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Empowerment of Health Cadre in Managing Antenatal Class in Tulikup Village, Gianyar-Bali Aryastuti, Sri Agung; Ratna Juwita, Dewa Ayu Putu; Cahyawati, Putu Nita; Witari, Ni Putu Diah; Pradnyawati, Luh Gede
International Journal of Community Service Learning Vol. 4 No. 4 (2020): November 2020
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.348 KB) | DOI: 10.23887/ijcsl.v4i4.22284

Abstract

Lack of public awareness and knowledge of pregnant women in maintaining their health during pregnancy was one of the problem found in Tulikup Village, Gianyar-Bali. The limited number of health workers in Puskesmas has resulted in the lack of information obtained by the community regarding pregnancy, childbirth and the puerperium. Therefore, cadre empowerment programs as a driving force in managing antenatal classes for pregnant women are expected to overcome these problems. This activity was held in  Tulikup Village Hall, and was attended by 6 cadres and 6 pregnant women. The counseling, training and simulation method was used to increase their knowledge and skills about the antenatal class. At the end of the activity, it was found that there was an increase in knowledge regarding the antenatal class. Cadres were able to design an antenatal class, arrange the material that could be given and become a facilitator in activities in it.
The Effect of Pilocarpine Hydrochloride on The Occurrence of Temporal Lobe Epileptic Seizures in White Mice (Mus musculus L.) BALB/C Strain Audria, Intan Safira; Harkitasari, Saktivi; Diah Witari, Ni Putu; Ningrum, Rima Kusuma; Putra Parwati, Tjok Istri; Sumadewi, Komang Trisna; Wiranatha, I Gede; Pratiwi, Cokorda Agung
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.67-72

Abstract

The objective of this research was to determine the effective dosage of pilocarpine hydrochloride to provoke epileptic seizures in animal models. In this study, a true-experimental method was utilized, employing a post-test only control group design. A total of 32 white mice (Mus musculus Linnaeus UICC 524) BALB/c strains were divided into four different groups for this study. The experimental groups were subjected to varying dosages of pilocarpine hydrochloride: 220 mg/kgBW as group I, 320 mg/kgBW as group II, and 350 mg/kgBW as group III. On the other hand, the control group was administered a saline solution (NaCl 0.9%) at a dosage of 0.16% ml/kgBW. Both pilocarpine hydrochloride and saline solution (NaCl 0.9%) were injected intraperitoneally (i.p) into mice. In group I, none of the mice experienced epileptic seizures, and they all survived. In contrast, in group III, all the mice experienced epileptic seizures, but none of them survived. The Man-Whitney Test showed significant differences in seizure occurrence across doses (p<0.01). The effective dose of pilocarpine hydrochloride for inducing epileptic seizures associated with temporal lobe epilepsy (TLE) in this study appears to be in the range of 320 mg/kgBW to 350 mg/kgBW.
Hematology Profiles in Colorectal Cancer Patients in Bali Kurniawati, Ida; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Witari, Ni Putu Diah; Adyasputri, A A I Ayesa Febrinia; Sueta, Made Agus Dwianthara; Sumadewi, Komang Trisna; Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka
Jurnal Ilmiah Kesehatan Vol 18 No 01 (2025): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v18i01.6936

Abstract

Colorectal cancer is a leading cause of cancer-related deaths worldwide. This study explores blood profile and cancer staging in colorectal cancer patients in Bali. It was a descriptive-analytical study that collected demographic and clinical data from medical records of colorectal cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital. The results of the study showed the basic characteristics and hematology profiles of 100 colorectal cancer patients. The average age of patients was 55.6 ± 11.4 years, with 54% of the total sample being male. The average body mass index (BMI) was 21.1 ± 3.6 kg/m², with an average height of 161.9 ± 6.1 cm and an average weight of 55.3 ± 10.0 kg. Laboratory tests revealed an average hemoglobin (Hb) level of 11.0 ± 3.6 g/dL, red blood cell count of 4.0 ± 0.9 million/μL, white blood cell count of 11.2 ± 7.3 thousand/μL, and platelet count of 302.8 ± 154.8 thousand/μL. The average hematocrit (HCT) level was 33.7 ± 6.6 L/L. Liver function parameters indicated average aspartate aminotransferase (AST/SGOT) levels of 45.6 ± 63.6 U/L and alanine aminotransferase (ALT/SGPT) levels of 24.6 ± 29.4 U/L. Renal function was described by an average blood urea nitrogen (BUN) level of 21.8 ± 21.0 mg/dL, urea levels of 21.9 ± 21.2 mg/dL, and creatinine levels of 2.3 ± 11.5 mg/dL. Our study highlights the importance of hematology profiles in colorectal cancer patients as part of cancer screening examination. Further study with a larger number of samples and more diverse populations is needed to analyze the relation between variables.
Female gender and time from injury to surgery as risk factors for decreased knee functions in ACL injury survivors Kurniawati, Ida; Witari, Ni Putu Diah; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Sumadewi, Komang Trisna; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gde
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.247

Abstract

Background: Anterior cruciate ligament (ACL) injuries are serious orthopedic conditions that require long-term recovery and significant costs. This study aimed to assess the risk of decreased knee function among ACL injury survivors in the Indonesian ACL community. Methods: This study used a prospective observational cohort design with a population of all members of the Indonesian ACL community who experienced ACL injury. The primary outcome of this study was a decrease in knee function was measured using the Lysholm knee score. We calculated univariate and multivariate analyses using logistic regression for each variable. Results: The results showed that female gender and time from injury to surgery were significant factors that influenced poor knee function after ACL reconstruction. Women had a significantly higher risk (odd ratio (OR) = 15.28; adjusted OR (AOR) = 23.47; p-value < 0.010). In addition, the time between injury and surgery significantly affected postoperative knee function (AOR = 1.05; p-value = 0.049). Other factors such as age and body mass index did not show significant associations in either univariate or multivariate analyses. Conclusion: This study confirmed that female gender and time from injury to surgery were important factors influencing poor knee function after ACL reconstruction. Timely intervention and focused rehabilitation programs are key steps to improve patient functional outcomes.
THE EFFECT OF SUBTOTAL NEPHRECTOMY PROCEDURE ON THE GLOMERULOSCLEROSIS INDEX Peranawa, I Wayan Yoga Diva; Witari, Ni Putu Diah; Cahyawati, Putu Nita
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4039

Abstract

Background:  Chronic kidney disease is one of the kidney disorders with a steadily increasing incidence rate.Objective: This study aims to determine the effect of subtotal nephrectomy on the renal glomerulosclerosis in Mus musculus L. at 7, 14, and 28 days post-operation. Methods: This true-experimental study with a randomized post-test-only control group design used 16 white mice divided into four treatment groups (SO, SN7, SN14, and SN28). Kidney specimens were stained using Hematoxylin-Eosin and imaged to assess the glomerulosclerosis index. The results were analyzed using one-way ANOVA.Results:  The findings showed that glomerulosclerosis could be observed as early as 7 days post-procedure. The highest score was found in the SN28 group (3.55 ± 0.129). A significant difference was observed between the SO and SN7, SN14, and SN28 groups (p 0.05). Significant differences were also found between the SN7 and SN14 and SN28 groups (p 0.05), while no significant difference was observed between the SN14 and SN28 groups.Conclusions: These results indicate that subtotal nephrectomy can induce glomerulosclerosis as early as day seven post-operation. The highest glomerulosclerosis index was observed on day 28, although statistically, it did not differ significantly from the index on day 14.
PEMBERDAYAAN GURU SEKOLAH DASAR GENTA SARASWATI GIANYAR DALAM MEMPERSIAPKAN PEMBELAJARAN TATAP MUKA DI MASA PANDEMI COVID-19 Aryastuti, Anak Agung Sri Agung; Ratna Juwita, Dewa Ayu Putu; Citra Udiyani, Desak Putu; Diah Witari, Ni Putu; Nita Cahyawati, Putu
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 9 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i9.3523-3529

Abstract

Sekolah Dasar Genta Saraswati Gianyar merupakan sekolah dasar yang baru mendapatkan ijin untuk melaksanakan pembelajaran pada tahun akademik 2021/2022. Untuk melaksanakan pembelajaran tatap muka di masa pandemi, mitra belum mempersiapkan protokol kesehatan secara optimal. Program ini bertujuan untuk mendampingi mitra dalam mempersiapkan protokol kesehatan pembelajaran tatap muka di masa pandemi. Metode yang digunakan antara lain dengan memberikan penyuluhan, mendampingi mitra merancang protokol kesehatan, memberikan sarana pendukung protokol kesehatan, simulasi dan pendampingan. Kegiatan diikuti oleh 11 orang mitra yang terdiri dari tenaga pengajar dan tenaga administratif. Hasil dari program ini adalah tersusunnya protokol kesehatan pembelajaran tatap muka yang telah diterapkan oleh mitra pada tahun ajaran 2021-2022. Selain protokol kesehatan, dihasilkan pula video simulasi penerapan protokol kesehatan pada pembelajaran tatap muka di masa pandemi yang disusun oleh mitra didampingi oleh tim pelaksana. Video telah diunggah di media sosial milik sekolah sebagai salah satu bentuk sosialisasi penerapan protokol kesehatan di sekolah selama masa pandemi. 
Penyuluhan Hipertensi dan Pemanfaatan Lahan Tanaman Pegagan (Centella asiatica) dan Kunyit (Curcuma longa) sebagai Teh Herbal dalam Pengendalian Hipertensi Sumadewi, Komang Trisna; Evayanti, Luh Gede; Witari, Ni Putu Diah
Paradharma: Jurnal Aplikasi IPTEK Vol. 6 No. 2 (2022): Paradharma: Jurnal Aplikasi IPTEK
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Dhyana Pura – Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (691.471 KB) | DOI: 10.36002/jpd.v6i2.2389

Abstract

ABSTRAKHipertensi merupakan salah satu penyakit tidak menular yang menjadi ancaman kesehatan masyarakat karena berpotensi memicu komplikasi seperti serangan jantung, stroke, gagal ginjal bahkan kematian. Kebanyakan orang yang menderita hipertensi tidak menyadari penyakitnya, sehingga hipertensi sering disebut sebagai silent killer. Lansia merupakan kelompok umur yang paling rentan menderita hipertensi. Pengendalian hipertensi seringkali menghadapi masalah seperti rendahnya kepatuhan penderita hipertensi untuk melakukan pengobatan rutin serta gaya hidup yang tidak sehat. Dewasa ini ada banyak penelitian yang mengarah ke pemanfaatan bahan alam untuk tambahan terapi dalam mengendalikan tekanan darah, seperti pegagan (Centella asiatica) dan kunyit (Curcuma longa). Tujuan dari pengabdian masyarakat ini adalah meningkatkan pengetahuan mitra terkait pengendalian hipertensi, sekaligus meningkatkan keterampilan mitra dalam memanfaatkan lahan dan mengolah bahan alami untuk mengendalikan hipertensi. Metode yang digunakan yaitu pendidikan kesehatan melalui focus group discussion, penyuluhan, dialog interaktif, dan pelatihan kepada kader lansia serta lansia di Posbindu Lansia Banjar Batur. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan mitra serta keterampilan dalam memelihara dan mengolah tanaman obat keluarga (TOGA). Pemberdayaan mitra diharapkan dapat meningkatkan peran serta masyarakat dan kesadaran masyarakat dalam usaha pengendalian angka kejadian hipertensi. Sangat penting menggalakkan pemberdayaan masyarakat sebagai kader pemantau dalam mengendalikan hipertensi serta menyebarkan informasi mengenai hipertensi serta pemanfaatan TOGA untuk menurunkan prevalensi hipertensi.Kata kunci: hipertensi, Lansia, Posbindu, TOGAABSTRACTHypertension is one of the non-contagious diseases that pose a threat to public health because it has the potential to trigger complications such as heart attack, strokes, kidney failure, and even death. Most people who suffer from hypertension are unaware of the disease, therefore hypertension is often referred to as the "silent killer". The elderly is the age group most susceptible to hypertension. Hypertension control and treatment often face challenges, including the low compliance of hypertensive patients to take medication regularly as well as an unhealthy lifestyle. Currently, there are many studies that lead to the use of medicinal plants for additional therapy in blood pressure control, such as Gotu kola (Centella asiatica) and turmeric (Curcuma longa). The purpose of this community service is to improve participants’ knowledge of controlling hypertension as well as their skills in using medicinal plants to control hypertension. The methods used included health education through FGD, counseling, interactive dialogue, and training for elderly and elderly cadres at Banjar Batur Posbindu. The results showed that participants' knowledge of hypertension and skills in maintaining and processing medicinal plants have improved. The empowerment is expected to increase community participation and public awareness to reduce the prevalence of hypertension. It isvery important to promote community empowerment in hypertension control and disseminateinformation about hypertension as well as the use of medicinal plants.Keywords: hypertension, elderly, integrated service post, medicinal plants
Optimalisasi Gizi Anak dengan Pemberian Multivitamin, Vitamin A serta Obat Cacing Apsari, Putu Indah Budi; Witari, Ni Putu Diah
Abdimas Mandalika Vol 5, No 1 (2025): November
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/am.v5i1.33765

Abstract

Abstract: Nutritional problems and infectious diseases are still a major challenge for most of the population, especially toddlers and children. One of the most frequently found problems is malnutrition, stunting and worm infections in children, which can affect the quality of life. The purpose of this service is to optimize toddler nutrition by providing multivitamins, vitamin A and worm medicine to toddlers aged 6-60 months, (2) the service method is to provide counseling and training and intervention through providing multivitamins, vitamin A and worm medicine to toddlers aged 6-60 months. (3) The results of this service are that most toddlers have received good nutritional intervention by providing multivitamins, worm medicine and vitamin A. Regular nutritional monitoring is needed to prevent the risk of malnutrition in toddlers.Abstrak: Masalah gizi dan penyakit infeksi, masih menjadi tantangan besar bagi sebagian besar penduduk, terutama balita dan anak-anak dan. Salah satu masalah yang paling sering ditemukan adalah malnutrisi, stunting  serta infeksi cacing pada anak-anak, yang dapat mempengaruhi kualitas hidup. Tujuan pengabdian ini adalah optimalisasi gizi balita dengan memberikan multivitamin, vitamin A serta obat cacing pada balita usia 6-60 bulan, (2) metode pengabdian dengan memberikan penyuluhan serta pelatihan dan intervensi melalui pemberian multivitamin, vitamin A serta obat cacing pada balita usia 6-60 bulan. (3) Hasil pengabdian ini sebagian besar balita undah mendapatkan intervensi gizi yang baik dengan pemberian multivitamin, obat cacing serta vitamin A. dibutuhkan pemantauan gizi berkala untuk mencegah risiko kekurangan gizi pada balita.
Negative Impact of Noise Exposure on the Mean Number of Neurons in the Frontal Lobe of Adult Wistar Rats Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Wijaya, Putu Austin Widyasari; Ekayanti, Ni Wayan Sri; Ekayani, Ni Wayan Diana
Jambura Medical and Health Science Journal Vol 5, No 1 (2026): Jambura Medical and Health Science Journal
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jmhsj.v5i1.32905

Abstract

Introduction: Noise exposure can induce oxidative stress and alter neurotransmitter dynamics within the nervous system. This oxidative stress is also associated with structural changes in the layers of the cerebrum. However, the effects of noise exposure on neuronal populations remain inadequately understood. This study aims to quantify the mean number of neurons in the frontal lobe of Wistar rats subjected to noise exposure.Methods: This study utilized an experimental design characterized by a randomized post-test only control group framework. A total of 30 male Wistar rats were selected through simple random sampling and subsequently divided into two groups: a control group without treatment (C1, n=15) and an experimental group exposed to 95 dB noise (E1, n=15) for four hours daily. Following a two-week exposure period, their brain tissue was excised and preserved in 10% neutral buffered formalin. Histological assessment was conducted using Hematoxylin and Eosin staining to evaluate the mean number of neurons in the frontal lobe. Statistical analysis was performed using the independent T-test.Results: The mean number of neurons was 1053.33 ± 55.529 in the E1 group and 720.167 ± 61.135 in the C1 group. The mean neurons of the frontal lobe of Wistar rats in the E1 group ws lower than the C1 group significantly (P 0.001).Conclusion: Neuronal death in the frontal lobe resulting from noise-induced stress can induce structural alterations within this region, leading to detrimental effects on cognitive function and behavior. Keywords: Frontal lobe, neuron, noise, stress
Correlation of Overexpression of PDL-1 With Lymph Node Metastasis in Penile Carcinoma Witari, Ni Putu Diah; Analysa, Analysa; Lestari, Putu Oki
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1360

Abstract

Background: Penile cancer cases are rarely found, but in the Bali area, the case is higher than in other regions in Indonesia. The death rate of penile cancer is still high, and 80% of cancer deaths are related to metastasis. As immunotherapy in cancer develops, PDL-1 is becoming one of the targets for immune therapies that promise to replace conventional therapies or serve as adjunct therapies. This study aims to see the correlation between the overexpression of PDL-1 and lymph node metastasis, which is one indicator of the poor prognosis of a cancer.Methods: This study used a case-control study design with a retrospective approach. The sample was 70 primary squamous type penile cancer formalin-fixed paraffin-embedded (FFPE) specimens with complete clinical data from several Anatomic Pathology laboratories in Bali, 2015-2023. FFPE sections that were damaged and did not have complete data were excluded. The case is 35 with lymph node metastasis, and 35 without lymph node metastasis as a control. In this study, the correlation between PDL-1 overexpression and tumor grading and lymph node metastasis in penile carcinoma will be explored. Data analysis with Chi-square using SPSS. The p-value for the significance test was less than 0.05. The accuracy of the data is determined by a 95% confidence interval (CI). The research was conducted from February 2024 to August 2024 Results: This study showed a significant correlation between PDL-1 overexpression and lymph node metastasis, p 0.05. There was a significant correlation of PDL-1 overexpression with lymph node metastasis (p = 0.001). There was a correlation between overexpression of PDL-1 and tumor size (p = 0.035), tumor grading (p = 0.027), and lymphatic invasion (p = 0.038). There was no correlation between PDL-1 overexpression with age (P = 0.424)Conclusions: This study demonstrates a significant correlation between PDL-1 overexpression and lymph node metastasis in penile carcinoma patients. Furthermore, PDL-1 overexpression is significantly associated with larger tumor size, higher tumor grade, and lymphatic invasion. These results suggest that PDL-1 serves as a critical prognostic biomarker for predicting disease aggressiveness and metastatic potential.
Co-Authors A A I Ayesa Febrinia Adyasputri A. A. Ayu Asri Prima Dewi A.A. Raka Budayasa A.A.Ayu Asri Prima Dewi Adhitya, I Putu Gde Surya Anak Agung Ayu Asri Prima Dewi Anak Agung Ayu Istri Prima Dewi Anak Agung Istri Aryastuti Anak Agung Sri Agung Aryastuti Analysa, Analysa Anny Eka Pratiwi Apsari, Putu Indah Budi Asri Prima Dewi AA Ayu Asri Prima Dewi, Anak Agung Ayu Astini, Dewa Ayu Agung Alit Suka Audria, Intan Safira Bayuningrat I Gusti Ngurah Made Budhitresna, A.A.G. Cahyawati, Putu Nita Citra Udiyani, Desak Putu Dewa Ayu Agung Alit Suka Astini Dewi, A.A. Ayu Asri Prima Dewi, A.A.Ayu Asri Prima Dewi, Anak Agung Ayu Asri Prima Dwiputra, Made Wahyu Dharma Eka Kartika Sari, Ni Luh Putu Ekayani, Ni Wayan Diana Ekayanti, Ni Wayan Sri Erly Sintya Evayanti, Luh Gede Fransiscus Fiano Anthony Kerans Gusti Ayu Made Landhevi Paramasanthi Hegard Sukmawati, Ni Made I Gede Ananta Widjaksana I Gede Ananta Widjaksana I Gusti Ayu Avinya Chintya Devi I Made Adi Putra Wiguna I Made Adi Putra Wiguna I Putu Gede Eka Ariawan Suyasa I Putu Satyawan Rama Natha I Wayan Sudiarta Ida Kurniawati Ida Kurniawati Ida Kurniawati, Ida K Tangking Widarsa Kadek Ananda Pratama Putra Kadek Ananda Pratama Putra Komang Aditya Yudistira Komang Trisna Sumadewi Komang Triyani Kartinawati Lestari, Putu Oki Luh Gde Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Evayanti Luh Gede Pradnyawati Made Dharmesti Wijaya Ni Kadek Elmy Saniathi Ni Kadek Nadia Ayu Agustini Ni Luh Putu Eka Kartika Sari Ni Luh Putu Putri Ni Nyoman Sunariasih Ni Putu Indah Kusumadewi Riandra Ni Wayan Aurelia Niriswari Darmawan Ni Wayan Aurelia Niriswari Darmawan Ni Wayan Rusni Ni Wayan Widhidewi Nita Cahyawati, Putu Peranawa, I Wayan Yoga Diva Pradnyawati, Luh Gede Pratiwi, Cokorda Agung Prima Dewi, A.A.A Asri Putra Parwati, Tjok Istri Putu Asih Primatanti Ratna Juwita, Dewa Ayu Putu Rima Kusuma Ningrum Saktivi Harkitasari, Saktivi Sri Ratna Dewi Sri Ratna Dewi, Sri Ratna Sueta, Made Agus Dwianthara Suka Astini, Dewa Ayu Agung Alit Sumadewi, Komang Trisna Wangsa, Putu Gde Hari Wijaya, Putu Austin Widyasari Wiranatha, I Gede