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All Journal Jurnal Farmasi Udayana Farmaka Indonesian Journal of Pharmaceutical Science and Technology Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmacon Al-Kimia ALCHEMY Jurnal Penelitian Kimia JRST (Jurnal Riset Sains dan Teknologi) Jurnal Penelitian Farmasi Indonesia KACANEGARA Jurnal Pengabdian pada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON Jurnal Katalisator Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Jurnal Ilmu Kefarmasian Indonesia Jurnal Anugerah: Jurnal Pengabdian Kepada Masyarakat Bidang Keguruan dan Ilmu Pendidikan Jurnal Empathy Pengabdian Kepada Masyarakat Yumary: Jurnal Pengabdian kepada Masyarakat Jurnal Farmasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Katalisator Jurnal Farmasi Indonesia Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Farmasi Galenika Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Haiyul Fadhli
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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ISOLASI β-AMIRIN DARI KULIT BATANG PULAI BASUNG (Alstonia spatulata Bl.) haiyul jurnal manager
Jurnal Penelitian Farmasi Indonesia Vol. 4 No. 1 (2015): jpfi
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (906.955 KB)

Abstract

Alstonia spatulata Bl is a traditionally important medicinal plant. Roots, stems, leaves, and fruits of this genus have been used in traditionalmedicine to treat malaria, diarrhea, fever, fatigue, liver disease, dysentery, and diabetes. The aim of this research was to isolation and characterizationthe secondary metabolites of stem bark of A. spatulata . The result of fitochemistry test for the stembark of A. spatulata showed that it containssecondary metabolite of terpenoid and alkaloid groups. The result of isolation process yielded a white crystal of ASSB-C with n-heksan solution. Ithas melting point 196-198 0C. The analysis of 1H-NMR, 13C-NMR, HSQC, HMBC, COSY, NOESY and FT-IR spectra for ASSB-C showed that it isincluded into triterpenoid group which is called β-Amirin
ISOLASI DAN UJI AKTIVITAS ANTIOKSIDAN FRAKSI ALKALOID DARI EKSTRAK METANOL KULIT BATANG BUNGA KUPU-KUPU (Bauhinia semibifida Roxb.) Haiyul Fadhli; Mustika Furi; Apriko Jauwahir
Jurnal Penelitian Farmasi Indonesia Vol. 7 No. 2: JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

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Abstract

Bauhinia semibifida Roxb. is a plant has potensial as antioxidant. The purpose of this research is to isolate alkaloids fraction from methanol extract and to examine the activity of antioxidant with DPPH method. The extraction was done by using maceration method with metanol solvent and an acid-base was performed on the extract with acid citric 2% and amonia, and fractionation with ethyl acetat and butanol solvents. The ethyl acetat fraction was separated by column chromtography. The isolates from column chromatography was labeled SA fraction, which a yellow colour oil. Based on phytochemicals data analysis, the spectroscopy of UV-Vis, FT-IR, and LC-MS, it can be concluded that the SA fraction is a compound has a NH functional group (alkaoids), and has very weak antioxidant activity with IC50 429,64 mg/mL.
KADAR FENOLIK DAN FLAVONOID TOTAL SERTA AKTIVITAS ANTIOKSIDAN DARI EKSTRAK METANOL AKAR, DAUN DAN BUNGA SIMPUR AIR (Dillenia suffroticosa Griff. Ex Hook) Rahayu Utami Utami; Ginta Rio Maranti; Mustika Furi; Melzi Octaviani; Septi Muharni; Fina Aryani; Husnawati; Wira Noviana Suhery; Musyirna Rahmah Nst; Haiyul Fadhli; Emma Susanti; Emrizal
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 2 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i2.1418

Abstract

Simpur air is one of plant that has been using as traditional medicine for treating several diseases. Some studies on its chemical constituents and biological activities of this species have been published. However, chemical constituents and antioxidant activity of this plant which is Riau origin has not been reported before. This study aims to determine the total of phenolic and flavonoid content as well as its antioxidant activity of methanol extracts of roots, leaves and flowers of simpur air. Determination of total of phenolic and flavonoid content was performed by spectrophotometric method using Folin Ciocalteu and AlCl3 as reagents, respectively. Whereas, its antioxidant activity was evaluated using DPPH method. The results showed that methanol extracts of its roots afforded the highest total of phenolic and flavonoid content and also its antioxidant activity. The total of phenolic content of methanol extracts of its roots of 428.131 GAE/mg extract; its total of flavonoid content of 766.164 QE/mg extract; as for its antioxidant activity gave IC50 value of 3.852 µg/ml.
Uji Aktivitas Antimikroba Ekstrak Etanol Kulit Bawang Merah (Allium cepa L.) dengan Metode Difusi Cakram Octaviani, Melzi; Fadhli, Haiyul; Yuneistya, Erenda
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Shallots (Allium cepa L.) are generally used as cooking ingredients by the community. The part of the shallot widely used is only a part of the tuber, while the outer shell of the shallot is thrown away because it is only considered as wastes. Based on phytochemical screening results, extract of shallot peels contains phenolics, flavonoids, and terpenoids that can inhibit the growth of microorganisms. The purpose of this research is to know the antimicrobial activity of ethanol extract of shallot peels against Staphylococcus epidermidis and Staphylococcus aureus as Gram positive bacteria, Salmonella thypi and Eschericia coli as Gram negative bacteria and also antifungal activity against Trichophyton mentagrophytes. The study was performed using disc diffusion method with the variation of concentration of ethanol extract of the peels of 50%, 25%, 12.5%, 6.25%, 3.125% and 1.5625% w/v, respectively, the positive control of chloramphenicol for bacteria, the positive control of nystatin for fungi and the negative control of DMSO. The diameter of the inhibition zone formed on the activity assay of ethanol extract of the shallot peels against Staphylococcus epidermidis, Staphylococcus aureus, Salmonella thypi and Eschericia coli at the concentration of 50% was 11.75 mm, 16.03 mm, 9.42 mm and 7.77 mm, respectively. The inhibition zone formed on the activity assay of ethanol extract of the shallot peels against Trichophyton mentagrophytes at the concentration of 50% was 18.53 mm. As conclusion, ethanol extract of the shallot peels could inhibit the growth of Staphylococcus aureus, Staphylococcus epidermidis, Salmonella thypi, Escherichia coli and Trichophyton mentagrophytes.
ALPHA-GLUCOSIDASE INHIBITORY ACTIVITIES OF KEDABU FRUIT (Sonneratia ovata BACKER) ETHANOL EXTRACT AND FRACTION Rahma Dona; Haiyul Fadhl; Mustika Furi; Tyasakti Viryana
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4165

Abstract

One of the antidiabetic activity tests is carried out through inhibition testing of the ɑ-glucosidase enzyme. Sonneratia ovata Backer is a mangrove plant that has been used traditionally in medicine. The antidiabetic activity of the fruit samples of Kedabu (Sonneratia ovata Backer) was tested by measuring the inhibition of the ɑ-glucosidase enzyme in vitro. The test sample used ethanol extract (EE) and 3 fruit fractions of Kedabu. The calculation result of the IC50 value obtained at EE was 1.86 µg / mL, the calculation result of the IC50 value obtained in the n-hexane (FH) fraction of Kedabu fruit was 193.32 µg / mL, the calculation result of the IC50 value obtained in the ethyl acetate fraction (FE) of fruit Kedabu is 2.32 µg / mL and finally the calculation result of the IC50 value of water fraction (FA) is 2.29 µg / mL. The positive control in this study, Akarbose, obtained an IC50 result of 0.75 µg / mL. Based on the results obtained, the ethanol extract of Kedabu (Sonneratia ovata Backer) fruit is very active and has the potential as an inhibitor of the ɑ-glucosidase enzyme, followed by the water fraction and ethyl acetate fraction, while the potentially inactive sample is in the n-hexane fraction.
S SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA 3ꞌ-BROMO-4-METOKSI KALKON TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli Rahma Dona; Haiyul Fadhli; Adel Zamri; Winda Tria Safitri; Abdi Wira Septama
Jurnal Penelitian Farmasi Indonesia Vol. 11 No. 2 (2022): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v11i2.1547

Abstract

Chalcone is a flavonoid derivative that has a variety of interesting biological activities. One of the compounds suspected of being an antibacterial agent is chalcone. The properties of chalcone compounds depend on the substituents that depend on the two aromatic rings, such as Cl, Br, OH groups and so on. The purpose of this study was to synthesize chalcone analogue compounds and determine the potential of these analog compounds as antibiotics. In this research, a chalcone analogue compound has been successfully synthesized, namely 3ꞌ-Bromo-4-methoxy-chalcone through the stirring method using KOH catalyst, ethanol solvent. The results of the synthesis carried out by recrystallization and the yield obtained were 64 %. Identification of compounds that have been carried out by TLC test, melting point, and HPLC analysis. The structure of the compound was characterized by UV-Vis spectroscopy, FTIR and 1H NMR, indicating that the analogue chalcone compound has a structure as expected. Testing the activity of chalcone analogue compounds was carried out on Staphylococcus aureus and Escherichia coli at a concentration of 1%, 5%, 10% and 20% test solutions. The test results showed that the antibacterial activity of the compound 3ꞌ-Bromo-4-methoxy-chalcone was categorized as weak.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI BUAH Syzygium polyanthum Wigh Walp TERHADAP BAKTERI GRAM NEGATIF Melzi Octaviani; Rahima; Haiyul Fadhli
JURNAL KATALISATOR Vol. 6 No. 2 (2021): Jurnal Katalisator, Volume 6, No 2, 2021
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (605.821 KB) | DOI: 10.22216/katalisator.v6i2.395

Abstract

Tumbuhan salam (Syzygium polyanthum Wigh Walp) digunakan oleh masyarakat sebagai rempah dan bumbu penyedap rasa makanan. Selain itu, tumbuhan salam juga dapat digunakan untuk mengobati berbagai penyakit. Bagian tumbuhan salam yang dapat dimanfaatkan sebagai obat selain daun adalah bagian buah. Buah salam memiliki kandungan metabolit sekunder yaitu flavonoid, fenolik, saponin dan alkaloid yang diketahui mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak etanol, fraksi n-heksana, fraksi etil asetat dan fraksi n-butanol buah salam terhadap bakteri Escherichia coli, Salmonella typhi dan Shigella dysenteriae dengan metode difusi cakram. Konsentrasi larutan uji yang digunakan 10%; 5%; 2,5%; 1,25%; 0,625%; 0,313%, 0,156% dan 0,078% b/v, serta kontrol positif ciprofloxacin 5 µg/disk dan kontrol negatif DMSO. Hasil uji aktivitas antibakteri dianalisis dengan menggunakan metode one way ANOVA dan uji Kruskall-Wallis. Didapatkan hasil (p<0,05) yang menunjukkan adanya perbedaan yang signifikan daya hambat yang diberikan antara kontrol dan seri konsentrasi. Hasil pengujian menunjukkan bahwa ekstrak dan fraksi buah salam memiliki aktivitas dalam menghambat pertumbuhan bakteri Escherichia coli, Salmonella typhi dan Shigella dysenteriae.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI DARI AKAR DAN BATANG TUMBUHAN SEKUNYIT (Fibraurea tinctoria Lour) Rahayu Utami; Dwi Winarsih; Armon Fernando; Haiyul Fadhli; Mustika Furi; Emma Susanti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 2 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.712 KB) | DOI: 10.35617/jfionline.v12i2.50

Abstract

Sekunyit (Fibraurea tinctoria Lour) is plant species that has been using widely as traditional medicine such as a cure for diarrhea. This study was conducted to determine the antibacterial activity of extract and fractions of its root and stem against bacteria that cause diarrhea. The sample of root and stem were macerated with ethanol and then followed by ultrasonication process for 30 minutes. Fractionation process was performed by acid-base method using three different solvents which were n-hexane, chloroform and n-butanol. The extract and fractions were tested for its antibacterial activity using agar diffusion method at tested concentrations of 30; 15; 7.5; 3.75 and 1.88%. The result showed that the ethanol extract, n-hexane, chloroform A and chloroform B fractions of the root and stem provided antibacterial activity against all tested bacteria with weak to medium activity. Whereas the n-butanol fraction did not give any activity, either to Escherichia coli, Salmonella typhi, Staphylococcus aureus as well as Vibrio cholerae.
REVIEW: PHYSICAL CHARACTERISTICS, ANTIOXIDANT, ANTIBACTERIAL AND WOUND HEALING EFFECTS OF BASIL LEAVES IN SEVERAL TYPES OF PHARMACEUTICAL BASES Rodhia Ulfa; Wildan Khairi Muhtadi; Nesa Agistia; Haiyul Fadhli
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.855

Abstract

Topical preparations are dosage forms applied to the skin for local therapy. These topical preparations contain several types of bases that are used for drug formulations. This review aimed to determine the type of base that is effective and widely used in basil leaf preparations that function as antioxidants, antibacterial agents, and in wound healing. The research method is comparative, namely, reviewing research articles on formulations of basil leaf products with various concentrations of base types, hydrogels, emulgels, lotions, hydrocarbons, water solubility, absorption, water washing, M/A-type creams, and pastes. The recommended formulation is a gel base type that has physical characteristics, non-irritating properties, antioxidant activity, antibacterial activity, and wound healing. This review contained articles published in the last 10 years.  Keywords: basil leaves, base type, physical characteristics, basil leaves, pharmacological activity
Uji Aktivitas Antioksidan Kulit Buah Pulasan (Nephelium mutabile Blume) Dan Bunga Turi Putih (Sesbania grandiflora) Dengan Metoda DPPH Haiyul Fadhli; Andika Bharada Rizky Soeharto; Tia Windarti
Jurnal Katalisator Vol 3, No 2 (2018): KATALISATOR
Publisher : LLDIKTI Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (738.706 KB) | DOI: 10.22216/jk.v3i2.2882

Abstract

Telah dilakukan penelitian tentang uji aktivitas antioksidan ekstrak kulit buah Pulasan (Nephelium mutabile Blume) dan bunga Turi Putih (Sesbania grandiflora). Ekstrak ekstrak kulit buah Pulasan (N. mutabile Blume) dan bunga Turi Putih (S. grandiflora) diperoleh secara terpisah dengan maserasi. Uji aktivitas antioksidan diuji dengan metode DPPH. Aktivitas antioksidan ditunjukkan dengan nilai IC50, pada ekstrak n-heksana kulit buah Pulasan > 1000 µg/ml; ekstrak etil asetat kulit buah Pulasan 468,24 µg/ml; ekstrak metanol kulit buah Pulasan 57,38 µg/ml; ekstrak n-heksana bunga Turi Putih > 1000 µg/ml; ekstrak etil asetat bunga Turi Putih > 1000 µg/ml; ekstrak metanol bunga Turi Putih 836,91 µg/ml
Co-Authors Abdi Wira Septama Adel Zamri Adriani Susanty agistia, nesa Agustini, Tiara Tri Ainun Nurain Nurdin Ainun Nurain Nurdin Alfayutia, Windi Allaya, Regina Alpasiri, Ikhsan Mauludi Ananto, Deswita Sandra Tsalsabila Andika Bharada Rizky Soeharto Anggraeni, Ica Winanda Anggraini, Silvana Anita Lukman Apriko Jauwahir Arif Arsaf, Mohammad Armon Fernando Arsaf, Mohammad Arif Arsaf, Muhammad Arif Asraf, Muhammad Arif Azizah, Wahyu BENNI ISKANDAR Dachriyanus Devi Safitri Dewi, Erna Puspita Difa, Faradini Ramsanjami DINA FITRIYAH Dwi Winarsih Emrizal Enda Mora Erenda Yuneistya Erna Puspita Dewi Fadhila, Qonita Nur Fadillah, Ma’isyatul Fatma Sri Wahyuni Fatmalia, Anggun Fellysya, Nadya Safha Feriansyah, Robby Fina Aryani, Fina Fitriah, Dina Frasesa, Roscha Ulfa Furi, Mustika Ginta Rio Maranti Hazimah Hazimah, Hazimah Husnawati Husnawati Husnawati Ihsan Ikhtiarudin Iriani, Revy Islamia, Elmas Ghalis Nur Jasril Jasril Jumadila, Ikhsal Mukri Kamil, Marshal M. Khoiriah, Anisah Maqfiroh, Wirdarani Mardianti, Tengku Shella Maspat, Rinta Meiriza Djohari, Meiriza Melzi Octaviani Miftahul Jannah Mudia, Whulan Muhtadi, Wildan Khairi Musyirna Rahmah Nst Muti’ah, Try Hadirah Nadilla Alfitri Neni Frimayanti Ningsih, Yozi Fiedya Nofri Hendri Sandi Noveri Rahmawati Nur Fitria Rohmatul Ummah Nurul fadillah, Nurul Pedro Anugrah Aswan Pratiwi, Amanda Putri Pratiwi, Erniza Putra, Diova Yuswidia Putri Lestari Putri Lestari, Putri Putri Pratiwi, Amanda Putri, Hefriza Putri, Rusnita Putri, Sella Hilmalia Nur Al Rahayu Utami Rahayu Utami Rahayu Utami Utami Rahima Rahma Dona Rahma Dona, Rahma Rahmatunnur, Siti Rahmayanı, Wıky Rahmiwati Hilma Ricardo, Nadira Atiqah Rifani, Mhd Rizki Wulandari Robiatun Adawiyah Rodhia Ulfa Ronapadua Musyirna Rahmah Nasution Sahara dan Emma Susanti Ruska, Shinta Liana Sajja Wanda, Taqqia Sandra Tsalsabila Ananto, Deswita Sari, Rinita Septi Muharni Siregar, Lisa Andriyani Sitanggang, Sarah Dianora Sumbarita, Silvia Trihardiyanto, Agus Tyasakti Viryana Ulfa Frasesa, Roscha Veithzal Rivai Zainal Viryana, Tyasakti Wanda, Taqqia Sajja Winda Tria Safitri Winda Yusma Ameliah Windarti Windarti Wira Noviana, Wira Noviana Wulandari, Venny Yanwirasti Yanwirasti Yuneistya, Erenda Yuswidia Putra, Diova Zamri, Wiedya Alfitrya