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OPTIMIZED HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF ARTIFICIAL SWEETENERS, PRESERVATIVES, AND CAFFEINE IN CARBONATED SOFT DRINKS Wardono, Sri; Putra, Effendy De Lux; Sinaga, Siti Morin; Dalimunthe, Aminah; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20975

Abstract

Sweeteners, preservatives, and caffeine in soft drinks can pose health risks if consumed excessively. This study aimed to develop a method for the simultaneous determination of acesulfame, saccharin, cyclamate, aspartame, caffeine, benzoate, and sorbate in carbonated soft drinks. The analysis was conducted using reversed-phase high-performance liquid chromatography (RP-HPLC) with a dual-wavelength PDA detector (Shimadzu LC-20AD), a C18 column (Shimadzu), and a UV-Vis spectrophotometer (Shimadzu). Standard materials included acesulfame-K, saccharin-Na, cyclamate-Na, aspartame, caffeine, benzoate-Na, and sorbic acid. Samples were obtained from a supermarket in Medan, Indonesia. Optimization parameters included detection wavelength, mobile phase pH, column oven temperature, and mobile phase composition. Validation parameters assessed were linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and selectivity. The optimized method employed a mobile phase of phosphate buffer (pH 3.8) and methanol (80:20, v/v) at a flow rate of 0.55 mL/min and column oven temperature of 40 °C. Detection was carried out at 200 nm for cyclamate, caffeine, aspartame, and benzoate, and at 220 nm for acesulfame, saccharin, and sorbate. Validation results showed the method met all requirements, with recovery rates ranging from 95.21% to 99.82%, system suitability values of 1.0%–1.9%, and precision values between 1.65% and 2.48%. The method also demonstrated good selectivity. The concentrations of acesulfame, saccharin, cyclamate, caffeine, benzoate, and sorbate in the analyzed samples did not exceed the maximum permissible limits.
Upaya Pencegahan Karies Gigi Pada Anak Usia Sekolah Dasar Kelas V Di SD Bineh Krueng Kabupaten Aceh Barat Daya Nuzul Wilda, Nuzul; Keumala, Cut Ratna; Nasri, Nasri
NASUWAKES: Jurnal Kesehatan Ilmiah Vol. 15 No. 2 (2022): September
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/nasuwakes.v15i2.445

Abstract

Sistem pelayanan kesehatan merupakam bagian penting dalam meningkatkan derajat kesehatan. Keberhasilan sistem pelayanan kesehatan tergantung dari berbagai komponen diantaranya perawat, dokter, atau tim kesehatan lainnya. Anak usia sekolah salah merupakan salah satu kelompok yang rentan terhadap karies, karena umunya masih mempunyai pengetahuan dan perilaku yang kurang terhadap karies gigi pada masa ini anak mulai belajar memperhatikan perilaku hidup dari lingkungan sekitar mulai berinteraksi dengan banyak teman, mengenal dan meniru apa yang dilihat, dampaknya dapat berakibat menguntungkan atau merugikan bagi kesehatan gigi. Penelitian ini bertujuan untuk mengatahui “Upaya Pencegahan Karies Gigi Pada Anak Usia Sekolah Dasar Kelas V di SD Bineh Krueng Kabupaten Abdya Tahun 2019” Penelitian ini dilakukan dengan metode deskriptif pada tanggal 15-18 juli 2019 populasinya adalah seluruh murid sekolah dasar kelas V SD Bineh Krueng berjumlah 90 orang dan sampelnya berjumlah 30 orang secara judgment sampling. Hasil penelitian menunjukan bahwa dari 30 responden yang paling banyak kategori kurang berjumlah 23 orang (76,7%) dan kategori baik berjumlah 7 orang (23,3%). Berdasarkan hasil penelitian dapat disimpulkan bahwa banyak murid berkriteria kurang sehingga perlu peningkatan pendidikan kesehatan gigi kepada anak anak sd tersebut dengan diadakan nya penyuluhan melalui program UKGS sehingga dapat menurunkan angka karies gigi pada anak sekolah dasar.
Analisa Dan Perancangan Sistem Informasi Pemesanan Tiket Bus Berbasis Web Pada Agen Bus Hiba Utama Klari Di Kabupaten Karawang Gunawan, Rahmat; Santoso, Muzi; Bakhri, Asep Samsul; Yudiana, Yudiana; Nasri, Nasri; Awalludin, Dudi
Jurnal Interkom: Jurnal Publikasi Ilmiah Bidang Teknologi Informasi dan Komunikasi Vol. 20 No. 1 (2025): Jurnal Interkom: Jurnal Publikasi Ilmiah Bidang Teknologi Informasi dan Komuni
Publisher : LPPM STMIK Rosma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35969/interkom.v20i1.437

Abstract

Kemajuan teknologi komputerisasi dan telekomunikasi telah mengubah budaya sehari-hari. Internet adalah salah satu media informasi yang digunakan di era yang sangat berkembang ini untuk komunikasi dan bisnis. Saat ini, calon penumpang harus datang langsung ke lokasi untuk membeli dan memesan tiket melalui metode pemesanan tiket bus tradisional. Calon penumpang sering bersusah payah untuk mendapatkan tiket pada periode tertentu, karena jarak dan keterbatasan waktu untuk datang langsung ke Agen Bus Malam Hiba Utama Klari. Agen bus malam Hiba Utama Klari didirikan pada tahun 2016 oleh Edi dengan satu jurusan, yaitu Klari-Wonosobo, bekerja sama dengan PO.Hiba Utama untuk membuka layanan pemesanan tiket bus malam. Pada tahun 2018, jurusan baru yaitu Karawang-Yogyakarta-Jombor dibuka, bekerja sama dengan PO.Hiba Utama lainnya. Agen bus ini semakin berkembang setiap tahun. Model Waterfall dipilih dalam penelitian ini. Aplikasi dibuat menggunakan bahasa pemrograman PHP dan database MySQL, dan sistem dirancang menggunakan notasi Unified Modelling Language (UML). Sistem pemesanan dan pembayaran tiket bus berbasis web adalah hasil dari penelitian ini.
Computational Study of E-Compound from the Vitex Family as Novel Potential Anti-Alzheimer Agents: An in Silico Study Syahputra, Hariyadi Dharmawan; Nasri, Nasri; Kaban, Vera Estefania
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.93

Abstract

The degenerative disease of memory that most attacks the frontal lobe is Alzheimer's. Therapy for Alzheimer's is mostly done by targeting an increase in the amount of acetylcholinesterase in the synapse cleft by inhibiting the enzyme acetylcholinesterase. The purpose of this study is to conduct a comparative study of vitexifolin E compounds from the vitexium plant family with donepezil to obtain more precise and targeted drug candidates in Alzheimer's therapy. The results showed that donepezil compounds have a more active probability (0.53) of being carcinogenic compared to vitexifolin E with the web-based application Protox II. Tests with in silico studies found that the hydrogen bonding results of vitexifolin E had values close to those of donepezil drugs, as well as RMSD results with receptors between donepezil and vitexifolin E (1,781; 1,281) and free energy obtained (-6.9; -7.8). Based on these results, it can be concluded that vitexifolin E compounds can have good enough potential to be developed in implementing the treatment of Alzheimer's disease therapy.
Implementation of the Total Quality Management Model to Support the Work Quality Culture at SMAN 1 Kelumpang Utara Rusda, Rusda; Lorenta, Hasiana; Nasri, Nasri; Aslamiah, Aslamiah; Cinantya, Celia
Eduvest - Journal of Universal Studies Vol. 5 No. 9 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i9.52101

Abstract

The implementation of an effective quality management system is essential in improving the quality of education in high school. This study aims to illustrate the implementation of the Total Quality Management (TQM) model in supporting the work quality culture at SMAN 1 Kelumpang Utara. This study uses a qualitative approach with a case study method. In-depth interviews, participant observations, and documentation were carried out on the principal, 15 teachers, 3 staff, 1 head of sub-division, and 15 students. The data was analyzed using the Miles and Huberman Models, which include data collection, data reduction, data presentation, and verification. The findings show that TQM has been implemented at SMAN 1 Kelumpang Utara with an emphasis on creating consistency of goals, improving the quality of graduates and services, improving the quality and productivity of school stakeholders, leadership in education, eliminating fear and obstacles to success, creating a culture of quality, process improvement, helping students succeed, commitment, and responsibility. However, there are still obstacles in the total involvement of all school members and continuous improvement. A TQM implementation model is necessary to support a quality work culture that involves staff engagement, leadership, partnerships, reward systems, and organizational quality. These components must be based on a system of values, norms, and culture formulated in a vision, mission, and goals that are understood by all members of the organization.
Evaluation of Curriculum Development with the CIPP Approach in the Context of Improving the Quality of Education at SMAN 1 Kelumpang Utara Rusda, Rusda; Nasri, Nasri; Sutrisno, Sutrisno; Sulistiyana, Sulistiyana
Journal of English Language and Education Vol 10, No 4 (2025)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jele.v10i4.1134

Abstract

This study is grounded in the importance of curriculum development in improving the quality of education at the secondary school level. An adaptive curriculum that aligns with the needs of both students and the wider community is expected to foster the optimal achievement of educational goals. This research employs a qualitative descriptive approach, with data collected through interviews, observations, and documentation. Data analysis followed the stages of reduction, presentation, and conclusion drawing to provide an in-depth understanding of the curriculum development process at SMAN 1 Kelumpang Utara. The findings reveal that curriculum development at SMAN 1 Kelumpang Utara has been implemented in accordance with established procedures, particularly in the aspects of planning, implementation, and evaluation. The results align with the CIPP model of curriculum evaluation, which emphasizes the integration of context, input, process, and product. Nevertheless, challenges remain, particularly the limited involvement of teachers and the community in each stage, indicating that the principle of relevance to learners’ and environmental needs has not been fully realized. Overall, the developed curriculum has contributed positively to educational quality, yet it still requires strengthened coordination, collaboration, and continuous adaptation to both national policy dynamics and local needs.
Pengaruh Kebocoran Sistem Pendingin pada Seating Exhaust Valve Cylinder No 1 terhadap Kinerja Diesel Engine Generator di KM. Oriental Galaxy Yusr, Daffa Izaz Rafi Afif Fauzi; Nasri, Nasri; Kusumawati, Elly; Prawoto, Agus; Nugroho, Azis; Robbi , Shofa Dai
J-Proteksion: Jurnal Kajian Ilmiah dan Teknologi Teknik Mesin Vol. 10 No. 1 (2025): J-Proteksion
Publisher : Universitas Muhammadiyah Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32528/jp.v10i1.3609

Abstract

Diesel engine generator merupakan permesinan yang mengubah tenaga mekanik menjadi energi listrik di atas kapal. Dalam pengoperasian generator, mesin didukung dengan sistem pendingin air tawar yang bersirkulasi agar mesin tidak menimbulkan panas yang berlebih. Pendingin air tawar ini mendinginkan komponen-komponen generator yang bergerak dan menimbulkan panas. Air tawar masuk melalui cylinder head pada seating exhaust valve untuk mendinginkan exhaust valve yang bekerja disuhu tinggi dikarenakan dari gas buang pembakaran. Kerusakan pada seating exhaust valve akan menimbulkan pengaruh besar bagi kinerja diesel engine generator. Penelitian ini membahas pengaruh kebocoran serta langkah penanganan pada seating exhaust valve generator cylinder nomor 1 di KM. Oriental Galaxy. Penelitian menggunakan metode kualitatif dengan fishbone analysis serta proses pengambilan data dilakukan dengan dokumentasi, wawancara, dan observasi. Hasil penelitian menunjukkan bahwa kebocoran sistem pendingin seating exhaust valve generator cylinder nomor 1 disebabkan oleh beberapa faktor seperti jam operasional yang melebihi dari panduan manual book dan minimnya perawatan pada mesin diesel generator. Faktor-faktor ini berdampak pada mesin yaitu penurunan suhu gas buang cylinder head nomor 1, peningkatan suhu fresh water out generator nomor 1, dan penurunan volume air pada expansion tk. Oleh karena itu, dilakukan penggantian cylinder head nomor 1 dengan sparepart yang baru agar generator dapat bekerja secara optimal dan kebutuhan listrik di kapal tetap terjaga.
Analisis Perbedaan Metode Canny Edge dan Region Segmentation Active Contour pada Aplikasi Deteksi Watermark pada Uang Kertas Rinaldi, Nasrullah; Syahroni, Muhammad; Nasri, Nasri
Jurnal Litek : Jurnal Listrik Telekomunikasi Elektronika Vol. 20 No. 2 (2023): Jurnal Litek, September 2023
Publisher : Jurusan Teknik Elektro Politeknik Negeri Lhokseumawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30811/litek.v20i2.30

Abstract

Penelitian ini bertujuan untuk menganalisis perbedaan antara Metode Canny Edge dan Metode Region Segmentation Active Contour dalam aplikasi deteksi watermark pada uang kertas menggunakan Matlab. Dalam penelitian ini, citra uang kertas yang digunakan ada dari nominal Rp 5.000 hingga Rp 100.000, dan ada 4 kondisi uang kertas yang digunakan sebagai citra, yaitu Normal, Terlipat, Sobek, dan Print. Metode pertama, Metode Canny Edge, digunakan untuk deteksi tepi objek pada citra, sementara metode kedua, Metode Region Segmentation Active Contour, dilakukan segmentasi wilayah objek dengan memanfaatkan kontur aktif. Hasil penelitian menunjukkan bahwa Metode Canny Edge memiliki tingkat akurasi 88%, sedangkan Metode Region Segmentation Active Contour memiliki tingkat akurasi 87%. Metode Canny Edge lebih efektif dalam mendeteksi tepi objek dengan kontras tinggi, sedangkan Metode Region Segmentation Active Contour lebih unggul dalam mendeteksi wilayah objek yang kompleks atau tidak teratur. Penelitian ini dapat menjadi panduan dalam memilih metode deteksi watermark yang sesuai untuk meningkatkan keamanan uang kertas dan mencegah potensi pemalsuan.
Analysis of Gross Motor Skills of Mentally Disabled Children at Dharma Bhakti Abcd Special School Class I-VI Ngempon Semarang Regency Rosnita, Windha; Nilawati, Ika; Aristiyanto, Aristiyanto; Amin, Nur; Nasri, Nasri; Nur Islami, Ina Prihati
Journal of International Conference Proceedings Vol 8, No 1 (2025): 2025 ICPM Malaysia Proceeding
Publisher : AIBPM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32535/jicp.v8i1.3931

Abstract

Gross motor skills are crucial abilities for daily life that involve the use of large muscles. Children with mental disabilities often face limitations in physical and mental aspects, which can hinder their gross motor development. This study employed a quantitative descriptive design to describe conditions without testing hypotheses. Data were collected through tests of flexibility, coordination, strength, speed, and endurance among students in grades I–VI at Dharma Bhakti Abcd Special School, Ngempon, Semarang Regency. The results showed that both boys and girls achieved a 100% score in the “good” category for flexibility. In coordination, boys were largely in the “less” category (47.1%), while girls achieved 100% in the “good” category. Strength tests indicated both groups were in the “moderate” category (100%). For sprint ability, boys were mostly “moderate” (85.7%), while girls were divided into “good” (40%), “moderate” (40%), and “less” (20%). Endurance results showed both boys and girls in the “less” category (100%). Overall, the findings highlight strong flexibility but challenges in coordination and endurance, providing insights for educators and therapists in designing targeted interventions.
Analysis Of Profile and Competence of U19 Football Coaches in Pemalang Regency Adnan, Naufal; Nilawati, Ika; Herdinata, Guntur Ratih Prestifa; Aristiyanto, Aristiyanto; Amin, Nur; Nasri, Nasri; Setiawan, Fredy Eko; Wicaksono, Maulana Tegar
Journal of International Conference Proceedings Vol 8, No 1 (2025): 2025 ICPM Malaysia Proceeding
Publisher : AIBPM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32535/jicp.v8i1.4135

Abstract

Football in Indonesia continues to grow rapidly, as reflected in the increasing number of clubs across various regions, including Pemalang Regency. However, the presence of many clubs has not translated into improved achievements due to the absence of a structured development system. Key issues include limited communication with stakeholders, unstructured training programs, and the lack of qualified coaches capable of designing and evaluating effective training. This study employed a descriptive qualitative approach with data collected through observation, interviews, and documentation. The subjects consisted of 48 respondents: 16 administrators, 16 coaches, and 16 players. Data validity was ensured using source triangulation, while analysis was conducted through data reduction and presentation. The findings indicate that coaches generally demonstrate good attitudes during training and matches, but most lack coaching licenses and the ability to design structured programs. Of 16 U19 clubs, only 3 coaches held official licenses and 1 had a youth assistant license. Overall, the results highlight that although coaches show positive behavior, the absence of licensing and structured training knowledge hinders the development of U19 football in Pemalang Regency. 
Co-Authors Abdur Rahman Arif, Abdur Rahman Absori Absori Adnan, Naufal Agastya, Ida Bagus Oka Ali, Muhammad Farhan Aminah Dalimunthe Amran Achmad Andriani Andriani Apdian, Donny Aprilia, Hijjatun Ari Sapti Mei Leni Arif, Dian Adhetya Arif Aristiyanto, Aristiyanto Aslamiah Aslamiah Asrianny Asrianny, Asrianny Awalludin, Dudi B.K, Felicia A. Stevanie Bakhri, Asep Samsul Barbyanavy, Dinda Ayu Chania, Lady Cinantya, Celia Cintya, Henni Dai Robbi, Shofa Denny Satria, Denny Dewi, Anies Prima Dinda Sari Utami Dwilaksana, Chryshnanda Dwiyani, Risye Edi Yanto, Edi Effendy De Lux Putra, Effendy De Lux Ferendina, Imelda Fithri Pulungan, Ainil Gabena Indrayani Dalimunthe Gunarti, Monika Retno Hamzah, Andi Siady Handika, Handika Haq, Hilman Syahrial Haris Munandar Nasution Haro, Ginda Herdinata, Guntur Ratih Prestifa Hussin, Syaryanti Ibrahim Ibrahim Ichsansyah, Ananta IMAWANTO, IMAWANTO Imran, Herry Ipa Sari Kardi Jansen Silalahi Jayawiguna, Rukmanta Kaimuddin Kaimuddin, Kaimuddin Karo Sekali, Elva Swandi Keumala, Cut Ratna Khairunnisa, Lia Khatimah, Khusnul Khudzaifah Dimyati Koesharyadi, Arif Kusumawati, Elly LATIF, MUH. WAHYUDIN Lorenta, Hasiana Lubis, Minda Sari lubis, muhammad fauzan Mas'ud, Wardiman Mochammad Imron Awalludin Muhammad Nur Muhammad Syahroni Munajat Nursaputra, Munajat Mutmainnah, Aisyah Niakurniawati, Niakurniawati Nilawati, Ika Nopiyanto, yahya eko Nugroho, Azis Nur Amin, Nur Nur Islami, Ina Prihati Nurqalbi, Maftukha Nuzul Wilda, Nuzul Pakpahan, Gita Asima E. Pintauli, Sondang Pramana, Didig Prawoto, Agus Purnama Dewi, Nanda Putra, Putu Supadma Putu Oka Ngakan Rachman, M. Taufik Rahman Nur, Abdul RAHMAT GUNAWAN Rahmi, Alfia Raisah Hayati Ramayanto, Ramayanto Ratna Keumala, Cut Ratna Ratna Ratna Wilis Retno Gunarti, Monika Rexi, Daniel Ridwanto Ridwanto Rinaldi, Nasrullah Rini Widarti Risma Illa Maulany Robbi , Shofa Dai Robbi, Shofa Dai Rosnita, Windha Rusda, Rusda Sagala, Hasel Untung Bersinar Salmi, Salmi Santoso, Muzi Saprudin Saprudin, Saprudin Sarudi, Sarudi Sefira, Inka Setiawan, Fredy Eko Sigit Purwanto Sitanggang, Sarah Novia S. Siti Morin Sinaga Suci, Nurul Suhati, Fadly Sulistiyana, Sulistiyana Supryadi, Ady Sutrisno, Sutrisno Syahdar, Fardi Ali Syahputra, Hariyadi Dharmawan Tania, Chyntia Glori TITAWATI, TITIN Urip Harahap Vera Estefania Kaban Wardana, Gusde Wardono, Sri Wicaksono, Maulana Tegar Yudiana, Yudiana Yudianto, Prima Yudha Yuliani, Tin Yuniarti, Rafita Yusr, Daffa Izaz Rafi Afif Fauzi Zakiah Drajat, Ulfah Ziza Putri Aisyia Fauzi Zulmai Rani