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All Journal HAYATI Journal of Biosciences Health Science Journal of Indonesia Indonesian Journal of Tropical and Infectious Disease Medula JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) The Indonesian Biomedical Journal BIOMA : Jurnal Biologi Makassar Nusantara Medical Science Journal Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Paediatrica Indonesiana Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Indonesian Contemporary Nursing Journal (ICON Journal) Jurnal Ilmu Alam dan Lingkungan Biosaintifika: Journal of Biology & Biology Education Alami Journal (Alauddin Islamic Medical) Journal Nurse and Health: Jurnal Keperawatan JKM (Jurnal Kebidanan Malahayati) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Biomedika Jurnal Riset Kesehatan Poltekkes Depkes Bandung Poltekita : Jurnal Ilmu Kesehatan Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal ABDINUS : Jurnal Pengabdian Nusantara Journal of Telenursing (JOTING) Indian Journal of Forensic Medicine & Toxicology Jurnal Midwifery Narra J Sasambo Journal of Pharmacy Jurnal Medika: Media Ilmiah Analis Kesehatan
Muh. Nasrum Massi
Microbiology Department, Faculty Of Medicine, Universitas Hasanuddin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Cord blood iron status and vitamin D concentration in newborns of anemic and non-anemic mothers in Makassar, Indonesia Ridha, Nadirah Rasyid; Massi, Muhammad Nasrum; Fikri, Bahrul; Putri, Sri Hardiyanti; Hidayah, Najdah; Arsyad, Andi Fatimah
Paediatrica Indonesiana Vol. 64 No. 6 (2024): November 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.6.2024.483-9

Abstract

Background Iron deficiency (ID) is a common micronutrient problem, especially in pregnant women in developing countries such as Indonesia. Moreover, vitamin D deficiency is also a major concern in worldwide public health. A correlation between anemia, ID, and vitamin D deficiency in children has been identified, but investigations in pregnant women and their newborn babies are still limited. Objective To assess association between iron status and vitamin D levels in umbilical cord blood and maternal anemia. Methods This cross-sectional study involved 109 pregnant women and their newborns. They were divided into two groups, with and without maternal anemia. Collected cord blood (2 mL) was placed in tubes with ethylenediaminetetraacetic acid (EDTA). Plasma ferritin and vitamin D (25-hydroxyvitamin D, 25(OH)D) levels were measured by enzyme-linked immunosorbent assay (ELISA). Results Maternal anemia was found in 60 mothers (55% subjects). The mean cord blood hemoglobin levels for the anemic and non-anemic groups were 15.19 (SD 2.25) g/dL and 15.12 (SD 1.98) g/dL, respectively (P=0.87). Median cord blood ferritin levels were slightly lower in anemic [12.95 (range 0.42-17.69) µg/L] than in non-anemic mothers[13.45 (range 7.10-22.12) µg/L], but were not significantly different (P=0.555). Median cord blood 25(OH)D levels were lower in the anemic group [12.24 (range 8.53-32.99) ng/dL] than in the non-anemic group [14.26 (range 9.84-61.44) ng/dL], but the difference was not significant (P=0.964). Conclusion Maternal anemia was not significantly associated with cord blood hemoglobin, ferritin, or 25(OH)D levels.
CYP2E1 POLYMORPHISMS AND SUSCEPTIBILITY TO ANTI-TUBERCULOSIS DRUG-INDUCED HEPATOTOXICITY IN INDONESIA POPULATION Suhuyanly, Nella; Bakri, Syakib; Yusuf, Irawan; Massi, Muh Nasrum
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.41251

Abstract

Pengobatan Tuberkulosis (TB), berdasarkan penggunaan isoniazid (INH), rifampisin (RMP) dan pirazinamid (PZA), terbukti menyebabkan hepatotoksisitas yang diinduksi oleh obat (Drug Induced Hepatotoxicity/DIH). Penelitian terbaru menunjukkan bahwa variasi genetik dapat dikaitkan dengan risiko DIH, seperti status asetilator INH, yang terkait dengan polimorfisme N-asetil transferase (NAT) 2, yang mana asetilator lambat pada umumnya lebih rentan terhadap efek samping obat. Proporsi asetilator cepat dan lambat sangat bervariasi pada populasi dengan etnis atau geografis yang berbeda yang telah dijelaskan dalam berbagai penelitian, tetapi, masih ada informasi yang terbatas dalam populasi kita. Tujuan dari penelitian ini adalah untuk menyelidiki kontribusi polimorfisme CYP2E1 terhadap DIH anti-TB pada populasi kami. Penelitian kasus kontrol ini dilakukan di Rumah Sakit Cipto Mangunkusumo, Jakarta dan Rumah Sakit Omni Alam Sutera, Tangerang, Indonesia dari Januari 2015 - Desember 2016. Kami merekrut 35 orang dengan DIH dan 34 orang tanpa DIH. Profil fungsi hati lengkap, bilirubin total serum, bilirubin tidak langsung, dan bilirubin langsung diukur. Kami melakukan genotipe polimorfisme CYP2E1 rs3813867, rs2031920 dan rs6413432. Kami menemukan bahwa polimorfisme CYP2E1 c1/c1 (tipe liar homozigot) pada 61 subjek (88,4%) dan tidak ada perbedaan yang signifikan secara statistik antara tipe liar homozigot dan varian yang jarang (mutan alel) dalam kejadian DIH (95% CI 0,403 - 8,383, P = 0,338). Kami mengusulkan bahwa polimorfisme CYP2E1 tidak dapat membantu dalam memprediksi kerentanan terhadap hepatotoksisitas yang diinduksi oleh obat anti-tuberkulosis pada populasi di Indonesia.
IN VITRO COMPARISON OF MINIMAL INHIBITORY CONCENTRATION (MIC) GRISEOFULVIN, ITRACONAZOLE, AND TERBINAFINE AGAINST THE CAUSATIVE AGENT OF DERMATOPHYTOSIS ON GLABROUS SKIN IN MAKASSAR Sari Handayani; Zakiani Sakka; Safruddin Amin; Nasrum Massi
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 7 No 01 (2025): April
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v7i01.299

Abstract

ABSTRAK Dermatofitosis adalah infeksi jamur golongan dermatofit, yaitu organisme yang menyerang jaringan keratin pejamunya. Tiga genus dermatofit yaitu: Epidermophyton, Microsporum dan Trichophyton.Menentukan KHM griseofulvin, itrakonazol dan terbinafin terhadap isolat agen penyebab dermatofitosis kulit glabrous. Pengambilan data deskriptif potong lintang dengan uji kepekaan griseofulvin, itrakonazol dan terbinafin terhadap isolat koloni dermatofit yang tumbuh melalui tehnik mikrodilusi kaldu pada Laboratorium Mikrobiologi RS Pendidikan UNHAS Makassar. Griseofulvin, itrakonazol dan terbinafin peka terhadap sebagian besar agen penyebab dermatofitosis pada kulit glabrous di Makassar yaitu dengan persentase kepekaan griseofulvin 96,15%, itrakonazole 96,30% dan terbinafin 100% dari 27 isolat dermatofit yang dapat diidentifikasi. Spesies yang telah resisten terhadap griseofulvin adalah Trichophyton rubrum, spesies yang resisten terhadap itrakonazole adalah Microsporum audouinii sedangkan terbinafin peka terhadap keduaSpesies Trichophyton dan Microsporum.KHM Itrakonazole lebih rendah dari griseofulvin dan lebih tinggi dibanding Terbinafin mengindikasikan bahwa terbinafin merupakan antifungal yang lebih peka dibanding kedua golongan obat tersebut. ABSTRACT Dermatophytosis is a fungal infection of the dermatophyte group, namely organisms that attack the keratin tissue of their host. The three genera of dermatophytes are: Epidermophyton, Microsporum and Trichophyton. Objectives: Determine the MIC of griseofulvin, itraconazole and terbinafine against isolates of the causative agent of glabrous skin dermatophytosis. Methods: Collecting descriptive cross-sectional data using griseofulvin, itraconazole and terbinafine sensitivity tests on dermatophyte colony isolates growing using the broth microdilution technique at the Microbiology Laboratory of the Makassar UNHAS Teaching Hospital. Result: Griseofulvin, itraconazole and terbinafine were sensitive to most of the agents that cause dermatophytosis on glabrous skin in Makassar, namely with a sensitivity percentage of griseofulvin 96.15%, itraconazole 96.30% and terbinafine 100% of the 27 dermatophyte isolates that could be identified. The species that is resistant to griseofulvin is Trichophyton rubrum, the species that is resistant to itraconazole is Microsporum audouinii while terbinafine is sensitive to both Trichophyton and Microsporum species. Conclusions: The MIC of Itraconazole is lower than griseofulvin and higher than Terbinafine, indicating that terbinafine is a more sensitive antifungal than these two groups of drugs.
Positive Blood Culture Results Predominantly Unrevealed among Adults Patients with Sepsis Hursepuny, Valentine; Baedah Madjid; Firdaus Hamid; Mochammad Hatta; Muh. Nasrum Massi; Rizalinda Sjahril; Yoeke Dewi Rasita; Lisa Tenriesa; Andi Rofian Sultan
Alami Journal (Alauddin Islamic Medical) Journal Vol 8 No 1 (2024): JANUARY
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/alami.v8i1.41777

Abstract

Sepsis is increasing every year and can be life-threatening. In the diagnosis of sepsis, it is challenging to identify the causative agent of infection. This research aims to determine the proportion of positive blood culture in sepsis patients at Hasanuddin University Hospital, Makassar. Blood cultures were collected from 98 adult patients with sepsis manifestations. This research design is cross-sectional with a descriptive observation approach. The data analysed in descriptive statistics were utilised to summarise patient demographics, treatments, and outcomes. Thirteen of 98 samples were positive for microbial pathogens (13.26%). The elderly group had the highest percentage (76.5%); eighty-seven patients (88.77%) were treated with antibiotic therapy prior to blood culture collection. Cephalosporins are the most administered antibiotics (72.4%). Administration of empirical therapy prior to blood culture collection may decrease the sensitivity of culture results. The culture of the infectious focus should be done to assist in the consideration of antimicrobial treatment.
Aktivitas Anti Mycobacterium tuberculosis Strain H37Rv dan MDR (Multi Drug Resistant) dari Ekstrak Rimpang Curcuma mangga Val.: Anti Mycobacterium tuberculosis Activity Strain H37Rv and MDR (Multi Drug Resistant) from Curcuma mangga Val. Rhizome Extract Pratiwi, Ritha; Alam, Gemini; Rante, Herlina; Massi, Nasrum
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.319 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13102

Abstract

TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Empirically the plants that have long been used in medicine are Curcuma mangga rhizome, which shows pharmacological activity as an anti Mycobacterium tuberculosis drug. The objective of the research is to determine the ability of hexane and methanol extracts of Curcuma mangga in inhibiting the growth of Mycobacterium tuberculosis Strain H37Rv and MDR. The extraction of Curcuma mangga rhizome was conducted by maceration methode using hexane and methanol as the solvents, respectively. Both of extracts were made in 1000 dan 500 ppm concentration, then tested for anti Mycobacterium tuberculosis activity using MODS (Microscopic Observation Drug Suspectibility) method. Determination of anti M.tuberculosis activity was based on microscopic observation on Mycobacterium tuberculosis colony in cord formation. The results showed that hexane and methanol extract in 1000 ppm concentration inhibited the growth of Mycobacterium tuberculosis Strain H37Rv dan MDR. However in 500 ppm only n-hexane extract showing the inhibiton activity. In conclusion, n-hexane extract have the ability to inhibit the growth of Mycobacterium tuberculosis Strain H37Rv dan MDR.
Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women Chalid, Maisuri Tadjuddin; Judistiani, Tina Dewi; Syahril, Rizalinda; Masadah, Rina; Febriani, Dwi Bahagia; Wahyuni, Ridha; Turyadi, Turyadi; Massi, Muh Nasrum
The Indonesian Biomedical Journal Vol 16, No 1 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i1.2726

Abstract

BACKGROUND: The risk factors for intrauterine transmission of hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-positive pregnant women are poorly understood. Numerous factors are considered to be involved, including placental barrier, obstetric environment, high viral load, and positivity of hepatitis B e antigen (HBeAg). This study was conducted to investigate the role of placenta barrier, clinical, and viral factors in intrauterine transmission of HBV.METHODS: A cross-sectional study was conducted involving 1,353 pregnant women who underwent HBsAg screening. Eighty-four (6.2%) women were detected as HBsAg positive and were examined for HBsAg level, anti-HBs, anti-HBc, HBeAg/hepatitis B e antibody (anti-HBe) status, and HBV DNA presence in cord blood. Quantitative HBV DNA was analyzed using real-time polymerase chain reaction (PCR).RESULTS: Eighty-four of 1,353 subjects were HBsAg-positive. HBV DNA was positive in 28/84 (33.7%) maternal sera, 19/79 (24.05%) placental specimens, and 9/83 (10.84%) in cord blood. There were significant associations between HBV DNA in maternal serum (p=0.000) and placental tissue (p=0.000) with HBV DNA in the cord blood. No clinical factors were associated with HBV DNA transmission in cord blood. Sixty percent of viral load >5.3 log10 copies/mL were found in the cord blood, of which 43.8% HBeAg positive and 3.1% HBeAg negative.CONCLUSION: Reduced transmission via compartments established the placenta’s barrier function in mother-to-child transmission. A high maternal viral load and positive HBeAg were risk factors for intrauterine transmission, while negative HBeAg still has the possibility of transmission.KEYWORDS: mother-to-child transmission, hepatitis B virus, intrauterine
Identification of Airborne Aerobic Bacteria in the Intensive Care Room using MALDI-TOF MS Palulun, Prajayanti; Rasita, Yoeke Dewi; Massi, Muhammad Nasrum; Sjahril, Rizalinda; Katu, Sudirman; Pattelongi, Ilhamjaya
JURNAL KESEHATAN LINGKUNGAN Vol. 16 No. 1 (2024): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v16i1.2024.68-75

Abstract

Introduction: Indoor air quality can affect the spread of airborne microorganisms which can lead to healthcare-associated infections (HAIs). The quality and quantity of airborne microorganisms are responsible for mortality and morbidity in infection-prone hosts such as patients admitted to the intensive care unit (ICU). The research aims to determine the quality of microorganisms in the air, identify the types of aerobic bacteria, and assess the physical parameters of the air in the ICU. Methods: This study was a cross-sectional study with a descriptive observational method. Air specimens were collected using the MAS-100 NT tool with blood agar plate solid culture media, which then incubated in an aerobic atmosphere for 24 hours at 37±2°C. Observation and measurement of air microbiological quality was by counting the number of microorganisms in CFU/m3 and identification of bacteria using MALDI-TOF MS. Results and Discussion: The maximum concentration of microorganisms in the air exceeds the standard value, and the average value of the concentration of microorganisms in the air is 736 CFU/m3. The most common types of aerobic bacteria in the air were Bacillus sp. (n=12), Coagulase-negative Staphylococci (n=5), and Staphylococcus aureus (n=5). There was an increase in physical parameters in the form of average temperature (26.24°C) and humidity (70%) with a ventilation system and air regulation using mechanical ventilation sourced from a split air conditioner with an exhaust fan without a high-efficiency particulate-absorbing (HEPA) filter. Conclusion: Low indoor air quality has the potential to increase the concentration of microorganisms and bacterial findings in the air
Peningkatan Keterampilan Kelompok Julu Atia melalui Pelatihan Pembuatan Nugget Rumput Laut Kasmiati, Kasmiati; Andriani, Irma; Massi, Muh. Nasrum; Rahmi, Rahmi; Anas, Lukman; Zakiyabarsi, Furqan
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 10 No 1 (2026): Volume 10 Nomor 1 Tahun 2026
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v10i1.24591

Abstract

Seaweed is a leading commodity in the fisheries sector that has not been optimally utilized, particularly by community groups, to increase its added value. The problem faced by these groups is a lack of knowledge and skills in processing and selling seaweed-based products. This activity aims to improve the knowledge and skills of "Julu Atia" partners in the production and marketing of seaweed nuggets. The method used was to directly involve 20 members in training and mentoring activities. The training included counseling and practical training on nugget production and marketing, while the mentoring aimed to evaluate the group's ability to independently produce and market the product. Initial knowledge and skills of partners were determined through pre- and post-tests. The results showed that partner knowledge was relatively low, with an average of 34.5%, increasing by 55% to 89.5% after participating in the community service activity. Through nugget production, the added value increased by IDR 222,000 per kg of seaweed. Thus, this activity effectively increased the empowerment level of "Julu Atia" and can be replicated in other groups to improve the welfare of coastal communities.
Co-Authors Adyatma Muhammad Nur Agus Sangka Pratama Ahmad, Mardiana Ahyar Ahmad Alwi A Mappiasse Amiruddin Laompo Anas, Lukman Andi Alfian Zainuddin Andi Ariyandi Andi Asadul Islam Andi M Ichsan Andi Nilawati Usman Andi Nur Asrinawaty Andi Rofian Sultan Andi Zulkifli AS Anita Anita Ari Yuniastuti Arif, Sitti M. Arsyad, Andi Fatimah Asaad Maidin Asty Amalia Nurhadi Azhar, Muh. Aprizal Baedah Madjid Bahrul Fikri Budu - Budu Budu Bukhari, Agussalim Chalid, Maisuri Tadjuddin Conny Tanjung Dasril Daud DAVID HANDOJO MULJONO Dewi Mutisari Dian Amelia Abdi Diana Muchsin Dwi Kesuma Sari Eddyman W Ferial Faisal Attamimi Faradillah Suhar Febriani, Dwi Bahagia Ferra Indrawati Fikri, Bahrul Firdaus Hamid Firdaus Kasim Furqan Zakiyabarsi Gemini Alam Gemini Alam Habibah S Muhiddin Hendra Wibawa Herlina Rante Hidayah, Najdah Hursepuny, Valentine Ibrahim Labeda Idham Jaya Ganda Ilhamjaya Patellongi Ilhamjaya Pattelongi Irawan Yusuf Irawati Djaharuddin Irma Andriani Irma Andrianys Kasmiati Kasmiati Khairuddin Djawad Khairuddin Djawad Kusrini S. Kadar Latief, Nikmatia Linda Runtuwene Lisa Tenriesa Lokita Purnamasari Luthfi, Muhammad M Natsir Djide Marcellus Simadibrata Mardiana Ahamad Mardiana Ahmad Mardiana Ahmad Meutiah Ilhamjaya Mochammad Hatta Mochammad Hatta Mochammad Hatta Muflihanah Muhammad Akmal A. Sukara Mustika Hutabarat Sari Mustika Sari Nadirah Rasyid Ridha, Nadirah Rasyid Nadyah Nasir Djide Nilawati Usman Nilawati, Andi Norma Tiku Kambuno Nur Fajri Nurfadillah S Nurmadilla, Nesyana Nurpajri, Nurpajri Palantei, Elyas Palulun, Prajayanti Pattelongi, Ilhamjaya Prihantono Prihantono Putri, Sri Hardiyanti Raden Tina Dewi Judistiani Rahmawaty Rahimi Rahmi Rahmi Rajia Rasita, Yoeke Dewi Ratna Ridha Wahyuni, Ridha Rina Masadah Rinda Nariswati Ritha Pratiwi Riza Linda Rizalinda Sjahril Rizalinda Sjahril Rosana Agus Rosdiana Natzir Rusdianto Rusdianto Safruddin Amin Saidah Syamsuddin Samara, Yulianti Sari Handayani Sartini Sartini Sharvianty Arifuddin Sharvianty Arifuddin Shelly Salmah Sjafaraenan Sjafaraenan, Sjafaraenan Solly Aryza Sri Vitayani Suanti Sudirman Katu Sudirman Katu, Sudirman Suhuyanly, Nella Supri Suryani As'ad Syahril, Rizalinda Syakib Bakri Tjahjadi Robert Tedjasaputra Turyadi Turyadi, Turyadi UPIK ANDERIANI MISKAD, UPIK ANDERIANI Veni Hadju Wardihan Sinrang Yenti Purnamasari Yoeke Dewi Rasita Zakiani Sakka