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All Journal HAYATI Journal of Biosciences Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Fitofarmaka Indonesia Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun JFIOnline Majalah Kedokteran Andalas Health and Medical Journal Real in Nursing Journal JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Riset Multidisiplin dan Inovasi Teknologi PEDAMAS (Pengabdian Kepada Masyarakat) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Akademika Baiturrahim Jambi Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan NERS Jurnal Keperawatan
Fatma Sri Wahyuni
Fakultas Farmasi, Universitas Andalas, Kampus Limau Manis, Padang, Sumatera Barat, Indonesia
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PERBANDINGAN GEJALA KEJADIAN IKUTAN PASCA IMUNISASI SETELAH VAKSIN COVID-19 ASTRAZENECA PERTAMA DAN KEDUA DI CENTRAL VAKSINASI UTA 45 JAKARTA Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1879

Abstract

Post-Immunization Adverse Events (AEFI) are common among vaccine participants. AEFI needs to be evaluated because Covid-19 vaccination is an effort to prevent Covid-19 infection which is still relatively new and people are still afraid of post-immunization adverse events occurring. In order for community participation to increase, it is deemed necessary to carry out an AEFI evaluation for both the first dose and the second dose (complete dose). This study aims to evaluate the symptoms of AEFI 1 with AEFI 2 by measuring the number of respondents who caused local and systemic reactions after COVID-19 vaccination. The retrospektive and prospective cross sectional study were used in this study with about 113 Astrazeneca vaccine participants at the UTA'45 Jakarta vaccine center and the data met the inclusion and exclusion criteria. Data was collected through questionnaires, AEFI forms and interviews based on symptoms of local and systemic reactions. Of the 113 participants, 29 were female, while 84 were male and the reactions they caused were different, such as pain, redness, swelling at the injection site, such as fever, muscle aches throughout the body, joint pain and also weakness. Comparison of symptoms of local and systemic reaction between KIPI 1and KIPI 2. In those without symptoms, there was increase number, but in those with symptoms, the number of respondens decrease, and statistically there was sig, P value <0,05.
Analysis of the Effectiveness of 20% Human Albumin Therapy Compared to 25% Human Albumin in Postoperative Digestive Surgery Patients With a Diagnosis of Hypoalbumin in the Intensive Care Room Witha, Nikenly Fajar; Sriwahyuni, Fatma; Nasif, Hansen
JURNAL PROTEKSI KESEHATAN Vol 13 No 1 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i1.728

Abstract

Hypoalbuminemia is generally identified in patients undergoing preoperative care, the recovery phase after surgery, and those in the healing process. At DR. M. Djamil General Hospital, the therapy to improve albumin levels in patients receiving intensive postoperative care involves using 20% human albumin and 25% human albumin. This study aims to evaluate and compare the effectiveness of 20% and 25% human albumin in increasing albumin levels in postoperative hypoalbuminemia patients at the institution. Data collection for this research was conducted retrospectively with a cross-sectional approach, where data were analyzed to determine how the increase in albumin levels after the administration of 20% or 25% human albumin affected clinical outcomes in patients. Findings from the proportionality testing in the subject characteristics involved in the research showed no disparity in the proportion of patient characteristics between the group receiving 20% human albumin (n=27) and the group receiving 25% human albumin (n=33) (p>0.05). Furthermore, the comparative mean analysis indicated a statistically significant difference in the levels of hypoalbuminemia before and after albumin infusion therapy in each group (p<0.05). The average increase in hypoalbuminemia in the group using 20% human albumin was recorded at 0.46 g/dL, while in the group with 25% human albumin, the increase reached 0.66 g/dL. Statistical analysis of the mean difference showed a statistically significant average increase in albumin concentration among the studied groups, with a p-value of less than 0.05. In this context, 25% of human albumin contributed to a significantly higher average increase in albumin concentration. Given the significant cost difference between 20% and 25% human albumin, it is recommended to use 20% human albumin for patients with albumin levels above 2.1 g/dL. Meanwhile, for patients with albumin levels below 2.1 g/dL, it is more appropriate to use 25% human albumin.
Isolation and Cytotoxic Activity Test of Alkaloids from Dichloromethane Fraction of Bark of Tampa Badak (Voacanga foetida (Blume) Rolfe) Against T47D Cell Line Adriani Susanty; Nurdina Putri; Ihsan Ikhtiarudin; Novia Sinata; Dira Dira; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 2 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i2.583

Abstract

Cancer is a problem in the health sector because this disease has an increasing incidence of morbidity and mortality. While the treatment still leaves some drug side effects, which cause discomfort for cancers sufferers. The arises because most cancer drugs work non-selectively. Because of some of the problems above, it is necessary to encourage the search for alternative drugs treatment of cancer. Voacanga foetida (Blume) Rolfe (Apocynaceae) is a species of plant from the genus Voacanga known as the tampa badak from West Sumatra. This plant is known to be source of indole alkaloids and also bis-indole alkaloids potential as cancer drugs. Therefore, in this study we are interested to explore the potency of this plant as natural product sources with potential cytotoxic activity. The study was started from the isolation process and continued by characterization of the isolated compounds and then testing their cytotoxic activity T47D breast cancer cell line. The isolation process of alkaloid compounds were performed by acid-base extraction, liquid-liquid fractionation, and followed by separation using column chromatography. Then,the potency of cytotoxic activity of the isolates were screened through Brine Shrimp Lethality Test (BSLT) method and evaluated by MTT assay. The structure of three isolated alkaloids (VFB-DB1.1; VFB-DB2.1; and VFB-DB2.2) were charachterized using spectroscopic analyses, including UV and FT-IR. One isolated compound (VFB-DB1.1) was also characterized using 1H NMR spectroscopy. Based on the similarity of 1H NMR spectra of isolated compound when compared with the literature, compound VFB-DB1.1 was identified as voacangine. Then, the BSLT and MTT assay result showed that VFB-DB1.1 exhibited LC50 value of 15.8 µg/mL againt Artemia salina L.and IC50 value of 8.9 µg/mL against T47D breast cancer cells, respectively.
Interaction between Fluoxetine and Risperidone and Its Association with Clinical Outcomes in Schizophrenic Patients Rachmaini, Fitri; Ayu Juwita, Dian; Abdillah, Rahmad; Dwi Afrianti, Rezy; Sri Wahyuni, Fatma
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data were collected from direct observation and notes from medical records. To provide an overview of the frequency distribution and percentage of the variables evaluated, the data were analysed through descriptive statistics and a chi-square test using SPSS v.22. Symptoms due to risperidone-fluoxetine interaction were found in four patients (10%). The symptoms experienced are categorised as extrapyramidal syndrome (EPS). The results of the clinical outcomes showed that 38 patients (88%) having recovered and five patients (12%) were in remission. The PANSS-EC in male patient (6.24±1.12) was higher than female (5.88±1.12). The length of hospitalization was higher in patient with age 36-45 years (23.72). This study showed no significant relationship between fluoxetine-risperidone interaction on the outcome of therapy (p>0.05). It can be concluded that EPS was found in 10% of schizophrenic patients. However, there was no significant association between EPS due to fluoxetine-risperidone interaction with clinical outcomes.
ANALISIS HUBUNGAN FUNGSI MANAJERIAL KEPALA RUANGAN DENGAN KUALITAS DOKUMENTASI ASUHAN KEPERAWATAN DI RUANG RAWAT INAP RSUD PARIAMAN Fithriyani Fithriyani; Fatma Sri Wahyuni; Vetty Priscilla
Jurnal Akademika Baiturrahim Jambi Vol. 6 No. 1 (2017): Maret
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v6i1.13

Abstract

Background: The quality of nursing care can be drawn from the documentation of nursing care. Nursing care documentation incomplete can degrade the quality of nursing services because it can’t identify the extent to which the success rate of nursing care given. It becomes of performance of nurses. Nurses in performing their duties are also influenced by the ability of the managerial functions of the head nurse that affects the performance of nurses. Methods: This study aimed to analyze the relationship between the head nurse managerial functions with documentation quality of nursing care in inpatient Pariaman Hospitals . The Study using analiytical descriptive  design with cross sectional approach. Samples were 86 nurses with proportional random technique sampling. The  result research showed that planning function, organizing function, directing function, monitoring function, controlling function  majority is good. Results: The statistical test result correlation between the function of directing the quality of nursing care documentation  (p value = 0.042). Suggestions for head of nursing revised Nursing Care Standards, assessing the performance of nurses regarding documentation of nursing care on a regular basis using an assessment instrument and the implementation of training related to nursing care documentation appropriate standard built by experts and professionals.
Effect of Anticoagulant Use on Coagulation Parameters in Covid-19 Comorbid Diabetic Patients Febria, Nurma; Wahyuni, Fatma Sri; Yufrialdi, Yufrialdi
JURNAL PROTEKSI KESEHATAN Vol 13 No 2 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i2.853

Abstract

Coagulation disorders, one of the causes of death of severe Covid-19 patients and comorbidities that also affect coagulation is Diabetes Mellitus. In the guidelines, it is recommended to use prophylactic anticoagulants, namely Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH) to overcome the problem of this coagulation disorder by paying attention to the value of coagulation parameters, namely, D-Dimer, PT, APTT and platelet values. The purpose of this study was to see the relationship between the use of prophylactic anticoagulants with a decrease / increase in the value of the coagulation parameter. The research design was retrospective pre-post test cohort study with research subjects of comorbid Covid-19 Diabetes patients treated in the ICU of RSUP Dr.M Djamil Padang. As a result, in the group of patients using UFH there was a significant decrease in D-Dimer values (p = 0.001) while the LMWH group was not significantly related (p = 0.05). For the association of anticoagulants with PT values, APTT in both groups was not significant. As for platelet values, there was a significant decrease in the UFH group. Conclusion for severe Covid-19 patients with comorbid Diabetes The use of UFH is recommended as a therapeutic option.
HUBUNGAN KOMORBIDITAS DAN PERILAKU TERHADAP TITER ANTIBODI DAN TERPAPAR COVID-19 PASCA VAKSIN ASTRAZENECA DOSIS LENGKAP DI UTA 45 JAKARTA Lukas, Stefanus; Diana Laila Ramatillah; Aldi, Yufri; Fatma Sri Wahyuni
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2028

Abstract

AstraZeneca vaccine has become one of the efforts to overcome the COVID-19 pandemic. This study aims to determine the relationship between the AstraZeneca vaccine and antibody titers and its association with exposure to COVID-19 infection. This study used a retrospective and prospective cohort design with convenience sampling. A total of 102 respondents who had received a complete dose of the AstraZeneca vaccine and were willing to be followed up for 18 months were involved in this study. Sociodemographic data, comorbidity history, lifestyle, and antibody titers were measured at two times: before the first dose and after the second dose of vaccinations. This study found that there was no significant relationship between comorbidities and respondent behavior (smoking and alcohol consumption) with COVID-19 antibody titers. Physical activity (exercise) showed a positive relationship with COVID-19 antibody titers. Respondents who exercised regularly had higher antibody titers than those who did not. There was a positive relationship between comorbidities, smoking, and alcohol consumption with the risk of exposure to COVID-19 infection after vaccination. This study found that physical activity (exercise) can increase COVID-19 antibody titers and provide protection against COVID-19 infection after vaccination.
Analisis Pelayanan Resep Konvensional dan Elektronik serta Pengaruhnya terhadap Kualitas Pelayanan Kefarmasian di RSUD M. Natsir Solok Indonesia Adrizal, Adrizal; Sriwahyuni, Fatma; Aldi, Yufri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.3.195-199.2019

Abstract

Rumah Sakit wajib memberikan pelayanan yang berkualitas sesuai dengan Standar Pelayanan Minimal (SPM) yang telah di tetapkan. Upaya untuk meningkatkan kualitas pelayanan kefarmasian di rumah sakit dapat dilakukan dengan penerapan peresepan elektronik. Penelitian bertujuan untuk mengetahui perbedaan kualitas pelayanan kefarmasian antara peresepan konvensional dan peresepan elektronik. Desain penelitian adalah observasional analitik dengan rancangan cross sectional study. Sampel berjumlah 431 resep diambil dengan teknik random sampling. Uji statistik pada variabel waktu tunggu dan kepuasan pasien yaitu uji t–independen sedangkan variabel kesalahan pemberian obat dan kesesuaian resep dengan formularium digunakan  uji  chi_square dengan tingkat kemaknaan 0,05. Hasil penelitian menunjukan terdapat perbedaan waktu tunggu (p value:0,000), kepuasan pasien (p value:0,000) dan kesesuaian resep dengan formularium (p value:0,000) antara peresepan elektronik dengan peresepan konvensional. Namun tidak terdapat perbedaan kejadian kesalahan pemberian obat antara peresepan elektronik dengan peresepan konvensional (p value:0,063). Penelitian ini menunjukkan bahwa kualitas pelayanan kefarmasian pada peresepan elektronik lebih baik dibandingkan dengan peresepan konvensional. Pimpinan dan manajerial RSUD M.Natsir hendaknya mengimplementasikan peresepan elektronik ini pada instalasi rawat jalan dan rawat inap sehingga kualitas pelayanan kefarmasian dapat ditingkatkan.
Wound-Healing Effect of Ethyl Acetate Subfraction Ointment from Meniran Leaves (Phyllathus niruri L.) at 5% Concentration on White Male Rats Tobat, Sanubari Rela; Wahyuni, Fatma Sri; Yenny, Satya Wydya; MYH, Etriyel; Annisa, Annisa; Wardi, Epi Supri; Fendri, Sandra Tri Juli
Jurnal Riset Multidisiplin dan Inovasi Teknologi Том 3 № 01 (2025): Jurnal Riset Multidisiplin dan Inovasi Teknologi
Publisher : PT. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/jimat.v3i01.1478

Abstract

A study has been conducted on the healing effect of excision wounds using subfraction ointment of ethyl acetate of meniran leaves (Phyllathus niruri L.) with a concentration of 5% on the percentage of wound healing area, epithelialization time, and hydroxyproline levels in male white rats. This study consisted of 3 groups of rats based on ointment grouping, and each group consisted of 15 rats; from 15 rats, they were grouped again into 3 groups based on the day of taking the results of the wound healing parameters, namely days (5, 10 and 15); each group consisted of 5 rats, where group 1 was control with the administration of ointment base, group 2 was given (T® ointment) as a comparison, and group 3 was treated with the administration of the test preparation topically with subfraction ethyl acetate concentration of 5%. Each group was observed and measured for the percentage of wound healing area, epithelialization time, and hydroxyproline levels on days 5, 10, and 15. The results of data analysis using one-way ANOVA and two-way ANOVA followed by Duncan's test (SPSS 23.0) showed a significant difference between the control group and the treatment group in terms of the percentage of wound healing area, epithelialization time and hydroxyproline levels (p<0.05), so it can be concluded that the preparation of ethyl acetate subfraction ointment of meniran leaves with a concentration of 5% has an effect as an excision wound therapy.
Hubungan Sosiodemografi dengan Hasil Klinis Pasien Covid-19 di RSUD Bengkulu Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Gloria, Fransisca; Michael, Michael; Wahyudi, Agung Aji; Astari, Lita Tri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 14 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.839 KB) | DOI: 10.35617/jfionline.v14i1.59

Abstract

Coronavirus disease 2019 (Covid-19) is an infectious disease caused by SARS-CoV-2 which has a shape and behavior resembling the SARS virus. The national mortality percentage is 4.23, which is above the national average. The purpose of the study was to determine what factors were associated with the deaths of Covid-19 patients at the Bengkulu Government Hospital. With the aim of knowing the sociodemographic relationship with the clinical outcomes of Covid-19 patients in Bengkulu. Methods A retrospective cohort study was conducted in this study. This study only involved patients with confirmed Covid-19, with a total sample of 127 patients who were hospitalized during April, May, and June 2021. + oseltamivir + vitamins as treatment. The outcome of Covid-19 infection had several significant correlation factors: age (0.0001), occupation (0.0001) and comorbidities (0.0001). In conclusion, the worst clinical outcomes were mostly found in patients with diabetes and those who were over 50 years old.
Co-Authors . Almahdy AA Sudharmawan, AA Aan Ardiansyah Aan Ardiansyah Abdillah, Rahmad Adinny Julmiza Adinny Julmiza Adriani Susanty Afifatul Achyar Afrina, Uci Alimin, Nur Almahdy A Almahdy Almahdy Almahdy Almahdy Almahdy, . Amir, Arni Annisa Annisa Arni Amir Astari, Lita Tri astri doris Astri Doris Aziz, Enda Desriansyah Benardo Benardo Benardo Benardo Berna Elya Cindy Elvionita Daan Khambri Dachriyanus Deddi Prima Deddi Prima Putra Dedi Prima Putra Dessy Arisanti Dessy Arisanty Dewi, Citra Kartika Dian Ayu Juwita Dian Ayu Juwita Dian Sanita Putri Diana Laila Ramatillah Dira Dira Dira Hefni Dwi Afrianti, Rezy Dwisari Dillasamola Eka Desnita Elidahanum Husni Enda Desriansyah Aziz Erizal Zaini Etriyel Myh Etriyel, Etriyel Fatiyah Nurazizah Febria, Nurma Fendri, Sandra Tri Juli Fithri Yani Fithriyani Fithriyani Fitriyani Siregar Frengki Frengki Frengki Frengki, Frengki Fridelly Mairani Apt Gloria, Fransisca Haiyul Fadhli Hansen Nasif Harmawati harmawati Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Vanda Ihsan Ikhtiarudin Ikhwan Resmala Sudji Intan Nedia Putri Jamilah Abbas Khairil Armal Lubis, Mutia Amalia Lukas, Stefanus Lusianti, Mittha Lusianti, Mittha Magdazaleni, Magdazaleni Mai Efdi Mawarti, Indah Mega Fatimah Rosana Meri Susanti Michael Michael Miming Andika Mira Febrina Mudinillah, Adam Nilda Lely Noni Zakiah Nurdina Putri Oktavia, Sri Paulina, Ida Pedro Anugrah Aswan Purnawan Pontana Putra Putra, Deddy Prima Putra, Deddy Prima Putri, Zifriyanthi Minanda Putri, Zifriyanthi Minanda Rachmaini, Fitri Rama Feriska Putra Ramatillah, Diana Laila Rani, Durrotul Nisa Rani, Jihan Shasika Ria Afrianti Rika Sepriani Rizki Amaliyah Amaliyah Rizqa Hasanah Salman - Salsabila Putri Khairani Sandra Hardini Sari , Yelly Oktavia Sari, Trisia Mayang Sari, Yelly Oktavia Satya Wydya Yenny Sekar, Andisyah Putri Sinata, Novia Siska Ferilda Sofia, Sri Esky Sri Oktavia Suci Sutma Surya Dharma Suryati Suryati Suryati Syofyan Syofyan Tessa Amanda Primadhini Tobat, Sanubari Rela Trisnawati, Nina Trisnawati, Nina Vetty Priscilla Vivi Sofia Wahyudi, Agung Aji Wardi, Epi Supri Wawan Wahyudi wessi windrasari Wida Ningsih Witha, Nikenly Fajar Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelly Oktavia Sari Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yoneta Srangenge Yufi Aldi Yufri Aldi Yulia, Revi Zolkapli Eshak