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All Journal MEDISAINS KOVALEN: Jurnal Riset Kimia CHEMPUBLISH JOURNAL Lantanida Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Justek : Jurnal Sains Dan Teknologi Pharmasipha Jurnal Farmasi Higea INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health Sciences and Pharmacy Journal INTEGRITAS : Jurnal Pengabdian Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Inovasi Farmasi Indonesia Medicra (Journal of Medical Laboratory Science/Technology) Prosiding Conference on Research and Community Services MAHESA : Malahayati Health Student Journal Environmental and Toxicology Management (ETM) Journal of Experimental and Clinical Pharmacy (JECP) CHEDS: Journal of Chemistry, Education, and Science Indonesian Journal of Chemistry and Environment Jurnal Pengabdian Sosial Lestari: Jurnal Pengabdian Kepada Masyarakat JI-KES (Jurnal Ilmu Kesehatan)
Ngibad, Khoirul
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Effectiveness of Ethanol Extract Dosage of Arabian Bidara Leaf (Zizphus spina-christi (L.) Desf.) on Reduction of Hypercholesterolemia in Mus musculus Valenata, Valenata; Patricia, Gaby Ayu; Ngibad, Khoirul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1449

Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular disease, which is characterized by increased cholesterol levels in the blood. The leaves of Ziziphus spina-christi (Arabian bidara) are known to contain flavonoids, saponins, tannins, and alkaloids that have the potential to provide antihypercholesterolemia effects. This study aimed to evaluate the effectiveness of ethanol extract of Z. spina-christi leaves on the reduction of total cholesterol in hypercholesterolemia mice. Extraction is carried out by the maceration method using 96% ethanol and produces a yield of 3.8%. A total of 36 male mice were divided into six groups (n=6): negative control, positive control (propylthiouracil induction), drug control (simvastatin), and three extract treatment groups with doses of 14, 28, and 56 mg/20 g BB. The treatment was given orally for four days, then cholesterol levels were analyzed using the enzymatic method CHOD-PAP. The results showed that the positive control cholesterol levels increased significantly (189.3 ± 6.2 mg/dL) compared to the negative control (112.7 ± 10.3 mg/dL). The administration of the extract lowered cholesterol levels gradually: 170.4 ± 6.3 mg/dL (10%), 159.6 ± 7.6 mg/dL (15.7%), and 147.3 ± 11.7 mg/dL (22.2%). Simvastatin decreased more (117.7 ± 12.5 mg/dL; 37.8%). It was concluded that bidara arabic leaf extract has antihypercholesterolemia potential with a multifactorial mechanism, although its effectiveness is lower than that of simvastatin.
EFFECT OF STARCH AND SULFURIC ACID ON DETERMINATION OF VITAMIN C IN PAPAYA FRUIT USING IODIMETRI Ngibad, Khoirul; Pradana, M Sungging; Y, Ingrid Retno
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 1 No 1 (2019): The Value, Importance, and Oversight of Health Research
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v1i1.893

Abstract

Vitamin C is an antioxidant that can be used to inactivate oxidation reactions and prevent the formation of free radicals. Sources of vitamin C are fruits, such as papaya fruit. The purpose of this study was to determine the effect of the indicator volume of 1% starch and 2 N sulfuric acid on the determination of vitamin C in papaya fruit samples. This study used the iodimetri method with a standard iodine solution, starch indicator and the addition of sulfuric acid. The variations of starch indicator volume include: 0.25; 0.5, 1, 2 and 3 mL and the variations of sulfuric acid volume include: 0, 2, 4, 6, and 8 mL. The results showed that the optimum 1% starch indicator volume was 1 mL and the optimum volume of 2 N sulfuric acid was 2 mL.
IDENTIFICATION OF ASCORBIC ACID CONTENT IN Carica papaya L. USING IODIMETRY AND UV-VIS SPECTROPHOTOMETRY Riscahyani, Nosy Maria; Ekawati, Evy Ratnasari; Ngibad, Khoirul
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 1 No 2 (2019): Laboratory Analysis Applied to Medical Properties
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v1i2.1291

Abstract

Ascorbic acid mostly comes from vegetables and fruits, especially fresh fruits. Vitamin C is a vitamin that can be formed by several types of plants. One of them is papaya which has various contents including vitamin C that can increase endurance, help skin rejuvenation and repair body tissues. The purpose of this study was to determine the levels of vitamin C contained in papaya using iodimetry and UV-Vis spectrophotometry. The sample used in this study was papaya fruit. Determination of vitamin C levels in papaya samples using the titration method bas done by adding sample filtrate with starch indicator then titrated with titrant I2 until the endpoint color of blue titration is formed. Other hands, the determination of vitamin C levels in papaya samples using the UV-Vis spectrophotometry method bas conducted by making an ascorbic acid calibration curve then the filtrated sample was added with H2SO4 5% and ammonium molybdate reagent, then the absorbance of the sample was measured at 494 nm wavelength. The results of the determination of vitamin C levels using the iodimetry was 0.0147% and the results of the determination of vitamin C levels using the UV-Vis spectrophotometry method was 0.1313%. In conclusion, vitamin C levels analyzed by using UV-Vis spectrophotometry methods were greater than vitamin C levels analyzed by using the iodimetry method.
Co-Authors Adhiba, Eka Indira Afidatul Muadifah Aldimas, Reven Ali Abraham, Ali Amanda, Lyrra Mirna Andriansyah, Firman Angge, Bagas Anton Sumarpo Ardiansah, Prianggara Arif Santoso Arif, Donny Arnando, Rasi Andante Arrafi, David Khalik As Syukri, Khoirul Anam Aulia, Rizza Fatma Ayu , Patricia Gaby Basyori, Imam Caesaria, Vica Ayu Candra Aldiansyah, Rio Chaniroh, St. Lutfi Choifin, Mochamad Cholik, Dimas Satria Nur Damayanti, Alvina Datin An Nisa Sukmawati Dianto, Annando Kusuma Dony Perdana Efawati, Susi Ekawati, Evy Ratnasari Fafa , Angelica Rosia Fahrudin, Ahmad Dani Farichatul , Wachda Farkhan, M. Farkhan, Muhammad Fernanda, Sofia Ayu Firdania Firdaus Rosyida Galuh Puspita Sari Indra Lasmana Tarigan Islami, Putri Nova Nur Jannah Triarini, Lailatul Jannah, Elok Faiqotul Karel Damayanti, Novita Khairil Anam, Khairil Kholifah, Siti Nurriyatul Kisdiati, Putri Yoggy Mayssa Kristijono, Ary Laila Fitria Lilla Puji Lestari LINGGAWAN, STEPHANI Lukman Hakim Margalin, Brilliant Maulana, Nabilah Rosdiana Melinda, Selvina Dwi Merlina, Diana Mey Miftahul Jannah Miftakhul Huda Muadifah , Afidatul Muadifah, Afidatul Muhammad Aziz Munandar, David Khalik Arrafi Muzakiyah, Nur Aini Nuardani, Hanifah Delima NURUL AZIZAH Oktaviani, Galuh Anggun Patricia, Gaby Ayu Pradana, M Sungging Pradana, Muhammad Sungging Pratama, Agung Firman Priambodo, Sigit Putra, Bayu Charisma Putri, Intan Syahrani RAHARJO, BUDIONO Rahma Diyan Martha Rahmatullah, Ilham Ramadani, Ade Ramadhina, Amanda Putri Ramadhini, Ananda Putri Rifqiyah, Jazilatur Rini, Yenny Puspa Riscahyani, Nosy Maria Rivaldo, M Ario Rizki Amalia, Laily Rodli, Achmad Fathoni Rosidin, Mochammad Khoirul Salsabila, Nabila Putri Saputra, Ahmad Bayu Saputra, Ifan Dwi Sari, Renny Nirwana Sari, Yuke Pramudita Savitri , Lisa Sembilu, Nambi Setiawan Setiawan Sowe, Momodou Salieu Sukmawati , Datin An Nisa Sungging Pradana, Muhammad Tilarso, Dara Pranidya Tria , Novitasari Valenata, Valenata Wahyu Ningtias, Titis Wijayanti, Cicik Winarti, Siti Sri WULAN PURNAMASARI, WULAN Y, Ingrid Retno Yanto, Fauzan Tri Yucha, Nikma Yuliantari, Sonia Devi Yusmiati, Siti Nur Husnul