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All Journal Sains Olahraga : Jurnal Ilmiah Ilmu Keolahragaan Buletin Farmatera Journal of Epidemiology and Public Health Indonesian Journal of Medicine Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Jurnal Prima Medika Sains Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Jurnal Pengabdian Pada Masyarakat METHABDI Majalah Ilmiah METHODA FARMASAINKES Health Community Service Cermin Dunia Kedokteran Jurnal Kedokteran Methodist Pengabdian Deli Sumatera
Siahaan, Jekson Martiar
Institut Kesehatan Deli Husada Deli Tua
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Journal : Majalah Ilmiah METHODA

 1 
TUMOR SUPRESOR GEN p53 SEBAGAI TARGET PENGOBATAN “CANCER” Jekson Martiar Siahaan; Tengku Muhammad Fauzi
Majalah Ilmiah METHODA Vol. 11 No. 1 (2021): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.845 KB) | DOI: 10.46880/methoda.Vol11No1.pp10-13

Abstract

The p53 protein functions as a biological molecule that breaks the cycle of damage to DNA damage, even the important function of this molecule is to check whether the organ cells are complete or damaged. However, p53 can undergo mutations that will instead be an oncogene. One way to deal with this is gene therapy, namely PRIMA-1 (p53 Reactivation and Induction of Massive Apoptosis). Until now, further studies are still needed on the effectiveness of this therapy
BRAIN NATRIURETIC PEPTIDE (BNP) SEBAGAI BIOMARKER GAGAL JANTUNG KONGESTIF Budi Darmanta Sembiring; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 10 No. 3 (2020): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (837.223 KB) | DOI: 10.46880/methoda.Vol10No3.pp130-138

Abstract

Brain Natriuretic Peptide (BNP) is mainly secreted by the heart ventricles and acts as an antagonist to Renin-Angiotensin-Aldosterone. BNP is secreted as pre-proBNP which is broken down into BNP and proBNP in circulation. The BNP examination is done by measuring the levels of BNP or N-Terminal-proBNP depending on the method and the manufacturer. Increased levels of BNP and NT-proBNP indicate heart failure so that BNP and NT-proBNP are considered markers of heart failure. This examination is also indicated to help establish the diagnosis, monitoring, and prognosis of heart failure. Natriuretic peptide examination can be done by several methods such as radioimmunoassay (RIA), Enzyme immunoassay (EIA), Fluorescence immunoassay (FIA), and Sandwich Electro Chemiluminescence Immuno Assay (Sandwich ECLIA).
TINJAUAN BIOMOLEKULER DAN KLINIS OCULAR COVID-19 Lylys Surjani; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 10 No. 2 (2020): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.386 KB) | DOI: 10.46880/methoda.Vol10No2.pp53-66

Abstract

The clinical manifestations of Covid -19 are not only in the airway but are also found in eyes with conjunctival epithelium and ACE-2 receptors as their entry points. The most common clinical manifestation is conjunctivitis, therefore it is not easy to make a diagnosis if it relies on clinical findings because it is similar to a common viral infection. This infection has clinical manifestations in the airway that triggers the immune response leading to a cytokine storm with fatal consequences. There is no specific treatment up to this time. The most important thing is to prevent infection.
ALVEOLAR SOFT PART SARCOMA Sanggam B. Hutagalung; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 3 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No3.pp7-13

Abstract

Alveolar Soft Part Sarcoma (ASPS) is a rare sarcoma, this sarcoma accours around 0,2 – 0,9% of all soft tissue sarcomas. This tumour can occur at any age, but the peak incidence is in the age range of 15 – 35 years, rarely under the age of 5 years and after the age of 50 years. In adults, ASPS most often occur in deep soft tissues in the lower extremites, especially the anterior part of the thighs and buttocks. But in children and infants these tumours often occur in the area of the head and neck, especially the tongue and eyes. Tumours that occur in the head and neck are usually smaller in size may be due to earlier detection. Diagnostic of ASPS can be through CT – Scan/MRI examination, Fnab Citology, Histopathology, and Immunophenotype.
PATOFISIOLOGI GASTROPATI NSAID Salomo Garda Utama Simanjuntak; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 2 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No2.pp73-82

Abstract

NSAIDs are first line therapy for arthritis and widely used in cases of trauma, postoperative pain and other aches. But in the use of NSAID drugs whether it is needed as an analgesic or as an anti-inflammatory all have more or less side effects on the gastrointestinal. The occurrence of side effects of NSAIDs on the gastrointestinal tract can be caused by the direct toxic effects of NSAIDs on the gastric mucosa so the mucosa becomes damaged. While the systemic effect is due to the ability of NSAIDs to inhibit the work of COX-1 which catalyzes the formation of prostaglandins. Prostaglandins in the gastrointestinal mucosa function to maintain mucosal integrity, regulate blood flow, mucous secretion, bicarbonate, epithelial proliferation, and mucosal resistance to damage. The clinical spectrum of NSAID gastropathy includes a wide range of clinical conditions, ranging from the mildest form of gastrointestinal discontrol. Endoscopically mucous congestion will occur, small erosions sometimes accompanied by bleeding
PEDOMAN DALAM PENANGANAN KANDIDIASIS Jadeny Sinatra; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 1 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No1.pp50-61

Abstract

Candida species is an important cause of nosocomial infection that lead to death and prolonged hospital stay. The number of immunocompromised patients, at greater risk of fungal infection, treated in intensive care units (ICUs) has increased considerably. The widespread use of invasive monitoring , therapeutic equipment and treatment with broad spectrum antibiotic increases the risk of fungal colonization and infection. An acute awareness of the increasing incidence of Candida as a pathogen and of the associated morbidity and mortality is necessary. Guidelines management of candidiasis by Infectious Disesase Society of America(IDSA) in 2009 previously, was revised. There have been new data pertaining to diagnosis, prevention, and treatment for proven or suspected invasive candidiasis, leading to significant modification in treatment recommendations, which released in 2016. This article provides a summary of the most recent guideline for the management of candidiasis.
POTENSI LABU SIAM SEBAGAI ANALGETIK Sinatra, Jadeny; Siahaan, Jekson M.
Majalah Ilmiah METHODA Vol. 14 No. 1 (2024): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pain is an unpleasant emotional sensation. Pain can begin after inflammation and/or after tissue damage. The use of analgesic or anti-pain drugs so far has undesirable side effects, so people have begun to look for alternative traditional medicines as a substitute. One of the plants that can be used as an alternative medicine for analgesics is chayote (S. edule). The purpose of this review is to provide information about chayote as an analgesic. This study focused on reviewing articles on experimental studies conducted in vivo and its bioactive components.
POTENSI LABU SIAM SEBAGAI ANALGETIK Sinatra, Jadeny; Siahaan, Jekson M.
Majalah Ilmiah METHODA Vol. 14 No. 1 (2024): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol14No1.pp8-16

Abstract

Pain is an unpleasant emotional sensation. Pain can begin after inflammation and/or after tissue damage. The use of analgesic or anti-pain drugs so far has undesirable side effects, so people have begun to look for alternative traditional medicines as a substitute. One of the plants that can be used as an alternative medicine for analgesics is chayote (S. edule). The purpose of this review is to provide information about chayote as an analgesic. This study focused on reviewing articles on experimental studies conducted in vivo and its bioactive components.
Co-Authors Ade Setiowati Agnes Imelda Manurung Ahmad Abiyyu Muda Lubis Ainun, Nur Azizah Ardinata, Dedi - Ariani, Peny Ariescha, Putri Ayu Yessy Atmawidjaja, Rachmat Bahar, Dinillah Salsabila Br Purba, Debora May Sary Br. T. Tambun, Gita Sradha Budi Darmanta Sembiring Butar-Butar, Harry Chalil, M. Jalaluddin A. Cristian Marito Siregar Damanik, Irene Data, Hariati Daulay, Agus Husein Diani Nazma Dina Riani Purba Dona Pasaribu Dwi Lunarta Doderina Siahaan Efbertias Sitorus Efrata, Efrata Eka Samuel P. Hutasoit Elvana, Ayu Endy Juli Anto Endy Juli Anto endyjulianto endyjulianto Fadinie, Wulan FAHDI, FIRDAUS Fauzi, Tengku M. Fauzi, Tengku Muhammad Firdaus Fahdi Frengky S. Manullang Girsang, Rostiodertina Girsang, Rostiodertina Hadyanto Lim Hadyanto Lim Hakim, Enggrek Pelita Hamdi, Tasrif Harahap, Nurul Dahlia Hariati Hariati Hariati, Hariati Hendrika A. Silitonga Hendrika Silitonga Hutagalung, Mangatas Halomoan Parluhutan Hutagalung, Sanggam B. Hutagalung, Sanggam Bangun Hutapea, Kenal P. Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Imelda Montes Monika Simanungkalit Indra Satrio Anantha Hasugian Irfan Hamdani, Irfan Irina, Sinta Jadeny Sinatra Jadeny Sinatra Jan Pieter Sihombing Jenita Oktavia Panjaitan Jones Simatupang Juli Anto, Endy Juli Jamnasi Juli Jamnasi Juli Jamnasi Juli Y. Mega kenvin rusli Laura Octavina Siagian Lesmana Syahrir Lesmana Syahrir, Lesmana Lubis, Andriamuri P. Maestro B. U. Simanjuntak Maludin Panjaitan Manik, Widya Dayanti Feronika Manullang, Frengky S. Maria, Lasma Mega, Juli Yosa Meliala, Alprindo Sembiring Menang Bastanta Tarigan Momot, Estela Salomina Nababan, Manaor Bismar Posman Nababan, Titus Imanuel Nadapdap, Thomson P. Nainggolan, Ranatha NH Nainggolan, Serevina Napitupulu, Helen Debora Natalie S., Karen Noviola Sari Kusuma Sagala Nurmala Sari Nurmala Sari Pakpahan, Edwin Anto Panataria, Lince Romauli Panjaitan, Bintang Andika Panjaitan, Goklas Parhusip, Rudolf S. Pasaribu, Sumihar Paul Saut Marganda L Tobing Pengarapen Tarigan Perangin-angin, Guntur Pratiwi, Ade Dwi Purba, Amril Putri C. Eyanoer Putri Chairani Eyanoer Putri Chairani Eyanoer, Putri Chairani Rahmi, Sofia Ria Oktavia Ricke Loesnihari Rifqi Aufan Rika Puspita Sari Rimbun, Surjadi Ronald T. H. Tambunan Ronald T. H. Tambunan Sagala, Daniela Salamon, Yuda Monang Salomo G. U. Simanjuntak Salomo Garda Utama Simanjuntak Sanggam B Hutagalung Sanggam B. Hutagalung SARAGIH, MEYLIN KRISTINA Sari, Nur Mala Sembiring, Bob Agustinus Sembiring, Budi Darmanta Sembiring, Mikael Siahaan, Dwi Lunarta D. S. Sihaloho, Kerin Repaskatri Sihaloho, Lovian Nauli Sihombing, Amordekhai Imvan Parlindungan Sihombing, Parsaoran Sihotang, Ruth Wydia Wati Sijabat, Kesia Silaen, Ester L. R. Silalahi, Veraci Silangit, Thomas Silitonga, Hendrika Adriana Silitonga, Hendrika Andriana Silitonga, Hendrika Andriani Simangunsong, Batara Simanjuntak , Salomo G. U. Simanjuntak, Jeremia Simanjuntak, Maestro Simanjuntak, Maestro Bina Utama Simanjuntak, Pantas Simanjuntak, Salomo Garda Utama Simanjuntak, Salomo Garda Utama Simatupang, Aditia Erick Cantona Simbolon, Boyke M. Sinatra, Jadeny Sinurat, Suryati Sirait, Kilian Sitepu, John Frans Siti Normi, Siti Sitompul, Michael Sabatino Sitorus, Friska Ernita Sitorus, Friska Ernita Sitorus, Ragnar Oktavianus Situngkir, Jesica Damayanti Stephanie S., Kezia Sucipto Sucipto Surjani, Lylys Suryati Sinurat Syahputra, Fahmi Tambunan, Nur Lela E. Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Ruth Septianna Br. Tanjung, Qodri F. Tarigan, Gracecilia Tarigan, Juliyanti Tarigan, Leonardo Tarigan, Menang Bastanta Tengku M. Fauzi Tengku M. Fauzi Tengku Muhammad Fauzi Tiji, Widjaya Taufik Tiji, Wijaya Taufik Tim Lions Club Medan Angkasa Tobing, Paul S. M. L. Urip Harahap Vandem Samuel Purba Vitrilina Hutabarat Vivian Vivian Widjaya Taufik Tiji Wijaya, Mega Yohanna Agustina Sinaga Yosy Cinthya Eriwaty Silalahi YUNAFRI, ANDRI Zainumi, Cut M. Zuliawati, Zuliawati