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Aktivitas Sitotoksik Ekstrak Etil Asetat Daun Tampa Badak (Voacanga foetida (Bl.)K.Schum) pada Kanker Kolon HTB-38 Adriani susanty; Dachriyanus Dachriyanus; Yanwirasti Yanwirasti; Fatma Sri Wahyuni; Haiyul Fadhli; Pedro Anugrah Aswan
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (9.7 KB) | DOI: 10.25077/jsfk.5.2.142-146.2018

Abstract

Kanker kolon merupakan penyakit yang ditandai oleh perkembangan sel yang tidak terkendali di lapisan epitel pada usus besar. Salah satu tumbuhan yang memiliki aktivitas sebagai antikanker yaitu tumbuhan tampa badak (Voacanga foetida (Bl.) K.Schum). Tumbuhan tampa badak adalah keluarga apocynaceae yang memiliki aktivitas antikanker terhadap sel kanker darah (L1210 dan K256), sel kanker paru (A549) dan sel kanker serviks (HeLa). Penelitian ini bertujuan untuk mengetahui efek sitotoksik ekstrak etil asetat daun tampa badak terhadap sel kanker kolon HTB-38. Metode yang digunakan pada pengujian ini adalah metode MTT Assay pada waktu 24, 48 dan 72 jam. Parameter yang digunakan adalah IC50. Hasil penelitian menujukkan bahwa nilai IC50 ekstrak etil asetat daun tampa badak terhadap sel kanker kolon HTB-38 pada waktu 24, 48 dan 72 jam masing-masing sebesar 0,0287, 0,0776 dan 0.0415 μg/mL. Hasil penelitian ini menunujukkan bahwa ekstrak etil asetat daun tampa badak mempunyai efek sitotoksik kuat terhadap sel kanker kolon HTB-38. Hasil uji ANOVA menyatakan bahwa terdapat perbedaan persen viabilitas antara konsentrasi 0,1 μg/mL, konsentrasi 0,5 μg/mL dan konsentrasi 1 μg/mL (p<0,05) tetapi lama waktu inkubasi tidak memiliki pengaruh terhadap nilai persen viabilitas (p>0,05).
Evaluasi Terapi  Adjuvant Hormonal  Dan Hubungannya Terhadap Outcome  Klinis  Pasien Kanker Payudara Stadium  Dini Di Kota Padang wessi windrasari; Fatma Sri Wahyuni; Daan Khambri
Jurnal Sains Farmasi & Klinis Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (12.666 KB) | DOI: 10.25077/jsfk.5.3.176-184.2018

Abstract

Terapi adjuvant hormonal merupakan pilihan terapi yang efektif bagi pasien kanker payudara stadium dini dengan hormonal responsif dan Her-2 negatif. Outcome klinis dari terapi kanker payudara adalah Disease Free Survival (DFS), Overall Survival (OS). Penelitian ini bertujuan mengevaluasi terapi adjuvant hormonal dan pengaruhnya terhadap outcome klinis pasien. Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study menggunakan data retrospektif registrasi kanker payudara Persatuan Ahli Bedah Onkologi Indonesia (PERABOI) Kota Padang selama periode 2008-2017. Analisis data menggunakan Kaplan Meier Analysis dengan Log rank. Diperoleh sebanyak 58 orang pasien yang memenuhi kriteri inklusi, dengan rerata umur yaitu 49,41 ± 8,69 tahun, kejadian relaps 22,4% dan sebanyak 6,9% pasien mengalami kematian. Terapi terbanyak pada pasien premenopause adalah tamoxifen (58,3%), pada pasien pascamenopause adalah Aromatase Inhibitor (54,5%). Secara statistik pada pasien premenopause tidak ada pengaruh terapi adjuvant hormonal yang berbeda terhadap DFS (P log rank test 0,243 dan HR = 0.513) dan OS (P log rank test 0,545 dan HR = 0.314). Pada pasien pascamenopause tidak ada pengaruh terapi yang berbeda terhadap DFS (P log rank test 0,586 dan HR = 0,10) dan OS (P log rank test 0,594 dan HR = 0,12).
Studi Fenomenologi : Pelaksanaan Komunikasi SBAR pada saat Timbang Terima di Bangsal Bedah dan Interne RSUP Dr. M. Djamil Padang Sandra Hardini; Harmawati harmawati; Fatma Sri Wahyuni
Jurnal Kesehatan Medika Saintika Vol 10, No 2 (2019): Desember 2019
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.956 KB) | DOI: 10.30633/jkms.v10i2.416

Abstract

ABSTRAKPeningkatan komunikasi efektif merupakan sasaran keselamatan pasien yang kedua. Komunikasi efektif menggunakan teknik SBAR merupakan kerangka teknik komunikasi yang disediakan untuk berkomunikasi antar petugas kesehatan. Kesalahan komunikasi menjadi tiga penyebab utama centimental event . Angka kejadian tidak diharapkan (KTD) 0,003% (SPM 0 %) di RSUP Dr. M. Djamil Padang. Tujuan penelitian ini adalah mengekplorasi pengalaman perawat melaksanakan komunikasi SBAR pada saat timbang terima (handover) di di bangsal Bedah dan Interne RSUP Dr. M. Djamil Padang. Penelitian ini menggunakan pendekatan deskriptif dengan desain penelitian kualitatif dan pendekatan fenomenologi. Teknik pengambilan sampling yang digunakan snowball sampling dan cara pengambilan data ke partisipan melalui wawancara mendalam/ indept interview. Partisipan dalam penelitian ini berjumlah 6 orang. Analisa data denganmetode collaizi. Hasil penelitian 1) Pelaksanaan komunikasi SBAR pada saat timbang terima sudah optimal 2) Waktu pelaksanaan komunikasi SBAR saat timbang terima, 3) Pelaksanaan komunikasi SBAR pada saat timbang terima dilakukan di nurse station dan ruang pasien, 4) Perawat merasakan manfaat yang baik dalam menggunakaan komunikasi SBAR, 5) harapan perawat terhadap pelaksanaan komunikasi SBAR saat timbang terima agar selalu diterapkan dan di tingkatkan, 6) Faktor pendukung dalam komunikasi SBAR berupa adanya SPO, pembekalan dan sosialisasi 7) Hambatan dalam melaksanakan komunikasi SBAR saat timbang terima berupa kondisi pasien yang berubah – ubah dan kendala waktu. Saran sebagai pelaksanaan komunikasi SBAR di lakuakan disetiap timbang terima walupun tanggal merah dan dilakukan setiap shift, sebaiknya timbang terima dilakukan di konter perawat dan ruangan rawat pasien dengan menjaga privasi pasien rawatan. Memanfaatkan Komunikasi SBAR dalam pelaporan lisan Kata kunci: Komunikasi SBAR; Timbang Terima ABSTRACTThe Effective communication improved a second target  of patient safety. Effective communication used a technique SBAR communication techniques was the framework provided to communicate between health workers. Misscommunication was causes centimental events . In RSUP Dr. M. Djamil Padang the centimental events was 0,003 % (0 % ) .The purpose of this research  explorated experience of nurse weared SBAR communication at the  handover  surgeon and interne department in RSUP Dr.M.Djamil. This study used descriptive approach with the design and phenomenology. Qualitative research approach mean techniques of sampling used snowball sampling with indepth interviews. The Participants in this study were 6 people. The analysts data  was collaizy method. The research results are 1 ) Applied sbarcommunication 2 ) the time of implementation communication SBAR 3) implementation of the communication SBAR was nurse station and patient rooms , 4 ) the benefit of SBAR communication , 5 ) nurses have hoped implementation of the SBAR communication, 6 SBAR comunication  7 ) the weigh of SBAR communication. the sugests of the research will the hospital  open recruirment news staff, hive them workshop abaout patient safety. keywords: SBAR communication , handover
The Anti-proliferation Effect of an Isolated Butanol Fraction of Tampa Badak (Voacanga foetida (Bl.) K. Schum) Leaves on Leukemia, Lung, and Cervical Cancer Susanty, Adriani; Dachriyanus, Dachriyanus; Yanwirasti, Yanwirasti; Sri Wahyuni, Fatma; Sekar, Andisyah Putri; Alimin, Nur; Magdazaleni, Magdazaleni; Sofia, Sri Esky; Dewi, Citra Kartika
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Voacanga foetida (Bl.) K.Schum leaves are known to have cytotoxic activity against blood cancer cells. This study was aimed to determine the potential of an isolated butanol fraction of Voacanga foetida (Bl.) K.Schum leaves (Tb3 compound) in inhibiting the proliferation of several cancer cells, including leukemia (K562), lung cancer (A549), and cervical cancer (He-La) using the dye exclusion method. We found that the percentage of anti-proliferation of the Tb3 compound was increased in a dose-dependent manner, where it showed 83% (K562), 72.3% (He-La), and 70.7% (A549) inhibition at higher concentration. These values were relatively higher compared to doxorubicin as a positive control, 77.1%, 63.8%, and 62.7%, respectively. Moreover, the IC50 values of the Tb3 compound were still in the range of active cytotoxic compounds based on NCI classification, which is less than 4 µg/mL; 0.5 μg/mL, 2.4 μg/mL, and 3.6 μg/mL for K562, A549, and He-La, respectively. Therefore, this study indicated the potential anticancer effect of an isolated butanol fraction of the Tb3 compound to inhibit cancer cell proliferation, which provides an alternative for cancer therapy.
Anti-Inflammatory Effect of Isolate Compounds from Ethyl Acetate Fraction of Piper crocatum Ruiz and Pav Leaves on Lipopolysaccharide-induced RAW 264.7 Cells Nilda Lely; . Dachriyanus; Yufi Aldi; . Almahdy; Fatma Sri Wahyuni
HAYATI Journal of Biosciences Vol. 30 No. 1 (2023): January 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.1.28-34

Abstract

Red betel (Piper crocatum Ruiz and Pav) is a traditional Indonesian plant. The ethyl acetate fraction of red betel leaf has the potential as an anti-inflammatory. This research aimed to determine the anti-inflammatory effect of isolate compound from ethyl acetate fraction of Piper crocatum leaves on the production of cytokine pro-inflammatory TNF-α and ICAM-1 in lipopolysaccharide-induced RAW 264.7 cells. Cell viability was determined by the MTT method in the concentration range of 1.25; 2.5; 5; 10; 20, and 40 µg/ml. The TNF-α and ICAM-1 level was determined by the TNF-α and ICAM-1 assay kit as measured by an ELISA plate reader. Cell viability test of isolate compound from ethyl acetate fraction, the concentrations that gave viability percentages above 80% were 10; 5; 2.5 and 1.25 ug/ml. Isolate compound at concentrations of 10, 5, 2.5 and 1.25 ug/ml significantly inhibited TNF-α and ICAM-1 production with p<0.05 (p = 0.000).
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki Frengki; Deddi Prima Putra; Fatma Sri Wahyuni; Daan Khambri; Henni Vanda; Vivi Sofia
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (855.035 KB) | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method “pharmacokinetics screening and molecular docking”. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
PEMBUATAN PRODUK SABUN CAIR DARI ECO-ENZYME DI KELURAHAN ANDALAS KECAMATAN PADANG TIMUR KOTA PADANG Purnawan Pontana Putra; Fatma Sri Wahyuni; Yelly Oktavia Sari; Erizal Erizal; Dachriyanus Dachriyanus; Yufri Aldi; Dedy Almasdy; Salman Salman
Jurnal Hilirisasi IPTEKS Vol 6 No 1 (2023)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v6i1.644

Abstract

Eco-Enzyme, a multifunctional liquid produced from a mixture of organic waste such as vegetables, fruits, brown sugar, coconut sugar, corn sugar, sugarcane, and water that has undergone fermentation, has various benefits for the environment and human health. Eco-Enzyme contains beneficial enzymes that accelerate biochemical reactions in the environment. The enzymes found in Eco-Enzyme can be used for various applications, such as organic liquid fertilizer for plants, an additive in detergents, floor cleaners, pesticide residue cleaners, and rust removers. Using Eco-Enzyme as a liquid soap can help reduce soil pollution. Meanwhile, using Eco-Enzyme as a cleaning agent can help reduce the use of hazardous chemicals that damage the environment. This integrated program is carried out in three stages: the first is to socialize the benefits of using Eco-Enzyme, the second is to make Eco-Enzyme, and the third is to make soap from Eco-Enzyme. The production of Eco-Enzyme begins with the collection of organic waste consisting of fruit and vegetable waste, which is then mixed with brown sugar and water and left to ferment for three months. After the Eco-Enzyme product is ready, soap-making uses ingredients such as potassium hydroxide (KOH), coconut oil, cooking oil, distilled water, orange-scented perfume, and Eco-Enzyme. Training on Eco-Enzyme and soap making is conducted in the Andalas Subdistrict, which is welcomed enthusiastically by the local community. This program is expected to serve as a reference for transforming organic waste into more practical and environmentally friendly sustainable products.
Penyuluhan dan Pelatihan Penggunaan Obat Tradisional serta Penerapan Hasil Penelitian Tumbuhan Sungkai (Peronema canescens Jack) kepada Masyarakat Dwisari Dillasamola; Yufri Aldi; Fatma Sri Wahyuni; Hansen Nasif; Yohannes Alen
Warta Pengabdian Andalas Vol 30 No 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.1.60-66.2023

Abstract

Indonesians, particularly those residing in rural areas with abundant plant diversity, have long relied on traditional medicine that utilizes plants. Sungkai (Peronema canescens Jack.) is one example of a widely-used traditional medicine known for its immunity-boosting properties. However, many people need more awareness of the potential benefits and risks of plants like Sungkai, so it is necessary to provide education and training to promote proper usage and ensure public safety. This community service activity aimed to equip individuals with the knowledge and skills to process plants accurately, utilize them appropriately based on the severity of the illness, and avoid any adverse side effects or toxicity. The counselling method used in this initiative involves lectures, which is effective for individuals with varying education levels, especially the general public. This program has yielded promising results, with the community displaying strong enthusiasm for the initiative. Ultimately, education and counselling services can significantly improve public understanding and use of traditional medicine.
Pengaruh Booklet Terhadap Pengetahuan Pasien Hipertensi di Puskesmas Rasimah Ahmad Kota Bukittinggi Rizqa Hasanah; Yelly Oktavia Sari; Fatma Sri Wahyuni; Miming Andika
JOPS (Journal Of Pharmacy and Science) Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3384

Abstract

Hipertensi merupakan penyakit kronis yang membutuhkan terapi jangka panjang. Prevalensi hipertensi setiap tahunnya terus mengalami peningkatan, tetapi pengetahuan pasien terhadap pengobatan tergolong masih rendah. Pengetahuan yang lebih baik akan meningkatkan kepatuhan pasien dalam pengobatan sehingga tekanan darah lebih terkontrol dan terhindar dari resiko komplikasi. Penelitian ini bertujuan untuk mengetahui pengaruh booklet terhadap pengetahuan pasien hipertensi prolanis di Puskesmas Rasimah Ahmad Kota Bukittinggi. Jenis penelitian yang digunakan adalah experimental pretest–posttest control group design dengan subjek penelitian 40 responden yang dibagi secara acak menjadi dua kelompok (kontrol dan intervensi). Media intervensi yang digunakan dalam penelitian ini adalah booklet. Instrumen yang digunakan adalah kuisioner HK-LS untuk menilai pengetahuan. Hasil penelitian menunjukkan adanya peningkatan pengetahuan pasien hipertensi. Analisis statistik yang digunakan adalah uji Wilcoxon Signed Ranks, untuk mengetahui pengaruh pemberian intervensi terhadap tingkat pengetahuan pasien. Dari hasil penelitian, menunjukkan bahwa pemberian booklet memperoleh nilai signifikan (p-value = 0,000), sehingga dapat disimpulkan bahwa, pemberian booklet
Efektivitas Penggunaan Analgetik dan Antibiotik pada Pasien Pasca Operasi Fraktur Tertutup di Instalasi Rawat Inap Bedah RSUD Arifin Achmad Provinsi Riau Fridelly Mairani Apt; Fatma Sri Wahyuni; Hansen Nasif
JOPS (Journal Of Pharmacy and Science) Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3393

Abstract

Penelitian bertujuan untuk mengkaji gambaran sosiodemografi, nilai visual analogue scale (VAS) sebelum dan sesudah pemberian analgetik, efektivitas penggunaan analgetik dan antibiotik. Penelitian menggunakan metode analisis deskriptif dengan rancangan prospective cross sectional. Pengambilan data dilakukan secara prospektif dengan observasi langsung mengenai nyeri yang dirasa pasien menggunakan kartu VAS pada jam ke-24 pasca operasi dan setelah pemberian analgetik. Dilakukan pengamatan pada luka operasi pasien pada hari ke 3-7 sampai 30 hari pasca operasi untuk mengamati ada tidaknya ILO. Dari 40 pasien yang diteliti berdasarkan umur terbanyak adalah usia 26 tahun sampai 35 tahun (27,77%), yang paling sedikit adalah usia 45 tahun sampai 55 tahun (11,11%) dan usia 56 tahun sampai 65 tahun (11,11%). Berdasarkan jenis kelamin sebanyak 27 orang (67,50%) laki-laki dan 13 orang (32,50%) perempuan. Dari 40 pasien Sebanyak 39 pasien (97,5%) tidak terjadi ILO dan 1 pasien ( 2,5%) terjadi ILO. Sebelum pemberian analgetik seluruh pasien mengalami nyeri. Setelah pemberian parasetamol infus sebanyak 8 pasien, ketorolak injeksi sebanyak 31 pasien, dan tramadol injeksi sebanyak 1 pasien terjadi penurunan skala nyeri. Analisa data menggunakan uji wilcoxon menunjukkan adanya efektivitas penggunaan analgetik terhadap perubahan skala nyeri pada pasien (p<0,05) dan analisa secara deskriptif menunjukkan terdapat efektivitas penggunaan antibiotik pada pasien pasca operasi fraktur tertutup
Co-Authors . Almahdy AA Sudharmawan, AA Aan Ardiansyah Adinny Julmiza Adriani Susanty Afrina, Uci Alimin, Nur Almahdy A Almahdy Almahdy Almahdy, . Amir, Arni Annisa Annisa Ardiansyah, Aan Arni Amir Astari, Lita Tri astri doris Aziz, Enda Desriansyah Benardo Benardo Benardo, Benardo Berna Elya Daan Khambri Dachriyanus Deddi Prima Deddi Prima Putra Dedi Prima Putra Dessy Arisanti Dewi, Citra Kartika Dian Ayu Juwita Dian Sanita Putri Diana Laila Ramatillah Dira Dira Dira Hefni Dwi Afrianti, Rezy Dwisari Dillasamola Elidahanum Husni Enda Desriansyah Aziz Erizal Erizal Etriyel Myh Etriyel, Etriyel Febria, Nurma Fendri, Sandra Tri Juli Fithri Yani Fithriyani Fithriyani Fitriyani Siregar Frengki Frengki Frengki Frengki, Frengki Fridelly Mairani Apt Gloria, Fransisca Haiyul Fadhli Hansen Nasif Harmawati harmawati Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Vanda Ihsan Ikhtiarudin Ikhwan Resmala Sudji Intan Nedia Putri Jamilah Abbas Julmiza, Adinny Khairil Armal Lubis, Mutia Amalia Lukas, Stefanus Lusianti, Mittha Lusianti, Mittha Magdazaleni, Magdazaleni Mai Efdi Mawarti, Indah Meri Susanti Michael Michael Miming Andika Mira Febrina Mudinillah, Adam Nilda Lely Noni Zakiah Nurdina Putri Oktavia, Sri Paulina, Ida Pedro Anugrah Aswan Putra, Deddy Prima Putra, Deddy Prima Putri, Zifriyanthi Minanda Putri, Zifriyanthi Minanda Rachmaini, Fitri Rahmad Abdillah Rahmad Abdillah Ramatillah, Diana Laila Rani, Durrotul Nisa Rani, Jihan Shasika Ria Afrianti Rika Sepriani Rizki Amaliyah Amaliyah Rizqa Hasanah Salman - Sandra Hardini Sari , Yelly Oktavia Sari, Trisia Mayang Sari, Yelly Oktavia Satya Wydya Yenny Sekar, Andisyah Putri Sinata, Novia Sofia, Sri Esky Srangenge, Yoneta Sri Oktavia Suci Sutma Surya Dharma Suryati Suryati Suryati Tobat, Sanubari Rela Trisnawati, Nina Trisnawati, Nina Vetty Priscilla Vivi Sofia Vivi Sofia Vivi Sofia Wahyudi, Agung Aji Wardi, Epi Supri Wawan Wahyudi wessi windrasari Witha, Nikenly Fajar Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yufi Aldi Yufri Aldi Yulia, Revi