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Effectiveness of Ethanol Extract Dosage of Arabian Bidara Leaf (Zizphus spina-christi (L.) Desf.) on Reduction of Hypercholesterolemia in Mus musculus Valenata, Valenata; Patricia, Gaby Ayu; Ngibad, Khoirul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1449

Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular disease, which is characterized by increased cholesterol levels in the blood. The leaves of Ziziphus spina-christi (Arabian bidara) are known to contain flavonoids, saponins, tannins, and alkaloids that have the potential to provide antihypercholesterolemia effects. This study aimed to evaluate the effectiveness of ethanol extract of Z. spina-christi leaves on the reduction of total cholesterol in hypercholesterolemia mice. Extraction is carried out by the maceration method using 96% ethanol and produces a yield of 3.8%. A total of 36 male mice were divided into six groups (n=6): negative control, positive control (propylthiouracil induction), drug control (simvastatin), and three extract treatment groups with doses of 14, 28, and 56 mg/20 g BB. The treatment was given orally for four days, then cholesterol levels were analyzed using the enzymatic method CHOD-PAP. The results showed that the positive control cholesterol levels increased significantly (189.3 ± 6.2 mg/dL) compared to the negative control (112.7 ± 10.3 mg/dL). The administration of the extract lowered cholesterol levels gradually: 170.4 ± 6.3 mg/dL (10%), 159.6 ± 7.6 mg/dL (15.7%), and 147.3 ± 11.7 mg/dL (22.2%). Simvastatin decreased more (117.7 ± 12.5 mg/dL; 37.8%). It was concluded that bidara arabic leaf extract has antihypercholesterolemia potential with a multifactorial mechanism, although its effectiveness is lower than that of simvastatin.
Co-Authors Adhiba, Eka Indira Afidatul Muadifah Aldimas, Reven Ali Abraham, Ali Amanda, Lyrra Mirna Andriansyah, Firman Angge, Bagas Anton Sumarpo Ardiansah, Prianggara Arif Santoso Arif, Donny Arnando, Rasi Andante Arrafi, David Khalik As Syukri, Khoirul Anam Aulia, Rizza Fatma Ayu , Patricia Gaby Basyori, Imam Caesaria, Vica Ayu Candra Aldiansyah, Rio Chaniroh, St. Lutfi Choifin, Mochamad Cholik, Dimas Satria Nur Damayanti, Alvina Datin An Nisa Sukmawati Dianto, Annando Kusuma Dony Perdana Efawati, Susi Fafa , Angelica Rosia Fahrudin, Ahmad Dani Farichatul , Wachda Farkhan, M. Farkhan, Muhammad Fernanda, Sofia Ayu Firdania Firdaus Rosyida Galuh Puspita Sari Indra Lasmana Tarigan Islami, Putri Nova Nur Jannah Triarini, Lailatul Jannah, Elok Faiqotul Karel Damayanti, Novita Khairil Anam, Khairil Kholifah, Siti Nurriyatul Kisdiati, Putri Yoggy Mayssa Kristijono, Ary Laila Fitria Lilla Puji Lestari LINGGAWAN, STEPHANI Lukman Hakim Margalin, Brilliant Maulana, Nabilah Rosdiana Melinda, Selvina Dwi Merlina, Diana Mey Miftahul Jannah Miftakhul Huda Muadifah , Afidatul Muadifah, Afidatul Muhammad Aziz Munandar, David Khalik Arrafi Muzakiyah, Nur Aini Nuardani, Hanifah Delima NURUL AZIZAH Oktaviani, Galuh Anggun Patricia, Gaby Ayu Pradana, Muhammad Sungging Pratama, Agung Firman Priambodo, Sigit Putra, Bayu Charisma Putri, Intan Syahrani RAHARJO, BUDIONO Rahma Diyan Martha Rahmatullah, Ilham Ramadani, Ade Ramadhina, Amanda Putri Ramadhini, Ananda Putri Rifqiyah, Jazilatur Rini, Yenny Puspa Rivaldo, M Ario Rizki Amalia, Laily Rodli, Achmad Fathoni Rosidin, Mochammad Khoirul Salsabila, Nabila Putri Saputra, Ahmad Bayu Saputra, Ifan Dwi Sari, Renny Nirwana Sari, Yuke Pramudita Savitri , Lisa Sembilu, Nambi Setiawan Setiawan Sowe, Momodou Salieu Sukmawati , Datin An Nisa Sungging Pradana, Muhammad Tilarso, Dara Pranidya Tria , Novitasari Valenata, Valenata Wahyu Ningtias, Titis Wijayanti, Cicik Winarti, Siti Sri WULAN PURNAMASARI, WULAN Yanto, Fauzan Tri Yucha, Nikma Yuliantari, Sonia Devi Yusmiati, Siti Nur Husnul