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Tati Herlina
Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran
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Dysobinol from Chisocheton macrophyllus Selectively Induces G1 Cell Cycle Arrest in MCF-7 Breast Cancer Cells Gaffar, Shabarni; Tambunan, Ghina Uli Felicia; Hafiz, Ersanda; Herlina, Tati; Wiraswati, Hesti Lina; Nurlelasari, Nurlelasari; Ma'ruf, Ilma Fauziah
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.100479

Abstract

Chisocheton macrophyllus is a medicinal plant that contains sesquiterpenoids, triterpenoids, limonoids, steroids, and phenolic compounds. This research aimed to assess the effect of Dysobinol, a limonoid compound from the seed of C. macrophyllus, on MCF-7 cell growth. Cell viability was evaluated using the MTS colorimetric assay, DNA fragmentation was assessed by agarose electrophoresis, apoptosis and cell cycle arrest were determined by flow cytometry, and gene expression levels were evaluated using qRT-PCR. Dysobinol was also analyzed in silico using drug-likeness, pharmacokinetic, and molecular docking analysis. Dysobinol demonstrated moderate cytotoxicity against MCF-7 cells, with an IC50 of 148.20 μg/mL. Dysobinol induced G1 phase cell cycle arrest that was not accompanied by the induction of apoptosis in MCF-7 cells. In silico studies showed that the EGFR/AKT/cyclin D1 proteins were affected by Dysobinol. Furthermore, drug-likeness and pharmacokinetics analysis showed that Dysobinol is bioavailable orally and has high gastrointestinal absorption and low penetration into the blood-brain barrier. Together, these results indicate that Dysobinol can regulate breast cancer cell proliferation through cell cycle arrest rather than apoptosis, and its pharmacological profile highlights its potential as a promising lead compound for anticancer drug development.
Pengaruh Konflik Kerja, Beban Kerja Dan Lingkungan Kerja Terhadap Stres Kerja Karyawan PT Thamrin Brothers Baturaja 2 Anita, Fitri; Herlina, Tati; Dahlia, Dahlia; Noviansyah, Noviansyah; Wiranawata, Hilmi
EKOMA : Jurnal Ekonomi, Manajemen, Akuntansi Vol. 5 No. 3: Maret 2026
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/ekoma.v5i3.14410

Abstract

Penelitian ini bertujuan untuk menganalisis pengaruh konflik kerja, beban kerja, dan lingkungan kerja terhadap stres kerja karyawan PT Thamrin Brothers Baturaja 2, baik secara parsial maupun simultan. Stres kerja merupakan salah satu permasalahan yang sering dihadapi karyawan akibat adanya perbedaan pendapat, tuntutan pekerjaan yang tinggi, serta kondisi lingkungan kerja yang kurang mendukung. Penelitian ini menggunakan metode kuantitatif dengan pendekatan survei. Data penelitian diperoleh melalui penyebaran kuesioner kepada seluruh karyawan yang berjumlah 31 responden. Instrumen penelitian terlebih dahulu diuji validitas dan reliabilitasnya untuk memastikan kelayakan data, kemudian dianalisis menggunakan metode regresi linier berganda. Hasil penelitian menunjukkan bahwa konflik kerja berpengaruh positif dan signifikan terhadap stres kerja karyawan. Ketidaksesuaian persepsi, komunikasi yang kurang efektif, serta perbedaan tujuan antar karyawan terbukti meningkatkan tekanan psikologis. Beban kerja juga memiliki pengaruh signifikan terhadap stres kerja, di mana tuntutan pekerjaan yang berlebihan, target yang tinggi, dan tekanan waktu menyebabkan kelelahan fisik maupun mental. Selain itu, lingkungan kerja berpengaruh signifikan terhadap stres kerja, terutama terkait kondisi fisik seperti suhu ruangan, tingkat kebisingan, dan kelengkapan fasilitas kerja. Secara simultan, konflik kerja, beban kerja, dan lingkungan kerja berpengaruh signifikan terhadap stres kerja karyawan. Oleh karena itu, perusahaan perlu melakukan pengelolaan konflik yang efektif, penyesuaian beban kerja, serta menciptakan lingkungan kerja yang nyaman guna menekan tingkat stres dan meningkatkan kinerja karyawan.
Co-Authors Ace Tatang Hidayat Achmad Rante Suparman, Achmad Rante Achmad Wahidy, Achmad Achmad Zainuddin Achmad Zainuddin Ade Akbar Abdilla Ade Kania Ningsih, Ade Kania Aditya Seiza Wibisono Adrian Nova, Gitta Destalya Ahmad Syahlani, Ahmad Ajeng Diantini, Ajeng Albayyinah, Dyandra Hera Alya Tsamrotul Amalia, Riezki Amir M. Suruwaky Anas Subarnas Aneu Wahyuni Anisa, Mutiara Apriani Sulu Parubak Apriani Sulu Parubak Apriani sulu parumbak Arif Rahman Hakim Arif Rahman Hakim Arif Rahman Hakim Azmi, Mohamad Nurul Binasthika, Tata Boima Ramses Situmeang Dadan Sumiarsa Dahlia Dahlia Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati Deden Deni Destiana . Dikdik Kurnia Elizabeth Fitriana Sari Ersanda Hafiz Euis Julaeha Euis Julaeha Faizal Hermanto Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fitri Anita, Fitri Gabriella Constantia Gultom, Angga Wibowo Hafiz, Ersanda Hamdi Hamdi HANA RATNAWATI Harizon Harizon Hesti Lina Wiraswati Hideo Hayashi Hideo Hayashi I Dewa Gde Sathya Deva Ida Indrawati Ida Nur Farida Indri Indriyani Indriyani, Indri Jihan Kadarusman Kansy Haikal Khadijah Awang Khairunnisa, Shofiyah Kindi Farabi Latifah Latifah Letmi Dwiridal Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah, Lilis Siti Ma'ruf, Ilma Fauziah Madihah Madihah Maesaroh Maesaroh Mohamad Nurzaman Muhammad Hanafi Muhammad Yudha Nugraha Murtihapsari . Nani Suryani Natalia, Titi Syahnaz Nayla Haraswati Niken Ayu Noor Rain Abdullah Noviansyah Noviansyah, Noviansyah Nurlelasari Nurlelasari Permadi, Nandang Putriani, Dyah Ayu Rabiulkhri, Mailani Radite Yogaswara Rahmawati Rahmawati RANI ANWAR, RANI Rian Prayudi Saputra Richa Mardianingrum Rima Melati Riza Apriani Riza Apriani Riza Apriani Riza Yulisar Rosmala Dewi Sari Purbaya Sari, Palupi Indah Satwika Nandiwardhana Shabarni Gaffar Shindi Zahra Shiono, Yoshihito Silfina Agustin Sinaga, Siska Elisahbet Supriatno Supriatno Supriyatna Sutardjo Supriyatna Sutardjo Suseno Amien Syafriani Syafriani, Syafriani Syafruddin Syafruddin Syarwani Ahmad Tambunan, Ghina Uli Felicia Tarso Rudiana, Tarso Tjomiadi, Cynthia Eka Fayuning Tri Mayanti Tri Rahayu Hidayat Tri Reksa Saputra Tri Reksa Saputra, Tri Reksa Tusri, Yudi Unang Supratman Vicki Nishinarizki Wahyu Widowati Wahyuni, Aneu Wibisono, Aditya Seiza Widayat, Agung Wiranawata, Hilmi Witriany Rayapratiwi Wulanda, Nourma Yasmiwar Susilawati Yenny Febriani Yun Yenny Febriani Yun, Yenny Febriani Yulisar, Riza Yunita Sari Zalinar Udin