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Sani K, Fathnur
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FORMULASI NANOPARTIKEL KITOSAN EKSTRAK METANOL ALGA LAUT COKLAT (Sargassum hystrix) DENGAN METODE GELASI IONIK Agung Giri Samudra; Nurfijrin Ramadhani; Fathnur Sani K; Gina Lestari; Bambang Hernawan Nugroho
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.428

Abstract

The content of marine algae Sargassum hystrix includes polysaccharides (alginates), polyphenols, proteins, peptides, amino acids, lipids, minerals, and several vitamins. However, the use of natural ingredients has limitations, namely that it often fails in the clinical phase due to low bioavailability. One effort that can be done to overcome this problem is to formulate nanoparticles using chitosan polymer and sodium tri-polyphosphate. This study aims to formulate nanoparticles from the methanol extract of Sargassum hystrix with various chitosan concentration ratios. The methanol extract of Sargassum hystrix was obtained by extraction using the maceration method with 50% methanol as a solvent. The results of the extract were made colloidal nanoparticles using ionic gelation techniques using a variation of the methanol extract of Sargassum hystrix: chitosan: NaTPP: Tween 80, Formulation 1 (0.75 gram: 0.1% 18 mL: 0.1% 9 mL: 0.5% 3 mL); Formulation 2 (0.75 gram: 0.2% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 3 (0.75 gram: 0.1% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 4 (0.75 gram: 0.2% 18 mL: 0.1% 9 mL: 0.5% 3 mL). The nanoparticle colloids formed were characterized by particle size (nm), and the zeta potential (mV), Formula 1 (212.65 ± 45.32; -11.4 ± 5.65), Formula 2 (514.55 ± 56.35; -8.85 ± 1.34), Formula 3 (219.35 ± 43.76; -14.5 ± 1.83), Formula 4 (326.5 ± 3.39; -1.25 ± 17.88). All formulas show that they can form nanoparticle formulas between 1-1000 nm., But the preparation that will be more stable is formula 3 because it has a zeta potential that is close to +/- 30 mV.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott) SEBAGAI ANTIHIPERGLIKEMIA TERHADAP MENCIT PUTIH JANTAN YANG DIINDUKSI SUKROSA Dian Lestari; Intan Lestari; Fathnur Sani K
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.433

Abstract

Hyperglycemia is a condition where blood glucose levels increase above normal. Hyperglycemia is a manifestation of diabetes mellitus (DM). Chronic hyperglycemia in diabetes mellitus has an important role in the damage to various organism, including the heart, gynecological eye, nervous and vascular system, which in turn causes complications of diabetes mellitus. Dragon tail leaf extract (Rhaphidophora pinnata (L.f) Schott) contains several compounds that function to reduce glucose in the blood including flavonoids, alkaloids, saponins, steroids and tanins which can inhibit the action of the enzyme α- glucosidase. The purpose of this study was to determine the effect of giving ethanol extract of dragon tail leaves in blood glucose levels and determine the best dose of ethanol extract of dragon tail leaves in reducing blood glucose levels. The samples used were ethanol extract of dragon tail leaves, acarbose as positive control. The study design used was a completely randomized design (CRD) with 5 treatments in which each treatment consisted of 7 mice. The treatment groups are K + acarbose solution at a dose of 50 mg / kgBB, P1 extract dose 125 mg / kgBB, P2 extract dose 250 mg / kgBB, and P3 extract dose 375 mg / kgBB. The testing method used is the Oral Glucose Tolerance Test (OGTT), which is a standard method in the testing antihiperglycemic effect. Observations were carried out for 120 minutes in the time span of 10; 30; 60; 100 and 120 minutes. The research data were analyzed descriptively and One Way ANOVA test. Based on the analysis of the One Way ANOVA test it was found that there were significant differences for each study treatment (p <0.05). Based on Duncan's further tests it was found that the results of the dragon tail leaf extract had antihiperglycemic effect. The best dose of ethanol extract of dragon tail leaves in percent reduction is dose III 375 mg / KgBB with a percent decrease (38,79%). Then followed by dose II 250 mg/KgBB with a percent decrease (17,01%) anf dose I 125 mg/KgBB with percent decrease (5,325%). So it can be concluded that the ethanol extract of dragon tail leaves has effectiveness as an antihiperglycemia.
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN KAYU MANIS (Cinnamomum burmanni) PADA MENCIT PUTIH JANTAN Rahmila Yuni Astika; Fathnur Sani K; Elisma
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.465

Abstract

Cinnamon (Cinnamomum burmannii) leaves extract contains secondary metabolites such as flavonoids, saponins, tannins, alakloids, steroids/terpenoids and phenols. The aims of this study was to examine the anti-inflammatory activity of the ethanolic extract of cinnamon leaves topically and to determine the best concentration for the treatment of inflammation. This research is an experimental research with a post test only control group design approach. The treatment group was devided into 5 groups where each treatment consisted of 7 test animals The treatments included positive control (hydrocortisone acetate 2.5%), negative control (vaselin flavum), ethanol extract of cinnamon leaves with concentrations of 5%, 10% and 20%. The results showed that the ethanolic extract of cinnamon leaves had an anti-inflammatory effect statistically had a significant difference between the treatment groups (p<0.05). The best concentration is 20% then followed by 10% and 5%.
UJI EFEKTIVITAS ANTIHIPERGLIKEMIA INFUSA ALGA LAUT COKLAT (Sargassum hystrix) PADA MENCIT JANTAN DENGAN METODE TOLERANSI GLUKOSA Agung Giri Samudra; Nurfijrin Ramadhani; Cyntia Dwi Utami; Nori Wirahmi; Fathnur Sani K
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.510

Abstract

One type of metabolic disease that is always experiencing an increase in sufferers every year in countries around the world is diabetes mellitus. Sargassum hystrix marine algae are the types that are found and quite abundant in Indonesia. This study aims to prove the hypoglycemic effect of Sargassum hystrix infusion in male white mice. The study was conducted using the oral glucose test method in the positive control group (I) given glibenclamide 0.52mg / 20gramBB; group (II) is a negative control given CMC Na 0.5%; group (III) infusion of Sargassum hystrix with a concentration of 2.5% with a volume of 0.2 mL / 20gram BW; group (IV) infusion of Sargassum hystrix with a concentration of 5% by volume of 0.2 mL / 20gram BW. The results were analyzed using One Way Anova which was then followed by Duncan's test. The results showed that Sargassum hystrix infusion had an antihyperglycemic effect (p <0.05) when compared with negative controls. Sargassum hystrix 5% infusion is the best dose with the antihyperglycemic effect statistically the same as the antihyperglycemic effect of glibenclamide.
PENGARUH EKSTRAK DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott) TERHADAP KADAR MALONDIALDEHID DARAH PADA TIKUS DIABETES YANG INDUKSI ALOKSAN Fathnur Sani K; Havizur Rahman; Yuliawati Yuliawati; Agung Giri Samudra
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.623

Abstract

Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves is a traditional medicinal plant that contains secondary metabolites of alkaloids, flavonoids, saponins, and tannins, which have antioxidant effects. Uncontrolled diabetes mellitus will be one of the triggers for high free radicals in the body. This study aims to determine the effect of the effect of ekor naga leaves extract which has potentian as an antioxidant on malondialdehyde levels as a prooxidant marker in alloxan-induced diabetes mellitus rats. The reseaech method used a post test only control group design. The test animals used were 20 animals, each group of 5 test animals. Group 1: Positive Control (Glibenclamide 10 mg/Kg BW), Group 2: Negative Control (Na CMC 0,5%), Group 3: Ekor Naga Leaf Extract 250 mg/Kg BW, and Group 4: Ekor Naga Leaves Extract 500 mg/Kg BW. The data taken is the level of malondialdehyde in the blood. The results were analyzed using One-way ANOVA with a 95% confidence level. The results showed that the ethanolic extract of the ekor naga leaves had a role in reducing Malondialdehyde or lipid peroxide in the blood in diabetic rats where the best dose is 500 mg/Kg with malondialdehyde yield of 0,569 nmol/mL. Followed by a dose of 250 mg/Kg BW with malondialdehyde value of 2,144 nmol/mL.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 50% BIJI PINANG (Areca catechu) DENGAN METODE DPPH (2,2-diphenyl-1-picryhydrazyl) Humaryanto; Fathnur Sani K; Yuliawati Yuliawati; Ave Olivia Rahman; Muhaimin Muhaimin
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 1 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i1.659

Abstract

Areca nut is a plant that contains secondary chemical metabolites of flavonoids, alkaloids, tannins, terpenoids, and steroids. Where content has activity as an antioxidant. The aim of this study were to determine the antioxidant activity of 50% ethanol extract of areca nut against DPPH free redicals based on the IC50 value. Extraction method using 50% ethanol with maceration method. The antioxidant activity test was made with 5 concentration series, namely 10 ppm, 50 ppm, 100 ppm, 150 ppm, and 200 ppm. The extract was tested for free radical scavenging against DPPH (2,2-diphenyl-1-picrylhydrazyl) with a wavelength of 517 nm using a UV-Vis spectrophotometer. The comparator used is Vitamin C. The results showed that the 50% ethanol extract of areca nut has a very strong category of antioxidant activity with an IC50 value of 27,565 ppm, while a positive control of Vitamin C has an IC50 value of 28,546 ppm. The conclusion obtained from the above results is that 50% ethanol extract has very strong antioxidant activity.
Gastroprotective effect test of ekor naga leaves extract (Rhaphidophora pinnata (L.f) Schott) on male white rats Sani K, Fathnur; Putri, Kresentia; Elisma, Elisma; Lestari, Uce; Maharini, Indri; Yuliawati, Yuliawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1698

Abstract

Rhaphidophora pinnata leaves are one of the herbal plants that have pharmacological effects. Previous research has shown that ekor naga leaves contain secondary metabolites with tonic pharmacological effects, including the ability to heal cut wounds, as well as antihyperglycemic and antidiabetic properties. This research aims to demonstrate the potential of ekor naga leaf extract as a gastroprotective agent. The extract was evaluated using standard methods, including determination of water content, ash content, phytochemical screening, and compound identification by LC-MS. Gastroprotective testing was carried out by dividing the treatment group into six groups, including the Group 1: normal group, Group 2: negative control (Sodium CMC 0.5%),  Group 3: positive control (Sucralfate), Group 4: 125mg/KgBW extract, Group 5: 250 mg/KgBW extract, and Group 6: 500mg/KgBW extract. The results of the observations were in the form of gastric ulcer severity scores and histological images of the gastric organs. Gastroprotective testing revealed significant differences between the treatment groups and the negative control group (p<0.05). The 500 mg/kgBW extract exhibited the most effective gastroprotective effect, with a 42.5% inhibition rate and minimal inflammation observed both macroscopically and microscopically. These results suggest that ethanol extract from ekor naga leaves may serve as an alternative or complementary therapy for gastritis.
Uji Iritasi Dan Uji Hedonik Sediaan Mouth Nanospray Berbasis Minyak Atsiri Jintan Hitam (Nigella Sativa L.) Septi Hariyani; Uce Lestari; Fathnur Sani K; Elisma
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.137

Abstract

Bau mulut (halitosis) merupakan salah satu masalah kesehatan mulut yang dapat memengaruhi kepercayaan diri seseorang. Salah satu upaya untuk mengatasi halitosis adalah dengan pengembangan sediaan mouth spray berbasis teknologi nano menggunakan minyak atsiri jintan hitam (Nigella sativa L.) yang memiliki aktivitas antibakteri terhadap Streptococcus mutans. Penelitian ini bertujuan untuk mengetahui keamanan dan tingkat penerimaan sensori sediaan mouth nano spray berbasis minyak atsiri jintan hitam melalui uji iritasi dan uji hedonik. Uji iritasi dilakukan pada 30 relawan dengan parameter kemerahan, gatal, dan alergi, sedangkan uji hedonik dilakukan untuk menilai rasa, aroma, kesegaran, dan kenyamanan menggunakan skala Likert. Hasil uji iritasi menunjukkan bahwa 90% relawan tidak mengalami reaksi iritasi, dengan skor total 3,06 yang termasuk kategori aman digunakan. Hasil uji hedonik menunjukkan tingkat penerimaan yang sangat baik, dengan mayoritas panelis memberikan penilaian “suka” hingga “sangat suka” terhadap semua parameter sensori. Berdasarkan hasil tersebut, dapat disimpulkan bahwa sediaan mouth nano spray berbasis minyak atsiri jintan hitam (Nigella sativa L.) aman digunakan dan memiliki daya terima yang tinggi sehingga berpotensi dikembangkan sebagai produk alami penyegar mulut.
Ethanolic Extract of Curcuma zedoaria Enhances Burn Wound Healing in Male White Rats Yuliawati, Yuliawati; Kasmadi, Fathnur Sani; Elisma, Elisma; Dewi, Hasna; Afryandes, Amelya; Puteri, Vanya Gita
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501488

Abstract

In addition to its widespread use as a culinary spice, white turmeric rhizome (Curcuma zedoaria (Christm.) Roscoe) exhibits important pharmacological activities, including anti-inflammatory, anticancer, and antioxidant effects. The rhizome contains secondary metabolites such as flavonoids, alkaloids, saponins, phenols, tannins, and terpenoids, which are believed to contribute to its potential efficacy in treating burns. This study used a fully randomized post-test-only control group design consisting of five treatment groups: P1 (5% ethanol extract of white turmeric rhizome), P2 (10%), P3 (15%), K⁺ (positive control: Bioplacenton), and K⁻ (negative control: Vaseline flavum). Parameters observed included reduction in burn wound diameter and collagen density, which were assessed through histological analysis. The results showed significant differences between treatment groups (p < 0.05). The 10% concentration showed the highest wound healing activity, reaching a healing rate of 54.72% and producing denser collagen compared to the other treatments. However, its effect did not exceed the positive control (Bioplacenton). The 5% concentration showed moderate healing activity (43.84%) with intermediate collagen density, while the 15% concentration produced the lowest effect. Overall, the findings indicate that the ethanol extract of white turmeric rhizome, particularly at a concentration of 10%, enhances burn wound healing and increases collagen formation, supporting its potential as a natural therapeutic agent for the treatment of burns.
Uji Aktivitas Sediaan Gel Berbasis Ekstrak Daun Kayu Manis (Cinnamomum burmannii) sebagai Agen Antiinflamasi pada Model Tikus Putih Jantan dengan Induksi Karagenan Kasmadi, Fathnur Sani; Putri, Azelia; Pratiwi, Puspa Dwi; Humaryanto, Humaryanto; Ekaputri, Tia Wida
Jurnal Ilmiah Pharmacy Vol 13, No 1 (2026)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v13i1.917

Abstract

Inflamasi merupakan mekanisme pertahanan fisiologis tubuh yang berperan dalam membatasi perluasan kerusakan jaringan, menekan pertumbuhan mikroorganisme patogen, serta memfasilitasi proses perbaikan jaringan yang mengalami cedera akibat suatu kondisi patologis. Proses ini tergolong respon biologis normal sebagai bagian dari sistem proteksi tubuh. Salah satu tanaman yang diketahui memiliki aktivitas dalam penyembuhan luka adalah daun kayu manis, yang dilaporkan mengandung berbagai metabolit sekunder yaitu fenolik, flavonoid, saponin, steroid, dan tanin yang berkontribusi dalam modulasi proses inflamasi. Formulasi ekstrak daun kayu manis dalam bentuk gel bertujuan untuk meningkatkan penetrasi zat aktif kejaringan target serta memberikan efek pendingin (cooling effect) yang mendukung proses penyembuhan inflamasi. Penelitian ini dilakukan untuk mengevaluasi aktivitas antiinflamasi sediaan gel ekstrak daun kayu manis serta menentukan konsentrasi yang paling optimal dalam menghasilkan efek terapeutik. Metode yang digunakan adalah penelitian eksperimental dengan desain post test only control group. Kelompok perlakuan dibagi menjadi 5 yaitu kontrol positif, kontrol negatif, formula I (ekstrak 2,5%), formula II (ekstrak 5%, dan formula III (ekstrak 10%) yang diaplikasikan secara topikal pada area punggung tikus yang telah diinduksi dengan karagenan 1%. Perlakuan dilakukan selama 4 hari parameter yang diamati berupa volume eksudat dan profil diferensiasi leukosit dalam darah. Hasil penelitian menunjukkan bahwa formulasi gel ekstrak daun kayu manis dengan konsentrasi 10% memberikan aktivitas antiinflamasi paling optimal yang dibuktikan dengan mampu menurunkan volume eksudat. Efektivitas terbaik di tunjukkan dengan nilai persen inhibisi inflamasi pada kosentrasi 10% adalah sebesar 89,47%.
Co-Authors Adisty, Aura Rasyanda Afryandes, Amelya Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Aina Fatkhil Haque Alfi Khatib Amalia Nasution, Riska Andriani, Annisa Anggia, Sonia Anggraini, Dewi Febrina Annisa Luthfiyyah Apriza Hongko Putra Asima Widyawaty Sinurat Ave Olivia Rahman Ave Olivia Rahman Ave Olivia Rahman Ave Olivia Rahman Bambang Hernawan Nugroho Bella Pascila Bernike Anatasya Cassa de Floris Cathelya, Bunga Cyntia Dwi Utami Daffa Akrama Yuda Danuartha, Dhimas Dara Permata Sari dewi, hasna Diah Riski Gusti Diah Tri Utami Diah Tri Utami DIAN LESTARI Dian Magfirah Dinofitri, Hanifah Dominica, Dwi Dwikanti Prindani Putri Dyah Fitriani Efendi, M. Rifki Ekaputri, Tia Wida Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Enda Oktri Mayora Evi Maryanti Fazariana, Anjaly Rizkya Febriyani, Ulfa Fitrianingsih Fitrianingsih Fitrianingsih Fitrianingsih Gatot Prasetya Gina Lestari Gina Lestari, Gina Haque, Aina Fatkhil Hasnaul Maritsa Havizur Rahman Havizur Rahman Havizur Rahman Havizur Rahman Herlina Herlina herlina herlina Humaryanto Humaryanto Humaryanto Humaryanto Humaryanto Humaryanto, Humaryanto Huntari Harahap Idamanda, Rahma Intan Lestari Iskandar, Mirna Marhami Jannah, Miptakul Jannah, Zahratul Joevanda, Salsabila Kristin Simamora Kusdiyah, Erni M. Rifqi Efendi Maharini, Indri Maimum Maulida, Dafa Riska Mayora, Enda Oktri Melisa Putri Mesa Sukmadani Rusdi Monic Sri Cahnia Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhammad Farhan Muhammad Syukri Nada Afrilia Naurah Nazifah Nazar, Armenia Neldi, Vina Novia Tri Astuti Nurfadilah Nurfadilah Nurfijrin Ramadhani Nurfijrin Ramadhani, Nurfijrin nurwani purnama aji Oktarina, Widiawati Pondawinata, Marizki Puspa Dwi Pertiwi Puspa Dwi Pratiwi Puteri, Vanya Gita Putri Aulia, Bilqis Putri, Andinni Putri, Azelia Putri, Fadilla Aliyah Putri, Kresentia Qiftiah, Mariatul Rahayu, Stepania Dwimulia Rahman , Ave Olivia Rahman, Havizur Rahman, Havizur Rahmila Yuni Astika Raudhatul Jannah Revis Asra Revis Asra Reza Pertiwi Reza Pertiwi Reza Yolandini Rizamevia, Fhidila Sadli, Nurul Kamilah Salsabilla, Navira Santi Perawati, Santi Sari, Dara Permata Sari, Indah Septi Hariyani Sofyan, Indah Sri Wulan Syamsul Arifin Syamsurizal Syamsurizal - - syamsurizal syamsurizal Tia Wida Eka Putri Uce Lestari Uce Lestari Uce Lestari Uce Lestari Uce Lestari 1 Ulfa Febriyani Usna, Rozatul Vanika, Niken Widiawati Oktarina Wirahmi, Nori Yesi Nursofia Yolandini, Reza Yudha Putra, Diky Okta Yuliana Yuliana Yuliandani, Yuliandani Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati, Yuliwati