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All Journal Elkawnie Al-Kimia JMM (Jurnal Masyarakat Mandiri) Pharmasipha JSFK (Jurnal Sains Farmasi & Klinis) Jambura Journal of Health Sciences and Research Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) ARSY : Jurnal Aplikasi Riset kepada Masyarakat Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian Kesehatan Masyarakat International Journal of Health Science & Medical Research Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Endah Nurrohwinta Djuwarno
Universitas Negeri Gorontalo
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Upaya Peningkatan Status Gizi Anak sebagai Pencegahan Stunting di Desa Mongiilo Utara Bone Bolango Fika Nuzul Ramadhani; Endah Nurrohwinta Djuwarno; Nur Ayun R Yusuf
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 3 (2022): Vol 1 Edisi 3 (2022)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.895 KB) | DOI: 10.3731/phar.soc.v1i3.18286

Abstract

Nutritional problem is one of the causes of increasing stunting incidence in an area which has a long term impact for children. Stunting in children is characterized by a child's height that is below average or also known as failure to thrive. Stunting in children can cause developmental delays in the brain so that long-term effects can cause mental retardation, low learning ability and the risk of chronic disease. Innovation in food sector by making biscuits with nuts and vegetable composition is very important to increase children's interest for consuming vegetables that are rich in nutrients for prevent stunting. This community service activity aims to prevent stunting in the people of North Mongiilo Village by providing information processing of biscuits with many nutrient. This service is carried out by providing information through video tutorials on making biscuits and explaining directly to the public about the benefits and nutritional content of the ingredients used in making biscuits. Providing information on how to make biscuits to the community received a good response because most people did not know about innovations in making biscuits made from nuts and vegetables that children could like. This service provides great benefits for the village community in order to gain knowledge about the benefits and important nutritional content of vegetables and improve the community's economy with innovations in production of biscuits made from nuts and vegetables.
Studi Pola Fragmentasi Jamu Terkonfirmasi Parasetamol Menggunakan Liquid Chromatography Mass Spectroscopy (LCMS) Muhammad Taupik; Endah Djuwarno; Muhamad Handoyo Sahumena
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i2.4558

Abstract

Salah satu bahan kimia obat yang sering ditambahkan pada jamu adalah parasetamol karena obat ini merupakan obat analgetik-antipiretik. Sampel terdiri atas 6 sampel jamu  dengan merek berbeda. Analisis kualitatif dengan metode KLT menggunakan fase gerak n-heksan:etil asetat (1:1) diperoleh tiga sampel yang positif mengandung parasetamol yakni sampel D, E, dan F. Ketiga sampel yang positif mengandung parasetamol dihitung kadarnya dengan metode LCMS. Analisis kuantitatif dengan LCMS menggunakan fase terbalik dengan fase gerak asetonitril:air (15%>:85%> v/v) pada laju alir 0.2 mL/menit dan volume injeksi 5 gL. Berdasarkan data kromatogram LCMS diperoleh waktu retensi (Rf) parasetamol 1,038 menit. Rata-rata waktu  retensi  sampel  jamu  mendekati   waktu  retensi parasetamol. Pendekatan selanjutnya berdasarkan pola fragmentasi dari Spektroskopi Massa. Berdasarkan data spektrum massa diperoleh fragmentasi dari parasetamol (152 m/z) membentuk  fragmen yakni p-aminofenol (109 m/z) dan asetalaldehid (44 m/z). Ion p-aminofenol,  menghasilkan subfragmen aldehyde (32 m/z) dan cyclopentadienylidene  (81 m/z). Berdasarkan hasil analisis menggunakan metode LCMS diperoleh empat sampel yang mengandung parasetamol, Sampel D. E dan F. Seharusnya ketiga sampel tersebut tidak diperbolehkan diperjualbelikan dan dikonsumsi karena  berdasarkan Peraturan  Menteri  Kesehatan  No. 006 Tahun 2012 pasal 33 dan pasal 37 tentang industri dan usaha obat tradisional bahwa obat tradisional dilarang mengandung bahan kimia hasil isolasi atau sintetik yang berkhasiat obat. Meski kandungan parasetamol dalam tergolong sedikit, tetapi menurut Permenkes RINo. 007 tahun 2012 bahwa bahan kimia obat mutlak tidak diperbolehkan terdapat dalam obat tradisional.
Studi Hepatoprotektor Gulma Siam (Chromolaena odorata) pada Tikus yang Diinduksi Parasetamol Endah Nurrohwinta Djuwarno; Widysusanti Abdulkadir; Muhammad Taupik
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i2.4559

Abstract

Gulma siam (Kopasanda) merupakan jenis tumbuhan gulma dari famili Asteraceae yang dikenal memiliki aktivitas antioksidan yang disebabkan oleh kandungan tinggi akan flavonoid dan adanya alkaloid, saponin, glikosida sianogenik, tanin dan asam fitat. Hati merupakan organ terbesar dan merupakan situs utama untuk metabolisme dan pengeluaran. Kerusakan hati dapat disebabkan paparan zat toksik (hepatotoksik) salah satunya parasetamol. Tujuan penelitian ini adalah untuk mengetahui efektivitas ekstrak etanol Chromolaena odorata terhadap penurunan enzim ALT dan AST pada mencit jantan yang diinduksi parasetamol serta konsentrasi optimalnya sebagai hepatoprotektor. Penelitian ini menggunakan desain eksperimental laboratorium, hewan coba mencit jantan dikelompokkan menjadi 5 kelompok dengan jumlah 3 ekor setiap kelompok yang diinduksi ekstrak selama 7 hari, dan diberi parasetamol dosis toksik pada hari ke-8. Hari ke 1-7 kontrol positif diberi Curcuma Z dosis 1 mg, kontrol negatif diberi Na.Cmc 1%, dan setiap kelompok dosis 1,05, 1,47 dan 1,89 mg untuk mencit 30g. Mencit diambil darah selama 3 kali, sebelum pemberian ekstrak, hari ke-8 dan setelah pemberian pct untuk diukur kadar ALT dan AST. Uji statistik menggunakan One way Annova dengan pengujian LSD. Hasil uji menunjukkan ekstrak gulma siam dosis 35 mg, 49 mg dan 63 mg memiliki kadar rata-rata ALT 34,3 µL, 36 µL, 28,3 µL dan AST 73 µL, 76,67 µL, 55 µL. Kesimpulannya ekstrak etanol 70% Chromolaena odorata memiliki hepatoprotektor dengan konsentrasi paling efektif yaitu pada 1,89 mg dengan rerata ALT 28,3 µL dan AST 55 µL.
Isolasi Senyawa Alkaloid dari Tumbuhan Mahoni (Switenia mahagoni Jacq) Muhammad Taupik; Endah Nurrohwinta Djuwarno; Moh Adam Mustapa
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 2 (2021): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i2.6663

Abstract

Penelitian ini bertujuan untuk mengidentifikasi senyawa Alkaloid yang terkandung didalam biji buah mahoni (Switenia mahagoni Jacq). Senyawa target hasil isolasi diidentifikasi menggunakan spektrofotometri UV-Vis. Proses pengambilan senyawa menggunakan metode refluks hingga diperoleh ekstrak kental berwarna hijau gelap sebanyak 27 gram. Identifikasi awal dilakukan dengan skrining fitokimia pada ekstrak kental methanol, meliputi skrining senyawa alakaloid, flavonoid, dan saponin. Proses fraksinasi dilakukan dengan sistem partisis cair-cair menggunakan n-heksanaa dan metanol dan selanjutnya hasil partisi dipekatkan dengan rotary evaporator. Fraksi metanol dielusi pada plat KLT (Kromatografi Lapis Tipis) guna mendapatkan formulasi eluen terbaik untuk dilanjutkan pada Kromatografi Cair Vakum (KCV) dan diperoleh formula eluen terbaik n-heksanaa:metanol (4:1). Proses pemisahan menggunakan KCV dengan silica gel 60 PF254, dengan system eluen n-heksana:metanol bergradien. Isolat dievaluasi kemurniannya menggunakan KLT. Isolat diidentifikasi menggunakan Spektrofotometri UV-Vis dan serapan diperoleh pada panjang gelombang gelombang 208, 240, 286 nm. Nilai absorbansi berturutturut 0,318; 0,852; dan 0,443 A. Hasil interpretasi data mengkonfirmasi bahwa terdapat ikatan rangkap terkonjugasi dikarenakan serapan terbentuk pada panjang gelombang 250-800 nm. Diduga terjadi transisi nπ* yang mengindikasikan gugus N-H dengan abrosbansi pada rentang ultraviolet kuarsa (200-400 nm).
Potensi Ekstrak Biji Pala (Myristica fragrans L) Terhadap Penyembuhan Luka Bakar pada Mencit (Mus musculus) Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Zulkarnain Marhaba
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18996

Abstract

The Nutmeg Plant (Myristica Fragrans L) is one of the spices plants empirically used as a therapeutic option for injury healing. Burn injury is damage to the skin's integrity caused by contact with a source with a high-temperature difference. This research aimed to determine the effectiveness of Nutmeg (Myristica Fragrans L) Seed extract on burn injury healing in Male Mice (Mus Musculus). Extraction was carried out through Maceration with Methanol solvent. Eighteen mice were divided into 6 groups: negative control (Na-CMC), positive control (Bioplacenton), and treatment groups with concentrations of 3%, 5%, 7%, and 10%. Burn injury was created using a 2 cm x 2 cm iron plate on the mice's back, and the healing of the burn injury diameter was observed from day 1 to day 20, with observation intervals at day 5, 10, 15, and 20. The data were analyzed using one-way ANOVA followed by an LSD test to determine the differences between test groups. The resalts indicate that the ethanol extract of Nutmeg (Myristica Fragrans L) see haseng effect on burn injury, with the most effective concentration being the extraet onoration of 10%, with a burn injury healing rate of up to 89,15%.
Uji Efektivitas Ekstrak Etanol Kulit Batang Kersen (Muntingia calabura L.) Sebagai Antidiabetes Pada Mencit Jantan Endah Nurrohwinta Djuwarno; Widy Susanti Abdulkadir; Febriyaningsi Radjak
Jambura Journal of Chemistry Vol 4, No 2 (2022): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i2.17510

Abstract

Diabetes is a degenerative disease characterized by high levels of glucose in the blood. Diabetes can lead to complications if left untreated. Treatment of diabetes can be done pharmacologically (using traditional medicines or synthetic) or non- pharmacologically (accustoming a healthy lifestyle). The use of traditional medicines is relatively cheap compared to synthetic drigs so that can be used as an anti-diabetic is the Jamaica Cherry (Muntingia calabura L.), as it contains secondary metabolites tha act as antidiabetics. Therefore, this present research aimed to determine the as an antidiabetic in male mice. The research methods used were maceration, phytochemical screening, anti-diabetic test with pre test and post test control design methods to determine if there was a decrease after the administration of the extract. The finding depicted that in the phytochemical screening test, it was observable that Jamaica Cherry (Muntingia calabura L.) bark contained secondary metabolites, incluiding alkaloids, flavonoids, and tannins, while the antidiabetic test indicated that all four extract with concentration of 50 mg, 100 mg, 200 mg and 400 mg were effective to reduce the blood sugar level with each percentage of 9%, 16%, 26%, and 42%. In brief, the antidiabetic compounds that play a role in the ethanol extract of Jamaica Cherry (Muntingia calabura L.) bark were flavonoids and tannins.
Uji Penyembuhan Luka Bakar Gel Enzim Bromelin Menggunakan Carbopol 940 Secara In Vivo Nur Ain Thomas; Muhammad Taupik; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Nabila Novreini Djunaidi
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20364

Abstract

Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in  burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.
Potensi Interaksi Obat Antidiabetes Melitus Tipe-2 dengan Obat Antihipertensi Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Nur Rasdianah; Juliyanty Akuba; Mimi Fauziah Tahir
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.18042

Abstract

The effect caused by the use of antidiabetic and antihypertensive drugs combination needs to be considered. The treatment therapy of the patient has the potential risk of drug interactions that are beneficial or detrimental to the patient. This study aims to determine the potential drug interactions in combinations of antidiabetic and antihypertensive drugs. This research is a descriptive study with a cross-sectional design and retrospective data collection. The sample used is medical records of diabetes mellitus patients with comorbid hypertension from January to December 2021 at Batudaa Public Health Center, Gorontalo Regency. The results showed that there were more female patients than male patients. Based on this study. there were 49 female patients (70%), while the largest age group of 50-59 years included 29 patients (41,43%). Whereas, those with the highest potential for drug interactions were metformin and amlodipine, totaling 54 patients (77%). The mechanism of interaction in this study was the pharmacodynamic phase, and the potential to cause the effect was hypoglycemic through the severity of the interaction was moderate level. 
IN VIVO TESTING OF ANTIPYRETIC LEAVES OF FENCE (JATROPHA CURCAS L) ORIGIN GORONTALO Widy Susanti Abdulkadir; Juliyanty Akuba; Endah Nurrohwinta Djuwarno; Dizky Ramadani Papeo; Arief Ibnu Haryanto
International Journal of Health Science & Medical Research Vol 2, No 2 (2023): August 2023
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v2i2.19428

Abstract

Jatropha (Jatropha Curcas L) is a plant that has been used empirically as a fever reducer. Fever is one of the symptoms of the disease which is characterized by a significant increase in body temperature. The novelty of this study was due to the effectiveness of Jatropha Curca L. leaf extract as an antipyretic. The purpose of this study was to determine the dose of antipyretic effectiveness of Jatropha Curcas (Jatropha Curcas L) Leaf Extract in Male Mice (Mus Musculus). Extraction by maceration using 96% ethanol solvent. 15 male mice (Mus Musculus) were divided into 5 groups, namely negative control (Na-cmc 1%), positive control (Paracetamol), and the treatment group given Jatropha leaf extract with doses of 150, 200, 250 mg/kgBW. Peptone 10% 1 ml orally as a fever inducer. And observed at 30, 60, 90 and 120 minutes after treatment. The data obtained were analyzed using one-way ANNOVA followed by the LSD test to determine differences between groups. The results showed that the leaf extract of Jatropha Curcas (Jatropha Curcas L) had an antipyretic effect where the most effective dose was at a dose of 250 mg/kgBW because it has a very stable temperature reducing power and effectiveness is comparable to Paracetamol. The conclusion of this study is that Jatropha Curcas L extract at a dose of 250 mg/kg can be used as an antipyretic.
Pengenalan Sejak Dini tentang Resistensi Antibiotik Kepada Mahasiswa Farmasi UNG dan Siswa SMK Farmasi di Kota Gorontalo melalui Program School of AMR PD IAI Gorontalo Mohamad Aprianto Paneo; Teti Sutriyati Tuloli; Nur Ain Thomas; Multiani S Latif; Muhammad Taupik; Endah Nurrohwinta Djuwarno
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 3, No 1 (2024): Vol 3. No. 1 (2024)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v3i1.25010

Abstract

Resistensi antibiotik telah menjadi perhatian utama dalam bidang kesehatan global karena dampaknya yang serius terhadap pengobatan infeksi bakteri. Fenomena ini terjadi ketika bakteri mengembangkan kemampuan untuk bertahan hidup dan berkembang biak meskipun terpapar antibiotik, mengurangi atau bahkan menghilangkan efektivitas obat tersebut. Penyebab utama resistensi antibiotik termasuk penggunaan antibiotik yang berlebihan, penggunaan yang tidak tepat, dan penyebaran gen resistensi melalui lingkungan. Konsekuensinya meliputi tingkat infeksi yang sulit diobati, peningkatan biaya perawatan kesehatan, dan peningkatan angka kematian. Upaya untuk mengatasi resistensi antibiotik melibatkan pendekatan multidisiplin termasuk penggunaan antibiotik yang bijaksana, pengembangan antibiotik baru, pengendalian infeksi, serta meningkatkan kesadaran masyarakat tentang masalah ini. Tujuan dilaksanakan kegiatan ini untuk memberikan edukasi sejak dini melalui program school of AMR Ikatan Apoteker Indonesia (IAI) kepada siswa dan mahasiswa bahwa pentingya mengenal antibiotik dan memutus rantai resistensi antibiotik. Kegiatan dilaksanakan dengan beberapa metode yang terdiri dari edukasi yang diberikan langsung oleh apoteker dan dosen, kemudian diskusi dan tanya jawab serta yang terakhir yaitu pemberian pre dan post kuesioner untuk melihat ketercapaian hasil dari kegiatan yang diberikan. Hasil menunjukan kenaikan yang progresif dari sebelumnya rata-rata pemahaman peserta berada dibawah nilai 80% menjadi rata-rata direntang 90%. Hal ini menunjukan pemberian edukasi secara terstruktur dan diberikan langsung oleh yang memiliki kompetensi akan memberikan dampak yang baik. Kegiatan seperti ini harus dilaksanakan secara berkelanjutan dengan harapan generasi berikutnya bebas dari penggunaan antibiotik yang tidak bijak.
Co-Authors A Muthi Andi Suryadi A. Mu'thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Abdulkadir, Widysusanty Adam Mustapa, Muhammad AM Andy Suryadi AM. Andy Suryadi Andi Makkulawu Anggai, Rifka Anggraini Aprianto Paneo, Mohamad Arief Ibnu Haryanto Asriyanti Asriyanti Awalludin Awalludin, Awalludin Defita Zubaidi Dewa Ayu Puspita Divia Handayani Mudjidu Dizky Ramadani Papeo Dr. Apt. Hamsidar Hasan S.Si.,M.Si Faradila Ratu Cindana Febriyaningsi Radjak Fika Nuzul Ramadhani Halada, Ichlasul Oktofandi Hamsidar Hasan Hamsidar Hasan Hamzah, Alifiah Ramawaty Hasan, Muadz Hasrita Samudi Hiola, Faramita Indriyani Ishak Isa Ishak, Siti Magfira Jafar La Kilo Julianty Akuba Kariem, Nazli LATIF, MULTIANI S Madania Madania, Madania Mahdalena Sy Pakaya Manno, Mohamad Reski Mimi Fauziah Tahir Mohamad Adam Mustapa Mohamad Aprianto Paneo Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Taupik Muhammad Taupik Muhammad Taupik Muhammad Taupik Multiani S Latif Mustapa  Khamal  Rokan Nabila Husnunnisa Ismail Nabila Novreini Djunaidi Nur Ain Thomas Nur Aisya Tonde Nur Ayini S Lalu Nur Ayun R Yusuf Nur Rasdianah Papeo, Dizky Ramadani Putri Puce, Faradilla Rahmatia Abdullah Rahmatia Baharuddin Rahmayani, Siti Farah Ratnawati Ratnawati Reski Manno, Mohamad Rezky Nur Aziz Robert Tungadi Ruslin Ruslin Selvi Marcellia Sulistya Yasin Susanti Pakaya Teti Sutriyati Tuloli Teti Sutriyati Tuloli Tirta Cahnia Usuli Virginia Balikan Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwin Rewini Kunusa Yelisnawati Harwanto Zulkarnain Marhaba Zulkarnain Marhaba Zulkifli B. Pomalango