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All Journal HAYATI Journal of Biosciences Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Fitofarmaka Indonesia Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun NERS Jurnal Keperawatan JFIOnline Majalah Kedokteran Andalas Health and Medical Journal Real in Nursing Journal JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Riset Multidisiplin dan Inovasi Teknologi Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Akademika Baiturrahim Jambi

Fatma Sri Wahyuni

Fakultas Farmasi, Universitas Andalas, Kampus Limau Manis, Padang, Sumatera Barat, Indonesia

Author-ID : 1938691

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Analisis Hubungan Manajerial Kepala Ruangan dan Faktor-Faktor yang Mempengaruhi Kinerja Perawat dengan Kualitas Dokumentasi Asuhan Keperawatan di Ruang Rawat Inap RSUD Pariaman Fithri Yani; Fatma Sri Wahyuni; Vetty Priscilla
Jurnal Ilmiah Universitas Batanghari Jambi Vol 19, No 3 (2019): Oktober
Publisher : Universitas Batanghari Jambi

The quality of nursing care can be drawn from the documentation of nursing care. Nursing care documentation incomplete can degrade the quality of nursing services because it can’t identify the extent to which the success rate of nursing care given. It becomes of performance of nurses. Nurses in performing their duties are also influenced by the ability of the managerial functions of the head nurse that affects the performance of nurses. This study aimed to analyze the relationship between the head nurse managerial functions and the factors that affect the performance of nurses with documentation quality of nursing care in inpatient Pariaman Hospitals . The Study using analiytical descriptive design with cross sectional approach. Samples were 86 nurses with proportional random technique sampling. The result research showed that planning function, organizing function, directing function, monitoring function, controlling function majority is good, the average age of nurses 31,5 years, the average life of 4,5 years, most of the employment status of civil servants and education level of nurses majority diploma nursing,organizational factors (rewards) majority is good, psychological factors (attitude, motivation majority is good). The statistical test result correlation between the function of directing the quality of nursing care documentation (p value = 0.042). Suggestions for head of nursing revised Nursing Care Standards, assessing the performance of nurses regarding documentation of nursing care on a regular basis using an assessment instrument and the implementation of training related to nursing care documentation appropriate standard built by experts and professionals.

Analysis of The Essential Oil from Lantana camara Leaves and Its Cytotoxic Potential Against T-47D Breast Cancer Cells Suryati Suryati; Enda Desriansyah Aziz; Mai Efdi; Fatma Sri Wahyuni; Dira Hefni
Jurnal Riset Kimia Vol. 12 No. 1 (2021): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i1.364

Lantana camara Linn is a family of Verbenaceae which grows wild and is widespread in various both tropical and sub-tropical countries. Isolation essential oil of the L. camara leaves extracted by hydrodistillation and were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). The results of GC-MS analysis show isocaryophyllene (14.39%), Ï-cymene (8.17 %), Î²-cubebene (7.8 %), Î±-pinene (7.64 %), and Î²-elemene (5.51 %) as the main compound. The cytotoxic activity of the isolated essential oil was highly toxic both to Artemia salina shrimp larvae (LC50 15.92 Âµg/mL) and to breast cancer cells T-47D (IC50 10.67 ÂµM).

ANALISIS FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PELAKSANAN SISTEM PEMBERIAN PELAYANAN KEPERAWATAN PROFESIONAL OLEH PERAWAT PELAKSANA DI RUANG RAWAT INAP RSUD RADEN MATTAHER JAMBI TAHUN 2014 Indah Mawarti; Fatma Sri Wahyuni; Wawan Wahyudi
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 4 No. 1 (2016): JAMBI MEDICAL JOURNAL Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Abstract Provision of nursing services profesionla system (SP2KP) is a component of the application of professional values in nursing practice, management and provision of nursing care in a hospital ward units and professional development of self. The purpose of this study was to determine the factors associated with the implementation SP2KP by nurses in the hospital inpatient Raden Mattaher Jambi Year 2014 The type of research conducted in this research is quantitative research design using cross sectional analytic study (n = 132 nurses). Test used in this study Chy-Square test. data collection was done by a questionnaire that was tested for validity and reliability. The results of the study analyzes the factors related to the implementation of the system of professional nursing care by nurses diruang Inpatient Hospital Edinburgh Raden Mattaher of the six factors were investigated only one factor of education has a significant association with the implementation SP2KP (p = 0.010). Suggestions researchers to improve the education of nurses ffor this will affect the skill and knowledge of nurses in implementing inpatient space hospitalRSUD Raden Mattaher Jambi Tahun 2014 Keywords : Nurse Executive, Implementation SP2KP, Inpatient space

In silico analysis of wild-type and mutant KRAS Frengki Frengki; Dedi Prima Putra; Fatma Sriwahyuni; Daan Khambri; Henni Vanda
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The mutations of the KRAS gene at codons 12, 13, and 61 have been widely reported with different prognosis. In silico is one approach to explain the characteristics of the mutant genes. This study aimed to reveal the potential energy and fluctuations of the binding site and active site of wild-type KRAS (KRAS Wt) and mutant KRAS (KRAS Mt) at codons 12, 13, and 61. The samples used in this study were the sequences of KRAS Wt and KRAS Mt genes, which were subjected to in-silico analysis that included molecular homology, docking, and dynamics using MOE, PyMOL, and online CABS servers. The results showed that fluctuations in the binding site of all KRAS Mt were lower than that of KRAS Wt. On the contrary, the active site (switch I and switch II) of KRAS Mt fluctuated more widely than KRAS Wt. The potential energy of KRAS Mt before forming a complex with GTP was higher (p<0.01) than KRAS Wt. After this formation, it remained higher at codons 12 and 61 but lower at codons 11 and 13 (p <0.001). Mt G12A did not show any changes. The higher fluctuations in the switch I and switch II regions and the post energy of KRAS-GTP complexes may explain why types of cancers with mutations at codons 11 and 13 have a better prognosis than those with mutations at codons 12 and 61.

Prediction of diacerein inhibition activity against interleukin-1 receptors through docking method and tracing of pharmacokinetic profiles and their toxicity Frengki Frengki; Vivi Sofia; Deddi Prima Putra; Fatma Sri Wahyuni; Daan Khambri; Henni Vanda
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

IL-1 is one of the cytokines involved in joint diseases such as osteoarthritis. IL-1 plays a role in maintaining the balance of proteolytic proteins:MMPs and TIMPs inhibitors. Increased expression and uncontrolled IL-1 activity tend to increase the role of MMPs in degrading proteoglycans and joint tissue collagen. This study aims to reveal the interaction model of one of the osteoarthritis drugs, namely diacerein. A drug belongs to a group of disease-modifying osteoarthritis drugs (DMOADs) to suppressthe development of the disease rate, improving the structure and function of the cartilage and surrounding tissue. "In silico" digital test uses the technique of "molecular docking: used as a method of the approach using the MOE 2007.09 software application. The test material was in the form of a diacerein 3D structure and five control ligands, while the IL-1Î² / IL-1RI receptor template was downloaded from pdb.org (PDB ID: 1ITB). The ligand pharmacokinetic profile will also be displayed obtained through the ADMETSAR server. The docking results showed diacerein had the lowest docking score of -12.3285 kcal/mol with the strongest affinity, the best pharmacokinetic profile but more toxic. This study proves that the mechanism of diacerein inhibition of IL-1Î² / IL-1RI receptors is similar to dexamethasone, prednisolone,and minocycline.

Analisis Hubungan Manajemen Konflik Kepala Ruangan dengan Kepuasan Kerja Perawat Pelaksana di Ruang Rawat Inap Rumah Sakit Tk. III Reksodiwiryo Padang astri doris; Fatma Sriwahyuni; Vetty Priscilla
Ners Jurnal Keperawatan Vol 15, No 2 (2019)
Publisher : Fakultas Keperawatan Universitas Andalas

ABSTRAK Dampak negatif yang dapat ditimbulkan oleh konflik akibat pengelolaan konflik yang tidak baik antara lain menurunnya produktivitas kerja, waktu terbuang sia-sia, dan proses pengambilan keputusan tertunda sehingga dapat menghambat kinerja organisasi. Tujuan dari penelitian ini adalah untuk menganalisis hubungan manajemen konflik kepala ruangan dengan kepuasan kerja perawat pelaksana. Jenis penelitian ini adalah dekriptif analitik dengan pendekatan cross sectional. Penelitian dilaksanakan mulai dari penyusan proposal sampai penelitian pada bulan April 2017 sampai dengan Juni 2018. Teknik pengambilan sampel dengan proportional random sampling dengan jumlah sampel 83 orang. Hasil penelitian didapatkan sebanyak 50,60% manajemen konflik dinyatakan baik. Terdapat hubungan yang bermakna antara manajemen konflik dengan kepuasan kerja di RS Tk III Dr.Reksodiwiryo (p-value < 0,05) Disarankan untuk pihak rumah sakit memberikan pelatihan manajemen konflik pada kepala ruangan tersebut. Kata Kunci : Manajemen Konflik, Kepuasan Kerja,Perawat PelaksanaDaftar Pustaka : 50 (1999-2016) ABSTRACTNegative impacts of conflict resulting from bad management of conflicts include declining productivity, wasted time, and delayed decision-making processes that can hinder the organization. While related to patients safety, the work satisfaction affect is not good enough to components of nursing care. In Reksodiwiryo Hospital Padang conflict management is necessary due to decreased productivity and patient satisfaction. The purpose of this research is to analyze the correlation of conflict management of chief of nursey room with work satisfaction of nurse executor. The type of this research is analytic decryption with crosssectional study. The study was conducted in April-August 2018. The sampling technique was proportional random sampling with 83 samples. The results obtained 50.6 % of conflict management is not good enough. There is a significant relationship between conflict management and work satisfaction in Reksodiwiryo Hospital (p-value 0,05). It is advisable for the hospital to provide conflict management training to the chief of nursery room.Keywords: Conflict Management, Work Satisfaction NursesReferences: 50 (1999-2016)

Uji Toksisitas Subkronis Fraksi Etil Asetat Kulit Buah Asam Kandis (Garcinia cowa Roxb.) terhadap Fungsi Hati dan Ginjal Mencit Putih Betina Fatma Sri Wahyuni; Intan Nedia Putri; Dessy Arisanti
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

The sub-chronic toxicity testing of ethyl acetate fraction of fruit rind of “asam kandis” (Garcinia cowa Roxb.) to the liver and kidney function has been carried out to female white mice. A total of 18 female white mice aged 2-3 months weighing 20-30 grams are used as test animals. Animals were divided into three groups: one control group and two treatment groups. Groups were given daily ethyl acetate fraction at the doses of 500 and 1000 mg/kg orally for 60 days. Parameters observed were the activity of SGPT and liver weight ratio to observe the liver function; serum creatinine level and kidney weight ratio to determine kidney function. Data of SGPT, serum creatinine and the weight ratio of liver and kidney were analyzed by two-way ANOVA. Results show that the activity of SGPT and serum creatinine level were directly affected by the dose (p<0.05), while the organ weight ratio of liver and kidney were not affected by the dose and duration of administration (p>0.05). The study concluded that the dosage of ethyl acetate fraction of the fruit rind of G. cowa had a significant effect on the activity of SGPT and serum creatinine level of female white mice. The duration of administration did not give a significant effect on the increase of serum creatine level as well as the organ weight ratio of liver and kidney of mice.

Analisis Pelayanan Resep Konvensional dan Elektronik serta Pengaruhnya terhadap Kualitas Pelayanan Kefarmasian di RSUD M. Natsir Solok Indonesia Adrizal Adrizal; Fatma Sriwahyuni; Yufri Aldi
Jurnal Sains Farmasi & Klinis Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Rumah Sakit wajib memberikan pelayanan yang berkualitas sesuai dengan Standar Pelayanan Minimal (SPM) yang telah di tetapkan. Upaya untuk meningkatkan kualitas pelayanan kefarmasian di rumah sakit dapat dilakukan dengan penerapan peresepan elektronik. Penelitian bertujuan untuk mengetahui perbedaan kualitas pelayanan kefarmasian antara peresepan konvensional dan peresepan elektronik. Desain penelitian adalah observasional analitik dengan rancangan cross sectional study. Sampel berjumlah 431 resep diambil dengan teknik random sampling. Uji statistik pada variabel waktu tunggu dan kepuasan pasien yaitu uji t–independen sedangkan variabel kesalahan pemberian obat dan kesesuaian resep dengan formularium digunakan uji chi_square dengan tingkat kemaknaan 0,05. Hasil penelitian menunjukan terdapat perbedaan waktu tunggu (p value:0,000), kepuasan pasien (p value:0,000) dan kesesuaian resep dengan formularium (p value:0,000) antara peresepan elektronik dengan peresepan konvensional. Namun tidak terdapat perbedaan kejadian kesalahan pemberian obat antara peresepan elektronik dengan peresepan konvensional (p value:0,063). Penelitian ini menunjukkan bahwa kualitas pelayanan kefarmasian pada peresepan elektronik lebih baik dibandingkan dengan peresepan konvensional. Pimpinan dan manajerial RSUD M.Natsir hendaknya mengimplementasikan peresepan elektronik ini pada instalasi rawat jalan dan rawat inap sehingga kualitas pelayanan kefarmasian dapat ditingkatkan.

Kajian Ketepatan Indikasi Penggunaan Alprazolam pada Pasien Stroke di Bangsal Rawat Inap Neurologi Rumah Sakit Stroke Nasional Bukittinggi Rika Sepriani; Fatma Sri Wahyuni; Almahdy Almahdy; Khairil Armal
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

Cerebrovascular disease such as stroke remains one of diseases that causes disability and death in the world. Having sufficient quality and quantity of good sleep is one important part of the healing process. Sleep disorders also increase the patient’s risk of developing recurrent stroke. The objective of this study was to analyze the accuracy of the indications for alprazolam in patients with stroke in neurology ward of National Stroke Hospital Bukittinggi, Indonesia. The study was conducted on November 2011 to February 2012 with the prospective method through observations on the condition of the patients, medical records, drug instruction cards, and the nursing care records of stroke patients who use alprazolam. Data were analyzed descriptively based on the treatment standards related to inaccuracy: alprazolam use without medical indications and indications which were not treated. The study showed that of 35 patients taking alprazolam, 1 of them was without medical indication 1 (3.45%) and another 1 was categorized as untreated indication (3.45%) of 29 incidences of drug related problems (DRP).

Evaluasi Sitotoksik Alfa Mangostin Pada Kultur Sel Leukosit Manusia Secara In Vitro dan Uji Aktivitas Antioksidan Fatma Sri Wahyuni; Ikhwan Resmala Sudji; Rizki Amaliyah Amaliyah
Jurnal Sains Farmasi & Klinis Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018
Publisher : Fakultas Farmasi Universitas Andalas

Ekstrak kulit manggis telah banyak digunakan sebagai obat herbal untuk pengobatan berbagai penyakit dan pemeliharaankesehatan. Senyawa kimia utama dari ekstrak kulit manggis adalah α-mangostin. Bioaktivitas senyawa alfa mangostin telah diuji secara ekstensif pada berbagai organisme in vitro. Namun, informasi tentang efek keamanannya belum diketahui. Penelitian ini bertujuan untuk meninjau keamanan alfamangostin dengan mengevaluasi aktivitas sitotoksik dari alfa mangostin pada kultur sel leukosit normal dan aktivitas antioksidan dari α-mangostin. Evaluasi sitotoksik dilakukan dengan 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay)dan aktivitas antioksidan dilakukan menggunakan1,1-difenil-2-pikrilhidrazil (DPPH assay). Konsentrasi alpha mangostin yang diuji yaitu: 3.125 μg/mL; 6,25 μg/mL; 12,5 μg/mL; 25 μg/mL; 50 μg/mL dan 100 μg/mL. Hasilnya menunjukkan bahwa alfa mangostintidak memiliki efek toksik padakulturselleukosit. Alfamangostin mampu memicu respon proliferasi sel leukosit pada 50 μg/mL dengan viabilitas sel 208,485 ± 21,21% dan pada 100 μg/mL dengan viabilitas sel 361.818 ± 86,37%. Alpha mangostinjuga menunjukkan aktivitas antioksidan yang kuat dengan nilai IC5013,57 μg/mL. Hasil penelitian ini membuktikan bahwa alfa mangostin tidak toksikpada sel leukosit manusia sehingga aman untuk dikonsumsi. Sebagai senyawa antioksidan alfamangostin dapat memicu proliferasi sel leukosit dalam kultur sel leukosit.

Co-Authors . Almahdy AA Sudharmawan, AA Aan Ardiansyah Adinny Julmiza Adriani Susanty Afrina, Uci Alimin, Nur Almahdy A Almahdy Almahdy Almahdy, . Amir, Arni Annisa Annisa Ardiansyah, Aan Arni Amir Astari, Lita Tri astri doris Aziz, Enda Desriansyah Benardo Benardo Benardo, Benardo Berna Elya Daan Khambri Dachriyanus Deddi Prima Deddi Prima Putra Dedi Prima Putra Dessy Arisanti Dewi, Citra Kartika Dian Ayu Juwita Dian Sanita Putri Diana Laila Ramatillah Dira Dira Dira Hefni Dwi Afrianti, Rezy Dwisari Dillasamola Elidahanum Husni Enda Desriansyah Aziz Erizal Erizal Etriyel Myh Etriyel, Etriyel Febria, Nurma Fendri, Sandra Tri Juli Fithri Yani Fithriyani Fithriyani Fitriyani Siregar Frengki Frengki Frengki Frengki, Frengki Fridelly Mairani Apt Gloria, Fransisca Haiyul Fadhli Hansen Nasif Harmawati harmawati Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Vanda Ihsan Ikhtiarudin Ikhwan Resmala Sudji Intan Nedia Putri Jamilah Abbas Julmiza, Adinny Khairil Armal Lubis, Mutia Amalia Lukas, Stefanus Lusianti, Mittha Lusianti, Mittha Magdazaleni, Magdazaleni Mai Efdi Mawarti, Indah Meri Susanti Michael Michael Miming Andika Mira Febrina Mudinillah, Adam Nilda Lely Noni Zakiah Nurdina Putri Oktavia, Sri Paulina, Ida Pedro Anugrah Aswan Putra, Deddy Prima Putra, Deddy Prima Putri, Zifriyanthi Minanda Putri, Zifriyanthi Minanda Rachmaini, Fitri Rahmad Abdillah Rahmad Abdillah Ramatillah, Diana Laila Rani, Durrotul Nisa Rani, Jihan Shasika Ria Afrianti Rika Sepriani Rizki Amaliyah Amaliyah Rizqa Hasanah Salman - Sandra Hardini Sari , Yelly Oktavia Sari, Trisia Mayang Sari, Yelly Oktavia Satya Wydya Yenny Sekar, Andisyah Putri Sinata, Novia Sofia, Sri Esky Srangenge, Yoneta Sri Oktavia Suci Sutma Surya Dharma Suryati Suryati Suryati Tobat, Sanubari Rela Trisnawati, Nina Trisnawati, Nina Vetty Priscilla Vivi Sofia Vivi Sofia Vivi Sofia Wahyudi, Agung Aji Wardi, Epi Supri Wawan Wahyudi wessi windrasari Witha, Nikenly Fajar Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yufi Aldi Yufri Aldi Yulia, Revi

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