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All Journal HAYATI Journal of Biosciences Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Jurnal Fitofarmaka Indonesia Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun NERS Jurnal Keperawatan JFIOnline Majalah Kedokteran Andalas Health and Medical Journal Real in Nursing Journal JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaceutical Sciences and Research (PSR) Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Riset Multidisiplin dan Inovasi Teknologi Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Akademika Baiturrahim Jambi
Fatma Sri Wahyuni
Fakultas Farmasi, Universitas Andalas, Kampus Limau Manis, Padang, Sumatera Barat, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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The Effect of miR-10b Mimic Transfection on Invasion and Proliferation Gene Expression as the Direct Target of the miR-10b Pathway in T47D Breast Cancer Cell Lines Arisanty, Dessy; Eshak, Zolkapli; Wahyuni, Fatma Sri; Achyar, Afifatul; Khairani, Salsabila Putri
Jurnal Kimia Sains dan Aplikasi Vol 29, No 1 (2026): Volume 29 Issue 1 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.1.58-63

Abstract

Breast cancer remains one of the leading causes of death in women worldwide, with high incidence and mortality rates. The abnormal expression of the small non-coding RNA, microRNA-10b (miR-10b), has been associated with breast cancer progression. miR-10b is involved in various biological processes, including proliferation, metastasis, and drug resistance. However, the underlying mechanism by which miR-10b contributes to breast cancer progression remains unclear. This study aimed to investigate the effect of miR-10b on the expression of HOXD10 and PI3K genes, as well as its impact on cell viability and proliferation in breast cancer cells. In this study, T47D breast cancer cells were transfected with mimic miR-10b using the FANA-oligo transfection method at concentrations of 1, 2.5, and 5 µM. Cell viability was assessed using the MTT assay, while HOXD10 and PI3K gene expression levels were measured using RT-qPCR and ELISA. Data were analysed using paired t-tests with SPSS, and results were considered statistically significant at p < 0.05. The results showed that mimic miR-10b induced a dose-dependent increase in cell proliferation. Notably, only HOXD10 gene expression was significantly affected by the transfection, while PI3K gene expression remained unchanged. Cells transfected with 5 µM miR-10b mimic exhibited the highest proliferation rate compared to non-transfected controls (p < 0.05). In conclusion, miR-10b promotes breast cancer cell proliferation by downregulating HOXD10 expression, independent of PI3K, suggesting it is a potential target for further investigation.
EDUKASI PENYULUHAN OBAT DAN PENGOBATAN GRATIS BAGI MASYARAKAT DI DESA PERKAMPUNGAN ADAT SIJUNJUNG Dwisari Dillasamola; Yoneta Srangenge; Aan Ardiansyah; Yufri Aldi; Fatma Sri Wahyuni; Elidahanum Husni; Rahmad Abdillah; Adinny Julmiza; Benardo Benardo
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 2 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i2.600

Abstract

Community health education is crucial, including education on the rational use of antibiotics, as well as halal food and medicine. Additionally, providing free medical treatment has a significant impact, encouraging the community to prioritize health and maintain it as a primary concern. This community service project was conducted in the Desa Perkampungan Adat Sijunjung. The objective of this activity is to maintain and improve the community's health status. One way to achieve this is through community service activities. The service involved educational sessions on medicines and health, as well as free medical treatment, in collaboration with the Faculty of Pharmacy and the Faculty of Medicine at Universitas Andalas. The education targeted pregnant women and the elderly, focusing on proper medication selection, rational use of antibiotics, and education on halal medicines and food. Free medical treatment involved specialist doctors and pharmacists, who also provided counseling on medications to patients. The results of the activity showed high community enthusiasm, with more than 100 prescriptions filled. The education on the rational use of medications, particularly antibiotics, is expected to increase community awareness and knowledge. This activity also highlights the importance of pharmacists in providing patient-oriented pharmaceutical services, as well as the importance of promotional and preventive efforts in maintaining public health. It can be concluded that free medical treatment is expected to encourage the community to be more health-conscious and less fearful of seeking medical care.
Co-Authors . Almahdy AA Sudharmawan, AA Aan Ardiansyah Aan Ardiansyah Abdillah, Rahmad Achyar, Afifatul Adinny Julmiza Adinny Julmiza Adriani Susanty Afrina, Uci Alimin, Nur Almahdy A Almahdy Almahdy Almahdy, . Amir, Arni Annisa Annisa Arni Amir Astari, Lita Tri astri doris Aziz, Enda Desriansyah Benardo Benardo Benardo Benardo Berna Elya Daan Khambri Dachriyanus Deddi Prima Deddi Prima Putra Dedi Prima Putra Dessy Arisanti Dessy Arisanty Dewi, Citra Kartika Dian Ayu Juwita Dian Sanita Putri Diana Laila Ramatillah Dira Dira Dira Hefni Dwi Afrianti, Rezy Dwisari Dillasamola Elidahanum Husni Enda Desriansyah Aziz Erizal Erizal Etriyel Myh Etriyel, Etriyel Febria, Nurma Fendri, Sandra Tri Juli Fithri Yani Fithriyani Fithriyani Fitriyani Siregar Frengki Frengki Frengki Frengki, Frengki Fridelly Mairani Apt Gloria, Fransisca Haiyul Fadhli Hansen Nasif Harmawati harmawati Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Vanda Ihsan Ikhtiarudin Ikhwan Resmala Sudji Intan Nedia Putri Jamilah Abbas Khairani, Salsabila Putri Khairil Armal Lubis, Mutia Amalia Lukas, Stefanus Lusianti, Mittha Lusianti, Mittha Magdazaleni, Magdazaleni Mai Efdi Mawarti, Indah Meri Susanti Michael Michael Miming Andika Mira Febrina Mudinillah, Adam Nilda Lely Noni Zakiah Nurdina Putri Oktavia, Sri Paulina, Ida Pedro Anugrah Aswan Putra, Deddy Prima Putra, Deddy Prima Putri, Zifriyanthi Minanda Putri, Zifriyanthi Minanda Rachmaini, Fitri Rahmad Abdillah Rahmad Abdillah Ramatillah, Diana Laila Rani, Durrotul Nisa Rani, Jihan Shasika Ria Afrianti Rika Sepriani Rizki Amaliyah Amaliyah Rizqa Hasanah Salman - Sandra Hardini Sari , Yelly Oktavia Sari, Trisia Mayang Sari, Yelly Oktavia Satya Wydya Yenny Sekar, Andisyah Putri Sinata, Novia Sofia, Sri Esky Sri Oktavia Suci Sutma Surya Dharma Suryati Suryati Suryati Tobat, Sanubari Rela Trisnawati, Nina Trisnawati, Nina Vetty Priscilla Vivi Sofia Vivi Sofia Vivi Sofia Wahyudi, Agung Aji Wardi, Epi Supri Wawan Wahyudi wessi windrasari Witha, Nikenly Fajar Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yoneta Srangenge Yufi Aldi Yufri Aldi Yulia, Revi Zolkapli Eshak