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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Teknik Industri Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Majalah Ilmiah Peternakan Jurnal Kedokteran Brawijaya JURNAL SAINS DAN TEKNOLOGI INDONESIA Biotropika Jurnal Ilmu Kimia Universitas Brawijaya Jurnal Teknologi Pertanian Proceeding International Conference on Global Resource Conservation Natural B The Journal of Pure and Applied Chemistry Research Indonesian Journal of Human Nutrition SEMIRATA 2015 agriTECH Indonesian Journal of Biotechnology Suhuf Animal Production : Indonesian Journal of Animal Production Journal of Applied Food Technology Islamika : Jurnal Agama, Pendidikan dan Sosial Budaya Jurnal Ilmiah Kesehatan (JIKA) Jurnal Kedokteran Hewan
Aulanni'am, Aulanni'am
Universitas Brawijaya
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Journal : Jurnal Ilmiah Kesehatan (JIKA)

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Pemberian Dietilnitrosamin dan Karbontetraklorida Pada Gambaran Histologi Ginjal Tikus (Rattus Norvegicus) Almas Dwi Khairana; Ricadonna Raissa; Wibi Riawan; Suharti Suharti; Hendra Susanto; Aulanni’am Aulanni’am
Jurnal Ilmiah Kesehatan (JIKA) Vol. 4 No. 1 (2022): Volume 4 Nomor 1 April 2022
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v4i1.242

Abstract

Diethylnitrosamine (DEN) is a metabolic product of various foods and beverages in which there are preservatives in the form of nitrate and nitrite. Nitrosamines are found in various products such as alcoholic beverages, processed meats, cigarettes, and cosmetic products. DEN is toxic and carcinogenic to organs such as the liver, lungs, kidneys, skin, stomach, and blood. In addition to giving DEN compounds, there are also CCl4 compounds as tumor promoter agents known as genotoxic substances that can increase the risk of genetic errors and stimulate cells to become malignant neoplasms. Administration of DEN and CCl4 induction can damage various organs of the body, one of which is the kidney. In a healthy body, angiogenesis plays a role in wound healing and the formation of new tissue. However, angiogenesis also contributes to carcinogenesis or the uncontrolled growth of cancer cells, and is malignant when the body is contaminated with toxic substances. Therefore, to determine the effect of the administration of DEN and CCl4 observations were made using the immunohistochemical method, to see differences in the histology of the kidneys of experimental animals, the positive control group, and the negative control group based on the VEGF angiogenesis factor. From these results, there are significant differences. In the negative group, there was no necrosis and high-value VEGF expression, but in the positive group, there was necrosis and a decrease in the value of VEGF expression compared to the negative control group.
Co-Authors A. Harijono A.A. Ketut Agung Cahyawan W Achmad Subagio Agung Pramana Warih Mahendra Agung Pramana Warih Marhendra, Agung Pramana Warih Alifiani Nur Rohma Almas Dwi Khairana Alvi Milliana Amiruddin A Anna Roosdiana Anna Roosdiana Annis Catur Adi Annisa Rizky Maulidiana Ardian Retno Sari Arie Srihardyastutie Arman Sayuti Avin Ainur Fitrianingsih Badriyah B Basuki B. Purnomo Basuki B. Purnomo Basuki B. Purnomo Betti Lukiati Binawati Ginting Budi Siswanto Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Charlotha I. Tupan D. Arfiati Darwadi, Rizky Prayoga Deasy Luandayanti Dewi, Devis Resita Diyan Ajeng Rossetyowati Dwinna Aliza E. Y. Herawati Elfi Anis Saati Erdiansyah Rahmi Erdiansyah Rahmi Eva Ari Wahyuni fatchiyah . Fauziah Fauziah Fauziah Usman G Riady, G G.P. Ganda Putra Gatot Ciptadi H. Purnomo Hamdan Hamdan Hendra Susanto I Nengah Kundera I.D. Retnaningtyas Ida Ayu Okarini Inggita Kusumastuty Ira Perdana Wati Izzatul Lailiyah Kurniasari, Balqis L. E. Radiati Lailia Nur Rachma Latifah Tribuana Dewi Luh Putu Gina Luh Putu Gina M. Aris Widodo M. Aris Widodo M. Aris Widodo M.F. Wadjdi Made Oka Adnyana Mahdi, Chanif Marhendra, Agung P.W. Maris Kurniawati Marissa Agnestiansyah Mahardhian Maulidya Aulia Fiqriyana Megawati Sistin Agustita Mudawamah Mudawamah Muhaimin Rifa'i Muhamad Agus Wibowo Muhammad Aris Widodo Muhammad Asadullah Muhammad Hambal Muhammad Hambal Mulyadi Adam Muslim Akmal Muslim Akmal Muslim Akmal Muslim Akmal Nany Suryani Noer Muhammad Dliyaul Haq, Noer Muhammad Dliyaul Nur Ducha Nur Ihsan Nurhaida Nurhaida Nurmahdi, Hilman Nurul Jadid Mubarokati P.S.W, kusuma Prawiro, Sumarno Reto Putri Puspitasari Rachmawati Dwi Agustin Rahma, Kartika Rahmawati, Siti Irma Rara Anggun Mei Nirbaya Retty Ratnawati Reviana Setin Ricadonna Raissa Rista Nikmatu Rohmah Rista Nikmatu Rohmah, Rista Nikmatu Roosdiana, Anna S. Susilowati Sanarto Santoso Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan SIMON BAMBANG WIDJANARKO SOETJIPTO . Soraya Widyasari Soraya Widyasari, Soraya Sri Kumalaningsih Sri Rahayu Sri Wahyuningsih Sri Winarsih Sudiyono Sudiyono Suharti Sukamto Sukamto Sutiman B. Sumitro Sutiman B. Sumitro Syafruddin S T Armansyah, T T Susilawati T. Armansyah THEOVILLA RRD, THEOVILLA Tinny Endang H Tinny Endang Hernowati TN Siregar, TN Tongku N. Siregar Tongku Nizwan Siregar Tri Susanto Vivi Shofia Wibi Riawan Win Darmanto Yenni Risjani Yuli Witono Yulianus Linggi Yustika, Agnes Ratna