusumawati Ratna Kusumawati Ratna Kusumawati Rebekah Setiabudi, Rebekah Retno Wahyunitisari, Manik Rosantia Sarassari S. Soedarsono Sarassari, Rosantia Sardjono, Lindawati Alim Sawitri Sawitri Semita, I Nyoman Setiawan, Firman Setya Wijoyo, Dhia Lintang Setyarini, Wahyu Shazia Hafazhah Aulia Silvia Sutandhio Sri Purwaningsih Steven Christian Susianto Sudarmo, Subijanto Marto Sugeng Harijono, Sugeng Sulistya, Rakhmatul Binti Terza Aflika Happy Titiek Sulistyowati Titiek Sulistyowati Ummi Maimunah Usman Hadi Vermasari, Naritha Wahyu Setyarini Wahyunitisari, Manik Retno Wardhani, Puspa Wiwin Retnowati Wulida Nuril Fajriyah Yelvi Levani Yitijuatni Yuani Setiawati Yudayanti, Elprania Credo Yuliati Hood Zamrotul Izzah