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Potensi Aktivitas Antioksidan dan Antibakteri Ekstrak Etanol Daun Kari (Murraya koenigii) terhadap Propionibacterium acnes Nasri, Nasri; Kaban, Vera Estefania; Rani, Zulmai; Suci, Nurul; Ferendina, Imelda; Tania, Chyntia Glori
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.881

Abstract

Indonesia is renowned for its rich natural resources, particularly medicinal plants with significant therapeutic potential. This study examined how the ethanolic extract of curry leaves (Murraya koenigii) can act as an antioxidant and antibacterial agent against Propionibacterium acnes, the primary cause of acne vulgaris. This study used phytochemical screening to identify secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, and glycosides, which are associated with biological activities such as killing bacteria and protecting cells from damage. The DPPH method for testing antioxidants showed that the extract had an IC50 value of 45.88 mg/L, which is not significantly different from quercetin as a reference, at 23.7 mg/L. This result is still significant for the strong antioxidant category. We assessed antibacterial efficiency using a disc diffusion technique, which showed a zone of inhibition corresponding to the extract concentration. The widest zone of inhibition, measuring 17.77 ± 0.15 mm, was recorded at a concentration of 250 mg/mL, classifying its activity as strong by existing standards. These findings underscore the extract's promise as a natural acne therapy, addressing bacterial growth and oxidative stress. Furthermore, these results support the development of safe and efficacious pharmaceutical or cosmetic products derived from natural components. Future investigations should examine synergistic formulations and enhance bioavailability to optimize therapeutic outcomes.
Penerapan Senam Lansia untuk Mengontrol Kadar Kolesterol Di Posyandu Marsudi Waras RW 12 Kota Surakarta Kardi, Ipa Sari; Widarti, Rini; Nasri, Nasri
Prosiding University Research Colloquium Proceeding of The 11th University Research Colloquium 2020: Bidang Pengabdian Masyarakat
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang:Meningkatnya usia harapan hidup berdampak pada lonjakan jumlah lansia. Data menunjukkan bahwa usia mempengaruhi tingkat kadar kolesterol dalam darah. Oleh karenanya, perlu dilakukan tindakan untuk mengontrol kadar kolesterol lansia dengan rutin melakukan aktivitas fisik atau olahraga. Metode: Metode yang digunakan dalam pengabdian masyarakat ini yaitu promotif melalui penyuluhan dan preventif melalui penerapan senam lansia. Kegiatan dilaksanakan di Posyandu Lansia Marsudi Waras RW 12 Jebres Kota Surakarta dengan jumlah 40 lansia. Hasil: hasil pemeriksaan kolesterol diperoleh data sebanyak 55% (22 orang) lansia dengan kadar kolesterol normal, 35% (14 orang) lansia dengan kadar kolesterol batas tinggi dan 10% (4 orang) lansia dengan kadar kolesterol tinggi. Berdasarkan hasil yang diperoleh disimpulkan bahwa penerapan senam lansia akan rutin dilaksanakan untuk mengontrol kadar kolesterol lansia, khususnya bagi yang telah memiliki kadar kolesterol tinggi.
Pengaruh gel ekstrak induk kunyit (Curcuma longa linn) terhadap penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Kaban, Vera Estefania; Nasri, Nasri; Rani, Zulmai; Suci, Nurul; Karo Sekali, Elva Swandi; Sagala, Hasel Untung Bersinar
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.590

Abstract

One plant that has been shown to aid wound healing is turmeric. Turmeric has been scientifically proven to have choleretic and anti-inflammatory properties. Turmeric contains curcumin, which has antibacterial and antioxidant qualities that can accelerate the migration and re-epithelialization of cells useful in wound healing, including myofibroblasts, fibroblasts, and macrophages. This study aimed to determine the effect of turmeric mother extract gel on wound healing in male white rats (Rattus norvegicus). This study was conducted using experimental tests. Turmeric extract was prepared using 96% ethanol solvent with a maceration process. A 2 cm long incision wound was made on the back of white rats. The test animals were then divided into five groups to receive different treatments. Groups 3, 4, and 5 received turmeric mother extract gel with concentrations of 1%, 5%, and 10%, while Group 1 was negative control and Group 2 was positive control. The results showed that the incision wounds in male white rats could heal faster - on average, about 7.10 days - when treated with 96% ethanol extract of turmeric mother with doses of 1%, 5%, and 10%. This study concludes that a 10% turmeric mother extract gel is the best method to accelerate wound healing.
The value of the Wallacea Region: Considerations behind the changing scope of JPK Wallacea Ngakan, Putu Oka; Nasri, Nasri; Putra, Putu Supadma
Jurnal Penelitian Kehutanan Wallacea Vol. 12 No. 1 (2023)
Publisher : Foresty Faculty of Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.108 KB) | DOI: 10.24259/jpkwallacea.v12i1.26952

Abstract

The Editorial Board has issued this editorial note in the form of a review to inform contributors about changes to the scope of the Journal of Wallacea Forestry Research (JPK Wallacea) following the transfer of management from Balai Penerapan Instrumen Lingkungan Hidup dan Kehutanan Makassar to Hasanuddin University's Forest Conservation Study Program in 2023. JPK Wallacea is no longer limiting its scope to forestry and is expanded to cover biodiversity in general by incorporating the term Wallaceae, which is a biogeographical area located between the continents of Asia and Australia. This area is well known for its unique biodiversity both on land and in water. The Wallacea region's biodiversity is famed for its distinctiveness yet, it is on the verge of extinction. Thus, the Editorial Board chose to focus on the scope of JPK Wallacea on scientific, technological, and policy conservation features. This scientific publication is expected to make a substantial contribution to the biodiversity conservation effort in the Wallacea region and its surroundings.
Antidiarrheal Effect of Lactobacillus fermentum Isolated from Dengke Naniura on Escherichia coli-induced Rats Nasri, Nasri; Harahap, Urip; Silalahi, Jansen; Satria, Denny
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i1.6478

Abstract

Diarrhea is discharge of abnormal and liquid stool with a frequency of 3-4 daily which caused by pathogenic organisms such as Escherichia coli, and other. Dengke Naniura is a traditional Batak Toba food that can produce probiotics (Lactobacillus fermentum). Probiotics are defined as live microorganisms that confer a health benefit on the host. Nutritional supplements combined between probiotics and prebiotics are called synbiotics, The purpose of this study was to analyze the preventive effect of diarrhea in rats given L.fermentum for 21 days. The preventive effect of diarrhea test begins with the giving of L.fermentum from day 1 to day 21. From day 7 to day 14 rats were induced with E.coli. Weight of the rats, stool consistency, onset of diarrhea, frequency of diarrhea, and duration of diarrhea were observed. The results of the observation that weight of rats in the L.fermentum group increased compared to group 1 (p<0.05). Consistency stool is soft (massless). Onset of diarrhea on day 1 after induced of E.coli in the group 1. Frequency of diarrhea increased to 9.25 ± 0.50 times on day 14 (group 1). And diarrhea occurs for 10 days. Conclusion L.fermentum showed a preventive effect of diarrhea in rats induced E.coli.
Antibacterial Activity Test of Malacca Leaf Extract (Phyllanthus emblica) Against Staphylococcus aureus and Staphylococcus epidermidis Bacteria Ridwanto, Ridwanto; Aprilia, Hijjatun; Rani, Zulmai; Putri Aisyia Fauzi, Ziza; Kaban, Vera Estefania; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i1.17912

Abstract

Antibacterials are substances that can interfere with the growth or even kill bacteria and have the side effect of antibacterial resistance. One effort to reduce resistance is choosing to use natural bacterial ingredients. One plant that can potentially contain antibacterial activity is malacca leaves (Phyllanthus emblica). The contents of this plant include flavonoids, alkaloids, tannins, saponins, and steroids/triterpenoids. This research aimed to prove the antibacterial activity test of malacca leaf extract. The stages in this research included phytochemical screening and testing the antibacterial activity of ethanol extract from Malacca leaves for Staphylococcus aureus and Staphylococcus epidermidis bacteria using the diffusion method using paper discs. The characteristics of malacca leaf simplicia obtained were water content of 4.6%, water-soluble content of 28%, ethanol-soluble essence content of 23.33%, total ash content of 2.00%, and insoluble ash content of 0.5%. The results of phytochemical screening showed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The antibacterial test results of malacca leaf extract at concentrations of 500 mg/ml, 400 mg/ml, 300 mg/ml, and 200 mg/ml have an antibacterial effect against Staphylococcus aureus and Staphylococcus epidermidis, and there is no difference in the effectiveness of the inhibitor against gram-positive and negative grams.
Pengembangan Formulasi Krim Pelembab Kulit Berbasis Ekstrak Sari Buah Mangga (Mangifera indica L.): Pendekatan Fungsional dan Kosmetika Alami Suci, Nurul; Khairunnisa, Lia; Nasri, Nasri; Kaban, Vera Estefania
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 7 No. 2 (2024): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v7i2.18220

Abstract

This study aimed to develop a formulation of mango fruit juice (Mangifera indica L.) as a moisturizing agent in the form of hand cream. The main component of mango, sucrose, has the ability to attract moisture from the air due to its hydroxyl groups, which helps reduce water evaporation from the skin. Mango juice was obtained by blending the mango pulp using a juicer, followed by the addition of 0.1% sodium metabisulfite as an antioxidant. The extract was then concentrated using a freeze-drying technique at -40°C and 2 atm pressure. The cream formulation developed was an oil-in-water (m/a) emulsion type, with mango fruit juice concentrations of 2.5%, 5%, 7.5%, and 10%. These were compared to cream containing 2% glycerin and a blank formulation. Various tests were conducted to evaluate the physical quality of the cream, including homogeneity, pH, stability, emulsion type, and irritation tests using a moisture-checker. The results showed that mango fruit juice was successfully formulated into a homogeneous m/a cream, with a pH ranging from 5.55 to 7.04, and remained stable for up to 12 weeks of storage. The cream formulated with mango juice was proven to increase skin moisture without causing irritation. The higher the concentration of mango fruit juice, the greater the moisturizing effect. The 2.5% concentration provided a moisturizing effect comparable to cream containing 2% glycerin. The best moisturizing effect was achieved at a 10% concentration, which increased skin moisture by up to 14.4% after 4 weeks of use. This mango juice is effectively used in m/a type creams as a skin moisturizer. Keyword: Mango fruit juice, cream, skin moisturizer
How Climate Change Disrupts Mango Phenology and Affects Fruit Production Hamzah, Andi Siady; Ngakan, Putu Oka; Kaimuddin, Kaimuddin; Nasri, Nasri; Putra, Putu Supadma; Mas'ud, Wardiman
Jurnal Penelitian Kehutanan Wallacea Vol. 14 No. 2 (2025)
Publisher : Foresty Faculty of Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24259/jpkwallacea.v14i2.47504

Abstract

Climatic elements are limiting factors for plants; therefore, climate change can impact the phenology of plants. This study aims to determine the impact of climate change on the reproductive phenology of four local mango cultivars on Sulawesi Island, Indonesia. Data were collected during 2013 and 2014 by observing and recording the production of vegetative shoots, generative shoots, and fruits from the trees of each mango cultivar weekly. To assess the impact of seasonal change on fruit quality, the weight and sugar level of the ripe fruits in each cultivar were measured. Climate data were obtained from the National Centers for Environmental Prediction and the Indonesian Agency for Meteorology, Climatology, and Geophysics Region IV, Makassar. Results show that from 1979 until 2014, the climate in the study site changed from type D to type C according to the Schmidt-Ferguson Climate Classification method, indicating that the wet season became longer. Following climate change, the reproductive phenology of the four mango cultivars also changed from once to twice annually, whereby the flush of vegetative and reproductive shoots that appeared during the first period in March did not successfully develop into mature fruit but developed following the second period in July. The change of season also impacted the quality of the mangoes, as fruit produced during the longer dry season had higher sugar levels than those produced during the shorter dry season.
PROTOTYPE ALAT PENDETEKSI GAS BERBAHAYA DI KAMAR MESIN UNTUK MENJAGA KESELAMATAN ABK BERBASIS WEMOS D1 DI KAPAL MT PLAJU Purnama Dewi, Nanda; Nasri, Nasri; Purwanto, Sigit; Retno Gunarti, Monika; Dai Robbi, Shofa
SIBATIK JOURNAL: Jurnal Ilmiah Bidang Sosial, Ekonomi, Budaya, Teknologi, Dan Pendidikan Vol. 5 No. 1 (2025)
Publisher : Penerbit Lafadz Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54443/sibatik.v5i1.4194

Abstract

Enclosed spaces in ship engine rooms pose significant risks due to toxic gas accumulation like carbon monoxide and carbon dioxide, contributing to maritime fatalities. This research aimed to develop a Wemos D1-based prototype for real-time hazardous gas detection to enhance crew safety on MT Plaju tanker. Experimental prototype development employed ADDIE model with static and dynamic testing on MQ-135 sensor, buzzer, LED, and WiFi web monitoring. Population comprised four main holes (A-D) in engine room enclosed spaces, sampled through 20 measurements during 12-month sea practice. Instruments included Arduino IDE for programming and Excel for regression linear analysis with <5% calibration error. Results showed average CO detection at 5.4 ppm and CO2 at 406 ppm, with alarm response under 6 seconds exceeding 30% threshold, achieving 95% accuracy in high humidity and vibration conditions. The prototype demonstrated superior WiFi connectivity over previous ATMega328P systems, reducing hazard zones by 40%. In conclusion, this cost-effective IoT solution validates hardware reliability for Indonesian maritime operations, recommending multi-gas sensor integration for industrial scaling.
Texture-Modified Diets and Practical Swallowing Interventions in Head and Neck Cancer Patients with Dysphagia: A Narrative Review Tania, Chyntia Glori; Nasri, Nasri
Majalah Kesehatan Indonesia Vol. 7 No. 1 (2026)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2026281

Abstract

Dysphagia is one of the most prevalent and persistent complications in patients with head and neck cancer (HNC), particularly nasopharyngeal carcinoma (NPC), with a reported prevalence of 45–83%. This narrative review aimed to synthesize recent evidence (2015–2025) on the effectiveness of texture-modified diets and swallowing therapies in improving nutritional intake, swallowing safety, and quality of life in HNC patients. Literature searches were performed systematically through PubMed, Scopus, Web of Science, Google Scholar, and Dimensions using predefined inclusion and exclusion criteria, resulting in 12 eligible articles for analysis. The findings showed that dysphagia significantly contributes to malnutrition, aspiration risk, prolonged hospitalization, reduced treatment adherence, and decreased survival. Interventions such as diets guided by the International Dysphagia Diet Standardisation Initiative (IDDSI), personalized nutritional strategies, and structured swallowing therapies demonstrated beneficial outcomes in reducing aspiration, maintaining oral intake, and improving clinical prognosis. In addition to synthesizing clinical outcomes, this review provides a theoretical contribution by framing dysphagia management as a multidisciplinary process that integrates nutritional science, swallowing physiology, and rehabilitative practice. Preventive swallowing exercises during radiotherapy and multidisciplinary management further enhanced long-term outcomes. The synthesis highlights the necessity of integrating nutrition and swallowing rehabilitation into routine oncology practice, with particular implications for healthcare facilities with limited resources where IDDSI adoption and preventive therapy remain underutilized. Future studies should prioritize high-quality randomized controlled trials, particularly in NPC populations, to validate intervention protocols and standardize best practices. This review contributes to bridging evidence with clinical application, providing a framework for safer and more effective patient-centered care.
Co-Authors Abdur Rahman Arif, Abdur Rahman Absori Absori Adnan, Naufal Agastya, Ida Bagus Oka Ali, Muhammad Farhan Aminah Dalimunthe Amran Achmad Andriani Andriani Apdian, Donny Aprilia, Hijjatun Ari Sapti Mei Leni Arif, Dian Adhetya Arif Aristiyanto, Aristiyanto Aslamiah Aslamiah Asrianny Asrianny, Asrianny Awalludin, Dudi B.K, Felicia A. Stevanie Bakhri, Asep Samsul Barbyanavy, Dinda Ayu Chania, Lady Cinantya, Celia Cintya, Henni Dai Robbi, Shofa Denny Satria, Denny Dewi, Anies Prima Dinda Sari Utami Dwilaksana, Chryshnanda Dwiyani, Risye Edi Yanto, Edi Effendy De Lux Putra, Effendy De Lux Ferendina, Imelda Fithri Pulungan, Ainil Gabena Indrayani Dalimunthe Gunarti, Monika Retno Hamzah, Andi Siady Handika, Handika Haq, Hilman Syahrial Haris Munandar Nasution Haro, Ginda Herdinata, Guntur Ratih Prestifa Hussin, Syaryanti Ibrahim Ibrahim Ichsansyah, Ananta IMAWANTO, IMAWANTO Imran, Herry Ipa Sari Kardi Jansen Silalahi Jayawiguna, Rukmanta Kaimuddin Kaimuddin, Kaimuddin Karo Sekali, Elva Swandi Keumala, Cut Ratna Khairunnisa, Lia Khatimah, Khusnul Khudzaifah Dimyati Koesharyadi, Arif Kusumawati, Elly LATIF, MUH. WAHYUDIN Lorenta, Hasiana Lubis, Minda Sari lubis, muhammad fauzan Mas'ud, Wardiman Mochammad Imron Awalludin Muhammad Nur Muhammad Syahroni Munajat Nursaputra, Munajat Mutmainnah, Aisyah Niakurniawati, Niakurniawati Nilawati, Ika Nopiyanto, yahya eko Nugroho, Azis Nur Amin, Nur Nur Islami, Ina Prihati Nurqalbi, Maftukha Nuzul Wilda, Nuzul Pakpahan, Gita Asima E. Pintauli, Sondang Pramana, Didig Prawoto, Agus Purnama Dewi, Nanda Putra, Putu Supadma Putu Oka Ngakan Rachman, M. Taufik Rahman Nur, Abdul RAHMAT GUNAWAN Rahmi, Alfia Raisah Hayati Ramayanto, Ramayanto Ratna Keumala, Cut Ratna Ratna Ratna Wilis Retno Gunarti, Monika Rexi, Daniel Ridwanto Ridwanto Rinaldi, Nasrullah Rini Widarti Risma Illa Maulany Robbi , Shofa Dai Robbi, Shofa Dai Rosnita, Windha Rusda, Rusda Sagala, Hasel Untung Bersinar Salmi, Salmi Santoso, Muzi Saprudin Saprudin, Saprudin Sarudi, Sarudi Sefira, Inka Setiawan, Fredy Eko Sigit Purwanto Sitanggang, Sarah Novia S. Siti Morin Sinaga Suci, Nurul Suhati, Fadly Sulistiyana, Sulistiyana Supryadi, Ady Sutrisno, Sutrisno Syahdar, Fardi Ali Syahputra, Hariyadi Dharmawan Tania, Chyntia Glori TITAWATI, TITIN Urip Harahap Vera Estefania Kaban Wardana, Gusde Wardono, Sri Wicaksono, Maulana Tegar Yudiana, Yudiana Yudianto, Prima Yudha Yuliani, Tin Yuniarti, Rafita Yusr, Daffa Izaz Rafi Afif Fauzi Zakiah Drajat, Ulfah Ziza Putri Aisyia Fauzi Zulmai Rani