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All Journal Jurnal Kependidikan: Penelitian Inovasi Pembelajaran Jurnal Penelitian Saintek Jurnal Ilmu Dasar Jurnal Matematika & Sains WIDYATAMA Pharmacon Jurnal Penelitian Kesehatan Suara Forikes Journal of Community Services and Engagement Journal of Nutraceuticals and Herbal Medicine PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Penyuluhan Perikanan dan Kelautan Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat INTEGRITAS : Jurnal Pengabdian Jurnal Ners Jurnal Layanan Masyarakat (Journal of Public Service) Yumary: Jurnal Pengabdian kepada Masyarakat IJECS: Indonesian Journal of Empowerment and Community Services Jurnal Farmasi dan Sains Indonesia (JFSI) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cakrawala: Jurnal Pengabdian Masyarakat Global Journal of Pharmaceutical and Sciences. Jurnal Ilmiah Kesehatan Jurnal Pengabdian Kesehatan Masyarakat Mulawarman CERATA Usadha Journal of Pharmacy Borneo Journal of Pharmacy Journal of Community Services and Engagement: Voice of Community (VOC) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Journal of Nutraceuticals and Herbal Medicine Jurnal Sains dan Kesehatan Altifani Journal: International Journal of Community Engagement Journal of World Future Medicine, Health and Nursing
Haryoto Haryoto
Fakultas Farmasi, Universitas Muhammadiyah Surakarta
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Aktivitas Antidiabetes Fraksi Dari Ekstrak Etanol Daun Yakon (Smallanthus sonchifolius) Pada Tikus Galur Wistar Yang Diinduksi Aloksan Secara In Vivo Triana Ariska Dewi; Haryoto Haryoto
CERATA Jurnal Ilmu Farmasi Vol 16 No 2 (2025): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v16i2.2015

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion or action. Conventional therapy with oral antidiabetic agents and insulin is often associated with adverse effects, including hypoglycemia and gastrointestinal disturbances, which encourage the development of safer alternatives. Yacon (Smallanthus sonchifolius) is known to have antidiabetic potential because it contains fructooligosaccharides (FOS), flavonoids, and phenolic compounds. This study aimed to evaluate the antidiabetic activity of ethanol extract fractions of yacon leaves in alloxan-induced diabetic Wistar rats. The ethanol extract was fractionated into n-hexane, ethyl acetate, and ethanol-water fractions. Male Wistar rats were divided into five groups: negative control, positive control (metformin 100 mg/kgBW), and three treatment groups receiving each fraction (100 mg/kgBW) orally for 21 days. Blood glucose levels were measured on days 0, 7, 14, and 21. Phytochemical screening was conducted using Thin Layer Chromatography (TLC). Data were analyzed using one-way ANOVA followed by LSD test. The results showed that all fractions significantly reduced blood glucose compared to the negative control (p < 0.05). Among them, the ethyl acetate fraction showed the strongest hypoglycemic effect (85.8 ± 5.8 mg/dL at day 21), comparable to metformin (103.2 ± 5.4 mg/dL). TLC analysis confirmed the presence of alkaloids, flavonoids, tannins, and triterpenoids in the ethyl acetate fraction. These compounds are known to act as antioxidants, stimulate insulin secretion, and inhibit glucose absorption. In conclusion, fractions of ethanol extract of yacon leaves, particularly the ethyl acetate fraction, exhibit strong antidiabetic activity and have potential to be developed as natural antidiabetic agents.
Aktivitas Sitotoksik Ekstrak Etanol Akar Jarak Merah (Jatropha gossypiifolia L.) terhadap Sel Kanker Payudara T47D dengan Metode MTT Assay Haryoto Haryoto; Zahrah Luthfiatul Fadhilah; Syifa Aulia Paramitha
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 02 Desember 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v22i2.28376

Abstract

Kanker payudara di Indonesia menempati kondisi tertinggi dengan persentase 16,86% dengan angka kejadian 65.858 penderita. Pengobatan antikanker dan agen kemoterapi yang beredar di Indonesia banyak memiliki kekurangan seperti efikasi yang belum memadai, adanya resistensi, dan efek samping yang merugikan. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dari ekstrak etanol akar jarak merah terhadap sel kanker payudara T47D dengan menggunakan metode MTT assay. Ekstrak etanol akar jarak merah diperoleh melalui maserasi dengan etanol 96%. Uji fitokimia menunjukkan kandungan terpenoid, flavonoid, alkaloid, tanin, dan senyawa fenolik. Dari hasil pengujian ekstrak etanol akar jarak merah didapatkan nilai IC₅₀ 21,67 μg/mL, hal ini menunjukkan adanya aktivitas sitotoksik yang cukup aktif berdasarkan kategori NCI.
Pemberdayaan Pekerja Migran Indonesia Melalui Peningkatan Literasi Kesehatan Herbal Berbasis Komunitas di Selangor, Malaysia Haryoto Haryoto; Agustono Wibowo; Ahmad Fauzi; Muhtadi Muhtadi; Andi Suhendi; Aditya Naova Sofyan
Altifani Journal: International Journal of Community Engagement Vol. 6 No. 1 (2026): Altifani Journal: International Journal of Community Engagement
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/altifani.v6i1.1496

Abstract

Indonesian Migrant Workers (PMI) in Shah Alam, Selangor, Malaysia, face limited access to formal healthcare services, thus heavily relying on herbal-based traditional medicine. Low literacy regarding the safe use of herbs potentially leads to misuse and negative interactions with modern medicine. This International Partnership Community Service (PkM-KI) activity aims to increase the knowledge and awareness of PMI and the community around the surau (Islamic prayer room) regarding the rational and evidence-based use of traditional medicine through a community-based educational approach. The program was conducted over three days through workshops, focus group discussions, and the distribution of bilingual Malay–Indonesian educational booklets containing an introduction to local medicinal plants, proper usage methods, and herbal safety aspects. The evaluation involved 24 respondents using a pre-test and post-test design to measure changes in participants' knowledge levels. Statistical analysis using the paired t-test revealed a highly significant increase in knowledge (p < 0.05), rising from 45.7% before the activity to 97.5% after the intervention. These findings indicate that the surau-based educational approach is effective as a contextual and sustainable medium for disseminating herbal health literacy. This activity not only strengthens PMI's understanding of safe traditional medicine use but also encourages the integration of local wisdom with modern pharmaceutical approaches. This program has the potential to serve as a cross-border community service model for improving herbal-based health literacy among migrant communities and local societies.
Potensi Fraksi Etil Asetat Pelepah Nipah (Nypa fruticans. Wurmb) sebagai Antihiperglikemia pada Tikus yang Diinduksi Streptozotocin Danang Raharjo; Haryoto Haryoto; Tanti Azizah Sujono
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 2 (2025): April-Juni 2025
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf16206

Abstract

 Diabetes mellitus remains a global health challenge. In Indonesia, diabetes ranks third as a killer disease after heart disease and cancer. Flavonoids as natural antioxidants have been proven effective in reducing the pathogenesis of diabetes and its complications. Nypa fruticans is one of the plants that has the potential as an antidiabetic with high flavonoid content. The purpose of this study was to explore the potential of the ethyl acetate fraction of nipah fronds as an antidiabetic, especially in reducing blood glucose levels, stimulating insulin secretion, improving pancreatic β-cells and increasing the number of pancreatic β-cells. This study was an experimental study conducted in-vivo with a streptozotocin (STZ)-induced diabetic rat model. The ethyl acetate fraction of nipah fronds with doses of 125, 250 and 500 mg/kgBW was administered to STZ-induced diabetic rats 65 mg/kgBW with glibenclamide 0.45 mg/kgBW as a comparison for 21 days with observed parameters including serum insulin levels and histopathology. The results showed that administration of the ethyl acetate fraction of nipah fronds at doses of 250 and 500 mg/kgBW caused a significant decrease (p<0.05) in blood glucose levels with a significant increase (p<0.05) in serum insulin levels compared to the negative control. In a histopathological study of the pancreas, the ethyl acetate fraction showed a regenerative effect on pancreatic β-cells by reducing the degree of insulitis and significantly increasing (p<0.05) the number of pancreatic β-cells in the islets of Langerhans compared to the negative control. Based on these results, it can be concluded that administration of the ethyl acetate fraction of nipah fronds exhibits antihyperglycemic activity by regenerating pancreatic β-cells and increasing the number of pancreatic β-cells, thereby increasing serum insulin levels.Keywords: Nypa fruticans Wurmb; antidiabetic; insulin secretion; insulitis; pancreatic β-cells ABSTRAK Diabetes mellitus masih menjadi tantangan kesehatan secara global. Di Indonesia, diabetes menduduki peringkat ketiga sebagai penyakit pembunuh setelah penyakit jantung dan kanker. Flavonoid sebagai antioksidan alami terbukti efektif dalam mengurangi patogenesis diabetes dan komplikasinya. Nypa fruticans merupakan salah satu tanaman yang berpotensi sebagai antidiabetes dengan kandungan tinggi flavonoid. Tujuan penelitian ini adalah mengeksplorasi potensi fraksi etil asetat pelepah nipah sebagai antidiabetes khususnya dalam menurunkan kadar glukosa darah, stimulasi sekresi insulin, perbaikan sel β-pankreas dan peningkatan jumlah sel β-pankreas. Penelitian ini merupakan studi eksperimental yang dilakukan secara in-vivo dengan model tikus diabetes yang diinduksi streptozotocin (STZ). Fraksi etil asetat pelepah nipah dengan dosis 125, 250 dan 500 mg/kgBB diberikan pada tikus diabetes yang diinduksi STZ 65 mg/kg BB dengan glibenclamide 0,45 mg/kgBB sebagai pembanding selama 21 hari dengan parameter yang diamati meliputi kadar insulin serum, dan histopatologi pankreas. Hasil penelitian menunjukkan bahwa pemberian fraksi etil asetat pelepah nipah dengan dosis 250 dan 500 mg/kgBB menyebabkan penurunan signifikan (p <0,05) kadar glukosa darah dengan peningkatan signifikan (p <0,05) kadar insulin serum jika dibandingkan dengan kontrol negatif. Dalam studi histopatologi pankreas fraksi etil asetat menunjukkan efek regenerasi sel β-pankreas dengan menurunkan derajat insulitis dan peningkatan secara signifikan (p <0,05) jumlah sel β-pankreas pulau Langerhans jika dibanding kontrol negatif. Berdasarkan hasil tersebut dapat disimpulkan bahwa pemberian fraksi etil asetat pelepah nipah menunjukkan aktivitas antihiperglikemik dengan meregenerasi sel-sel β-pankreas dan meningkatkan jumlah sel β-pankreas, sehingga meningkatkan kadar insulin serum.Kata kunci: Nypa fruticans Wurmb; antidiabetes; sekresi insulin; insulitis; sel β-pankreas
Standardization and Antioxidant Activity Test of Karamunting Leaf Extract (Melastoma malabathricum L.) Using the DPPH Method Haryoto Haryoto; Ahmad Fauzi; Herda Ariyani; Danang Raharjo; Erlinda Novita Sari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1484

Abstract

Introduction: Karamunting leaves (Melastoma malabathricum L.) are a typical plant of Kalimantan, empirically used by local communities as traditional medicine to treat diarrhea, dysentery, vaginal discharge, mouth ulcers, and to enhance immune function. The presence of phenolic compounds, flavonoids, and saponins in karamunting leaves indicates their potential as natural antioxidant agents. Standardization of simplicia and extracts is an essential prerequisite to ensure the quality, safety, and consistency of traditional medicinal raw materials in a scientific and measurable manner. Objective: This study aimed to standardize the 70% ethanol extract of karamunting leaves through specific and non-specific parameter testing and to evaluate its antioxidant activity using the DPPH method. Methods: Extraction was performed using the maceration method with 70% ethanol solvent for 24 hours. Standardization included specific parameter tests (organoleptic and phytochemical screening) and non-specific parameter tests (water content, drying loss, total ash content, acid-insoluble ash content, heavy metal contamination of Pb and Cd, as well as ethanol-soluble and water-soluble extractive values) in accordance with the Indonesian Herbal Pharmacopoeia (FHI) Edition II standards. Antioxidant activity was assessed using the DPPH radical scavenging method and expressed as the IC₅₀ value. Results: The karamunting leaf extract exhibited a thick consistency, green color, characteristic odor, and bitter taste. Phytochemical screening showed positive results for phenolic compounds (blue-black coloration with FeCl₃) and flavonoids (orange coloration with Mg/HCl). Non-specific parameter testing revealed water content of 15.05±0.36%, drying loss of 6.54±0.51%, total ash content of 3.40±0.31%, acid-insoluble ash content of 0.79±0.02%, and ethanol-soluble and water-soluble extractive values of 98.52% and 96.60%, respectively. No Pb and Cd heavy metal contamination was detected. The antioxidant activity assay yielded an IC₅₀ value of 54.63±1.97 ppm, which falls into the strong antioxidant category, although it remained lower than vitamin C (IC₅₀=8.80±1.27 ppm). Conclusion: The karamunting leaf extract has met the quality parameter requirements according to FHI standards and demonstrates significant potential as a source of natural antioxidants. Further research is required for the identification of specific active compounds, quantitative heavy metal analysis using AAS, and in vivo activity testing to confirm its efficacy and safety.
IN VITRO POTENTIAL OF A-AMYLASE ENZYME INHIBITION OF A COMBINATION OF ETHANOL EXTRACT OF YAKON POTATO LEAVES (SMALLANTHUS SONCHIFOLIUS) AND KARAS TULANG ROOTS (CHLORANTHUS ERECTUS) AND ITS PHYTOCHEMICAL SCREENING Haryoto Haryoto; Dinda Nurochmah Mujiyati; Agustono Wibowo
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 3 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i3.4032

Abstract

Inhibiting carbohydrate-digesting enzymes such ?-amylase may help regulate type 2 diabetes mellitus, a long-term metabolic condition marked by continuous high blood sugar levels. The purpose of this research was to examine the phytochemical composition and in vitro ?-amylase inhibitory action of a mixture of yacon leaf (Smallanthus sonchifolius) and karas tulang root (Chloranthus erectus) ethanolic extracts. The plant materials were macerated in 70% ethanol to remove their constituent parts, and then the two extracts were mixed in a weight-for-weight ratio of 1:1. The DNS technique was used to assess the ?-amylase inhibitory activity, with acarbose as the positive control, and thin-layer chromatography was used for phytochemical screening. The yield of yacon leaves was 14.2% and that of karas tulang roots was 11.4% when extracted. There were terpenoids, polyphenols, alkaloids, flavonoids, and polyphenols found in the phytochemical screening. The combined extract exhibited an increase in ?-amylase inhibition ratio of 34.528 percent at 20 ppm to 90.359 percent at 200 ppm, which was concentration dependant. The combined extract had an IC?? value of 63.298 ± 0.162 ppm, while acarbose had an IC?? value of 43.183 ± 1.335 ppm. The inhibitory action of the combined extract was encouraging, even if it was not as strong as acarbose. These results indicate that a possible natural antidiabetic candidate might be created by combining yacon leaves and karas tulang roots via ?-amylase inhibition..
Potensi Antidiabetes Fraksi Etil Asetat dari Ekstrak Etanol Batang Ubi Yakon (Smallanthus sonchifolius) Secara in Vivo Alvira Efendi; Haryoto Haryoto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1150

Abstract

Diabetes mellitus is one of the global health problems that requires alternative therapies based on natural products. The stem of yacon (Smallanthus sonchifolius) is known to contain various secondary metabolites with potential antidiabetic effects. This study aimed to identify the secondary metabolites in the ethyl acetate fraction of yacon stem, evaluate its antidiabetic activity in alloxan-induced male Wistar rats, and determine the lowest effective dose. Phytochemical screening revealed the presence of flavonoids, terpenoids, steroids, tannins, and alkaloids. The in vivo test was conducted by administering the ethyl acetate fraction at doses of 25, 50, and 100 mg/kgBW to Wistar rats, with negative and positive control groups using metformin. The results showed that all treatment doses significantly reduced blood glucose levels compared to the negative control, with hypoglycemic effects observed from day 7 and becoming more pronounced until day 21. The 25 mg/kgBW dose was the lowest dose that produced effects comparable to metformin and thus can be considered the lowest effective dose. These findings indicate that yacon stem has the potential to be developed as a natural agent for antidiabetic therapy.
Pemberdayaan Kelompok Wanita Tani (KWT) melalui Budidaya dan Pengolahan TOGA Berbasis Ekonomi Kreatif di Desa Potronayan, Boyolali Haryoto Haryoto; Ahmad Fauzi; Ady Irawan; Danang Raharjo
Cakrawala: Jurnal Pengabdian Masyarakat Global Vol. 5 No. 3 (2026): Agustus: Cakrawala: Jurnal Pengabdian Masyarakat Global
Publisher : Universitas 45 Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30640/cakrawala.v5i3.7930

Abstract

This community service program aimed to empower the Women Farmers’ Group (Kelompok Wanita Tani/KWT) in Potronayan Village, Boyolali, through the cultivation and processing of Family Medicinal Plants (Tanaman Obat Keluarga/TOGA) based on a creative economy approach. The program was implemented through participatory, educational, and innovative methods involving training, mentoring, and direct practice. The activities focused on improving TOGA cultivation and diversification, developing processed products, strengthening simple business management, and improving product branding and marketing. The results showed that the KWT was able to cultivate seven types of TOGA, with 95% of members participating in the training activities. The program also produced three value-added TOGA products, namely herbal tea bags, instant herbal powder, and dried simplicia, marketed under the brand “Berkah TOGA.” In addition, improvements were achieved in financial administration, organizational management, packaging, and product branding. These activities demonstrate that TOGA can be developed not only as a source of family health but also as a potential resource for strengthening community-based creative economic activities. The integration of cultivation, processing, management, and marketing provides a foundation for sustainable empowerment and increased utilization of local resources in Potronayan Village.
Co-Authors A Anifatussaa'dah abdul, ahwan Abdul, Rasyid Aditya Naova Sofyan Ady Irawan Agustono Wibowo Agustono Wibowo Ahmad Fauzi Ahwanti Rukdiatma Nur’aini Alfa Frista Alvira Efendi Amalia Suci Medisusyanti Amaliyah Dina Anggraeni Andi Suhendi Andi Suhendi Ani Syafriati Annisa Meyndra Komala Aprilianingtyas, Tri Ardalia Rinanda Oktaviani Arly Syahputri , Janies Azzahra, Hanifa Putri Bama, Samsun Ari Bela Purnama Dewi Brillian Nur Diansari Broto Santoso Burhanudin Ichsan Cast Torizellia Chairunnisa, Alya Cita Hanif Muflihah Danang Raharjo Danang Raharjo Danang Raharjo Diah Siwi Ardiyani Dina Ayu Amalia Dinda Nurochmah Mujiyati Dwi Bagus Pambudi Dwi Sarbini Dyah Rahmawatie Ratna Budi Utami Dyera Forestryana Erika Nuur Anisa Putri Erlinda Novita Sari Erna Herawati Euis Holisotan Hakim Fahriza Mei Trihatmoko Fahrun Nur Rosyid Faridita khoirun Nisa' Fida' Husein Fida’ Husain Fidhia Nur Rifaini Firdaus, Gita Firstca Aulia Rachma Frida Rosenova Gita Firdaus Hafid Nugroho Hafiz Ramadhan Hafiz Ramadhan Haliza Arzeti Nurseptiria Haya Nabilah Utama Heng Yen Khong Henggar Prasetyo Wikan Saputro Herda Ariyani Hidayah Karuniawati Ida Maesaroh Ikhsan, Maulida Nur Jalifah Latip Joko Kristianto Khusnul Khotimah Kosworo Kosworo Laila Dzafira Leni Wijaya Lestari, Retna Dewi Lia Dewi Juliawaty Lina Ayu Kusumastuti Listiana Masyita Dewi Listyana Dewi Prastiwi Lusia, Eka Luthfiyyah Amalia Zahra Mariska Sri Harlianti Marlupi Dwi Lestari Marsilia Rosa Sinensis HI Maryatun maryatun maryatun Muhammad Irfan Muhammad Irfan Muhammad Priyadi Muhtadi Muhtadi Munti Sarida Niati Ambarsari Nugroho Adi Suseno Nursalinda Kusumawati Nuryanti, Yulia Dwi Nur’aini, Ahwanti Rukdiatma Peni Indrayudha Pramudya Kurnia Pratiwi Widowati Puguh Ika Listyorini Putri Agustina Putri, Annisa Nur Lathifah Amanda Raafika Studiviani Rahardian Surya Basusena Riska Rosita Rizki Ainun Fitriani Rosnah, Rosnah RR. Ella Evrita Hestiandari Rusdin Rauf Sabar Narimo Saputri, Luki Rahmadani Tulus Sayyidah Nurul Muslihah Sekarsari, Devina Sendy Pradila Putri Siyama, Anis Sjamsul Arifin Achmad Suranto Suranto Suranto Suranto Suranto, Choirun Nisa Sutama Syifa Aulia Paramitha Tanti Azizah Tanti Azizah Sujono Tanti Azizah Sujono Tia Mella Citra Tista Ayu Fortuna Tri Aprilianingtyas Triana Ariska Dewi Utomo, Chandra Wahyu Vitania Marsya Widowati, Pratiwi Wildan Firdaus, Muhammad Yana Maolana Syah Yulia Dwi Nuryanti Yuliana Dwi Jayanti Yurnanda Ambar Mustika Zahrah Luthfiatul Fadhilah