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All Journal HAYATI Journal of Biosciences Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Fitofarmaka Indonesia Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun NERS Jurnal Keperawatan JFIOnline Majalah Kedokteran Andalas Health and Medical Journal Real in Nursing Journal JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Riset Multidisiplin dan Inovasi Teknologi Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Akademika Baiturrahim Jambi
Fatma Sri Wahyuni
Fakultas Farmasi, Universitas Andalas, Kampus Limau Manis, Padang, Sumatera Barat, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Cytotoxic Activity of Ethyl Acetate Extract from Voacanga foetida (Bl.) Rolfe Leaves Against T47D Breast Cancer Cells Adriani Susanty; Mira Febrina; Dian Sanita Putri; Ihsan Ikhtiarudin; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.3499

Abstract

The cytotoxicity of ethyl acetate extract from Tampa badak (Voacanga foetida (Bl.) Rolfe) leaves against Artemia salina leach larvae was determined using the brine shrimp lethality test (BSLT) method and was evaluated against T47D breast cancer cells using MTT assay method. The result of BSLT showed a consistent result with MTT assay, which is the result obtained that ethyl acetate extract is very toxic against A. salina Leach larvae with LC50 value of 8.61 µg/mL and very cytotoxic against T47D breast cancer cells with IC50 values of 0.87; 0.66; and 0.95 µg/mL at the 24, 48 and 72 hours of incubation times, respectively. The MTT assay data were analyzed using a two-way ANOVA statistical method to see the effect of the dependent variable (concentration and time) on the independent variable (% viability). Based on the statistical test result, there is a difference in % viability between concentrations of 0.1; 1; and 10 µg/mL (p <0.05), but the length of incubation does not affect % viability (p >0.05).
Time and Concentration-dependent Cytotoxicity of Piperine on Hela Cells Sri Oktavia; Arni Amir; Fatma Sri Wahyuni; Hasmiwati Hasmiwati
Majalah Kedokteran Andalas Vol 46, No 7 (2023): Supplementary December 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i7.p1174-1179.2023

Abstract

Piperine, the primary alkaloid of Piper nigrum and Piper longum, is believed to have anticancer properties. Although research on cervical cancer is still in its early stages, piperine's anticancer capabilities have been established in numerous types of cancer and have been shown to target pathways involved in the cell cycle and apoptosis. This study aims to determine how piperine administration time and concentration affect the viability of Hela cells. The MTT method was used to conduct this study. The concentration of piperine utilized was 1,000; 500; 250; 125, and 62.5 µg/mL, and it was administered for 24 and 48 hours. The IC50 values, obtained after incubation for 24 and 48 hours, were 711.21 µg/mL and 419.75 µg/mL, respectively. We may conclude that the viability of HeLa cells is influenced by piperine in a time- and concentration-dependent manner (p<0.05).
EDUKASI PENYULUHAN OBAT DAN PENGOBATAN GRATIS BAGI MASYARAKAT DI DESA PERKAMPUNGAN ADAT SIJUNJUNG Dwisari Dillasamola; Yoneta Srangenge; Aan Ardiansyah; Yufri Aldi; Fatma Sri Wahyuni; Elidahanum Husni; Rahmad Abdillah; Adinny Julmiza; Benardo Benardo
BULETIN ILMIAH NAGARI MEMBANGUN Vol 7 No 2 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i2.600

Abstract

Community health education is crucial, including education on the rational use of antibiotics, as well as halal food and medicine. Additionally, providing free medical treatment has a significant impact, encouraging the community to prioritize health and maintain it as a primary concern. This community service project was conducted in the Desa Perkampungan Adat Sijunjung. The objective of this activity is to maintain and improve the community's health status. One way to achieve this is through community service activities. The service involved educational sessions on medicines and health, as well as free medical treatment, in collaboration with the Faculty of Pharmacy and the Faculty of Medicine at Universitas Andalas. The education targeted pregnant women and the elderly, focusing on proper medication selection, rational use of antibiotics, and education on halal medicines and food. Free medical treatment involved specialist doctors and pharmacists, who also provided counseling on medications to patients. The results of the activity showed high community enthusiasm, with more than 100 prescriptions filled. The education on the rational use of medications, particularly antibiotics, is expected to increase community awareness and knowledge. This activity also highlights the importance of pharmacists in providing patient-oriented pharmaceutical services, as well as the importance of promotional and preventive efforts in maintaining public health. It can be concluded that free medical treatment is expected to encourage the community to be more health-conscious and less fearful of seeking medical care.
PERBANDINGAN GEJALA KEJADIAN IKUTAN PASCA IMUNISASI SETELAH VAKSIN COVID-19 ASTRAZENECA PERTAMA DAN KEDUA DI CENTRAL VAKSINASI UTA 45 JAKARTA Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1879

Abstract

Post-Immunization Adverse Events (AEFI) are common among vaccine participants. AEFI needs to be evaluated because Covid-19 vaccination is an effort to prevent Covid-19 infection which is still relatively new and people are still afraid of post-immunization adverse events occurring. In order for community participation to increase, it is deemed necessary to carry out an AEFI evaluation for both the first dose and the second dose (complete dose). This study aims to evaluate the symptoms of AEFI 1 with AEFI 2 by measuring the number of respondents who caused local and systemic reactions after COVID-19 vaccination. The retrospektive and prospective cross sectional study were used in this study with about 113 Astrazeneca vaccine participants at the UTA'45 Jakarta vaccine center and the data met the inclusion and exclusion criteria. Data was collected through questionnaires, AEFI forms and interviews based on symptoms of local and systemic reactions. Of the 113 participants, 29 were female, while 84 were male and the reactions they caused were different, such as pain, redness, swelling at the injection site, such as fever, muscle aches throughout the body, joint pain and also weakness. Comparison of symptoms of local and systemic reaction between KIPI 1and KIPI 2. In those without symptoms, there was increase number, but in those with symptoms, the number of respondens decrease, and statistically there was sig, P value <0,05.
Analysis of the Effectiveness of 20% Human Albumin Therapy Compared to 25% Human Albumin in Postoperative Digestive Surgery Patients With a Diagnosis of Hypoalbumin in the Intensive Care Room Witha, Nikenly Fajar; Sriwahyuni, Fatma; Nasif, Hansen
JURNAL PROTEKSI KESEHATAN Vol 13 No 1 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i1.728

Abstract

Hypoalbuminemia is generally identified in patients undergoing preoperative care, the recovery phase after surgery, and those in the healing process. At DR. M. Djamil General Hospital, the therapy to improve albumin levels in patients receiving intensive postoperative care involves using 20% human albumin and 25% human albumin. This study aims to evaluate and compare the effectiveness of 20% and 25% human albumin in increasing albumin levels in postoperative hypoalbuminemia patients at the institution. Data collection for this research was conducted retrospectively with a cross-sectional approach, where data were analyzed to determine how the increase in albumin levels after the administration of 20% or 25% human albumin affected clinical outcomes in patients. Findings from the proportionality testing in the subject characteristics involved in the research showed no disparity in the proportion of patient characteristics between the group receiving 20% human albumin (n=27) and the group receiving 25% human albumin (n=33) (p>0.05). Furthermore, the comparative mean analysis indicated a statistically significant difference in the levels of hypoalbuminemia before and after albumin infusion therapy in each group (p<0.05). The average increase in hypoalbuminemia in the group using 20% human albumin was recorded at 0.46 g/dL, while in the group with 25% human albumin, the increase reached 0.66 g/dL. Statistical analysis of the mean difference showed a statistically significant average increase in albumin concentration among the studied groups, with a p-value of less than 0.05. In this context, 25% of human albumin contributed to a significantly higher average increase in albumin concentration. Given the significant cost difference between 20% and 25% human albumin, it is recommended to use 20% human albumin for patients with albumin levels above 2.1 g/dL. Meanwhile, for patients with albumin levels below 2.1 g/dL, it is more appropriate to use 25% human albumin.
Isolation and Cytotoxic Activity Test of Alkaloids from Dichloromethane Fraction of Bark of Tampa Badak (Voacanga foetida (Blume) Rolfe) Against T47D Cell Line Adriani Susanty; Nurdina Putri; Ihsan Ikhtiarudin; Novia Sinata; Dira Dira; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.583

Abstract

Cancer is a problem in the health sector because this disease has an increasing incidence of morbidity and mortality. While the treatment still leaves some drug side effects, which cause discomfort for cancers sufferers. The arises because most cancer drugs work non-selectively. Because of some of the problems above, it is necessary to encourage the search for alternative drugs treatment of cancer. Voacanga foetida (Blume) Rolfe (Apocynaceae) is a species of plant from the genus Voacanga known as the tampa badak from West Sumatra. This plant is known to be source of indole alkaloids and also bis-indole alkaloids potential as cancer drugs. Therefore, in this study we are interested to explore the potency of this plant as natural product sources with potential cytotoxic activity. The study was started from the isolation process and continued by characterization of the isolated compounds and then testing their cytotoxic activity T47D breast cancer cell line. The isolation process of alkaloid compounds were performed by acid-base extraction, liquid-liquid fractionation, and followed by separation using column chromatography. Then,the potency of cytotoxic activity of the isolates were screened through Brine Shrimp Lethality Test (BSLT) method and evaluated by MTT assay. The structure of three isolated alkaloids (VFB-DB1.1; VFB-DB2.1; and VFB-DB2.2) were charachterized using spectroscopic analyses, including UV and FT-IR. One isolated compound (VFB-DB1.1) was also characterized using 1H NMR spectroscopy. Based on the similarity of 1H NMR spectra of isolated compound when compared with the literature, compound VFB-DB1.1 was identified as voacangine. Then, the BSLT and MTT assay result showed that VFB-DB1.1 exhibited LC50 value of 15.8 µg/mL againt Artemia salina L.and IC50 value of 8.9 µg/mL against T47D breast cancer cells, respectively.
Interaction between Fluoxetine and Risperidone and Its Association with Clinical Outcomes in Schizophrenic Patients Rachmaini, Fitri; Ayu Juwita, Dian; Abdillah, Rahmad; Dwi Afrianti, Rezy; Sri Wahyuni, Fatma
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data were collected from direct observation and notes from medical records. To provide an overview of the frequency distribution and percentage of the variables evaluated, the data were analysed through descriptive statistics and a chi-square test using SPSS v.22. Symptoms due to risperidone-fluoxetine interaction were found in four patients (10%). The symptoms experienced are categorised as extrapyramidal syndrome (EPS). The results of the clinical outcomes showed that 38 patients (88%) having recovered and five patients (12%) were in remission. The PANSS-EC in male patient (6.24±1.12) was higher than female (5.88±1.12). The length of hospitalization was higher in patient with age 36-45 years (23.72). This study showed no significant relationship between fluoxetine-risperidone interaction on the outcome of therapy (p>0.05). It can be concluded that EPS was found in 10% of schizophrenic patients. However, there was no significant association between EPS due to fluoxetine-risperidone interaction with clinical outcomes.
ANALISIS HUBUNGAN FUNGSI MANAJERIAL KEPALA RUANGAN DENGAN KUALITAS DOKUMENTASI ASUHAN KEPERAWATAN DI RUANG RAWAT INAP RSUD PARIAMAN Fithriyani Fithriyani; Fatma Sri Wahyuni; Vetty Priscilla
Jurnal Akademika Baiturrahim Jambi Vol. 6 No. 1 (2017): Maret
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v6i1.13

Abstract

Background: The quality of nursing care can be drawn from the documentation of nursing care. Nursing care documentation incomplete can degrade the quality of nursing services because it can’t identify the extent to which the success rate of nursing care given. It becomes of performance of nurses. Nurses in performing their duties are also influenced by the ability of the managerial functions of the head nurse that affects the performance of nurses. Methods: This study aimed to analyze the relationship between the head nurse managerial functions with documentation quality of nursing care in inpatient Pariaman Hospitals . The Study using analiytical descriptive  design with cross sectional approach. Samples were 86 nurses with proportional random technique sampling. The  result research showed that planning function, organizing function, directing function, monitoring function, controlling function  majority is good. Results: The statistical test result correlation between the function of directing the quality of nursing care documentation  (p value = 0.042). Suggestions for head of nursing revised Nursing Care Standards, assessing the performance of nurses regarding documentation of nursing care on a regular basis using an assessment instrument and the implementation of training related to nursing care documentation appropriate standard built by experts and professionals.
Effect of Anticoagulant Use on Coagulation Parameters in Covid-19 Comorbid Diabetic Patients Febria, Nurma; Wahyuni, Fatma Sri; Yufrialdi, Yufrialdi
JURNAL PROTEKSI KESEHATAN Vol 13 No 2 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i2.853

Abstract

Coagulation disorders, one of the causes of death of severe Covid-19 patients and comorbidities that also affect coagulation is Diabetes Mellitus. In the guidelines, it is recommended to use prophylactic anticoagulants, namely Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH) to overcome the problem of this coagulation disorder by paying attention to the value of coagulation parameters, namely, D-Dimer, PT, APTT and platelet values. The purpose of this study was to see the relationship between the use of prophylactic anticoagulants with a decrease / increase in the value of the coagulation parameter. The research design was retrospective pre-post test cohort study with research subjects of comorbid Covid-19 Diabetes patients treated in the ICU of RSUP Dr.M Djamil Padang. As a result, in the group of patients using UFH there was a significant decrease in D-Dimer values (p = 0.001) while the LMWH group was not significantly related (p = 0.05). For the association of anticoagulants with PT values, APTT in both groups was not significant. As for platelet values, there was a significant decrease in the UFH group. Conclusion for severe Covid-19 patients with comorbid Diabetes The use of UFH is recommended as a therapeutic option.
HUBUNGAN KOMORBIDITAS DAN PERILAKU TERHADAP TITER ANTIBODI DAN TERPAPAR COVID-19 PASCA VAKSIN ASTRAZENECA DOSIS LENGKAP DI UTA 45 JAKARTA Lukas, Stefanus; Diana Laila Ramatillah; Aldi, Yufri; Fatma Sri Wahyuni
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2028

Abstract

AstraZeneca vaccine has become one of the efforts to overcome the COVID-19 pandemic. This study aims to determine the relationship between the AstraZeneca vaccine and antibody titers and its association with exposure to COVID-19 infection. This study used a retrospective and prospective cohort design with convenience sampling. A total of 102 respondents who had received a complete dose of the AstraZeneca vaccine and were willing to be followed up for 18 months were involved in this study. Sociodemographic data, comorbidity history, lifestyle, and antibody titers were measured at two times: before the first dose and after the second dose of vaccinations. This study found that there was no significant relationship between comorbidities and respondent behavior (smoking and alcohol consumption) with COVID-19 antibody titers. Physical activity (exercise) showed a positive relationship with COVID-19 antibody titers. Respondents who exercised regularly had higher antibody titers than those who did not. There was a positive relationship between comorbidities, smoking, and alcohol consumption with the risk of exposure to COVID-19 infection after vaccination. This study found that physical activity (exercise) can increase COVID-19 antibody titers and provide protection against COVID-19 infection after vaccination.
Co-Authors . Almahdy AA Sudharmawan, AA Aan Ardiansyah Adinny Julmiza Adriani Susanty Afrina, Uci Alimin, Nur Almahdy A Almahdy Almahdy Almahdy, . Amir, Arni Annisa Annisa Ardiansyah, Aan Arni Amir Astari, Lita Tri astri doris Aziz, Enda Desriansyah Benardo Benardo Benardo, Benardo Berna Elya Daan Khambri Dachriyanus Deddi Prima Deddi Prima Putra Dedi Prima Putra Dessy Arisanti Dewi, Citra Kartika Dian Ayu Juwita Dian Sanita Putri Diana Laila Ramatillah Dira Dira Dira Hefni Dwi Afrianti, Rezy Dwisari Dillasamola Elidahanum Husni Enda Desriansyah Aziz Erizal Erizal Etriyel Myh Etriyel, Etriyel Febria, Nurma Fendri, Sandra Tri Juli Fithri Yani Fithriyani Fithriyani Fitriyani Siregar Frengki Frengki Frengki Frengki, Frengki Fridelly Mairani Apt Gloria, Fransisca Haiyul Fadhli Hansen Nasif Harmawati harmawati Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Vanda Ihsan Ikhtiarudin Ikhwan Resmala Sudji Intan Nedia Putri Jamilah Abbas Julmiza, Adinny Khairil Armal Lubis, Mutia Amalia Lukas, Stefanus Lusianti, Mittha Lusianti, Mittha Magdazaleni, Magdazaleni Mai Efdi Mawarti, Indah Meri Susanti Michael Michael Miming Andika Mira Febrina Mudinillah, Adam Nilda Lely Noni Zakiah Nurdina Putri Oktavia, Sri Paulina, Ida Pedro Anugrah Aswan Putra, Deddy Prima Putra, Deddy Prima Putri, Zifriyanthi Minanda Putri, Zifriyanthi Minanda Rachmaini, Fitri Rahmad Abdillah Rahmad Abdillah Ramatillah, Diana Laila Rani, Durrotul Nisa Rani, Jihan Shasika Ria Afrianti Rika Sepriani Rizki Amaliyah Amaliyah Rizqa Hasanah Salman - Sandra Hardini Sari , Yelly Oktavia Sari, Trisia Mayang Sari, Yelly Oktavia Satya Wydya Yenny Sekar, Andisyah Putri Sinata, Novia Sofia, Sri Esky Srangenge, Yoneta Sri Oktavia Suci Sutma Surya Dharma Suryati Suryati Suryati Tobat, Sanubari Rela Trisnawati, Nina Trisnawati, Nina Vetty Priscilla Vivi Sofia Vivi Sofia Vivi Sofia Wahyudi, Agung Aji Wardi, Epi Supri Wawan Wahyudi wessi windrasari Witha, Nikenly Fajar Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yufi Aldi Yufri Aldi Yulia, Revi